Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
Navigation
Downloads
Results for TCF3_MYOG
Z-value: 1.19
Motif logo
Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF3 | hg19_v2_chr19_-_1650666_1650744 | 0.78 | 3.6e-07 | Click! |
| MYOG | hg19_v2_chr1_-_203055129_203055164 | -0.04 | 8.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 46.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.2 | 16.1 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 2.9 | 14.7 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.1 | 12.4 | GO:0030308 | negative regulation of cell growth(GO:0030308) |
| 0.2 | 10.9 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 9.9 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.9 | 9.6 | GO:0007144 | female meiosis I(GO:0007144) |
| 1.2 | 7.2 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
| 0.1 | 6.5 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.2 | 5.7 | GO:0070831 | basement membrane assembly(GO:0070831) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 42.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 17.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 13.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 12.9 | GO:0000922 | spindle pole(GO:0000922) |
| 0.7 | 12.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 11.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 10.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 8.4 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 7.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 5.5 | GO:0030673 | axolemma(GO:0030673) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 3.7 | 14.7 | GO:0030395 | lactose binding(GO:0030395) |
| 0.1 | 11.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 10.5 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 8.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 7.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.7 | 7.2 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.1 | 7.2 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 5.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 5.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 12.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 11.6 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.7 | 9.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 8.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 7.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 6.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 5.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 4.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.7 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.4 | 9.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 7.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.3 | 6.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 6.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 5.4 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 4.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 4.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.1 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 4.0 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |