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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZBTB33_CHD2
Z-value: 2.24
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | 0.73 | 5.8e-06 | Click! |
| CHD2 | hg19_v2_chr15_+_93443419_93443580 | -0.47 | 8.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_7761013 Show fit | 29.27 |
ENST00000571846.1
|
cytochrome b5 domain containing 1 |
|
| chr17_+_7761301 Show fit | 22.72 |
ENST00000332439.4
ENST00000570446.1 |
cytochrome b5 domain containing 1 |
|
| chr10_-_75118611 Show fit | 9.99 |
ENST00000355577.3
ENST00000394865.1 ENST00000310715.3 ENST00000401621.2 |
tetratricopeptide repeat domain 18 |
|
| chr22_+_45809560 Show fit | 9.98 |
ENST00000342894.3
ENST00000538017.1 |
RIB43A domain with coiled-coils 2 |
|
| chr10_-_75118471 Show fit | 9.88 |
ENST00000340329.3
|
tetratricopeptide repeat domain 18 |
|
| chr3_+_108308513 Show fit | 9.46 |
ENST00000361582.3
|
DAZ interacting zinc finger protein 3 |
|
| chr2_-_207629997 Show fit | 9.37 |
ENST00000454776.2
|
malate dehydrogenase 1B, NAD (soluble) |
|
| chrX_+_53449887 Show fit | 9.31 |
ENST00000375327.3
|
RIB43A domain with coiled-coils 1 |
|
| chr2_-_207630033 Show fit | 8.89 |
ENST00000449792.1
|
malate dehydrogenase 1B, NAD (soluble) |
|
| chr2_-_99757977 Show fit | 8.73 |
ENST00000355053.4
|
testis specific, 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 19.3 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.9 | 17.8 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 0.0 | 15.9 | GO:0030031 | cell projection assembly(GO:0030031) |
| 4.7 | 14.0 | GO:0032203 | telomere formation via telomerase(GO:0032203) |
| 0.3 | 13.0 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 1.2 | 10.6 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.1 | 9.3 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.1 | 9.3 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.2 | 8.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 2.0 | 8.0 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.3 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 16.1 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.5 | 14.9 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 14.9 | GO:0031514 | motile cilium(GO:0031514) |
| 1.2 | 10.6 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 1.4 | 9.5 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.0 | 9.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 8.4 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.4 | 8.0 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 6.6 | GO:0000786 | nucleosome(GO:0000786) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 19.3 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 2.1 | 18.5 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.4 | 17.5 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.1 | 9.4 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.5 | 9.0 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.5 | 8.1 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 8.0 | GO:0042805 | actinin binding(GO:0042805) |
| 0.7 | 5.7 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.2 | 5.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 4.9 | GO:0042162 | telomeric DNA binding(GO:0042162) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 3.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 3.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 2.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 1.9 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.7 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.2 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.4 | 8.3 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 5.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 3.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 2.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 2.5 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.1 | 2.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.2 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.1 | 2.0 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.2 | 1.9 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |