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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TFAP2E

Z-value: 0.41

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.384.1e-02Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_65503801 1.09 ENST00000261883.4
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr19_+_45504688 0.94 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr2_+_38893208 0.85 ENST00000410063.1
galactose mutarotase (aldose 1-epimerase)
chr19_-_35981358 0.64 ENST00000484218.2
ENST00000338897.3
keratinocyte differentiation-associated protein
chr1_-_151778630 0.57 ENST00000368820.3
leucine rich repeat and Ig domain containing 4
chr11_-_82612727 0.45 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
prolylcarboxypeptidase (angiotensinase C)
chr5_-_179499108 0.39 ENST00000521389.1
ring finger protein 130
chr19_-_54676884 0.39 ENST00000376591.4
transmembrane channel-like 4
chr5_-_179499086 0.38 ENST00000261947.4
ring finger protein 130
chr19_-_54676846 0.37 ENST00000301187.4
transmembrane channel-like 4
chr12_-_15942503 0.37 ENST00000281172.5
epidermal growth factor receptor pathway substrate 8
chr17_+_72428218 0.35 ENST00000392628.2
G protein-coupled receptor, family C, group 5, member C
chr14_-_25519095 0.33 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
syntaxin binding protein 6 (amisyn)
chr19_-_11039188 0.33 ENST00000588347.1
Yip1 domain family, member 2
chr14_-_25519317 0.32 ENST00000323944.5
syntaxin binding protein 6 (amisyn)
chr12_-_15942309 0.32 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
epidermal growth factor receptor pathway substrate 8
chr2_-_45236540 0.31 ENST00000303077.6
SIX homeobox 2
chr1_-_32801825 0.31 ENST00000329421.7
MARCKS-like 1
chr2_-_174828892 0.31 ENST00000418194.2
Sp3 transcription factor
chr1_+_211433275 0.29 ENST00000367005.4
REST corepressor 3
chr9_-_86432547 0.28 ENST00000376365.3
ENST00000376371.2
G kinase anchoring protein 1
chr2_+_38893047 0.26 ENST00000272252.5
galactose mutarotase (aldose 1-epimerase)
chr2_+_232573208 0.26 ENST00000409115.3
prothymosin, alpha
chr20_+_55205825 0.24 ENST00000544508.1
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chrX_+_128872998 0.23 ENST00000371106.3
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr2_+_232573222 0.23 ENST00000341369.7
ENST00000409683.1
prothymosin, alpha
chrX_-_124097620 0.23 ENST00000371130.3
ENST00000422452.2
teneurin transmembrane protein 1
chr17_-_39769005 0.21 ENST00000301653.4
ENST00000593067.1
keratin 16
chr1_+_17634689 0.20 ENST00000375453.1
ENST00000375448.4
peptidyl arginine deiminase, type IV
chr17_+_37824700 0.20 ENST00000581428.1
phenylethanolamine N-methyltransferase
chr3_+_49591881 0.18 ENST00000296452.4
bassoon presynaptic cytomatrix protein
chr16_+_69599861 0.17 ENST00000354436.2
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69599899 0.17 ENST00000567239.1
nuclear factor of activated T-cells 5, tonicity-responsive
chr3_+_32280159 0.17 ENST00000458535.2
ENST00000307526.3
CKLF-like MARVEL transmembrane domain containing 8
chr16_+_69600058 0.16 ENST00000393742.2
nuclear factor of activated T-cells 5, tonicity-responsive
chr22_+_31608219 0.16 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIM domain kinase 2
chr3_-_136471204 0.16 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
stromal antigen 1
chr11_-_118305921 0.15 ENST00000532619.1
RP11-770J1.4
chr17_-_42992856 0.15 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
glial fibrillary acidic protein
chr20_+_36888551 0.14 ENST00000418004.1
ENST00000451435.1
bactericidal/permeability-increasing protein
chr3_+_105086056 0.14 ENST00000472644.2
activated leukocyte cell adhesion molecule
chr12_+_75784850 0.14 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLI pathogenesis-related 1 like 2
chr11_+_64009072 0.14 ENST00000535135.1
ENST00000394540.3
FK506 binding protein 2, 13kDa
chr1_+_152943122 0.14 ENST00000328051.2
small proline-rich protein 4
chrX_+_152990302 0.13 ENST00000218104.3
ATP-binding cassette, sub-family D (ALD), member 1
chr1_-_201346761 0.13 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
troponin T type 2 (cardiac)
chr19_+_36195429 0.13 ENST00000392197.2
zinc finger and BTB domain containing 32
chrX_+_51636629 0.12 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
melanoma antigen family D, 1
chr10_-_112678976 0.12 ENST00000448814.1
BBSome interacting protein 1
chr12_-_65153175 0.12 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
glucosamine (N-acetyl)-6-sulfatase
chr12_+_53773944 0.11 ENST00000551969.1
ENST00000327443.4
Sp1 transcription factor
chr17_-_47755436 0.11 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
speckle-type POZ protein
chr10_-_98480243 0.11 ENST00000339364.5
phosphoinositide-3-kinase adaptor protein 1
chr16_-_28506840 0.11 ENST00000569430.1
ceroid-lipofuscinosis, neuronal 3
chr17_+_48423453 0.11 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
xylosyltransferase II
chr1_+_233749739 0.11 ENST00000366621.3
potassium channel, subfamily K, member 1
chr22_+_31644388 0.10 ENST00000333611.4
ENST00000340552.4
LIM domain kinase 2
chr1_+_9599540 0.10 ENST00000302692.6
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chrX_+_152783131 0.10 ENST00000349466.2
ENST00000370186.1
ATPase, Ca++ transporting, plasma membrane 3
chr9_+_19230433 0.10 ENST00000434457.2
ENST00000602925.1
DENN/MADD domain containing 4C
chr8_+_146277764 0.10 ENST00000331434.6
chromosome 8 open reading frame 33
chr5_-_179498703 0.10 ENST00000522208.2
ring finger protein 130
chr19_-_46389359 0.10 ENST00000302165.3
interferon regulatory factor 2 binding protein 1
chr3_+_4535025 0.09 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
inositol 1,4,5-trisphosphate receptor, type 1
chr19_-_11039261 0.09 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
Yip1 domain family, member 2
chr1_+_35225339 0.09 ENST00000339480.1
gap junction protein, beta 4, 30.3kDa
chr2_-_24149977 0.09 ENST00000238789.5
ATPase family, AAA domain containing 2B
chr11_+_63974135 0.09 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
fermitin family member 3
chr19_+_50936142 0.08 ENST00000357701.5
myosin binding protein C, fast type
chr3_-_55521323 0.08 ENST00000264634.4
wingless-type MMTV integration site family, member 5A
chr19_+_36195467 0.08 ENST00000426659.2
zinc finger and BTB domain containing 32
chr10_+_99894380 0.08 ENST00000370584.3
R3H domain and coiled-coil containing 1-like
chr7_+_100464760 0.08 ENST00000200457.4
thyroid hormone receptor interactor 6
chr20_+_58508817 0.08 ENST00000358293.3
family with sequence similarity 217, member B
chr3_+_110790590 0.08 ENST00000485303.1
poliovirus receptor-related 3
chr8_+_125463048 0.07 ENST00000328599.3
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr1_-_154531095 0.07 ENST00000292211.4
ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_52813932 0.07 ENST00000537050.1
inter-alpha-trypsin inhibitor heavy chain 1
chr10_-_112678692 0.07 ENST00000605742.1
BBSome interacting protein 1
chr5_-_179719048 0.07 ENST00000523583.1
ENST00000393360.3
ENST00000455781.1
ENST00000347470.4
ENST00000452135.2
ENST00000343111.6
mitogen-activated protein kinase 9
chrX_-_118826784 0.07 ENST00000394616.4
septin 6
chr5_+_176237478 0.06 ENST00000329542.4
unc-5 homolog A (C. elegans)
chr3_+_155860751 0.06 ENST00000471742.1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_901847 0.06 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
pleckstrin homology domain containing, family N member 1
chr19_+_3572758 0.05 ENST00000416526.1
high mobility group 20B
chr1_+_9005917 0.05 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
carbonic anhydrase VI
chr1_+_104068562 0.05 ENST00000423855.2
RNA-binding region (RNP1, RRM) containing 3
chr5_+_133984462 0.05 ENST00000398844.2
ENST00000322887.4
SEC24 family member A
chr10_-_112678904 0.05 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBSome interacting protein 1
chr12_-_48213568 0.04 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
histone deacetylase 7
chr1_+_150122034 0.04 ENST00000025469.6
ENST00000369124.4
pleckstrin homology domain containing, family O member 1
chr4_+_41992489 0.04 ENST00000264451.7
solute carrier family 30 (zinc transporter), member 9
chr20_-_30539773 0.04 ENST00000202017.4
p53 and DNA-damage regulated 1
chr17_+_37824411 0.04 ENST00000269582.2
phenylethanolamine N-methyltransferase
chr17_-_47755338 0.04 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
speckle-type POZ protein
chr8_+_17780346 0.04 ENST00000325083.8
pericentriolar material 1
chr11_-_66056596 0.04 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
Yip1 interacting factor homolog A (S. cerevisiae)
chr1_+_104068312 0.04 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNA-binding region (RNP1, RRM) containing 3
chr10_+_99894399 0.04 ENST00000298999.3
ENST00000314594.5
R3H domain and coiled-coil containing 1-like
chr19_-_43969796 0.04 ENST00000244333.3
LY6/PLAUR domain containing 3
chr11_-_47869865 0.03 ENST00000530326.1
ENST00000532747.1
nucleoporin 160kDa
chr20_-_13619550 0.03 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
taspase, threonine aspartase, 1
chr2_+_232572361 0.03 ENST00000409321.1
prothymosin, alpha
chr17_+_37824217 0.03 ENST00000394246.1
phenylethanolamine N-methyltransferase
chr11_-_47870019 0.03 ENST00000378460.2
nucleoporin 160kDa
chr1_+_43148625 0.02 ENST00000436427.1
Y box binding protein 1
chr9_+_128024067 0.02 ENST00000461379.1
ENST00000394084.1
ENST00000394105.2
ENST00000470056.1
ENST00000394104.2
ENST00000265956.4
ENST00000394083.2
ENST00000495955.1
ENST00000467750.1
ENST00000297933.6
GTPase activating protein and VPS9 domains 1
chr1_+_182584314 0.02 ENST00000566297.1
RP11-317P15.4
chr1_-_114355083 0.02 ENST00000261441.5
round spermatid basic protein 1
chr19_+_3572925 0.02 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
high mobility group 20B
chr6_+_37787262 0.01 ENST00000287218.4
zinc finger, AN1-type domain 3
chr13_-_76056250 0.01 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1 domain family, member 4
chr6_+_42531798 0.01 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
ubiquitin protein ligase E3 component n-recognin 2
chr14_-_64010046 0.01 ENST00000337537.3
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr3_+_51428704 0.01 ENST00000323686.4
RNA binding motif protein 15B
chr2_-_241831424 0.01 ENST00000402775.2
ENST00000307486.8
chromosome 2 open reading frame 54
chr20_-_25371412 0.01 ENST00000339157.5
ENST00000376542.3
abhydrolase domain containing 12
chr10_-_108924284 0.01 ENST00000344440.6
ENST00000263054.6
sortilin-related VPS10 domain containing receptor 1
chr19_+_11039391 0.01 ENST00000270502.6
chromosome 19 open reading frame 52
chr22_+_35653445 0.01 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMG box domain containing 4
chr3_+_4535155 0.01 ENST00000544951.1
inositol 1,4,5-trisphosphate receptor, type 1
chr1_-_231175964 0.00 ENST00000366654.4
family with sequence similarity 89, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.7 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.5 GO:0002254 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 1.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.3 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.1 0.9 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:0061346 cardiac right atrium morphogenesis(GO:0003213) negative regulation of melanin biosynthetic process(GO:0048022) positive regulation of anagen(GO:0051885) mediolateral intercalation(GO:0060031) cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) negative regulation of secondary metabolite biosynthetic process(GO:1900377) regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.5 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0005940 septin ring(GO:0005940) septin collar(GO:0032173)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.3 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.1 1.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis