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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for THRB
Z-value: 0.32
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Transcription factors associated with THRB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| THRB | hg19_v2_chr3_-_24536253_24536328 | 0.20 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of THRB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.2 | 1.8 | GO:0010994 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.5 | 1.5 | GO:0051780 | mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780) |
| 0.1 | 0.8 | GO:0014038 | regulation of Schwann cell differentiation(GO:0014038) |
| 0.0 | 0.7 | GO:0043320 | natural killer cell degranulation(GO:0043320) |
| 0.0 | 0.7 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.0 | 0.6 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.1 | 0.4 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.0 | 0.3 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.0 | 0.3 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 0.7 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 0.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.4 | GO:0036502 | Derlin-1-VIMP complex(GO:0036502) |
| 0.0 | 0.2 | GO:0071797 | LUBAC complex(GO:0071797) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 1.8 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.5 | 1.5 | GO:0015130 | mevalonate transmembrane transporter activity(GO:0015130) |
| 0.0 | 0.8 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.7 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.6 | GO:0010385 | double-stranded methylated DNA binding(GO:0010385) |
| 0.0 | 0.4 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.1 | 0.3 | GO:0008169 | C-methyltransferase activity(GO:0008169) |
| 0.0 | 0.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.2 | GO:0005497 | androgen binding(GO:0005497) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.5 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 0.8 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.2 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |