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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TCF7L2

Z-value: 0.43

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Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
TCF7L2
ENSG00000148737.11 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114710516_1147106750.301.1e-01Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_24144509 1.59 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr17_-_63557309 1.44 ENST00000580513.1
AXIN2
axin 2
chr17_-_63556414 1.36 ENST00000585045.1
AXIN2
axin 2
chr13_+_24144796 1.24 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_-_36429763 1.01 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr17_-_63557759 0.84 ENST00000307078.5
AXIN2
axin 2
chr17_+_68100989 0.83 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr3_-_45957088 0.73 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr1_+_61330931 0.69 ENST00000371191.1
NFIA
nuclear factor I/A
chr20_+_18794370 0.68 ENST00000377428.2
SCP2D1
SCP2 sterol-binding domain containing 1
chr1_+_162351503 0.63 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr2_+_204801471 0.63 ENST00000316386.6
ENST00000435193.1
ICOS
inducible T-cell co-stimulator
chr3_-_45957534 0.61 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr17_-_39165366 0.55 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr10_+_114133773 0.50 ENST00000354655.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_123542224 0.50 ENST00000264497.3
IL21
interleukin 21
chr12_-_49582978 0.47 ENST00000301071.7
TUBA1A
tubulin, alpha 1a
chr15_-_93632421 0.44 ENST00000329082.7
RGMA
repulsive guidance molecule family member a
chrX_-_43832711 0.44 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr2_+_69240302 0.42 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr11_-_62474803 0.42 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_+_19222479 0.40 ENST00000568433.1
SYT17
synaptotagmin XVII
chr17_-_46035187 0.40 ENST00000300557.2
PRR15L
proline rich 15-like
chr11_-_108422926 0.39 ENST00000428840.1
ENST00000526312.1
EXPH5
exophilin 5
chr6_+_12717892 0.38 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr10_+_7745232 0.37 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_-_25702669 0.35 ENST00000446840.1
AC003090.1
AC003090.1
chr3_+_137483579 0.33 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr9_-_130712995 0.32 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr9_-_27005686 0.31 ENST00000380055.5
LRRC19
leucine rich repeat containing 19
chr10_-_61900762 0.31 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr13_-_67802549 0.30 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr20_-_13971255 0.30 ENST00000284951.5
ENST00000378072.5
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr12_-_6982442 0.29 ENST00000523102.1
ENST00000524270.1
ENST00000519357.1
SPSB2
splA/ryanodine receptor domain and SOCS box containing 2
chr22_+_29279552 0.29 ENST00000544604.2
ZNRF3
zinc and ring finger 3
chr6_-_11779840 0.28 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr12_+_1738363 0.28 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr1_-_40367668 0.27 ENST00000397332.2
ENST00000429311.1
MYCL
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
chrX_+_15525426 0.27 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr9_-_32635667 0.26 ENST00000242310.4
TAF1L
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
chr17_+_59529743 0.25 ENST00000589003.1
ENST00000393853.4
TBX4
T-box 4
chr15_-_82338460 0.25 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chrX_-_100183894 0.25 ENST00000328526.5
ENST00000372956.2
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr11_-_41481135 0.25 ENST00000528697.1
ENST00000530763.1
LRRC4C
leucine rich repeat containing 4C
chr14_-_61124977 0.25 ENST00000554986.1
SIX1
SIX homeobox 1
chr5_+_133450365 0.24 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr12_-_23737534 0.24 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr13_+_76334498 0.23 ENST00000534657.1
LMO7
LIM domain 7
chr2_-_71357344 0.23 ENST00000494660.2
ENST00000244217.5
ENST00000486135.1
MCEE
methylmalonyl CoA epimerase
chrX_-_10588595 0.23 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr11_-_40315640 0.23 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr8_-_16859690 0.23 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr8_-_95220775 0.23 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr12_+_6982725 0.23 ENST00000433346.1
LRRC23
leucine rich repeat containing 23
chr14_-_53258180 0.22 ENST00000554230.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr16_-_73082274 0.22 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr7_+_27282319 0.22 ENST00000222761.3
EVX1
even-skipped homeobox 1
chrX_-_10588459 0.21 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr16_+_53242350 0.20 ENST00000565442.1
CHD9
chromodomain helicase DNA binding protein 9
chr17_-_56065484 0.20 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr15_+_43885252 0.20 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr5_-_111093167 0.20 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr11_+_7597639 0.20 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_86525299 0.20 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr4_-_85419603 0.19 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr15_+_43985084 0.19 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr1_-_115053781 0.19 ENST00000358465.2
ENST00000369543.2
TRIM33
tripartite motif containing 33
chr1_+_147013182 0.18 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr3_+_29323043 0.18 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr3_+_183353356 0.17 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr21_-_32185570 0.17 ENST00000329621.4
KRTAP8-1
keratin associated protein 8-1
chr15_+_43985725 0.17 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr11_-_76155700 0.16 ENST00000572035.1
RP11-111M22.3
RP11-111M22.3
chr8_+_29952914 0.16 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr5_-_160973649 0.16 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr1_-_32801825 0.16 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr2_+_69240415 0.16 ENST00000409829.3
ANTXR1
anthrax toxin receptor 1
chr2_+_71357434 0.16 ENST00000244230.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr1_+_223101757 0.15 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr17_-_38256973 0.15 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr7_+_99613195 0.15 ENST00000324306.6
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr20_+_57875658 0.15 ENST00000371025.3
EDN3
endothelin 3
chr18_-_52989217 0.14 ENST00000570287.2
TCF4
transcription factor 4
chr5_+_175288631 0.14 ENST00000509837.1
CPLX2
complexin 2
chr4_-_69215699 0.14 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr17_+_1674982 0.14 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_-_15510287 0.13 ENST00000397519.2
PSIP1
PC4 and SFRS1 interacting protein 1
chr4_+_30721968 0.13 ENST00000361762.2
PCDH7
protocadherin 7
chr5_+_149546334 0.13 ENST00000231656.8
CDX1
caudal type homeobox 1
chr10_+_114710425 0.13 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr2_+_71357744 0.13 ENST00000498451.2
MPHOSPH10
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr4_+_170581213 0.13 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr4_+_95972822 0.13 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr5_+_102201509 0.12 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr2_+_69240511 0.12 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr8_-_42234745 0.12 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr1_-_201096312 0.12 ENST00000449188.2
ASCL5
achaete-scute family bHLH transcription factor 5
chr1_+_207039154 0.12 ENST00000367096.3
ENST00000391930.2
IL20
interleukin 20
chr12_+_85673868 0.12 ENST00000316824.3
ALX1
ALX homeobox 1
chr7_+_99613212 0.12 ENST00000426572.1
ENST00000535170.1
ZKSCAN1
zinc finger with KRAB and SCAN domains 1
chr6_-_25930819 0.11 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr2_+_89890533 0.11 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr14_-_75179774 0.11 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr9_+_136399929 0.11 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chrX_-_122866874 0.11 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr15_-_90294523 0.11 ENST00000300057.4
MESP1
mesoderm posterior 1 homolog (mouse)
chr12_+_31477250 0.11 ENST00000313737.4
AC024940.1
AC024940.1
chr5_-_24645078 0.11 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr11_-_76155618 0.11 ENST00000530759.1
RP11-111M22.3
RP11-111M22.3
chr15_-_65670360 0.11 ENST00000327987.4
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr5_+_102201430 0.10 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr10_+_114710516 0.10 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr17_+_79679299 0.10 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr6_-_112575838 0.10 ENST00000455073.1
LAMA4
laminin, alpha 4
chr6_-_25930904 0.10 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr11_-_62572901 0.10 ENST00000439713.2
ENST00000531131.1
ENST00000530875.1
ENST00000531709.2
ENST00000294172.2
NXF1
nuclear RNA export factor 1
chr1_-_231005310 0.10 ENST00000470540.1
C1orf198
chromosome 1 open reading frame 198
chr5_+_170846640 0.10 ENST00000274625.5
FGF18
fibroblast growth factor 18
chrX_-_47004437 0.10 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr5_-_153857819 0.10 ENST00000231121.2
HAND1
heart and neural crest derivatives expressed 1
chr2_+_177028805 0.10 ENST00000249440.3
HOXD3
homeobox D3
chr17_-_39316983 0.09 ENST00000390661.3
KRTAP4-4
keratin associated protein 4-4
chr2_+_201936458 0.09 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr6_-_28220002 0.09 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr10_-_104179682 0.09 ENST00000406432.1
PSD
pleckstrin and Sec7 domain containing
chrX_+_152760397 0.09 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chr5_+_140235469 0.09 ENST00000506939.2
ENST00000307360.5
PCDHA10
protocadherin alpha 10
chr18_+_46065483 0.09 ENST00000382998.4
CTIF
CBP80/20-dependent translation initiation factor
chr19_-_3061397 0.08 ENST00000586839.1
AES
amino-terminal enhancer of split
chr3_-_42452050 0.08 ENST00000441172.1
ENST00000287748.3
LYZL4
lysozyme-like 4
chr20_+_57875457 0.08 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr5_+_175815732 0.08 ENST00000274787.2
HIGD2A
HIG1 hypoxia inducible domain family, member 2A
chr7_+_80275621 0.08 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr12_-_49582593 0.08 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr6_-_11779174 0.07 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr17_+_37618257 0.07 ENST00000447079.4
CDK12
cyclin-dependent kinase 12
chr1_-_40367530 0.07 ENST00000372816.2
ENST00000372815.1
MYCL
v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
chr6_+_132873832 0.07 ENST00000275200.1
TAAR8
trace amine associated receptor 8
chr7_+_150076406 0.07 ENST00000329630.5
ZNF775
zinc finger protein 775
chr20_+_57875758 0.07 ENST00000395654.3
EDN3
endothelin 3
chr11_+_45944190 0.07 ENST00000401752.1
ENST00000389968.3
ENST00000325468.5
ENST00000536139.1
GYLTL1B
glycosyltransferase-like 1B
chr1_+_16330723 0.06 ENST00000329454.2
C1orf64
chromosome 1 open reading frame 64
chr6_-_89927151 0.06 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr9_+_125796806 0.06 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr19_+_50084561 0.06 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr7_+_80275752 0.06 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr3_-_134093395 0.06 ENST00000249883.5
AMOTL2
angiomotin like 2
chr14_+_75230011 0.06 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr8_-_119964434 0.06 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr22_+_31742875 0.06 ENST00000504184.2
AC005003.1
CDNA FLJ20464 fis, clone KAT06158; HCG1777549; Uncharacterized protein
chrX_-_47004878 0.06 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr13_-_72440901 0.06 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr13_+_76334795 0.05 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr12_+_52056548 0.05 ENST00000545061.1
ENST00000355133.3
SCN8A
sodium channel, voltage gated, type VIII, alpha subunit
chr3_+_174577070 0.05 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr4_-_69215467 0.05 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr10_+_114710211 0.05 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr13_-_72441315 0.05 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr5_+_66300446 0.05 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_+_80416482 0.05 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr18_+_46065393 0.04 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr12_-_31477072 0.04 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr1_-_160549235 0.04 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chr5_-_175815565 0.04 ENST00000509257.1
ENST00000507413.1
ENST00000510123.1
NOP16
NOP16 nucleolar protein
chrX_+_100646190 0.04 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr1_-_20250110 0.04 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr7_+_73868439 0.04 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr1_-_11907829 0.04 ENST00000376480.3
NPPA
natriuretic peptide A
chr10_+_7745303 0.04 ENST00000429820.1
ENST00000379587.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_112575758 0.04 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr2_+_201936707 0.04 ENST00000433898.1
ENST00000454214.1
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr7_+_80275953 0.03 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr7_-_27219849 0.03 ENST00000396344.4
HOXA10
homeobox A10
chr22_-_32860427 0.03 ENST00000534972.1
ENST00000397450.1
ENST00000397452.1
BPIFC
BPI fold containing family C
chrX_-_110655306 0.03 ENST00000371993.2
DCX
doublecortin
chr2_-_80531399 0.03 ENST00000409148.1
ENST00000415098.1
ENST00000452811.1
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr2_+_171571827 0.03 ENST00000375281.3
SP5
Sp5 transcription factor
chr20_+_59654146 0.03 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr11_-_6677018 0.03 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chrX_-_39956656 0.02 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr17_-_39646116 0.02 ENST00000328119.6
KRT36
keratin 36
chr2_+_33701286 0.02 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr6_-_32083106 0.02 ENST00000442721.1
TNXB
tenascin XB
chr12_-_54694807 0.02 ENST00000435572.2
NFE2
nuclear factor, erythroid 2
chr14_+_32798462 0.02 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_204732487 0.02 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr13_+_76334567 0.02 ENST00000321797.8
LMO7
LIM domain 7
chrX_+_54835493 0.01 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr10_-_87551311 0.01 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr10_+_114709999 0.01 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr6_+_152130240 0.01 ENST00000427531.2
ESR1
estrogen receptor 1
chr10_-_104192405 0.01 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr6_+_29427548 0.01 ENST00000377132.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chrX_+_100645812 0.01 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr1_+_154244987 0.01 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr15_+_57511609 0.01 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12
transcription factor 12
chr17_-_67138015 0.00 ENST00000284425.2
ENST00000590645.1
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr14_+_32798547 0.00 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_148725733 0.00 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr16_+_29819372 0.00 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.4 1.3 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.2 0.7 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.1 0.4 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.3 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.3 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.3 GO:2000051 Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0018032 protein amidation(GO:0018032)
0.1 0.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0060086 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.3 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.2 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0003241 growth involved in heart morphogenesis(GO:0003241) cardiac cell fate determination(GO:0060913) negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.0 0.6 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.4 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.1 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.0 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:2000332 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 1.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 2.3 GO:0001942 hair follicle development(GO:0001942)
0.0 0.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.8 GO:0010107 potassium ion import(GO:0010107)
0.0 0.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 0.1 GO:0043203 axon hillock(GO:0043203)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.6 GO:0070411 I-SMAD binding(GO:0070411)
0.1 2.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.3 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.5 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0097100 supercoiled DNA binding(GO:0097100)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins