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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TP53
Z-value: 0.85
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Transcription factors associated with TP53
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP53 | hg19_v2_chr17_-_7590745_7590856 | -0.27 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP53
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 8.0 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.6 | 7.6 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.2 | 5.2 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.1 | 5.1 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.2 | 4.3 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.0 | 4.1 | GO:0070268 | cornification(GO:0070268) |
| 1.1 | 3.4 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.0 | 3.3 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.3 | 3.1 | GO:2000467 | positive regulation of glycogen (starch) synthase activity(GO:2000467) |
| 1.0 | 2.9 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.0 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 6.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.6 | 5.2 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 3.3 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 2.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 2.0 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 1.7 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.1 | 1.6 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.3 | 1.5 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.3 | 1.3 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.1 | 6.8 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.1 | 5.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 4.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.9 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 3.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 3.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 2.9 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.3 | 2.5 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.1 | 2.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 5.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 3.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.3 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 3.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 2.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 1.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.5 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 3.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 3.2 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 3.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.6 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |