ISMARA results: YBX1_FOS_NFYC_NFYA_NFYB

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.06

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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Gene Symbol	Gene ID	Gene Info
YBX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000065978.13	Y-box binding protein 1
FOS Ensembl NCBI GeneCards UniProt NextProt	ENSG00000170345.5	Fos proto-oncogene, AP-1 transcription factor subunit
NFYC Ensembl NCBI GeneCards UniProt NextProt	ENSG00000066136.15	nuclear transcription factor Y subunit gamma
NFYA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000001167.10	nuclear transcription factor Y subunit alpha
NFYB Ensembl NCBI GeneCards UniProt NextProt	ENSG00000120837.3	nuclear transcription factor Y subunit beta
CEBPZ Ensembl NCBI GeneCards UniProt NextProt	ENSG00000115816.9	CCAAT enhancer binding protein zeta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOS	hg19_v2_chr14_+_75745477_75745680	0.64	1.5e-04	Click!
NFYA	hg19_v2_chr6_+_41040678_41040722	0.44	1.5e-02	Click!
YBX1	hg19_v2_chr1_+_43148059_43148111	0.33	7.9e-02	Click!
NFYC	hg19_v2_chr1_+_41157671_41157695	-0.25	1.8e-01	Click!
NFYB	hg19_v2_chr12_-_104531945_104531996	0.17	3.8e-01	Click!
CEBPZ	hg19_v2_chr2_-_37458749_37458856	-0.16	4.1e-01	Click!

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_54863739 Show fit	25.45	ENST00000541304.1	CDKN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin-dependent kinase inhibitor 3
chr14_+_54863667 Show fit	24.43	ENST00000335183.6	CDKN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin-dependent kinase inhibitor 3
chr14_+_54863682 Show fit	24.15	ENST00000543789.2 ENST00000442975.2 ENST00000458126.2 ENST00000556102.2	CDKN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin-dependent kinase inhibitor 3
chr17_-_38574169 Show fit	20.98	ENST00000423485.1	TOP2A Ensembl NCBI GeneCards UniProt NextProt Show fit	topoisomerase (DNA) II alpha 170kDa
chr1_+_206138457 Show fit	17.71	ENST00000367128.3 ENST00000431655.2	FAM72A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 72, member A
chr8_+_25316489 Show fit	15.86	ENST00000330560.3	CDCA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cell division cycle associated 2
chr5_+_162887556 Show fit	15.27	ENST00000393915.4 ENST00000432118.2 ENST00000358715.3	HMMR Ensembl NCBI GeneCards UniProt NextProt Show fit	hyaluronan-mediated motility receptor (RHAMM)
chr17_-_8113886 Show fit	15.12	ENST00000577833.1 ENST00000534871.1 ENST00000583915.1 ENST00000316199.6 ENST00000581511.1 ENST00000585124.1	AURKB Ensembl NCBI GeneCards UniProt NextProt Show fit	aurora kinase B
chr17_+_6347729 Show fit	13.70	ENST00000572447.1	FAM64A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 64, member A
chr2_-_111435610 Show fit	13.63	ENST00000447014.1 ENST00000420328.1 ENST00000535254.1 ENST00000409311.1 ENST00000302759.6	BUB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	BUB1 mitotic checkpoint serine/threonine kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	130.5	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
1.4	52.0	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4	41.6	GO:0007062	sister chromatid cohesion(GO:0007062)
4.5	40.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.7	35.5	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
1.4	31.5	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.8	31.1	GO:0051310	metaphase plate congression(GO:0051310)
1.8	26.7	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
4.9	24.4	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.4	23.7	GO:0007077	mitotic nuclear envelope disassembly(GO:0007077)

Showing 1 to 10 of 697 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	67.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.8	58.0	GO:0005871	kinesin complex(GO:0005871)
0.1	53.1	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
6.3	50.7	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	41.7	GO:0005739	mitochondrion(GO:0005739)
0.4	41.3	GO:0000777	condensed chromosome kinetochore(GO:0000777)
8.0	40.0	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
6.5	32.7	GO:0097149	centralspindlin complex(GO:0097149)
1.2	27.8	GO:0010369	chromocenter(GO:0010369)
0.2	27.6	GO:0005913	cell-cell adherens junction(GO:0005913)

Showing 1 to 10 of 280 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	69.7	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4	53.2	GO:0017048	Rho GTPase binding(GO:0017048)
6.9	48.2	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.9	47.8	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.5	46.9	GO:0003777	microtubule motor activity(GO:0003777)
0.2	43.9	GO:0008017	microtubule binding(GO:0008017)
4.8	42.9	GO:0035174	histone serine kinase activity(GO:0035174)
2.2	37.6	GO:0003688	DNA replication origin binding(GO:0003688)
0.5	26.9	GO:0097472	cyclin-dependent protein kinase activity(GO:0097472)
0.6	22.1	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)

Showing 1 to 10 of 437 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	174.8	PID PLK1 PATHWAY	PLK1 signaling events
1.7	115.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.8	40.8	PID AURORA A PATHWAY	Aurora A signaling
0.7	39.4	PID AURORA B PATHWAY	Aurora B signaling
0.3	30.9	PID E2F PATHWAY	E2F transcription factor network
0.3	24.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.4	24.2	PID FANCONI PATHWAY	Fanconi anemia pathway
0.2	15.2	PID CDC42 PATHWAY	CDC42 signaling events
0.2	13.3	PID RHOA PATHWAY	RhoA signaling pathway
0.1	10.9	PID TELOMERASE PATHWAY	Regulation of Telomerase

Showing 1 to 10 of 81 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	134.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
3.0	96.0	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
3.3	90.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
1.8	64.9	REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS	Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1.4	53.1	REACTOME KINESINS	Genes involved in Kinesins
2.6	47.0	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.4	30.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
1.4	29.4	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.5	26.4	REACTOME G1 PHASE	Genes involved in G1 Phase
0.8	20.4	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks

Showing 1 to 10 of 134 entries

Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.06

Motif logo

Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Activity-expression correlation:

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: