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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZFX
Z-value: 1.15
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Transcription factors associated with ZFX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFX | hg19_v2_chrX_+_24167828_24167907 | 0.51 | 4.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_76256557 Show fit | 2.08 |
ENST00000275569.4
ENST00000310842.4 |
POM121 and ZP3 fusion |
|
| chr19_+_2096868 Show fit | 2.05 |
ENST00000395296.1
ENST00000395301.3 |
IZUMO family member 4 |
|
| chr8_-_144651024 Show fit | 2.02 |
ENST00000524906.1
ENST00000532862.1 ENST00000534459.1 |
maestro heat-like repeat family member 6 |
|
| chr8_-_143859197 Show fit | 1.76 |
ENST00000395192.2
|
Ly6/neurotoxin 1 |
|
| chr8_-_143858590 Show fit | 1.73 |
ENST00000398906.1
ENST00000522929.1 |
Ly6/neurotoxin 1 |
|
| chr16_+_66638685 Show fit | 1.69 |
ENST00000565003.1
|
CKLF-like MARVEL transmembrane domain containing 3 |
|
| chr7_-_1199781 Show fit | 1.38 |
ENST00000397083.1
ENST00000401903.1 ENST00000316495.3 |
zinc finger, AN1-type domain 2A |
|
| chr2_+_64681103 Show fit | 1.28 |
ENST00000464281.1
|
lectin, galactoside-binding-like |
|
| chr3_-_52090461 Show fit | 1.27 |
ENST00000296483.6
ENST00000495880.1 |
dual specificity phosphatase 7 |
|
| chr5_+_176560742 Show fit | 1.20 |
ENST00000439151.2
|
nuclear receptor binding SET domain protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.1 | 3.4 | GO:0099601 | regulation of neurotransmitter receptor activity(GO:0099601) |
| 0.1 | 3.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 2.3 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.0 | 2.3 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.0 | 2.3 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.1 | 2.2 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 2.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.3 | 2.1 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.1 | 2.1 | GO:0071318 | cellular response to ATP(GO:0071318) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 5.7 | GO:0005924 | cell-substrate adherens junction(GO:0005924) |
| 0.0 | 3.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 2.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 2.5 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 2.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 2.2 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 2.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 4.7 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 4.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.1 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 3.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 3.5 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
| 0.0 | 3.5 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 3.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 2.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.2 | 2.5 | GO:0051434 | BH3 domain binding(GO:0051434) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 2.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 2.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 2.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.0 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 3.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 2.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 2.6 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.0 | 2.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 2.2 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 2.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |