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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZBTB3

Z-value: 0.53

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Transcription factors associated with ZBTB3

Gene Symbol Gene ID Gene Info
ZBTB3
ENSG00000185670.7 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB3hg19_v2_chr11_-_62521614_625216600.532.4e-03Click!

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_152240819 2.05 ENST00000421798.3
ENST00000535416.1
PNMA6C
PNMA6A
paraneoplastic Ma antigen family member 6C
paraneoplastic Ma antigen family member 6A
chrX_+_152338301 2.04 ENST00000453825.2
PNMA6A
paraneoplastic Ma antigen family member 6A
chr11_+_73661364 1.26 ENST00000339764.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr14_-_92413727 1.24 ENST00000267620.10
FBLN5
fibulin 5
chr5_+_76506706 0.99 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
PDE8B
phosphodiesterase 8B
chr6_+_29274403 0.96 ENST00000377160.2
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr6_-_46138676 0.96 ENST00000371383.2
ENST00000230565.3
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr2_-_154335300 0.95 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate
chr14_-_92413353 0.91 ENST00000556154.1
FBLN5
fibulin 5
chr14_-_92414055 0.91 ENST00000342058.4
FBLN5
fibulin 5
chr16_-_68406161 0.86 ENST00000568373.1
ENST00000563226.1
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr1_+_211433275 0.71 ENST00000367005.4
RCOR3
REST corepressor 3
chr19_+_49496705 0.68 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr16_-_19896220 0.63 ENST00000562469.1
ENST00000300571.2
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr19_+_49496782 0.60 ENST00000601968.1
ENST00000596837.1
RUVBL2
RuvB-like AAA ATPase 2
chr1_+_110036699 0.60 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
CYB561D1
cytochrome b561 family, member D1
chr7_+_23719749 0.58 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr5_+_140514782 0.58 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr1_+_110036728 0.57 ENST00000369868.3
ENST00000430195.2
CYB561D1
cytochrome b561 family, member D1
chr17_-_17109579 0.52 ENST00000321560.3
PLD6
phospholipase D family, member 6
chr4_-_123542224 0.50 ENST00000264497.3
IL21
interleukin 21
chr10_-_118032979 0.49 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr19_-_40023450 0.47 ENST00000326282.4
EID2B
EP300 interacting inhibitor of differentiation 2B
chr14_-_90085458 0.46 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr6_-_31939734 0.44 ENST00000375356.3
DXO
decapping exoribonuclease
chr5_-_82969405 0.43 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr4_-_7436671 0.41 ENST00000319098.4
PSAPL1
prosaposin-like 1 (gene/pseudogene)
chr1_+_160121356 0.37 ENST00000368081.4
ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chr17_+_33895090 0.36 ENST00000592381.1
RP11-1094M14.11
RP11-1094M14.11
chr2_+_42396472 0.35 ENST00000318522.5
ENST00000402711.2
EML4
echinoderm microtubule associated protein like 4
chr6_-_41122063 0.34 ENST00000426005.2
ENST00000437044.2
ENST00000373127.4
TREML1
triggering receptor expressed on myeloid cells-like 1
chr5_+_170288856 0.34 ENST00000523189.1
RANBP17
RAN binding protein 17
chr10_-_73533255 0.34 ENST00000394957.3
C10orf54
chromosome 10 open reading frame 54
chr1_-_32801825 0.33 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr2_-_40679186 0.33 ENST00000406785.2
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr19_+_52848659 0.32 ENST00000327920.8
ZNF610
zinc finger protein 610
chr6_+_30850697 0.32 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr2_+_42396574 0.32 ENST00000401738.3
EML4
echinoderm microtubule associated protein like 4
chr11_-_67980744 0.31 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr2_+_241631262 0.30 ENST00000337801.4
ENST00000429564.1
AQP12A
aquaporin 12A
chr16_+_24266874 0.30 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr16_-_2185899 0.29 ENST00000262304.4
ENST00000423118.1
PKD1
polycystic kidney disease 1 (autosomal dominant)
chr16_+_53164833 0.26 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr9_+_72002837 0.25 ENST00000377216.3
FAM189A2
family with sequence similarity 189, member A2
chr16_+_87636474 0.25 ENST00000284262.2
JPH3
junctophilin 3
chr5_+_74807581 0.22 ENST00000241436.4
ENST00000352007.5
POLK
polymerase (DNA directed) kappa
chr12_-_114843889 0.22 ENST00000405440.2
TBX5
T-box 5
chr6_+_42141029 0.22 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr5_-_74807418 0.22 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr1_+_210001309 0.20 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr6_-_107436473 0.19 ENST00000369042.1
BEND3
BEN domain containing 3
chr17_+_46018872 0.19 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
PNPO
pyridoxamine 5'-phosphate oxidase
chr1_-_154458520 0.19 ENST00000486773.1
SHE
Src homology 2 domain containing E
chr1_-_236046872 0.18 ENST00000536965.1
LYST
lysosomal trafficking regulator
chr18_+_32073253 0.18 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA
dystrobrevin, alpha
chrX_+_23801280 0.17 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr7_-_38403077 0.17 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr17_-_39623681 0.17 ENST00000225899.3
KRT32
keratin 32
chr7_+_16793160 0.17 ENST00000262067.4
TSPAN13
tetraspanin 13
chr11_-_130786400 0.16 ENST00000265909.4
SNX19
sorting nexin 19
chr11_-_18548426 0.15 ENST00000357193.3
ENST00000536719.1
TSG101
tumor susceptibility 101
chr10_-_71906342 0.15 ENST00000287078.6
ENST00000335494.5
TYSND1
trypsin domain containing 1
chr20_+_62289640 0.15 ENST00000508582.2
ENST00000360203.5
ENST00000356810.4
RTEL1
regulator of telomere elongation helicase 1
chr6_+_123100853 0.14 ENST00000356535.4
FABP7
fatty acid binding protein 7, brain
chr19_+_47852538 0.14 ENST00000328771.4
DHX34
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr5_+_75379224 0.14 ENST00000322285.7
SV2C
synaptic vesicle glycoprotein 2C
chr7_+_100081542 0.14 ENST00000300179.2
ENST00000423930.1
NYAP1
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
chr19_-_55549624 0.13 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chrX_-_154563889 0.13 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr2_-_136594740 0.12 ENST00000264162.2
LCT
lactase
chr11_-_82782952 0.12 ENST00000534141.1
RAB30
RAB30, member RAS oncogene family
chr17_-_56595196 0.11 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4
myotubularin related protein 4
chr7_-_38394118 0.10 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr11_-_130786333 0.10 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
SNX19
sorting nexin 19
chr17_+_72983674 0.09 ENST00000337231.5
CDR2L
cerebellar degeneration-related protein 2-like
chr4_-_140216948 0.09 ENST00000265500.4
NDUFC1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr5_-_169725231 0.08 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr4_+_159236462 0.07 ENST00000460056.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr4_-_5894777 0.06 ENST00000324989.7
CRMP1
collapsin response mediator protein 1
chr1_+_159141397 0.06 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr17_-_10325261 0.06 ENST00000403437.2
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr1_+_154229547 0.06 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr6_+_12958137 0.06 ENST00000457702.2
ENST00000379345.2
PHACTR1
phosphatase and actin regulator 1
chr2_-_25565377 0.05 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_-_111148241 0.05 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr4_-_17783135 0.05 ENST00000265018.3
FAM184B
family with sequence similarity 184, member B
chr13_+_27998681 0.04 ENST00000381140.4
GTF3A
general transcription factor IIIA
chr3_-_149688502 0.03 ENST00000481767.1
ENST00000475518.1
PFN2
profilin 2
chr19_-_19006890 0.03 ENST00000247005.6
GDF1
growth differentiation factor 1
chr3_+_98250743 0.03 ENST00000284311.3
GPR15
G protein-coupled receptor 15
chr9_+_74526532 0.03 ENST00000486911.2
C9orf85
chromosome 9 open reading frame 85
chr5_+_112074029 0.03 ENST00000512211.2
APC
adenomatous polyposis coli
chr3_+_178276488 0.02 ENST00000432997.1
ENST00000455865.1
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr5_+_74807886 0.02 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chrX_+_70364667 0.02 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr11_+_67007518 0.02 ENST00000530342.1
ENST00000308783.5
KDM2A
lysine (K)-specific demethylase 2A
chr6_+_123100620 0.02 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr3_-_195163803 0.02 ENST00000326793.6
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr14_+_60715928 0.01 ENST00000395076.4
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr1_-_155270770 0.01 ENST00000392414.3
PKLR
pyruvate kinase, liver and RBC
chr3_-_149688655 0.01 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2
profilin 2
chr8_+_42196000 0.00 ENST00000518925.1
ENST00000538005.1
POLB
polymerase (DNA directed), beta
chr21_-_48024986 0.00 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.3 1.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.2 3.1 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.2 GO:0003218 cardiac left ventricle formation(GO:0003218)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.1 0.3 GO:0072237 distal tubule morphogenesis(GO:0072156) metanephric proximal tubule development(GO:0072237)
0.1 0.9 GO:0006685 sphingomyelin catabolic process(GO:0006685) positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.3 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.2 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.5 GO:0010635 regulation of mitochondrial fusion(GO:0010635)
0.1 0.2 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.2 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.0 0.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.5 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 1.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.4 GO:0071027 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.4 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.5 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.4 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.0 GO:0072678 T cell migration(GO:0072678)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.1 GO:0071953 elastic fiber(GO:0071953)
0.1 1.3 GO:0097255 R2TP complex(GO:0097255)
0.1 0.9 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0036398 TCR signalosome(GO:0036398)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.4 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.1 0.5 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.9 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.3 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.5 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 1.0 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0097001 ceramide binding(GO:0097001)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 3.1 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0000182 rDNA binding(GO:0000182)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID MYC PATHWAY C-MYC pathway
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins