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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for THRA_RXRB

Z-value: 0.73

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Transcription factors associated with THRA_RXRB

Gene Symbol Gene ID Gene Info
THRA
ENSG00000126351.8 thyroid hormone receptor alpha
RXRB
ENSG00000204231.6 retinoid X receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRAhg19_v2_chr17_+_38219063_38219154-0.571.1e-03Click!
RXRBhg19_v2_chr6_-_33168391_33168465-0.222.5e-01Click!

Activity profile of THRA_RXRB motif

Sorted Z-values of THRA_RXRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_162887556 3.32 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chr10_+_77056134 2.22 ENST00000528121.1
ENST00000416398.1
ZNF503-AS1
ZNF503 antisense RNA 1
chr1_+_152881014 1.90 ENST00000368764.3
ENST00000392667.2
IVL
involucrin
chr10_+_11784360 1.89 ENST00000379215.4
ENST00000420401.1
ECHDC3
enoyl CoA hydratase domain containing 3
chr15_-_34629922 1.79 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr19_+_54371114 1.79 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
MYADM
myeloid-associated differentiation marker
chr15_-_34630234 1.48 ENST00000558667.1
ENST00000561120.1
ENST00000559236.1
ENST00000397702.2
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr1_-_150693318 1.46 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1
HORMA domain containing 1
chr15_-_75017711 1.44 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr9_+_125133315 1.43 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_220491973 1.43 ENST00000358055.3
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr1_+_45212074 1.42 ENST00000372217.1
KIF2C
kinesin family member 2C
chr1_+_45212051 1.41 ENST00000372222.3
KIF2C
kinesin family member 2C
chr3_-_50340996 1.39 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
HYAL1
hyaluronoglucosaminidase 1
chr12_-_25102252 1.30 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr9_+_36572851 1.29 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr1_+_17531614 1.24 ENST00000375471.4
PADI1
peptidyl arginine deiminase, type I
chr9_+_116298778 1.23 ENST00000462143.1
RGS3
regulator of G-protein signaling 3
chr22_-_29137771 1.14 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr5_+_147691979 1.11 ENST00000274565.4
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr19_+_45281118 1.11 ENST00000270279.3
ENST00000341505.4
CBLC
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr2_-_192016316 1.09 ENST00000358470.4
ENST00000432798.1
ENST00000450994.1
STAT4
signal transducer and activator of transcription 4
chr12_-_95510743 1.08 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr19_+_6739662 1.06 ENST00000313285.8
ENST00000313244.9
ENST00000596758.1
TRIP10
thyroid hormone receptor interactor 10
chr3_+_12330560 1.03 ENST00000397026.2
PPARG
peroxisome proliferator-activated receptor gamma
chr3_+_10068095 0.98 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr11_-_123756334 0.97 ENST00000528595.1
ENST00000375026.2
TMEM225
transmembrane protein 225
chr2_+_220492116 0.91 ENST00000373760.2
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr11_-_119599794 0.91 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr22_-_37584321 0.87 ENST00000397110.2
ENST00000337843.2
C1QTNF6
C1q and tumor necrosis factor related protein 6
chr8_-_144651024 0.87 ENST00000524906.1
ENST00000532862.1
ENST00000534459.1
MROH6
maestro heat-like repeat family member 6
chr1_-_38218577 0.80 ENST00000540011.1
EPHA10
EPH receptor A10
chrX_-_30327495 0.80 ENST00000453287.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr4_-_111119804 0.78 ENST00000394607.3
ENST00000302274.3
ELOVL6
ELOVL fatty acid elongase 6
chr22_+_23264766 0.77 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr1_+_150522222 0.77 ENST00000369039.5
ADAMTSL4
ADAMTS-like 4
chr12_+_102513950 0.76 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
PARPBP
PARP1 binding protein
chr20_+_43343886 0.75 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chrX_+_135230712 0.75 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr1_-_175162048 0.74 ENST00000444639.1
KIAA0040
KIAA0040
chr12_+_119616447 0.73 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr12_+_102514019 0.72 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
PARPBP
PARP1 binding protein
chr11_-_58343319 0.72 ENST00000395074.2
LPXN
leupaxin
chr2_+_210517895 0.70 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr2_+_219472488 0.70 ENST00000450993.2
PLCD4
phospholipase C, delta 4
chr22_-_20255212 0.69 ENST00000416372.1
RTN4R
reticulon 4 receptor
chr17_-_58469591 0.69 ENST00000589335.1
USP32
ubiquitin specific peptidase 32
chr19_-_52227221 0.69 ENST00000222115.1
ENST00000540069.2
HAS1
hyaluronan synthase 1
chr16_+_85942594 0.68 ENST00000566369.1
IRF8
interferon regulatory factor 8
chr12_+_7023491 0.67 ENST00000541477.1
ENST00000229277.1
ENO2
enolase 2 (gamma, neuronal)
chr12_+_7023735 0.67 ENST00000538763.1
ENST00000544774.1
ENST00000545045.2
ENO2
enolase 2 (gamma, neuronal)
chr22_-_29138386 0.65 ENST00000544772.1
CHEK2
checkpoint kinase 2
chr1_+_150954493 0.65 ENST00000368947.4
ANXA9
annexin A9
chr9_+_75263565 0.65 ENST00000396237.3
TMC1
transmembrane channel-like 1
chr20_+_3776371 0.61 ENST00000245960.5
CDC25B
cell division cycle 25B
chr20_+_3776936 0.60 ENST00000439880.2
CDC25B
cell division cycle 25B
chr17_-_15496722 0.60 ENST00000472534.1
CDRT1
CMT1A duplicated region transcript 1
chr17_-_27503770 0.59 ENST00000533112.1
MYO18A
myosin XVIIIA
chr22_-_36784035 0.57 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr1_-_175161890 0.56 ENST00000545251.2
ENST00000423313.1
KIAA0040
KIAA0040
chr8_+_27632083 0.54 ENST00000519637.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr12_-_102513843 0.51 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr10_-_116164239 0.51 ENST00000419268.1
ENST00000304129.4
ENST00000545353.1
AFAP1L2
actin filament associated protein 1-like 2
chr18_+_19749386 0.50 ENST00000269216.3
GATA6
GATA binding protein 6
chr10_-_116164450 0.50 ENST00000369271.3
AFAP1L2
actin filament associated protein 1-like 2
chr1_-_204121102 0.50 ENST00000367202.4
ETNK2
ethanolamine kinase 2
chr19_+_16187085 0.49 ENST00000300933.4
TPM4
tropomyosin 4
chr5_-_131562935 0.49 ENST00000379104.2
ENST00000379100.2
ENST00000428369.1
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr17_+_37894179 0.48 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr1_-_204121298 0.48 ENST00000367199.2
ETNK2
ethanolamine kinase 2
chr17_+_37894570 0.45 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr19_+_16186903 0.45 ENST00000588507.1
TPM4
tropomyosin 4
chr17_-_58469687 0.45 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr19_-_46974741 0.43 ENST00000313683.10
ENST00000602246.1
PNMAL1
paraneoplastic Ma antigen family-like 1
chr1_-_6453426 0.43 ENST00000545482.1
ACOT7
acyl-CoA thioesterase 7
chr19_-_46974664 0.43 ENST00000438932.2
PNMAL1
paraneoplastic Ma antigen family-like 1
chr5_-_131563501 0.43 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr1_+_154300217 0.42 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr16_-_74734742 0.41 ENST00000308807.7
ENST00000573267.1
MLKL
mixed lineage kinase domain-like
chr17_-_7082861 0.40 ENST00000269299.3
ASGR1
asialoglycoprotein receptor 1
chr4_+_177241094 0.40 ENST00000503362.1
SPCS3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr16_-_74734672 0.40 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr12_+_32655110 0.40 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_-_6453399 0.39 ENST00000608083.1
ACOT7
acyl-CoA thioesterase 7
chr5_-_162887054 0.39 ENST00000517501.1
NUDCD2
NudC domain containing 2
chrX_+_101380642 0.38 ENST00000372780.1
ENST00000329035.2
TCEAL2
transcription elongation factor A (SII)-like 2
chr15_-_30113676 0.38 ENST00000400011.2
TJP1
tight junction protein 1
chr1_+_155583012 0.38 ENST00000462250.2
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr4_+_169842707 0.38 ENST00000503290.1
PALLD
palladin, cytoskeletal associated protein
chr19_-_41196534 0.38 ENST00000252891.4
NUMBL
numb homolog (Drosophila)-like
chr22_+_23243156 0.37 ENST00000390323.2
IGLC2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr1_+_20396649 0.37 ENST00000375108.3
PLA2G5
phospholipase A2, group V
chr9_+_27109133 0.36 ENST00000519097.1
ENST00000380036.4
TEK
TEK tyrosine kinase, endothelial
chr9_+_34652164 0.36 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr2_-_65593784 0.36 ENST00000443619.2
SPRED2
sprouty-related, EVH1 domain containing 2
chr15_+_67430339 0.36 ENST00000439724.3
SMAD3
SMAD family member 3
chr10_-_76859247 0.35 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
DUSP13
dual specificity phosphatase 13
chr4_+_48343339 0.34 ENST00000264313.6
SLAIN2
SLAIN motif family, member 2
chr10_-_33625154 0.34 ENST00000265371.4
NRP1
neuropilin 1
chr1_-_205904950 0.34 ENST00000340781.4
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr9_-_104249319 0.34 ENST00000374847.1
TMEM246
transmembrane protein 246
chr1_-_244006528 0.33 ENST00000336199.5
ENST00000263826.5
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr17_-_1395954 0.33 ENST00000359786.5
MYO1C
myosin IC
chr11_+_122709200 0.33 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr5_-_162887071 0.33 ENST00000302764.4
NUDCD2
NudC domain containing 2
chr9_+_139839711 0.32 ENST00000224181.3
C8G
complement component 8, gamma polypeptide
chr14_-_58893832 0.32 ENST00000556007.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr2_+_55459808 0.32 ENST00000404735.1
RPS27A
ribosomal protein S27a
chr7_-_151433342 0.32 ENST00000433631.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr20_+_33464238 0.31 ENST00000360596.2
ACSS2
acyl-CoA synthetase short-chain family member 2
chr13_+_76123883 0.31 ENST00000377595.3
UCHL3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr18_-_19748379 0.31 ENST00000579431.1
GATA6-AS1
GATA6 antisense RNA 1 (head to head)
chr20_+_57430162 0.31 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
GNAS
GNAS complex locus
chr7_-_56160625 0.31 ENST00000446428.1
ENST00000432123.1
ENST00000452681.2
ENST00000537360.1
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr7_-_151433393 0.31 ENST00000492843.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_105319536 0.30 ENST00000477775.1
ATXN7L1
ataxin 7-like 1
chr12_+_123874589 0.30 ENST00000437502.1
SETD8
SET domain containing (lysine methyltransferase) 8
chr10_+_99332529 0.30 ENST00000455090.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr2_-_165698662 0.30 ENST00000194871.6
ENST00000445474.2
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr14_-_70655684 0.30 ENST00000356921.2
ENST00000381269.2
ENST00000357887.3
SLC8A3
solute carrier family 8 (sodium/calcium exchanger), member 3
chr22_+_18121356 0.29 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr10_+_99332198 0.29 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ANKRD2
ankyrin repeat domain 2 (stretch responsive muscle)
chr8_+_27632047 0.29 ENST00000397418.2
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_+_14989186 0.29 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr16_-_58328923 0.28 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
PRSS54
protease, serine, 54
chr1_+_70876891 0.28 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr19_+_39989535 0.27 ENST00000356433.5
DLL3
delta-like 3 (Drosophila)
chr18_+_268148 0.27 ENST00000581677.1
RP11-705O1.8
RP11-705O1.8
chr22_-_24316648 0.27 ENST00000403754.3
ENST00000430101.2
ENST00000398344.4
DDT
D-dopachrome tautomerase
chr7_-_56160666 0.27 ENST00000297373.2
PHKG1
phosphorylase kinase, gamma 1 (muscle)
chr3_+_141105235 0.27 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr19_+_39989580 0.27 ENST00000596614.1
ENST00000205143.4
DLL3
delta-like 3 (Drosophila)
chr12_-_80328949 0.26 ENST00000450142.2
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr7_+_23749894 0.26 ENST00000433467.2
STK31
serine/threonine kinase 31
chr3_-_197024965 0.26 ENST00000392382.2
DLG1
discs, large homolog 1 (Drosophila)
chr2_+_74757050 0.26 ENST00000352222.3
ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr3_+_9404526 0.25 ENST00000452837.2
ENST00000417036.1
ENST00000419437.1
ENST00000345094.3
ENST00000515662.2
THUMPD3
THUMP domain containing 3
chr1_-_155880672 0.25 ENST00000609492.1
ENST00000368322.3
RIT1
Ras-like without CAAX 1
chr12_-_110011288 0.25 ENST00000540016.1
ENST00000266839.5
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type
chr1_+_70876926 0.25 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr5_+_142125161 0.24 ENST00000432677.1
AC005592.1
AC005592.1
chr11_+_1860200 0.24 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr16_-_58328870 0.24 ENST00000543437.1
PRSS54
protease, serine, 54
chr17_-_39211463 0.24 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chr2_-_74667612 0.24 ENST00000305557.5
ENST00000233330.6
RTKN
rhotekin
chr20_+_56884752 0.24 ENST00000244040.3
RAB22A
RAB22A, member RAS oncogene family
chr14_-_80677815 0.23 ENST00000557125.1
ENST00000555750.1
DIO2
deiodinase, iodothyronine, type II
chr13_-_46756351 0.23 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr12_+_48876275 0.23 ENST00000314014.2
C12orf54
chromosome 12 open reading frame 54
chr14_-_80677970 0.23 ENST00000438257.4
DIO2
deiodinase, iodothyronine, type II
chr7_+_128312346 0.23 ENST00000480462.1
ENST00000378704.3
ENST00000477515.1
FAM71F2
family with sequence similarity 71, member F2
chr14_+_81421861 0.23 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr15_-_44487408 0.22 ENST00000402883.1
ENST00000417257.1
FRMD5
FERM domain containing 5
chr1_-_85156216 0.22 ENST00000342203.3
ENST00000370612.4
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr17_+_27369918 0.22 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr22_+_23134974 0.22 ENST00000390314.2
IGLV2-11
immunoglobulin lambda variable 2-11
chr3_-_197025447 0.21 ENST00000346964.2
ENST00000357674.4
ENST00000314062.3
ENST00000448528.2
ENST00000419553.1
DLG1
discs, large homolog 1 (Drosophila)
chr2_-_165698521 0.21 ENST00000409184.3
ENST00000392717.2
ENST00000456693.1
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr15_-_80215984 0.21 ENST00000485386.1
ENST00000479961.1
ST20
ST20-MTHFS
suppressor of tumorigenicity 20
ST20-MTHFS readthrough
chr16_-_50715196 0.21 ENST00000423026.2
SNX20
sorting nexin 20
chr10_+_64893039 0.21 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chr9_+_27109392 0.21 ENST00000406359.4
TEK
TEK tyrosine kinase, endothelial
chr19_+_19639670 0.21 ENST00000436027.5
YJEFN3
YjeF N-terminal domain containing 3
chr2_+_219472637 0.21 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr1_-_43855444 0.21 ENST00000372455.4
MED8
mediator complex subunit 8
chr14_-_80677613 0.21 ENST00000556811.1
DIO2
deiodinase, iodothyronine, type II
chr9_+_140145713 0.20 ENST00000388931.3
ENST00000412566.1
C9orf173
chromosome 9 open reading frame 173
chr19_+_19639704 0.20 ENST00000514277.4
YJEFN3
YjeF N-terminal domain containing 3
chr15_+_40531621 0.20 ENST00000560346.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_117049854 0.20 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr2_+_173686303 0.20 ENST00000397087.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr7_+_102389434 0.20 ENST00000409231.3
ENST00000418198.1
FAM185A
family with sequence similarity 185, member A
chr6_+_53976235 0.19 ENST00000502396.1
ENST00000358276.5
MLIP
muscular LMNA-interacting protein
chr8_+_103563792 0.19 ENST00000285402.3
ODF1
outer dense fiber of sperm tails 1
chr1_+_28764653 0.19 ENST00000373836.3
PHACTR4
phosphatase and actin regulator 4
chr17_-_39222131 0.19 ENST00000394015.2
KRTAP2-4
keratin associated protein 2-4
chr19_-_49176264 0.19 ENST00000270235.4
ENST00000596844.1
NTN5
netrin 5
chr16_-_3074231 0.19 ENST00000572355.1
ENST00000248089.3
ENST00000574980.1
ENST00000354679.3
ENST00000396916.1
ENST00000573842.1
HCFC1R1
host cell factor C1 regulator 1 (XPO1 dependent)
chr2_-_49381572 0.18 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr18_+_61144160 0.18 ENST00000489441.1
ENST00000424602.1
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr15_-_45422056 0.18 ENST00000267803.4
ENST00000559014.1
ENST00000558851.1
ENST00000559988.1
ENST00000558996.1
ENST00000558422.1
ENST00000559226.1
ENST00000558326.1
ENST00000558377.1
ENST00000559644.1
DUOXA1
dual oxidase maturation factor 1
chr1_+_16010779 0.18 ENST00000375799.3
ENST00000375793.2
PLEKHM2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr6_-_150039170 0.18 ENST00000458696.2
ENST00000392273.3
LATS1
large tumor suppressor kinase 1
chr13_-_33760216 0.18 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_3862206 0.18 ENST00000351018.4
RHOG
ras homolog family member G
chr22_-_38699003 0.17 ENST00000451964.1
CSNK1E
casein kinase 1, epsilon
chr2_-_49381646 0.17 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr6_-_89673280 0.17 ENST00000369475.3
ENST00000369485.4
ENST00000538899.1
ENST00000265607.6
RNGTT
RNA guanylyltransferase and 5'-phosphatase
chr6_+_35773070 0.17 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chr22_+_23165153 0.17 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr7_-_19813192 0.17 ENST00000422233.1
ENST00000433641.1
TMEM196
transmembrane protein 196
chr6_+_30594619 0.17 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr2_+_232457569 0.16 ENST00000313965.2
C2orf57
chromosome 2 open reading frame 57
chr17_+_60457914 0.16 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr11_+_33563821 0.16 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr12_-_78753496 0.16 ENST00000548512.1
RP11-38F22.1
RP11-38F22.1
chr2_+_228190066 0.16 ENST00000436237.1
ENST00000443428.2
ENST00000418961.1
MFF
mitochondrial fission factor
chr12_+_56211703 0.16 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr17_+_58499844 0.16 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr5_-_176056974 0.16 ENST00000510387.1
ENST00000506696.1
SNCB
synuclein, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of THRA_RXRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.3 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.6 1.9 GO:0018262 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.6 1.8 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.5 1.5 GO:0042138 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.5 1.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.4 1.8 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.3 1.4 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.3 0.7 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.3 2.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.3 1.0 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.2 1.3 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.8 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.2 0.6 GO:1903028 positive regulation of opsonization(GO:1903028)
0.2 1.0 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.2 0.5 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 0.5 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.1 1.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.5 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.1 0.4 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.1 3.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 1.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.1 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.1 1.2 GO:0007144 female meiosis I(GO:0007144)
0.1 0.6 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.6 GO:1900756 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.1 0.4 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.7 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.4 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.1 0.8 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.3 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.3 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.3 GO:0060301 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1 0.3 GO:0001828 inner cell mass cell fate commitment(GO:0001827) inner cell mass cellular morphogenesis(GO:0001828)
0.1 0.2 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.2 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.1 0.5 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.9 GO:0051639 actin filament network formation(GO:0051639)
0.1 1.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 0.8 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.1 0.3 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 0.8 GO:0030238 male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327)
0.0 0.3 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.0 0.2 GO:0019474 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.7 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.7 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.9 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.3 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 2.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 1.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:2001302 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.0 0.3 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.9 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.6 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 1.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.7 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.6 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.2 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.2 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 1.3 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.4 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:1902164 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.2 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.0 0.2 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 1.3 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0 0.9 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.4 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0098976 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0033227 dsRNA transport(GO:0033227)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.4 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.0 0.1 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.0 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.6 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.2 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 1.0 GO:0046847 filopodium assembly(GO:0046847)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0097513 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.1 0.3 GO:0045160 myosin I complex(GO:0045160)
0.1 3.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.8 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.6 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.8 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.4 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.5 GO:0043219 lateral loop(GO:0043219)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0071751 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.0 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.3 GO:0097443 sorting endosome(GO:0097443)
0.0 1.9 GO:0001533 cornified envelope(GO:0001533)
0.0 1.5 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.8 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.3 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.3 GO:0072562 blood microparticle(GO:0072562)
0.0 0.2 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.0 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 2.2 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0005861 troponin complex(GO:0005861)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.4 1.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 3.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.3 1.4 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.3 2.8 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 0.7 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 1.3 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 1.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.2 0.6 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.4 GO:0052857 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.1 0.9 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 1.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.4 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.0 GO:0050692 DBD domain binding(GO:0050692)
0.1 2.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 0.6 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.4 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.1 0.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 0.2 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.3 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
0.1 0.6 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.3 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.1 0.6 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.5 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.4 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.6 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.3 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0047977 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.2 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.8 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.7 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.8 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.6 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0060230 lipase binding(GO:0035473) lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.0 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 0.0 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.0 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:1903136 cuprous ion binding(GO:1903136)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.8 PID ATM PATHWAY ATM pathway
0.0 2.6 PID AURORA B PATHWAY Aurora B signaling
0.0 1.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.9 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.8 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.8 REACTOME KINESINS Genes involved in Kinesins
0.1 1.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 6.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL