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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for TP63
Z-value: 1.34
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Transcription factors associated with TP63
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP63 | hg19_v2_chr3_+_189349162_189349305 | 0.76 | 1.0e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51504411 Show fit | 14.45 |
ENST00000593490.1
|
kallikrein-related peptidase 8 |
|
| chr19_-_51471381 Show fit | 8.57 |
ENST00000594641.1
|
kallikrein-related peptidase 6 |
|
| chr19_-_19051103 Show fit | 5.60 |
ENST00000542541.2
ENST00000433218.2 |
homer homolog 3 (Drosophila) |
|
| chr2_-_216003127 Show fit | 4.94 |
ENST00000412081.1
ENST00000272895.7 |
ATP-binding cassette, sub-family A (ABC1), member 12 |
|
| chr1_+_151030234 Show fit | 4.78 |
ENST00000368921.3
|
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
|
| chr12_-_52845910 Show fit | 4.54 |
ENST00000252252.3
|
keratin 6B |
|
| chr20_-_43280325 Show fit | 4.51 |
ENST00000537820.1
|
adenosine deaminase |
|
| chr4_-_10023095 Show fit | 4.43 |
ENST00000264784.3
|
solute carrier family 2 (facilitated glucose transporter), member 9 |
|
| chr12_+_119616447 Show fit | 4.17 |
ENST00000281938.2
|
heat shock 22kDa protein 8 |
|
| chr2_-_31361543 Show fit | 4.00 |
ENST00000349752.5
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP63
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 14.4 | GO:0031642 | negative regulation of myelination(GO:0031642) |
| 0.4 | 8.7 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 2.7 | 8.1 | GO:0006154 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 0.4 | 6.2 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 5.7 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.3 | 5.6 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 5.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 1.2 | 4.9 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.3 | 4.8 | GO:0051901 | positive regulation of mitochondrial depolarization(GO:0051901) |
| 0.0 | 4.8 | GO:0016579 | protein deubiquitination(GO:0016579) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 10.0 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.2 | 8.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 5.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.7 | 4.9 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 4.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 4.3 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 4.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 3.7 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 1.2 | 3.5 | GO:0031523 | Myb complex(GO:0031523) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 8.1 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.0 | 7.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.2 | 7.3 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.4 | 5.6 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
| 0.2 | 5.6 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 1.2 | 4.9 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
| 0.3 | 4.5 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.3 | 4.4 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 1.4 | 4.3 | GO:0070506 | high-density lipoprotein particle receptor activity(GO:0070506) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 9.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 7.2 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 3.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 2.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 2.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.2 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.1 | 5.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.2 | 4.9 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 4.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.2 | 4.4 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 4.2 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 4.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 3.9 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 3.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |