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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for UBP1

Z-value: 0.42

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Transcription factors associated with UBP1

Gene Symbol Gene ID Gene Info
UBP1
ENSG00000153560.7 upstream binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UBP1hg19_v2_chr3_-_33481835_33481905-0.604.1e-04Click!

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_38071615 2.51 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr4_-_57524061 1.60 ENST00000508121.1
HOPX
HOP homeobox
chr12_-_47473425 1.49 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr19_-_51538148 1.44 ENST00000319590.4
ENST00000250351.4
KLK12
kallikrein-related peptidase 12
chr17_+_74381343 1.36 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr2_+_228678550 1.30 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr19_+_917287 1.17 ENST00000592648.1
ENST00000234371.5
KISS1R
KISS1 receptor
chr17_-_5138099 0.94 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SCIMP
SLP adaptor and CSK interacting membrane protein
chr12_-_8815215 0.93 ENST00000544889.1
ENST00000543369.1
MFAP5
microfibrillar associated protein 5
chr12_-_8815299 0.91 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr1_-_150208320 0.91 ENST00000534220.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr11_-_102668879 0.82 ENST00000315274.6
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr9_-_35685452 0.79 ENST00000607559.1
TPM2
tropomyosin 2 (beta)
chr12_+_100041527 0.69 ENST00000324341.1
FAM71C
family with sequence similarity 71, member C
chr12_+_47473369 0.67 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr19_+_41257084 0.65 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr2_-_89442621 0.57 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr10_-_75676400 0.54 ENST00000412307.2
C10orf55
chromosome 10 open reading frame 55
chr19_-_49864746 0.53 ENST00000598810.1
TEAD2
TEA domain family member 2
chrX_-_65253506 0.48 ENST00000427538.1
VSIG4
V-set and immunoglobulin domain containing 4
chr1_-_150208291 0.48 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr5_+_95998070 0.46 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chr1_-_150208363 0.45 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr13_-_23949671 0.44 ENST00000402364.1
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_+_111718173 0.42 ENST00000494932.1
TAGLN3
transgelin 3
chr21_+_43823983 0.41 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
UBASH3A
ubiquitin associated and SH3 domain containing A
chr2_+_17721920 0.38 ENST00000295156.4
VSNL1
visinin-like 1
chr4_+_156587979 0.37 ENST00000511507.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr15_-_101835110 0.34 ENST00000560496.1
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr17_+_48450575 0.34 ENST00000338165.4
ENST00000393271.2
ENST00000511519.2
EME1
essential meiotic structure-specific endonuclease 1
chr11_-_11374904 0.33 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr3_+_111718036 0.33 ENST00000455401.2
TAGLN3
transgelin 3
chr16_+_29823427 0.27 ENST00000358758.7
ENST00000567659.1
ENST00000572820.1
PRRT2
proline-rich transmembrane protein 2
chr6_+_29429217 0.27 ENST00000396792.2
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr1_-_150208412 0.27 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_-_47009996 0.26 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr2_-_2334888 0.26 ENST00000428368.2
ENST00000399161.2
MYT1L
myelin transcription factor 1-like
chr6_+_31555045 0.26 ENST00000396101.3
ENST00000490742.1
LST1
leukocyte specific transcript 1
chr4_+_156588115 0.26 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr11_-_60623437 0.24 ENST00000332539.4
PTGDR2
prostaglandin D2 receptor 2
chr5_+_150051149 0.24 ENST00000523553.1
MYOZ3
myozenin 3
chrX_+_38420623 0.23 ENST00000378482.2
TSPAN7
tetraspanin 7
chr6_-_29395509 0.23 ENST00000377147.2
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr2_+_61244697 0.23 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr4_+_156587853 0.22 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chrX_+_78426469 0.21 ENST00000276077.1
GPR174
G protein-coupled receptor 174
chr12_+_123717967 0.21 ENST00000536130.1
ENST00000546132.1
C12orf65
chromosome 12 open reading frame 65
chr5_+_34656331 0.20 ENST00000265109.3
RAI14
retinoic acid induced 14
chr1_+_206223941 0.20 ENST00000367126.4
AVPR1B
arginine vasopressin receptor 1B
chr19_-_11039188 0.19 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr17_-_48450534 0.18 ENST00000503633.1
ENST00000442592.3
ENST00000225969.4
MRPL27
mitochondrial ribosomal protein L27
chr1_-_150208498 0.17 ENST00000314136.8
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr14_-_75330537 0.16 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
PROX2
prospero homeobox 2
chr15_+_81475047 0.16 ENST00000559388.1
IL16
interleukin 16
chr8_-_66474884 0.14 ENST00000520902.1
CTD-3025N20.2
CTD-3025N20.2
chr9_+_15422702 0.14 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr8_-_107782463 0.14 ENST00000311955.3
ABRA
actin-binding Rho activating protein
chr1_+_155108294 0.13 ENST00000303343.8
ENST00000368404.4
ENST00000368401.5
SLC50A1
solute carrier family 50 (sugar efflux transporter), member 1
chrX_+_139791917 0.13 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr1_-_153599732 0.12 ENST00000392623.1
S100A13
S100 calcium binding protein A13
chr14_+_21214039 0.12 ENST00000326842.2
EDDM3A
epididymal protein 3A
chr1_-_156217875 0.12 ENST00000292291.5
PAQR6
progestin and adipoQ receptor family member VI
chr15_+_28624878 0.11 ENST00000450328.2
GOLGA8F
golgin A8 family, member F
chr3_+_111260980 0.11 ENST00000438817.2
CD96
CD96 molecule
chr1_-_182641367 0.10 ENST00000508450.1
RGS8
regulator of G-protein signaling 8
chr12_+_123717458 0.10 ENST00000253233.1
C12orf65
chromosome 12 open reading frame 65
chr8_+_77593448 0.10 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr19_-_54784937 0.10 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr11_+_10326612 0.10 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr2_+_113033164 0.10 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr7_+_132937820 0.09 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr3_+_111260954 0.08 ENST00000283285.5
CD96
CD96 molecule
chr11_-_113345995 0.08 ENST00000355319.2
ENST00000542616.1
DRD2
dopamine receptor D2
chr19_-_51875523 0.08 ENST00000593572.1
ENST00000595157.1
NKG7
natural killer cell group 7 sequence
chr22_+_22676808 0.07 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr22_+_22730353 0.07 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr20_+_59654146 0.07 ENST00000441660.1
RP5-827L5.1
RP5-827L5.1
chr7_+_29874341 0.07 ENST00000409290.1
ENST00000242140.5
WIPF3
WAS/WASL interacting protein family, member 3
chr1_+_48688357 0.06 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr2_+_162087577 0.06 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr5_-_41510656 0.05 ENST00000377801.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr1_-_152332480 0.05 ENST00000388718.5
FLG2
filaggrin family member 2
chr3_+_111260856 0.05 ENST00000352690.4
CD96
CD96 molecule
chr19_-_11039261 0.04 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr10_-_27443294 0.04 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1L1
YME1-like 1 ATPase
chr5_+_122847908 0.00 ENST00000511130.2
ENST00000512718.3
CSNK1G3
casein kinase 1, gamma 3

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.5 1.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 1.3 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.8 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.1 0.3 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 0.2 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.1 0.3 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.2 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.1 1.6 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.1 GO:1901656 glycoside transport(GO:1901656)
0.0 1.8 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 2.3 GO:0043486 histone exchange(GO:0043486)
0.0 0.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.7 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.5 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.2 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 1.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.8 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 0.1 GO:1900168 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.6 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.3 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.0 0.1 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0007320 insemination(GO:0007320)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 1.2 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.4 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.1 0.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.1 2.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.3 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.9 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0070852 cell body fiber(GO:0070852)
0.0 0.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0030395 lactose binding(GO:0030395)
0.4 1.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 1.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.8 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 2.3 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 1.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.4 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.2 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.1 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.8 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction