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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TEAD3_TEAD1
Z-value: 1.02
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Transcription factors associated with TEAD3_TEAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD3 | hg19_v2_chr6_-_35464727_35464738, hg19_v2_chr6_-_35464817_35464894 | 0.48 | 6.9e-03 | Click! |
| TEAD1 | hg19_v2_chr11_+_12695944_12695989 | 0.42 | 2.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51472031 Show fit | 8.47 |
ENST00000391808.1
|
kallikrein-related peptidase 6 |
|
| chr19_-_51472222 Show fit | 8.05 |
ENST00000376851.3
|
kallikrein-related peptidase 6 |
|
| chr10_-_90712520 Show fit | 5.48 |
ENST00000224784.6
|
actin, alpha 2, smooth muscle, aorta |
|
| chr9_-_139891165 Show fit | 4.78 |
ENST00000494426.1
|
chloride intracellular channel 3 |
|
| chr15_+_39873268 Show fit | 3.68 |
ENST00000397591.2
ENST00000260356.5 |
thrombospondin 1 |
|
| chr19_-_51512804 Show fit | 3.09 |
ENST00000594211.1
ENST00000376832.4 |
kallikrein-related peptidase 9 |
|
| chr19_+_45409011 Show fit | 2.80 |
ENST00000252486.4
ENST00000446996.1 ENST00000434152.1 |
apolipoprotein E |
|
| chr19_-_51504411 Show fit | 2.78 |
ENST00000593490.1
|
kallikrein-related peptidase 8 |
|
| chr7_+_134464376 Show fit | 2.73 |
ENST00000454108.1
ENST00000361675.2 |
caldesmon 1 |
|
| chr7_+_134464414 Show fit | 2.72 |
ENST00000361901.2
|
caldesmon 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 16.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.0 | 5.8 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.3 | 5.1 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 4.9 | GO:0035878 | nail development(GO:0035878) |
| 0.6 | 4.6 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.0 | 4.1 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 1.2 | 3.7 | GO:0002605 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605) |
| 0.0 | 3.7 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.4 | 3.5 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 3.3 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.9 | GO:0030141 | secretory granule(GO:0030141) |
| 0.5 | 7.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 6.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.5 | 6.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.9 | 5.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 5.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 4.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 4.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 4.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 3.6 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 7.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 7.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 4.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 4.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 4.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 3.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.2 | 3.7 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.0 | 3.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 3.6 | GO:0038132 | neuregulin binding(GO:0038132) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.2 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 10.1 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 8.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 4.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 4.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 3.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 2.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 2.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 2.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 12.0 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 4.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 4.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.6 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 3.1 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 2.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 2.6 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 2.6 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |