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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TFAP2E

Z-value: 0.41

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.384.1e-02Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_65503801 1.09 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr19_+_45504688 0.94 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr2_+_38893208 0.85 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr19_-_35981358 0.64 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr1_-_151778630 0.57 ENST00000368820.3
LINGO4
leucine rich repeat and Ig domain containing 4
chr11_-_82612727 0.45 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr5_-_179499108 0.39 ENST00000521389.1
RNF130
ring finger protein 130
chr19_-_54676884 0.39 ENST00000376591.4
TMC4
transmembrane channel-like 4
chr5_-_179499086 0.38 ENST00000261947.4
RNF130
ring finger protein 130
chr19_-_54676846 0.37 ENST00000301187.4
TMC4
transmembrane channel-like 4
chr12_-_15942503 0.37 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr17_+_72428218 0.35 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_25519095 0.33 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr19_-_11039188 0.33 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr14_-_25519317 0.32 ENST00000323944.5
STXBP6
syntaxin binding protein 6 (amisyn)
chr12_-_15942309 0.32 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr2_-_45236540 0.31 ENST00000303077.6
SIX2
SIX homeobox 2
chr1_-_32801825 0.31 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr2_-_174828892 0.31 ENST00000418194.2
SP3
Sp3 transcription factor
chr1_+_211433275 0.29 ENST00000367005.4
RCOR3
REST corepressor 3
chr9_-_86432547 0.28 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr2_+_38893047 0.26 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr2_+_232573208 0.26 ENST00000409115.3
PTMA
prothymosin, alpha
chr20_+_55205825 0.24 ENST00000544508.1
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chrX_+_128872998 0.23 ENST00000371106.3
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr2_+_232573222 0.23 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chrX_-_124097620 0.23 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr17_-_39769005 0.21 ENST00000301653.4
ENST00000593067.1
KRT16
keratin 16
chr1_+_17634689 0.20 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr17_+_37824700 0.20 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr3_+_49591881 0.18 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr16_+_69599861 0.17 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69599899 0.17 ENST00000567239.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr3_+_32280159 0.17 ENST00000458535.2
ENST00000307526.3
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr16_+_69600058 0.16 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr22_+_31608219 0.16 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIMK2
LIM domain kinase 2
chr3_-_136471204 0.16 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
STAG1
stromal antigen 1
chr11_-_118305921 0.15 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr17_-_42992856 0.15 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr20_+_36888551 0.14 ENST00000418004.1
ENST00000451435.1
BPI
bactericidal/permeability-increasing protein
chr3_+_105086056 0.14 ENST00000472644.2
ALCAM
activated leukocyte cell adhesion molecule
chr12_+_75784850 0.14 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr11_+_64009072 0.14 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr1_+_152943122 0.14 ENST00000328051.2
SPRR4
small proline-rich protein 4
chrX_+_152990302 0.13 ENST00000218104.3
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr1_-_201346761 0.13 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
TNNT2
troponin T type 2 (cardiac)
chr19_+_36195429 0.13 ENST00000392197.2
ZBTB32
zinc finger and BTB domain containing 32
chrX_+_51636629 0.12 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr10_-_112678976 0.12 ENST00000448814.1
BBIP1
BBSome interacting protein 1
chr12_-_65153175 0.12 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
GNS
glucosamine (N-acetyl)-6-sulfatase
chr12_+_53773944 0.11 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr17_-_47755436 0.11 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP
speckle-type POZ protein
chr10_-_98480243 0.11 ENST00000339364.5
PIK3AP1
phosphoinositide-3-kinase adaptor protein 1
chr16_-_28506840 0.11 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr17_+_48423453 0.11 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2
xylosyltransferase II
chr1_+_233749739 0.11 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr22_+_31644388 0.10 ENST00000333611.4
ENST00000340552.4
LIMK2
LIM domain kinase 2
chr1_+_9599540 0.10 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chrX_+_152783131 0.10 ENST00000349466.2
ENST00000370186.1
ATP2B3
ATPase, Ca++ transporting, plasma membrane 3
chr9_+_19230433 0.10 ENST00000434457.2
ENST00000602925.1
DENND4C
DENN/MADD domain containing 4C
chr8_+_146277764 0.10 ENST00000331434.6
C8orf33
chromosome 8 open reading frame 33
chr5_-_179498703 0.10 ENST00000522208.2
RNF130
ring finger protein 130
chr19_-_46389359 0.10 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr3_+_4535025 0.09 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr19_-_11039261 0.09 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr1_+_35225339 0.09 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr2_-_24149977 0.09 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr11_+_63974135 0.09 ENST00000544997.1
ENST00000345728.5
ENST00000279227.5
FERMT3
fermitin family member 3
chr19_+_50936142 0.08 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr3_-_55521323 0.08 ENST00000264634.4
WNT5A
wingless-type MMTV integration site family, member 5A
chr19_+_36195467 0.08 ENST00000426659.2
ZBTB32
zinc finger and BTB domain containing 32
chr10_+_99894380 0.08 ENST00000370584.3
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr7_+_100464760 0.08 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr20_+_58508817 0.08 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr3_+_110790590 0.08 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr8_+_125463048 0.07 ENST00000328599.3
TRMT12
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr1_-_154531095 0.07 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr3_+_52813932 0.07 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr10_-_112678692 0.07 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr5_-_179719048 0.07 ENST00000523583.1
ENST00000393360.3
ENST00000455781.1
ENST00000347470.4
ENST00000452135.2
ENST00000343111.6
MAPK9
mitogen-activated protein kinase 9
chrX_-_118826784 0.07 ENST00000394616.4
SEPT6
septin 6
chr5_+_176237478 0.06 ENST00000329542.4
UNC5A
unc-5 homolog A (C. elegans)
chr3_+_155860751 0.06 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_901847 0.06 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr19_+_3572758 0.05 ENST00000416526.1
HMG20B
high mobility group 20B
chr1_+_9005917 0.05 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chr1_+_104068562 0.05 ENST00000423855.2
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr5_+_133984462 0.05 ENST00000398844.2
ENST00000322887.4
SEC24A
SEC24 family member A
chr10_-_112678904 0.05 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1
chr12_-_48213568 0.04 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7
histone deacetylase 7
chr1_+_150122034 0.04 ENST00000025469.6
ENST00000369124.4
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr4_+_41992489 0.04 ENST00000264451.7
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr20_-_30539773 0.04 ENST00000202017.4
PDRG1
p53 and DNA-damage regulated 1
chr17_+_37824411 0.04 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr17_-_47755338 0.04 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP
speckle-type POZ protein
chr8_+_17780346 0.04 ENST00000325083.8
PCM1
pericentriolar material 1
chr11_-_66056596 0.04 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr1_+_104068312 0.04 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
RNPC3
RNA-binding region (RNP1, RRM) containing 3
chr10_+_99894399 0.04 ENST00000298999.3
ENST00000314594.5
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr19_-_43969796 0.04 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr11_-_47869865 0.03 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr20_-_13619550 0.03 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
TASP1
taspase, threonine aspartase, 1
chr2_+_232572361 0.03 ENST00000409321.1
PTMA
prothymosin, alpha
chr17_+_37824217 0.03 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr11_-_47870019 0.03 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr1_+_43148625 0.02 ENST00000436427.1
YBX1
Y box binding protein 1
chr9_+_128024067 0.02 ENST00000461379.1
ENST00000394084.1
ENST00000394105.2
ENST00000470056.1
ENST00000394104.2
ENST00000265956.4
ENST00000394083.2
ENST00000495955.1
ENST00000467750.1
ENST00000297933.6
GAPVD1
GTPase activating protein and VPS9 domains 1
chr1_+_182584314 0.02 ENST00000566297.1
RP11-317P15.4
RP11-317P15.4
chr1_-_114355083 0.02 ENST00000261441.5
RSBN1
round spermatid basic protein 1
chr19_+_3572925 0.02 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
HMG20B
high mobility group 20B
chr6_+_37787262 0.01 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr13_-_76056250 0.01 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr6_+_42531798 0.01 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr14_-_64010046 0.01 ENST00000337537.3
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr3_+_51428704 0.01 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr2_-_241831424 0.01 ENST00000402775.2
ENST00000307486.8
C2orf54
chromosome 2 open reading frame 54
chr20_-_25371412 0.01 ENST00000339157.5
ENST00000376542.3
ABHD12
abhydrolase domain containing 12
chr10_-_108924284 0.01 ENST00000344440.6
ENST00000263054.6
SORCS1
sortilin-related VPS10 domain containing receptor 1
chr19_+_11039391 0.01 ENST00000270502.6
C19orf52
chromosome 19 open reading frame 52
chr22_+_35653445 0.01 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr3_+_4535155 0.01 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr1_-_231175964 0.00 ENST00000366654.4
FAM89A
family with sequence similarity 89, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.7 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.5 GO:0002254 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 1.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.3 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.1 0.9 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 0.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.3 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.1 GO:0061346 cardiac right atrium morphogenesis(GO:0003213) negative regulation of melanin biosynthetic process(GO:0048022) positive regulation of anagen(GO:0051885) mediolateral intercalation(GO:0060031) cervix development(GO:0060067) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346) negative regulation of secondary metabolite biosynthetic process(GO:1900377) regulation of cell proliferation in midbrain(GO:1904933)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.2 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.5 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.6 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0005940 septin ring(GO:0005940) septin collar(GO:0032173)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:0034464 BBSome(GO:0034464)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 0.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.3 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.1 1.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis