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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZIC3_ZIC4

Z-value: 0.54

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ENSG00000156925.7 Zic family member 3
ENSG00000174963.13 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC4hg19_v2_chr3_-_147124547_1471246470.374.2e-02Click!
ZIC3hg19_v2_chrX_+_136648297_1366483190.134.9e-01Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_76506706 0.97 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
phosphodiesterase 8B
chr1_-_32801825 0.73 ENST00000329421.7
MARCKS-like 1
chr5_-_180018540 0.66 ENST00000292641.3
secretoglobin, family 3A, member 1
chr20_+_35201857 0.61 ENST00000373874.2
TGFB-induced factor homeobox 2
chr9_-_124989804 0.58 ENST00000373755.2
ENST00000373754.2
LIM homeobox 6
chr4_+_81951957 0.57 ENST00000282701.2
bone morphogenetic protein 3
chr2_-_99552620 0.57 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211-like
chr2_+_219187871 0.56 ENST00000258362.3
paroxysmal nonkinesigenic dyskinesia
chr13_+_35516390 0.54 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
neurobeachin
chr4_-_149363662 0.54 ENST00000355292.3
ENST00000358102.3
nuclear receptor subfamily 3, group C, member 2
chrX_-_34675391 0.52 ENST00000275954.3
transmembrane protein 47
chr2_+_8822113 0.52 ENST00000396290.1
ENST00000331129.3
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr4_-_168155730 0.52 ENST00000502330.1
ENST00000357154.3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_74137374 0.51 ENST00000322957.6
forkhead box J1
chr11_-_2182388 0.50 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
insulin
INS-IGF2 readthrough
chr7_+_302918 0.49 ENST00000599994.1
Protein LOC100996433
chr20_+_35201993 0.48 ENST00000373872.4
TGFB-induced factor homeobox 2
chr11_-_67272794 0.48 ENST00000436757.2
ENST00000356404.3
phosphatidylinositol transfer protein, membrane-associated 1
chr2_+_238768187 0.45 ENST00000254661.4
ENST00000409726.1
receptor (G protein-coupled) activity modifying protein 1
chr14_+_100848311 0.44 ENST00000542471.2
WD repeat domain 25
chr4_-_168155700 0.43 ENST00000357545.4
ENST00000512648.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_+_56160768 0.43 ENST00000579991.2
dynein, light chain, LC8-type 2
chr2_+_10183651 0.43 ENST00000305883.1
Kruppel-like factor 11
chr4_-_168155300 0.42 ENST00000541637.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_168155417 0.42 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_78194147 0.42 ENST00000534910.1
ENST00000326317.6
N-sulfoglucosamine sulfohydrolase
chr10_+_50818343 0.42 ENST00000374115.3
solute carrier family 18 (vesicular acetylcholine transporter), member 3
chr17_-_5026397 0.41 ENST00000250076.3
zinc finger protein 232
chr17_+_78194205 0.41 ENST00000573809.1
ENST00000361193.3
ENST00000574967.1
ENST00000576126.1
ENST00000411502.3
ENST00000546047.2
solute carrier family 26 (anion exchanger), member 11
chr6_+_33168637 0.41 ENST00000374677.3
solute carrier family 39 (zinc transporter), member 7
chr6_-_29595779 0.41 ENST00000355973.3
ENST00000377012.4
gamma-aminobutyric acid (GABA) B receptor, 1
chr9_-_117880477 0.40 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
tenascin C
chr6_+_33168597 0.40 ENST00000374675.3
solute carrier family 39 (zinc transporter), member 7
chr16_-_88717482 0.39 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr14_-_21994525 0.37 ENST00000538754.1
spalt-like transcription factor 2
chr4_-_168155169 0.36 ENST00000534949.1
ENST00000535728.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr11_+_73676281 0.35 ENST00000543947.1
DnaJ (Hsp40) homolog, subfamily B, member 13
chr9_+_116638562 0.35 ENST00000374126.5
ENST00000288466.7
zinc finger protein 618
chr4_-_168155577 0.34 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr11_+_2466218 0.34 ENST00000155840.5
potassium voltage-gated channel, KQT-like subfamily, member 1
chr12_+_49932886 0.32 ENST00000257981.6
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr12_+_56075330 0.32 ENST00000394252.3
methyltransferase like 7B
chr12_-_51420128 0.30 ENST00000262051.7
ENST00000547732.1
ENST00000262052.5
ENST00000546488.1
ENST00000550714.1
ENST00000548193.1
ENST00000547579.1
ENST00000546743.1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr21_+_46117087 0.30 ENST00000400365.3
keratin associated protein 10-12
chr12_-_51420108 0.29 ENST00000547198.1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr10_+_28966271 0.29 ENST00000375533.3
BMP and activin membrane-bound inhibitor
chr11_+_73675873 0.29 ENST00000537753.1
ENST00000542350.1
DnaJ (Hsp40) homolog, subfamily B, member 13
chr12_-_51419924 0.29 ENST00000541174.2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr12_+_51785057 0.27 ENST00000535225.2
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr1_-_38273840 0.26 ENST00000373044.2
yrdC N(6)-threonylcarbamoyltransferase domain containing
chr9_-_140082983 0.26 ENST00000323927.2
anaphase promoting complex subunit 2
chr22_-_47134077 0.25 ENST00000541677.1
ENST00000216264.8
ceramide kinase
chr1_+_3607228 0.25 ENST00000378285.1
ENST00000378280.1
ENST00000378288.4
tumor protein p73
chr14_+_31343747 0.24 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
cochlin
chr19_+_13906250 0.24 ENST00000254323.2
zinc finger, SWIM-type containing 4
chr12_+_108523133 0.24 ENST00000547525.1
WSC domain containing 2
chr5_-_76383133 0.23 ENST00000255198.2
zinc finger, BED-type containing 3
chr16_+_67596310 0.23 ENST00000264010.4
ENST00000401394.1
CCCTC-binding factor (zinc finger protein)
chr13_+_25254693 0.23 ENST00000381946.3
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr13_+_25254545 0.22 ENST00000218548.6
ATPase, H+/K+ transporting, nongastric, alpha polypeptide
chr17_+_260097 0.22 ENST00000360127.6
ENST00000571106.1
ENST00000491373.1
chromosome 17 open reading frame 97
chr1_+_3569129 0.22 ENST00000354437.4
ENST00000357733.3
ENST00000346387.4
tumor protein p73
chr12_+_108523489 0.22 ENST00000261400.3
WSC domain containing 2
chr17_-_15903002 0.22 ENST00000399277.1
zinc finger, SWIM-type containing 7
chr8_+_67976593 0.22 ENST00000262210.5
ENST00000412460.1
centrosome and spindle pole associated protein 1
chr16_+_4897912 0.21 ENST00000545171.1
ubinuclein 1
chr1_+_85527987 0.21 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WD repeat domain 63
chr10_+_45455207 0.21 ENST00000334940.6
ENST00000374417.2
ENST00000340258.5
ENST00000427758.1
Ras association (RalGDS/AF-6) domain family member 4
chr20_-_18038521 0.21 ENST00000278780.6
ovo-like zinc finger 2
chr10_-_28287968 0.21 ENST00000305242.5
armadillo repeat containing 4
chrX_+_106871713 0.21 ENST00000372435.4
ENST00000372428.4
ENST00000372419.3
ENST00000543248.1
phosphoribosyl pyrophosphate synthetase 1
chr1_-_154928562 0.20 ENST00000368463.3
ENST00000539880.1
ENST00000542459.1
ENST00000368460.3
ENST00000368465.1
pre-B-cell leukemia homeobox interacting protein 1
chr19_+_33685490 0.20 ENST00000253193.7
low density lipoprotein receptor-related protein 3
chr10_-_13390270 0.20 ENST00000378614.4
ENST00000545675.1
ENST00000327347.5
selenophosphate synthetase 1
chr12_-_48398104 0.20 ENST00000337299.6
ENST00000380518.3
collagen, type II, alpha 1
chr4_+_74718906 0.20 ENST00000226524.3
platelet factor 4 variant 1
chr11_-_119211525 0.20 ENST00000528368.1
C1q and tumor necrosis factor related protein 5
chr9_-_130742792 0.19 ENST00000373095.1
family with sequence similarity 102, member A
chr9_-_34662651 0.19 ENST00000259631.4
chemokine (C-C motif) ligand 27
chr6_+_3849584 0.19 ENST00000380274.1
ENST00000380272.3
family with sequence similarity 50, member B
chr17_-_43045439 0.19 ENST00000253407.3
complement component 1, q subcomponent-like 1
chr10_-_13390021 0.19 ENST00000537130.1
selenophosphate synthetase 1
chr7_+_150758304 0.18 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
solute carrier family 4 (anion exchanger), member 2
chr13_+_39261224 0.18 ENST00000280481.7
FRAS1 related extracellular matrix protein 2
chr17_-_50236039 0.18 ENST00000451037.2
carbonic anhydrase X
chr17_-_73178599 0.18 ENST00000578238.1
small ubiquitin-like modifier 2
chr17_+_38599693 0.18 ENST00000542955.1
ENST00000269593.4
insulin-like growth factor binding protein 4
chr5_+_137688285 0.18 ENST00000314358.5
lysine (K)-specific demethylase 3B
chr10_+_134145735 0.18 ENST00000368613.4
leucine rich repeat containing 27
chr11_+_73019282 0.18 ENST00000263674.3
Rho guanine nucleotide exchange factor (GEF) 17
chr20_-_3154162 0.18 ENST00000360342.3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr6_+_32006042 0.17 ENST00000418967.2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr17_+_38219063 0.17 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
thyroid hormone receptor, alpha
chr6_+_32006159 0.17 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr8_-_27462822 0.17 ENST00000522098.1
clusterin
chr11_-_118023490 0.17 ENST00000324727.4
sodium channel, voltage-gated, type IV, beta subunit
chr16_+_89753070 0.17 ENST00000353379.7
ENST00000505473.1
ENST00000564192.1
cyclin-dependent kinase 10
chr16_+_30996502 0.17 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr10_+_35416223 0.16 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
cAMP responsive element modulator
chr7_-_100808843 0.16 ENST00000249330.2
VGF nerve growth factor inducible
chr9_-_98279241 0.16 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
patched 1
chr6_+_143857949 0.16 ENST00000367584.4
phosphatase and actin regulator 2
chr17_-_50235423 0.16 ENST00000340813.6
carbonic anhydrase X
chr8_-_102217796 0.16 ENST00000519744.1
ENST00000311212.4
ENST00000521272.1
ENST00000519882.1
zinc finger protein 706
chr1_-_212873267 0.16 ENST00000243440.1
basic leucine zipper transcription factor, ATF-like 3
chr19_-_2721412 0.16 ENST00000323469.4
DIRAS family, GTP-binding RAS-like 1
chr3_-_112356944 0.16 ENST00000461431.1
coiled-coil domain containing 80
chr2_+_11273179 0.16 ENST00000381585.3
ENST00000405022.3
chromosome 2 open reading frame 50
chr19_-_18385246 0.16 ENST00000608950.1
ENST00000600328.3
ENST00000600359.3
ENST00000392413.4
KIAA1683
chr16_+_4364762 0.16 ENST00000262366.3
GLIS family zinc finger 2
chr5_-_179499108 0.16 ENST00000521389.1
ring finger protein 130
chr19_+_13135731 0.15 ENST00000587260.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_-_100808394 0.15 ENST00000445482.2
VGF nerve growth factor inducible
chr19_+_45251804 0.15 ENST00000164227.5
B-cell CLL/lymphoma 3
chr3_-_132441209 0.15 ENST00000383282.2
ENST00000326682.8
ENST00000343113.4
ENST00000337331.5
nephronophthisis 3 (adolescent)
chr1_+_3569072 0.15 ENST00000378295.4
ENST00000604074.1
tumor protein p73
chr5_-_179499086 0.15 ENST00000261947.4
ring finger protein 130
chr19_-_12992244 0.15 ENST00000538460.1
deoxyribonuclease II, lysosomal
chr20_+_30458431 0.15 ENST00000375938.4
ENST00000535842.1
ENST00000310998.4
ENST00000375921.2
tubulin tyrosine ligase-like family, member 9
chr11_-_73694346 0.15 ENST00000310473.3
uncoupling protein 2 (mitochondrial, proton carrier)
chr16_-_69364467 0.14 ENST00000288022.1
peptide deformylase (mitochondrial)
chr13_+_27131798 0.14 ENST00000361042.4
WAS protein family, member 3
chr19_+_19174795 0.14 ENST00000318596.7
solute carrier family 25, member 42
chr16_+_29466426 0.14 ENST00000567248.1
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr11_-_407103 0.14 ENST00000526395.1
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr2_-_98280383 0.14 ENST00000289228.5
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr17_+_79761997 0.14 ENST00000400723.3
ENST00000570996.1
glucagon receptor
chr3_-_50540854 0.14 ENST00000423994.2
ENST00000424201.2
ENST00000479441.1
ENST00000429770.1
calcium channel, voltage-dependent, alpha 2/delta subunit 2
chrX_-_78622805 0.14 ENST00000373298.2
integral membrane protein 2A
chr4_+_52917451 0.14 ENST00000295213.4
ENST00000419395.2
spermatogenesis associated 18
chr22_-_31328881 0.13 ENST00000445980.1
MORC family CW-type zinc finger 2
chr19_+_49122548 0.13 ENST00000245222.4
ENST00000340932.3
ENST00000601712.1
ENST00000600537.1
sphingosine kinase 2
chr16_+_58059470 0.13 ENST00000219271.3
matrix metallopeptidase 15 (membrane-inserted)
chr21_+_46020497 0.13 ENST00000380102.2
keratin associated protein 10-7
chr11_-_67275542 0.13 ENST00000531506.1
cyclin-dependent kinase 2 associated protein 2
chr12_-_59314246 0.13 ENST00000320743.3
leucine-rich repeats and immunoglobulin-like domains 3
chr7_-_150020750 0.13 ENST00000539352.1
ARP3 actin-related protein 3 homolog C (yeast)
chr2_-_56150184 0.13 ENST00000394554.1
EGF containing fibulin-like extracellular matrix protein 1
chr16_+_67840986 0.13 ENST00000561639.1
ENST00000567852.1
ENST00000565148.1
ENST00000388833.3
ENST00000561654.1
ENST00000431934.2
translin-associated factor X interacting protein 1
chr17_-_80291818 0.13 ENST00000269389.3
ENST00000581691.1
secreted and transmembrane 1
chr16_+_67840668 0.13 ENST00000415766.3
translin-associated factor X interacting protein 1
chr7_+_150020329 0.13 ENST00000323078.7
leucine rich repeat containing 61
chr9_+_214842 0.13 ENST00000453981.1
ENST00000432829.2
dedicator of cytokinesis 8
chr10_+_134258649 0.12 ENST00000392630.3
ENST00000321248.2
chromosome 10 open reading frame 91
chrX_-_54070607 0.12 ENST00000338154.6
ENST00000338946.6
PHD finger protein 8
chr12_-_51785182 0.12 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr17_-_73179046 0.12 ENST00000314523.7
ENST00000420826.2
small ubiquitin-like modifier 2
chr10_-_100027943 0.12 ENST00000260702.3
lysyl oxidase-like 4
chr5_+_121647764 0.12 ENST00000261368.8
ENST00000379533.2
ENST00000379536.2
ENST00000379538.3
synuclein, alpha interacting protein
chr1_+_114471809 0.12 ENST00000426820.2
homeodomain interacting protein kinase 1
chr17_-_4871085 0.12 ENST00000575142.1
ENST00000206020.3
sperm associated antigen 7
chr18_+_11752040 0.12 ENST00000423027.3
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr7_+_150020363 0.12 ENST00000359623.4
ENST00000493307.1
leucine rich repeat containing 61
chr19_+_49122785 0.12 ENST00000598088.1
sphingosine kinase 2
chr2_+_20646824 0.12 ENST00000272233.4
ras homolog family member B
chr10_+_98592674 0.12 ENST00000356016.3
ENST00000371097.4
ligand dependent nuclear receptor corepressor
chr2_-_51259229 0.12 ENST00000405472.3
neurexin 1
chr6_-_39082922 0.12 ENST00000229903.4
SAYSVFN motif domain containing 1
chr10_+_49514698 0.12 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
mitogen-activated protein kinase 8
chr20_+_60698180 0.12 ENST00000361670.3
LSM14B, SCD6 homolog B (S. cerevisiae)
chr8_-_41522719 0.12 ENST00000335651.6
ankyrin 1, erythrocytic
chr3_+_184097836 0.12 ENST00000204604.1
ENST00000310236.3
chordin
chr11_+_121322832 0.12 ENST00000260197.7
sortilin-related receptor, L(DLR class) A repeats containing
chr13_+_27131887 0.12 ENST00000335327.5
WAS protein family, member 3
chr3_-_134093395 0.12 ENST00000249883.5
angiomotin like 2
chr6_+_134274322 0.12 ENST00000367871.1
ENST00000237264.4
TBP-like 1
chr4_+_492985 0.11 ENST00000296306.7
ENST00000536264.1
ENST00000310340.5
ENST00000453061.2
ENST00000504346.1
ENST00000503111.1
ENST00000383028.4
ENST00000509768.1
phosphatidylinositol glycan anchor biosynthesis, class G
chr19_-_40724246 0.11 ENST00000311308.6
tetratricopeptide repeat domain 9B
chr9_-_74383799 0.11 ENST00000377044.4
transmembrane protein 2
chr21_+_43442100 0.11 ENST00000455701.1
ENST00000596595.1
ZNF295 antisense RNA 1
chr15_+_65822756 0.11 ENST00000562901.1
ENST00000261875.5
ENST00000442729.2
ENST00000565299.1
ENST00000568793.1
protein tyrosine phosphatase-like A domain containing 1
chr11_-_65150103 0.11 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
solute carrier family 25, member 45
chr5_+_121647877 0.11 ENST00000514497.2
ENST00000261367.7
synuclein, alpha interacting protein
chr11_-_74109422 0.11 ENST00000298198.4
phosphoglucomutase 2-like 1
chr17_-_3182268 0.11 ENST00000408891.2
olfactory receptor, family 3, subfamily A, member 2
chr20_+_49411523 0.11 ENST00000371608.2
breast carcinoma amplified sequence 4
chr2_-_202645835 0.11 ENST00000264276.6
amyotrophic lateral sclerosis 2 (juvenile)
chr17_-_27893990 0.11 ENST00000307201.4
abhydrolase domain containing 15
chr17_-_39197699 0.11 ENST00000306271.4
keratin associated protein 1-1
chr19_+_10531150 0.11 ENST00000352831.6
phosphodiesterase 4A, cAMP-specific
chr15_+_85147127 0.11 ENST00000541040.1
ENST00000538076.1
ENST00000485222.2
zinc finger and SCAN domain containing 2
chr1_-_6052463 0.11 ENST00000378156.4
nephronophthisis 4
chr19_-_291365 0.11 ENST00000591572.1
ENST00000269812.3
ENST00000434325.2
phosphatidic acid phosphatase type 2C
chr21_-_45682099 0.11 ENST00000270172.3
ENST00000418993.1
DNA (cytosine-5-)-methyltransferase 3-like
chr1_+_38273988 0.10 ENST00000446260.2
chromosome 1 open reading frame 122
chr16_-_8962544 0.10 ENST00000570125.1
calcium regulated heat stable protein 1, 24kDa
chr3_+_54156570 0.10 ENST00000415676.2
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr20_-_4982132 0.10 ENST00000338244.1
ENST00000424750.2
solute carrier family 23 (ascorbic acid transporter), member 2
chr12_+_3000073 0.10 ENST00000397132.2
tubby like protein 3
chr21_-_45681765 0.10 ENST00000431166.1
DNA (cytosine-5-)-methyltransferase 3-like
chr1_+_33352036 0.10 ENST00000373467.3
hippocalcin
chr19_-_1174226 0.10 ENST00000587024.1
ENST00000361757.3
strawberry notch homolog 2 (Drosophila)
chr19_-_58609570 0.10 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
zinc finger and SCAN domain containing 18
chr16_-_8962200 0.10 ENST00000562843.1
ENST00000561530.1
ENST00000396593.2
calcium regulated heat stable protein 1, 24kDa
chr17_-_1083078 0.10 ENST00000574266.1
ENST00000302538.5
active BCR-related
chr19_-_12992274 0.10 ENST00000592506.1
ENST00000222219.3
deoxyribonuclease II, lysosomal
chr16_+_1128781 0.10 ENST00000293897.4
ENST00000562758.1
somatostatin receptor 5
chr16_+_4897632 0.10 ENST00000262376.6
ubinuclein 1
chr15_+_65823092 0.10 ENST00000566074.1
protein tyrosine phosphatase-like A domain containing 1
chr16_-_8962853 0.10 ENST00000565287.1
ENST00000311052.5
calcium regulated heat stable protein 1, 24kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 0.9 GO:0015692 lead ion transport(GO:0015692)
0.2 0.5 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.2 0.5 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.4 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.6 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 2.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.3 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1 0.4 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.4 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.1 0.4 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.2 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.1 0.1 GO:0060434 bronchus morphogenesis(GO:0060434)
0.1 0.4 GO:0015870 acetylcholine transport(GO:0015870)
0.1 0.2 GO:0008050 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.1 0.2 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.4 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 1.1 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.1 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.1 GO:0080121 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.0 0.3 GO:0060214 endocardium formation(GO:0060214)
0.0 0.2 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188) histone H3-K27 demethylation(GO:0071557)
0.0 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.0 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.2 GO:0010157 response to chlorate(GO:0010157)
0.0 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.1 GO:1902771 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.4 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.1 GO:0070904 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.2 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.6 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.2 GO:0060994 regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994)
0.0 0.4 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.2 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.0 0.2 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.2 GO:1902996 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.1 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
0.0 0.7 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.1 GO:1902075 cellular response to salt(GO:1902075)
0.0 0.3 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 0.0 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.3 GO:0008212 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.1 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.3 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.1 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.0 0.0 GO:0036216 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.5 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847) negative regulation of protein import into nucleus, translocation(GO:0033159) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.2 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.1 GO:0071105 response to interleukin-11(GO:0071105)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.2 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.0 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.1 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.0 0.1 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 0.2 GO:0060326 cell chemotaxis(GO:0060326)
0.0 0.1 GO:0038183 bile acid signaling pathway(GO:0038183)
0.0 0.0 GO:0071344 diphosphate metabolic process(GO:0071344)
0.0 0.1 GO:0008272 sulfate transport(GO:0008272)
0.0 0.0 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.0 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.1 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.0 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.5 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 0.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.4 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.3 GO:0097196 Shu complex(GO:0097196)
0.1 0.4 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.1 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.2 GO:0044301 climbing fiber(GO:0044301)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.2 0.9 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.4 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.5 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1 0.4 GO:0031716 calcitonin receptor activity(GO:0004948) calcitonin receptor binding(GO:0031716)
0.1 0.4 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.1 2.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.5 GO:0001727 lipid kinase activity(GO:0001727)
0.1 0.6 GO:0045545 syndecan binding(GO:0045545)
0.1 0.2 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.3 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.1 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.3 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.1 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0008523 L-ascorbate:sodium symporter activity(GO:0008520) sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.2 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.2 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 1.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.3 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.0 0.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0038181 bile acid receptor activity(GO:0038181)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.0 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway