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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZFHX3

Z-value: 0.42

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274,
hg19_v2_chr16_-_73093597_73093597		0.212.7e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_7921090 1.23 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr1_-_247921982 1.12 ENST00000408896.2
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr2_-_68052694 1.03 ENST00000457448.1
AC010987.6
AC010987.6
chr11_-_125366089 0.95 ENST00000366139.3
ENST00000278919.3
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr1_-_197036364 0.94 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr12_-_131200810 0.83 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chr22_+_31488433 0.69 ENST00000455608.1
SMTN
smoothelin
chr5_-_35195338 0.67 ENST00000509839.1
PRLR
prolactin receptor
chr20_-_21494654 0.62 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr6_-_32374900 0.41 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
BTNL2
butyrophilin-like 2 (MHC class II associated)
chr6_+_25754927 0.38 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr17_+_41052808 0.37 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr10_-_75226166 0.37 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr11_+_8040739 0.34 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr14_+_39703112 0.32 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr14_+_95027772 0.32 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_-_155511887 0.31 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr12_-_11184006 0.29 ENST00000390675.2
TAS2R31
taste receptor, type 2, member 31
chr16_+_87636474 0.25 ENST00000284262.2
JPH3
junctophilin 3
chr8_-_87242589 0.25 ENST00000419776.2
ENST00000297524.3
SLC7A13
solute carrier family 7 (anionic amino acid transporter), member 13
chr12_-_7818474 0.24 ENST00000229304.4
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr13_-_103719196 0.21 ENST00000245312.3
SLC10A2
solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr2_+_185463093 0.21 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr2_-_60780536 0.20 ENST00000538214.1
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr15_+_76352178 0.19 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr12_+_59989918 0.19 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chrY_-_20935572 0.18 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
HSFY2
heat shock transcription factor, Y linked 2
chr12_+_59989791 0.18 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr9_-_95298314 0.18 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr6_-_29013017 0.18 ENST00000377175.1
OR2W1
olfactory receptor, family 2, subfamily W, member 1
chrY_+_20708557 0.17 ENST00000307393.2
ENST00000309834.4
ENST00000382856.2
HSFY1
heat shock transcription factor, Y-linked 1
chr3_+_35722487 0.16 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_+_74347400 0.16 ENST00000226355.3
AFM
afamin
chr11_+_5410607 0.16 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr18_+_5748793 0.15 ENST00000566533.1
ENST00000562452.2
RP11-945C19.1
RP11-945C19.1
chr3_+_69915385 0.15 ENST00000314589.5
MITF
microphthalmia-associated transcription factor
chr3_+_77088989 0.14 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr1_+_76540386 0.14 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr3_+_147795932 0.14 ENST00000490465.1
RP11-639B1.1
RP11-639B1.1
chr8_-_41504878 0.14 ENST00000524115.2
NKX6-3
NK6 homeobox 3
chr12_-_68553512 0.14 ENST00000229135.3
IFNG
interferon, gamma
chr6_-_116447283 0.13 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr6_+_34204642 0.13 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chrM_+_9207 0.13 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr1_-_67266939 0.12 ENST00000304526.2
INSL5
insulin-like 5
chr4_-_69111401 0.12 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr19_+_54466179 0.12 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chrX_+_84258832 0.12 ENST00000373173.2
APOOL
apolipoprotein O-like
chr3_+_69812701 0.11 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr7_+_130126012 0.11 ENST00000341441.5
MEST
mesoderm specific transcript
chr1_+_159557607 0.11 ENST00000255040.2
APCS
amyloid P component, serum
chr2_+_190541153 0.11 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ANKAR
ankyrin and armadillo repeat containing
chrX_-_18690210 0.10 ENST00000379984.3
RS1
retinoschisin 1
chr7_-_7575477 0.10 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr9_-_123812542 0.10 ENST00000223642.1
C5
complement component 5
chr11_+_22696314 0.10 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr6_+_47749718 0.09 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr9_+_44868935 0.09 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr6_+_28317685 0.09 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
ZKSCAN3
zinc finger with KRAB and SCAN domains 3
chr7_+_130126165 0.08 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr2_-_14541060 0.08 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chrX_-_15288154 0.08 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
ASB9
ankyrin repeat and SOCS box containing 9
chr11_-_107729887 0.08 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr19_-_46234119 0.07 ENST00000317683.3
FBXO46
F-box protein 46
chr3_-_164796269 0.07 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr2_-_60780702 0.07 ENST00000359629.5
BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr13_-_30881134 0.06 ENST00000380617.3
ENST00000441394.1
KATNAL1
katanin p60 subunit A-like 1
chr17_+_17685422 0.05 ENST00000395774.1
RAI1
retinoic acid induced 1
chr14_+_39703084 0.05 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr22_-_30970560 0.05 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_-_160549235 0.04 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chr20_+_42187608 0.04 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr19_+_926000 0.03 ENST00000263620.3
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr20_+_42187682 0.03 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr17_-_26733179 0.03 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr1_-_168464875 0.02 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr12_-_2944184 0.02 ENST00000337508.4
NRIP2
nuclear receptor interacting protein 2
chr1_+_192544857 0.02 ENST00000367459.3
ENST00000469578.2
RGS1
regulator of G-protein signaling 1
chr8_-_70745575 0.02 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr5_+_60933634 0.02 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr15_+_58724184 0.02 ENST00000433326.2
LIPC
lipase, hepatic
chr7_+_48211048 0.01 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr2_+_88047606 0.01 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr21_+_40824003 0.01 ENST00000452550.1
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr4_-_152149033 0.01 ENST00000514152.1
SH3D19
SH3 domain containing 19
chrX_+_1710484 0.01 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr3_+_35722424 0.00 ENST00000396481.2
ARPP21
cAMP-regulated phosphoprotein, 21kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 1.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.7 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.3 GO:1904799 negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1 0.9 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.2 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.1 0.3 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:2000309 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.0 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.3 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.4 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.1 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) negative regulation by host of symbiont molecular function(GO:0052405)
0.0 1.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0036028 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.7 GO:0031904 endosome lumen(GO:0031904)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 0.7 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.4 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.5 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts