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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZNF274

Z-value: 0.33

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.13 zinc finger protein 274

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF274hg19_v2_chr19_+_58694396_58694485-0.222.5e-01Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_45205498 0.77 ENST00000372218.4
KIF2C
kinesin family member 2C
chr1_+_45205478 0.77 ENST00000452259.1
ENST00000372224.4
KIF2C
kinesin family member 2C
chr2_+_11864458 0.38 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr6_+_31553901 0.37 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr12_-_54653313 0.37 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr6_+_31553978 0.34 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr16_+_29818857 0.33 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_30687978 0.33 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr2_-_42991257 0.32 ENST00000378661.2
OXER1
oxoeicosanoid (OXE) receptor 1
chr22_+_39353527 0.28 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr17_-_41132410 0.27 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr14_+_22409308 0.24 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr6_-_32784687 0.24 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr18_+_9885760 0.24 ENST00000536353.2
ENST00000584255.1
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr12_+_109273806 0.23 ENST00000228476.3
ENST00000547768.1
DAO
D-amino-acid oxidase
chr3_+_102153859 0.21 ENST00000306176.1
ENST00000466937.1
ZPLD1
zona pellucida-like domain containing 1
chr19_+_40195101 0.20 ENST00000360675.3
ENST00000601802.1
LGALS14
lectin, galactoside-binding, soluble, 14
chr20_+_60174827 0.20 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr12_+_113344755 0.20 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_10590118 0.19 ENST00000529598.1
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr6_+_36165133 0.19 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr11_+_55653396 0.18 ENST00000244891.3
TRIM51
tripartite motif-containing 51
chr8_-_4852494 0.18 ENST00000520002.1
ENST00000602557.1
CSMD1
CUB and Sushi multiple domains 1
chr8_-_4852218 0.16 ENST00000400186.3
ENST00000602723.1
CSMD1
CUB and Sushi multiple domains 1
chr10_-_29811456 0.16 ENST00000535393.1
SVIL
supervillin
chr16_-_80603558 0.16 ENST00000567317.1
RP11-18F14.1
RP11-18F14.1
chr19_+_6135646 0.15 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr16_+_29819096 0.15 ENST00000568411.1
ENST00000563012.1
ENST00000562557.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_-_89292422 0.15 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr18_+_9885961 0.14 ENST00000306084.6
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr19_+_40194946 0.14 ENST00000392052.3
LGALS14
lectin, galactoside-binding, soluble, 14
chr15_+_89164520 0.14 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr19_+_6887571 0.13 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr14_-_24047965 0.11 ENST00000397118.3
ENST00000356300.4
JPH4
junctophilin 4
chr5_+_32531893 0.11 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr10_+_5488564 0.11 ENST00000449083.1
ENST00000380359.3
NET1
neuroepithelial cell transforming 1
chr16_+_29819372 0.11 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr5_-_74162605 0.10 ENST00000389156.4
ENST00000510496.1
ENST00000380515.3
FAM169A
family with sequence similarity 169, member A
chr18_+_9885934 0.10 ENST00000357775.5
TXNDC2
thioredoxin domain containing 2 (spermatozoa)
chr16_+_29819446 0.10 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chrX_+_52920336 0.08 ENST00000452154.2
FAM156B
family with sequence similarity 156, member B
chr7_+_30791743 0.06 ENST00000013222.5
ENST00000409539.1
INMT
indolethylamine N-methyltransferase
chrX_+_119737806 0.05 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr3_+_50284321 0.05 ENST00000451956.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr19_+_41949054 0.05 ENST00000378187.2
C19orf69
chromosome 19 open reading frame 69
chr16_+_31470179 0.03 ENST00000538189.1
ENST00000268314.4
ARMC5
armadillo repeat containing 5
chr17_-_3461092 0.02 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr2_+_9696028 0.02 ENST00000607241.1
RP11-214N9.1
RP11-214N9.1
chr2_+_178977143 0.01 ENST00000286070.5
RBM45
RNA binding motif protein 45
chr19_-_19774473 0.01 ENST00000357324.6
ATP13A1
ATPase type 13A1
chr1_+_42928945 0.01 ENST00000428554.2
CCDC30
coiled-coil domain containing 30
chr4_-_121993673 0.00 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1 0.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.1 0.4 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.3 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.5 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.0 0.3 GO:0070234 positive regulation of T cell apoptotic process(GO:0070234)
0.0 0.0 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation