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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZNF143
Z-value: 1.23
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Transcription factors associated with ZNF143
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF143 | hg19_v2_chr11_+_9482551_9482604 | 0.47 | 9.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF143
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 12.8 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 0.5 | 12.5 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 2.3 | 6.8 | GO:0051300 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 1.1 | 6.3 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.0 | 4.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.1 | 2.9 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 2.8 | GO:1903750 | regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751) |
| 0.5 | 2.7 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.8 | 2.5 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 0.6 | 2.3 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 11.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.3 | 6.8 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 0.4 | 6.1 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 5.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 2.9 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 2.8 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.3 | 2.7 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 0.2 | 2.7 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.6 | 2.5 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.2 | 2.3 | GO:0000796 | condensin complex(GO:0000796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 12.8 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.2 | 12.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 7.4 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.6 | 6.1 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.1 | 4.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.5 | 3.8 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.0 | 2.9 | GO:0002039 | p53 binding(GO:0002039) |
| 0.2 | 2.8 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 2.8 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.3 | 2.7 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 2.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 2.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 1.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 0.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.8 | 15.2 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.2 | 6.3 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.2 | 5.6 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 3.5 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.2 | 3.2 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 1.7 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |