ISMARA results: ZNF263

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZNF263

Z-value: 1.62

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Transcription factors associated with ZNF263

Gene Symbol	Gene ID	Gene Info
ZNF263 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000006194.6	zinc finger protein 263

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF263	hg19_v2_chr16_+_3313791_3313834	-0.19	3.0e-01	Click!

Activity profile of ZNF263 motif

Sorted Z-values of ZNF263 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_51504852 Show fit	15.93	ENST00000391806.2 ENST00000347619.4 ENST00000291726.7 ENST00000320838.5	KLK8 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 8
chr19_-_51466681 Show fit	13.36	ENST00000456750.2	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6
chr1_+_150480576 Show fit	10.89	ENST00000346569.6	ECM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	extracellular matrix protein 1
chr1_+_150480551 Show fit	10.18	ENST00000369049.4 ENST00000369047.4	ECM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	extracellular matrix protein 1
chr19_-_51487071 Show fit	9.80	ENST00000391807.1 ENST00000593904.1	KLK7 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 7
chr19_-_55658687 Show fit	8.96	ENST00000593046.1	TNNT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin T type 1 (skeletal, slow)
chr19_-_51456198 Show fit	8.66	ENST00000594846.1	KLK5 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 5
chr17_+_70117153 Show fit	7.45	ENST00000245479.2	SOX9 Ensembl NCBI GeneCards UniProt NextProt Show fit	SRY (sex determining region Y)-box 9
chr6_-_30654977 Show fit	7.38	ENST00000399199.3	PPP1R18 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 18
chr19_-_51472031 Show fit	6.59	ENST00000391808.1	KLK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF263

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	22.7	GO:0016540	protein autoprocessing(GO:0016540)
0.8	21.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
3.1	18.5	GO:0002225	positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
2.0	18.2	GO:0031444	slow-twitch skeletal muscle fiber contraction(GO:0031444)
2.0	15.9	GO:0031642	negative regulation of myelination(GO:0031642)
1.9	11.2	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
1.0	11.1	GO:0034465	response to carbon monoxide(GO:0034465)
1.0	10.7	GO:0060753	regulation of mast cell chemotaxis(GO:0060753)
0.3	8.3	GO:0034380	high-density lipoprotein particle assembly(GO:0034380)
1.4	8.2	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)

Showing 1 to 10 of 448 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	18.9	GO:0005861	troponin complex(GO:0005861)
2.6	18.5	GO:0097209	epidermal lamellar body(GO:0097209)
1.0	17.4	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	17.2	GO:0005730	nucleolus(GO:0005730)
0.1	16.0	GO:0005901	caveola(GO:0005901)
0.0	14.6	GO:0005924	cell-substrate adherens junction(GO:0005924)
0.1	9.4	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	9.4	GO:0000781	chromosome, telomeric region(GO:0000781)
0.0	8.4	GO:0044798	nuclear transcription factor complex(GO:0044798)
2.5	7.6	GO:1990666	PCSK9-LDLR complex(GO:1990666)

Showing 1 to 10 of 169 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	65.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.9	23.5	GO:0005134	interleukin-2 receptor binding(GO:0005134)
1.4	20.2	GO:0031014	troponin T binding(GO:0031014)
1.9	11.2	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
1.4	11.1	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.0	9.4	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0	9.4	GO:0005096	GTPase activator activity(GO:0005096)
0.1	9.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.4	8.2	GO:0004084	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1	8.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)

Showing 1 to 10 of 288 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	23.0	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	21.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	18.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	16.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	12.4	NABA COLLAGENS	Genes encoding collagen proteins
0.1	11.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.7	10.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	8.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.3	8.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	7.8	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 74 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	24.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	14.3	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.5	12.9	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	12.6	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.5	11.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.6	9.6	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.2	8.6	REACTOME G1 PHASE	Genes involved in G1 Phase
0.3	8.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.4	6.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	6.1	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins

Showing 1 to 10 of 115 entries

Results for ZNF263

Z-value: 1.62

Motif logo

Transcription factors associated with ZNF263

Activity-expression correlation:

Activity profile of ZNF263 motif

Sorted Z-values of ZNF263 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF263

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: