Project
Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for UAGUGUU
Z-value: 0.77
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_25102252 Show fit | 3.96 |
ENST00000261192.7
|
branched chain amino-acid transaminase 1, cytosolic |
|
| chr5_-_39219705 Show fit | 2.90 |
ENST00000351578.6
|
FYN binding protein |
|
| chr20_+_37554955 Show fit | 2.42 |
ENST00000217429.4
|
family with sequence similarity 83, member D |
|
| chr2_-_113542063 Show fit | 1.88 |
ENST00000263339.3
|
interleukin 1, alpha |
|
| chr7_+_36429409 Show fit | 1.80 |
ENST00000265748.2
|
anillin, actin binding protein |
|
| chr20_-_23030296 Show fit | 1.73 |
ENST00000377103.2
|
thrombomodulin |
|
| chr12_-_54813229 Show fit | 1.72 |
ENST00000293379.4
|
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
|
| chr22_+_33197683 Show fit | 1.72 |
ENST00000266085.6
|
TIMP metallopeptidase inhibitor 3 |
|
| chr14_-_35182994 Show fit | 1.49 |
ENST00000341223.3
|
cofilin 2 (muscle) |
|
| chr3_+_172468472 Show fit | 1.48 |
ENST00000232458.5
ENST00000392692.3 |
epithelial cell transforming sequence 2 oncogene |
Network of associatons between targets according to the STRING database.
First level regulatory network of UAGUGUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.0 | GO:0009099 | branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099) |
| 0.1 | 2.4 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 2.4 | GO:0072698 | protein localization to microtubule cytoskeleton(GO:0072698) |
| 0.1 | 2.0 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.3 | 1.9 | GO:2000391 | positive regulation of neutrophil extravasation(GO:2000391) |
| 0.1 | 1.9 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.6 | 1.8 | GO:1904172 | regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172) |
| 0.4 | 1.7 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.1 | 1.7 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.1 | 1.7 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 2.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 1.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.4 | 1.8 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 1.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.4 | 1.7 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 1.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 1.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 1.5 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.4 | 1.4 | GO:0005606 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.0 | GO:0004084 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.0 | 2.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 2.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 1.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.7 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.1 | 1.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 1.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 1.2 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 1.2 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 2.4 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 2.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 2.0 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.0 | 2.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.4 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 3.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 2.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.9 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 1.1 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 1.0 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 0.9 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |