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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for TLX1_NFIC

Z-value: 1.17

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Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
TLX1
ENSG00000107807.8 T cell leukemia homeobox 1
NFIC
ENSG00000141905.13 nuclear factor I C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TLX1hg19_v2_chr10_+_102891048_1028910780.319.9e-02Click!
NFIChg19_v2_chr19_+_3359561_3359681-0.096.3e-01Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_74372662 3.59 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr18_+_21529811 3.11 ENST00000588004.1
LAMA3
laminin, alpha 3
chr8_-_42065075 2.96 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
PLAT
plasminogen activator, tissue
chr8_-_42065187 2.74 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
PLAT
plasminogen activator, tissue
chr7_+_143079000 2.41 ENST00000392910.2
ZYX
zyxin
chr19_+_10397621 2.30 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr8_+_22022800 2.27 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr19_+_10397648 2.26 ENST00000340992.4
ENST00000393717.2
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr20_+_58251716 2.07 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr14_+_85996471 2.05 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_143078652 2.04 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr12_-_54813229 1.98 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr7_+_116165038 1.98 ENST00000393470.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr17_+_7344057 1.85 ENST00000575398.1
ENST00000575082.1
FGF11
fibroblast growth factor 11
chr14_+_24867992 1.77 ENST00000382554.3
NYNRIN
NYN domain and retroviral integrase containing
chr3_+_186915274 1.77 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chr12_+_13349650 1.73 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
EMP1
epithelial membrane protein 1
chr3_+_52350335 1.66 ENST00000420323.2
DNAH1
dynein, axonemal, heavy chain 1
chr20_+_33759854 1.66 ENST00000216968.4
PROCR
protein C receptor, endothelial
chr1_+_203595689 1.57 ENST00000357681.5
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr9_+_136399929 1.56 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chrX_-_128788914 1.56 ENST00000429967.1
ENST00000307484.6
APLN
apelin
chr2_-_192711968 1.55 ENST00000304141.4
SDPR
serum deprivation response
chr4_-_103266219 1.54 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr1_-_153363452 1.51 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr4_+_110834033 1.47 ENST00000509793.1
ENST00000265171.5
EGF
epidermal growth factor
chr3_+_46742823 1.42 ENST00000326431.3
TMIE
transmembrane inner ear
chr6_-_43595039 1.41 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr20_-_60942361 1.36 ENST00000252999.3
LAMA5
laminin, alpha 5
chr14_+_85996507 1.25 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr17_-_3182268 1.25 ENST00000408891.2
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr12_+_53491220 1.19 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr14_+_75746781 1.18 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr8_+_22022653 1.18 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr11_-_65325664 1.17 ENST00000301873.5
LTBP3
latent transforming growth factor beta binding protein 3
chr12_+_66217911 1.15 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr14_+_73704201 1.11 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
PAPLN
papilin, proteoglycan-like sulfated glycoprotein
chr15_+_90728145 1.09 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr18_+_33877654 1.03 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr6_-_34524049 0.99 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr1_+_203595903 0.98 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr12_-_109025849 0.95 ENST00000228463.6
SELPLG
selectin P ligand
chr19_-_42927251 0.93 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chr1_-_161193349 0.90 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr11_-_65325430 0.89 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr11_-_10715163 0.89 ENST00000541483.1
MRVI1
murine retrovirus integration site 1 homolog
chr11_-_128457446 0.85 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr12_+_113682066 0.85 ENST00000392569.4
ENST00000552542.1
TPCN1
two pore segment channel 1
chrX_+_99899180 0.84 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr6_-_30043539 0.83 ENST00000376751.3
ENST00000244360.6
RNF39
ring finger protein 39
chr1_+_39456895 0.82 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr10_+_5454505 0.81 ENST00000355029.4
NET1
neuroepithelial cell transforming 1
chr11_+_18417813 0.81 ENST00000540430.1
ENST00000379412.5
LDHA
lactate dehydrogenase A
chr1_+_113217309 0.79 ENST00000544796.1
ENST00000369644.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr17_+_37894179 0.79 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr17_+_37894570 0.77 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr17_+_19314505 0.75 ENST00000461366.1
RNF112
ring finger protein 112
chr1_+_113217345 0.74 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr11_-_62313090 0.73 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr22_-_39640756 0.72 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr6_-_34524093 0.72 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr10_+_124320195 0.72 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr10_+_124320156 0.71 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr1_+_177140633 0.71 ENST00000361539.4
BRINP2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr7_-_45128472 0.70 ENST00000490531.2
NACAD
NAC alpha domain containing
chr21_-_28217721 0.70 ENST00000284984.3
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr2_+_228337079 0.70 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
AGFG1
ArfGAP with FG repeats 1
chr12_+_100867486 0.70 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_+_113217043 0.69 ENST00000413052.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chrX_-_54522558 0.67 ENST00000375135.3
FGD1
FYVE, RhoGEF and PH domain containing 1
chr14_-_85996332 0.67 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr1_+_113217073 0.66 ENST00000369645.1
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr22_-_20368028 0.65 ENST00000404912.1
GGTLC3
gamma-glutamyltransferase light chain 3
chr7_+_22766766 0.65 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
IL6
interleukin 6 (interferon, beta 2)
chr10_+_88718314 0.63 ENST00000348795.4
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr11_-_62457371 0.62 ENST00000317449.4
LRRN4CL
LRRN4 C-terminal like
chr7_-_100076873 0.61 ENST00000300181.2
TSC22D4
TSC22 domain family, member 4
chr19_-_40324255 0.61 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr2_+_219187871 0.60 ENST00000258362.3
PNKD
paroxysmal nonkinesigenic dyskinesia
chr4_-_140544386 0.60 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr2_+_7017796 0.60 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr6_-_46922659 0.59 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr19_-_49864746 0.59 ENST00000598810.1
TEAD2
TEA domain family member 2
chr17_-_76921459 0.59 ENST00000262768.7
TIMP2
TIMP metallopeptidase inhibitor 2
chr5_+_72251793 0.59 ENST00000430046.2
ENST00000341845.6
FCHO2
FCH domain only 2
chr7_-_100076765 0.58 ENST00000393991.1
TSC22D4
TSC22 domain family, member 4
chrX_-_52258669 0.58 ENST00000441417.1
XAGE1A
X antigen family, member 1A
chrX_+_52513455 0.58 ENST00000446098.1
XAGE1C
X antigen family, member 1C
chrX_-_52531609 0.57 ENST00000438079.1
XAGE1D
X antigen family, member 1D
chr12_+_21168630 0.57 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chrX_+_52240504 0.57 ENST00000399805.2
XAGE1B
X antigen family, member 1B
chr9_-_130617029 0.56 ENST00000373203.4
ENG
endoglin
chr7_-_100065686 0.56 ENST00000423266.1
ENST00000456330.1
TSC22D4
TSC22 domain family, member 4
chr11_-_57089671 0.56 ENST00000532437.1
TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr1_-_160040038 0.56 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr2_+_113875466 0.56 ENST00000361779.3
ENST00000259206.5
ENST00000354115.2
IL1RN
interleukin 1 receptor antagonist
chr7_-_81399411 0.56 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr19_+_49258775 0.55 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr6_+_123100620 0.55 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr15_+_89182178 0.54 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr5_+_176784837 0.54 ENST00000408923.3
RGS14
regulator of G-protein signaling 14
chr15_-_40213080 0.53 ENST00000561100.1
GPR176
G protein-coupled receptor 176
chr10_+_106034637 0.53 ENST00000401888.2
GSTO2
glutathione S-transferase omega 2
chr9_-_132515302 0.52 ENST00000340607.4
PTGES
prostaglandin E synthase
chr1_+_151512775 0.52 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr2_+_128293323 0.52 ENST00000389524.4
ENST00000428314.1
MYO7B
myosin VIIB
chr3_-_50340996 0.52 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
HYAL1
hyaluronoglucosaminidase 1
chrX_+_102631248 0.51 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr7_+_143013198 0.51 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr22_+_40390930 0.51 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr4_+_144303093 0.50 ENST00000505913.1
GAB1
GRB2-associated binding protein 1
chr20_+_48884002 0.50 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr22_+_25003626 0.50 ENST00000451366.1
ENST00000406383.2
ENST00000428855.1
GGT1
gamma-glutamyltransferase 1
chr9_-_130616915 0.50 ENST00000344849.3
ENG
endoglin
chr17_+_42429493 0.49 ENST00000586242.1
GRN
granulin
chr8_-_10512569 0.49 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr5_-_115872142 0.49 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr20_-_50722183 0.48 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr2_-_47142884 0.48 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr14_+_24540046 0.48 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chrX_+_102631844 0.47 ENST00000372634.1
ENST00000299872.7
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chrX_+_49126294 0.47 ENST00000466508.1
ENST00000438316.1
ENST00000055335.6
ENST00000495799.1
PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr19_-_11450249 0.47 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr2_-_238322770 0.46 ENST00000472056.1
COL6A3
collagen, type VI, alpha 3
chr7_-_27187393 0.46 ENST00000222728.3
HOXA6
homeobox A6
chrX_-_128977364 0.46 ENST00000371064.3
ZDHHC9
zinc finger, DHHC-type containing 9
chr1_-_153588765 0.46 ENST00000368701.1
ENST00000344616.2
S100A14
S100 calcium binding protein A14
chr2_-_47143160 0.46 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr3_-_98620500 0.46 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr17_-_48474828 0.45 ENST00000576448.1
ENST00000225972.7
LRRC59
leucine rich repeat containing 59
chr5_+_32531893 0.45 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr2_-_238322800 0.45 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
COL6A3
collagen, type VI, alpha 3
chr1_-_242612779 0.45 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr2_-_238323007 0.45 ENST00000295550.4
COL6A3
collagen, type VI, alpha 3
chr11_+_64004888 0.44 ENST00000541681.1
VEGFB
vascular endothelial growth factor B
chr21_+_17792672 0.43 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr12_+_57522258 0.43 ENST00000553277.1
ENST00000243077.3
LRP1
low density lipoprotein receptor-related protein 1
chr15_+_89181974 0.43 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_+_79086088 0.43 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr17_+_48503603 0.42 ENST00000502667.1
ACSF2
acyl-CoA synthetase family member 2
chr17_+_38599693 0.42 ENST00000542955.1
ENST00000269593.4
IGFBP4
insulin-like growth factor binding protein 4
chr16_-_51185172 0.41 ENST00000251020.4
SALL1
spalt-like transcription factor 1
chr1_+_110453109 0.41 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr17_+_48503519 0.40 ENST00000300441.4
ENST00000541920.1
ENST00000506582.1
ENST00000504392.1
ENST00000427954.2
ACSF2
acyl-CoA synthetase family member 2
chr13_+_113030625 0.40 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr3_+_57882024 0.40 ENST00000494088.1
SLMAP
sarcolemma associated protein
chr15_-_68724490 0.40 ENST00000315757.7
ENST00000423218.2
ITGA11
integrin, alpha 11
chr12_+_119616447 0.40 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr2_-_37899323 0.39 ENST00000295324.3
ENST00000457889.1
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr11_+_45825616 0.39 ENST00000442528.2
ENST00000456334.1
ENST00000526817.1
SLC35C1
solute carrier family 35 (GDP-fucose transporter), member C1
chr15_+_89182156 0.39 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr4_+_54966198 0.38 ENST00000326902.2
ENST00000503800.1
GSX2
GS homeobox 2
chr5_+_72251857 0.38 ENST00000507345.2
ENST00000512348.1
ENST00000287761.6
FCHO2
FCH domain only 2
chr7_+_86274145 0.38 ENST00000439827.1
ENST00000394720.2
ENST00000421579.1
GRM3
glutamate receptor, metabotropic 3
chr1_-_32169920 0.37 ENST00000373672.3
ENST00000373668.3
COL16A1
collagen, type XVI, alpha 1
chr1_+_12538594 0.37 ENST00000543710.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_32169761 0.37 ENST00000271069.6
COL16A1
collagen, type XVI, alpha 1
chr7_-_5569588 0.37 ENST00000417101.1
ACTB
actin, beta
chr16_+_57662419 0.37 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr19_-_49258606 0.36 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr11_+_45825896 0.36 ENST00000314134.3
SLC35C1
solute carrier family 35 (GDP-fucose transporter), member C1
chr4_+_86748898 0.36 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr16_-_27899478 0.36 ENST00000380897.3
GSG1L
GSG1-like
chr12_+_6644443 0.35 ENST00000396858.1
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr5_-_176923846 0.35 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr7_-_81399355 0.34 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_+_7211656 0.33 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_41950342 0.33 ENST00000372587.4
EDN2
endothelin 2
chr1_+_70034081 0.33 ENST00000310961.5
ENST00000370958.1
LRRC7
leucine rich repeat containing 7
chr9_+_102584128 0.33 ENST00000338488.4
ENST00000395097.2
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr20_-_30060816 0.33 ENST00000317676.2
DEFB124
defensin, beta 124
chr7_-_81399438 0.32 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr21_+_45937497 0.32 ENST00000354333.5
C21orf90
chromosome 21 open reading frame 90
chr1_+_64059332 0.32 ENST00000540265.1
PGM1
phosphoglucomutase 1
chr12_+_8662057 0.32 ENST00000382064.2
CLEC4D
C-type lectin domain family 4, member D
chr19_+_50936142 0.32 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr11_+_74862100 0.32 ENST00000532236.1
ENST00000531756.1
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr8_+_85097110 0.32 ENST00000517638.1
ENST00000522647.1
RALYL
RALY RNA binding protein-like
chr4_-_110723134 0.31 ENST00000510800.1
ENST00000512148.1
CFI
complement factor I
chr16_+_57662138 0.31 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
GPR56
G protein-coupled receptor 56
chr11_-_111637083 0.31 ENST00000427203.2
ENST00000341980.6
ENST00000311129.5
ENST00000393055.2
ENST00000426998.2
ENST00000527614.1
PPP2R1B
protein phosphatase 2, regulatory subunit A, beta
chr1_-_27216729 0.31 ENST00000431781.2
ENST00000374135.4
GPN2
GPN-loop GTPase 2
chr5_-_176923803 0.31 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr2_+_220325441 0.31 ENST00000396688.1
SPEG
SPEG complex locus
chr14_-_50999190 0.31 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr5_+_92919043 0.30 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_168250194 0.30 ENST00000367821.3
TBX19
T-box 19
chr2_-_219151487 0.30 ENST00000444881.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr6_+_36922209 0.30 ENST00000373674.3
PI16
peptidase inhibitor 16
chr16_+_30662050 0.29 ENST00000568754.1
PRR14
proline rich 14
chr11_-_117186946 0.29 ENST00000313005.6
ENST00000528053.1
BACE1
beta-site APP-cleaving enzyme 1
chr2_+_228336849 0.29 ENST00000409979.2
ENST00000310078.8
AGFG1
ArfGAP with FG repeats 1
chr4_-_110723194 0.29 ENST00000394635.3
CFI
complement factor I
chr8_-_141728760 0.29 ENST00000430260.2
PTK2
protein tyrosine kinase 2
chr1_-_120190396 0.29 ENST00000421812.2
ZNF697
zinc finger protein 697
chr2_+_223536428 0.29 ENST00000446656.3
MOGAT1
monoacylglycerol O-acyltransferase 1
chr2_+_220325977 0.29 ENST00000396686.1
ENST00000396689.2
SPEG
SPEG complex locus
chr20_-_25207370 0.29 ENST00000593352.1
AL035252.1
HCG2018895; Uncharacterized protein
chr8_+_104384616 0.29 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr19_+_42788172 0.29 ENST00000160740.3
CIC
capicua transcriptional repressor

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0046521 sphingoid catabolic process(GO:0046521)
0.8 2.5 GO:1900082 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.7 2.0 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.6 3.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.5 1.6 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.5 2.1 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.4 1.8 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.4 1.1 GO:0001300 chronological cell aging(GO:0001300)
0.3 2.6 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.3 1.0 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.3 1.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.3 1.4 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.3 1.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 0.8 GO:0002384 hepatic immune response(GO:0002384)
0.3 2.9 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 1.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 5.7 GO:0031639 plasminogen activation(GO:0031639)
0.2 0.6 GO:0090294 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.2 0.6 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 1.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.2 0.8 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.2 0.7 GO:1905174 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.2 0.4 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2 1.8 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 1.5 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 1.8 GO:0015074 DNA integration(GO:0015074)
0.1 1.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 3.4 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.1 0.5 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.5 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1 0.5 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 2.0 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 0.7 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 1.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.6 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.1 0.6 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 0.3 GO:0060584 positive regulation of the force of heart contraction by chemical signal(GO:0003099) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.3 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.1 3.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.9 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.6 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.4 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.5 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.6 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.3 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.1 0.4 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 1.6 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.2 GO:0097359 UDP-glucosylation(GO:0097359)
0.1 1.4 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.4 GO:0015722 canalicular bile acid transport(GO:0015722)
0.1 0.6 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 0.2 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.1 0.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.6 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.6 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 0.8 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.7 GO:0032060 bleb assembly(GO:0032060)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 1.4 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 0.5 GO:1904970 brush border assembly(GO:1904970)
0.1 1.0 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.2 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.2 GO:0043686 co-translational protein modification(GO:0043686)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 0.2 GO:0009584 detection of visible light(GO:0009584) detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.4 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 1.2 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.8 GO:0051451 myoblast migration(GO:0051451)
0.1 0.6 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.3 GO:0048241 epinephrine transport(GO:0048241)
0.0 1.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.7 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.2 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.0 0.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.3 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 1.4 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.3 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.4 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.7 GO:0033622 integrin activation(GO:0033622)
0.0 0.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.1 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 4.4 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 0.5 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.2 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.5 GO:0002544 chronic inflammatory response(GO:0002544)
0.0 0.3 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 1.4 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.6 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.5 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.1 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392) endothelial cell-cell adhesion(GO:0071603)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.8 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 1.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.5 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.1 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.0 0.1 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.0 1.1 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.6 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.0 0.3 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.7 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.0 1.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.5 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.6 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.7 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 1.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.7 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.7 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.0 0.3 GO:0090177 establishment of planar polarity involved in neural tube closure(GO:0090177)
0.0 0.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.1 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.0 GO:0099640 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) axo-dendritic protein transport(GO:0099640)
0.0 0.1 GO:1903921 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) protein processing in phagocytic vesicle(GO:1900756) regulation of plasma membrane raft polarization(GO:1903906) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.0 4.2 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.7 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.5 GO:0005610 laminin-5 complex(GO:0005610)
0.5 2.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.4 1.7 GO:0036156 inner dynein arm(GO:0036156)
0.4 1.1 GO:0072563 endothelial microparticle(GO:0072563)
0.2 0.8 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 0.5 GO:0036027 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 1.2 GO:0035976 AP1 complex(GO:0035976)
0.1 0.6 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 2.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.4 GO:0034681 integrin alpha11-beta1 complex(GO:0034681)
0.1 1.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.1 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.1 0.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 1.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.9 GO:0042588 zymogen granule(GO:0042588)
0.1 0.7 GO:0005593 FACIT collagen trimer(GO:0005593)
0.1 2.6 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.2 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.1 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.4 GO:0097452 GAIT complex(GO:0097452)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 5.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.9 GO:0042627 chylomicron(GO:0042627)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.3 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 2.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 3.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.8 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.4 GO:0010369 chromocenter(GO:0010369)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 11.5 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.8 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.9 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0032982 myosin filament(GO:0032982)
0.0 1.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 1.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.6 GO:0000791 euchromatin(GO:0000791)
0.0 1.7 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.5 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.7 2.0 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.6 3.6 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.5 1.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.4 1.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 1.6 GO:0050436 microfibril binding(GO:0050436)
0.3 0.9 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.3 1.5 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.3 1.1 GO:0035501 MH1 domain binding(GO:0035501)
0.3 2.4 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.2 0.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 3.3 GO:0045499 chemorepellent activity(GO:0045499)
0.2 1.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 0.9 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 0.6 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.2 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 0.8 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.2 0.6 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.1 1.1 GO:0005534 galactose binding(GO:0005534)
0.1 0.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.8 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.5 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.1 0.4 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.3 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.1 0.3 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.1 0.5 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 0.6 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 0.4 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 0.8 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.4 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.5 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.9 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.3 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 1.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.6 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.5 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 1.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.6 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.3 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.1 2.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 1.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.5 GO:0032190 acrosin binding(GO:0032190)
0.1 1.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.7 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 1.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.2 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 1.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 5.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 1.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 6.8 GO:0005178 integrin binding(GO:0005178)
0.0 5.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.8 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 1.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.5 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 4.1 GO:0008083 growth factor activity(GO:0008083)
0.0 0.1 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.0 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 1.2 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 2.2 GO:0004386 helicase activity(GO:0004386)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 10.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 4.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 2.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 3.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 0.8 ST STAT3 PATHWAY STAT3 Pathway
0.1 4.1 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 2.3 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 2.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.5 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 3.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.6 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 4.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.5 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 0.5 REACTOME GAB1 SIGNALOSOME Genes involved in GAB1 signalosome
0.1 3.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 0.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.5 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 1.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 8.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 8.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.0 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 3.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.0 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)