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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZEB1
Z-value: 1.62
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31610064_31610159 | -0.48 | 6.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_51471362 Show fit | 9.30 |
ENST00000376853.4
ENST00000424910.2 |
kallikrein-related peptidase 6 |
|
| chr19_-_51471381 Show fit | 9.20 |
ENST00000594641.1
|
kallikrein-related peptidase 6 |
|
| chr19_-_51504411 Show fit | 7.47 |
ENST00000593490.1
|
kallikrein-related peptidase 8 |
|
| chr13_-_20806440 Show fit | 6.49 |
ENST00000400066.3
ENST00000400065.3 ENST00000356192.6 |
gap junction protein, beta 6, 30kDa |
|
| chr4_-_57522470 Show fit | 4.72 |
ENST00000503639.3
|
HOP homeobox |
|
| chr11_-_65667997 Show fit | 4.19 |
ENST00000312562.2
ENST00000534222.1 |
FOS-like antigen 1 |
|
| chr4_+_75311019 Show fit | 3.98 |
ENST00000502307.1
|
amphiregulin |
|
| chr4_+_75310851 Show fit | 3.84 |
ENST00000395748.3
ENST00000264487.2 |
amphiregulin |
|
| chr14_+_75745477 Show fit | 3.78 |
ENST00000303562.4
ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1 |
FBJ murine osteosarcoma viral oncogene homolog |
|
| chr1_+_183155373 Show fit | 3.77 |
ENST00000493293.1
ENST00000264144.4 |
laminin, gamma 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 26.8 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.3 | 9.9 | GO:0034755 | iron ion transmembrane transport(GO:0034755) |
| 1.0 | 9.0 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 1.1 | 8.7 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.1 | 8.5 | GO:0051017 | actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572) |
| 1.0 | 8.1 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.6 | 7.9 | GO:0071493 | cellular response to UV-B(GO:0071493) |
| 1.3 | 7.8 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.0 | 7.8 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.1 | 7.6 | GO:0018149 | peptide cross-linking(GO:0018149) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 43.7 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 24.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 12.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.6 | 11.3 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 10.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 9.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.1 | 8.6 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 8.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.3 | 8.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 7.5 | GO:0001726 | ruffle(GO:0001726) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 38.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 18.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 14.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 13.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 11.4 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 1.0 | 9.0 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.1 | 8.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 7.6 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 1.8 | 7.0 | GO:0033906 | hyaluronoglucuronidase activity(GO:0033906) |
| 0.1 | 7.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 21.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 16.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.6 | 13.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 11.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 9.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.5 | 8.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 8.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 8.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 7.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 14.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 11.1 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.5 | 10.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.3 | 10.1 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.4 | 8.3 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 8.3 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.2 | 7.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 7.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 6.3 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |