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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZNF35

Z-value: 0.34

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Transcription factors associated with ZNF35

Gene Symbol Gene ID Gene Info
ZNF35
ENSG00000169981.6 zinc finger protein 35

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF35hg19_v2_chr3_+_44690211_446902670.328.1e-02Click!

Activity profile of ZNF35 motif

Sorted Z-values of ZNF35 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_36429763 1.32 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr3_-_148939835 0.99 ENST00000264613.6
CP
ceruloplasmin (ferroxidase)
chr6_+_32812568 0.97 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr14_+_76776957 0.77 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chrX_+_9431324 0.61 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr17_-_63557759 0.43 ENST00000307078.5
AXIN2
axin 2
chr7_+_80231466 0.32 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr14_-_31889782 0.31 ENST00000543095.2
HEATR5A
HEAT repeat containing 5A
chr1_+_61869748 0.31 ENST00000357977.5
NFIA
nuclear factor I/A
chr17_-_39324424 0.28 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr18_+_74240610 0.25 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
LINC00908
long intergenic non-protein coding RNA 908
chr12_+_51318513 0.23 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr18_+_39535152 0.23 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
PIK3C3
phosphatidylinositol 3-kinase, catalytic subunit type 3
chr3_+_69985734 0.22 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chr5_+_139028510 0.21 ENST00000502336.1
ENST00000520967.1
ENST00000511048.1
CXXC5
CXXC finger protein 5
chr5_+_139027877 0.21 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr14_-_92198403 0.18 ENST00000553329.1
ENST00000256343.3
CATSPERB
catsper channel auxiliary subunit beta
chr13_-_41240717 0.17 ENST00000379561.5
FOXO1
forkhead box O1
chr15_+_96876340 0.17 ENST00000453270.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr9_+_42671887 0.16 ENST00000456520.1
ENST00000377391.3
CBWD7
COBW domain containing 7
chr4_+_129730947 0.15 ENST00000452328.2
ENST00000504089.1
PHF17
jade family PHD finger 1
chr17_-_63557309 0.14 ENST00000580513.1
AXIN2
axin 2
chr1_+_220701456 0.13 ENST00000366918.4
ENST00000402574.1
MARK1
MAP/microtubule affinity-regulating kinase 1
chr7_+_27282319 0.13 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr3_+_141105705 0.11 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr3_+_69985792 0.11 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr12_+_54891495 0.11 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr4_+_78804393 0.10 ENST00000502384.1
MRPL1
mitochondrial ribosomal protein L1
chr10_-_4285923 0.10 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr21_+_35552978 0.09 ENST00000428914.2
ENST00000609062.1
ENST00000609947.1
LINC00310
long intergenic non-protein coding RNA 310
chr20_+_56964169 0.09 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr3_-_58523010 0.08 ENST00000459701.2
ENST00000302819.5
ACOX2
acyl-CoA oxidase 2, branched chain
chrM_+_4431 0.08 ENST00000361453.3
MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr9_+_130853715 0.08 ENST00000373066.5
ENST00000432073.2
SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr8_+_85095769 0.08 ENST00000518566.1
RALYL
RALY RNA binding protein-like
chr1_-_12677714 0.07 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr17_+_41561317 0.07 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
DHX8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr7_+_123488124 0.07 ENST00000476325.1
HYAL4
hyaluronoglucosaminidase 4
chr12_+_25205666 0.07 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chrX_-_138724677 0.07 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr1_+_214161272 0.05 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr2_+_177015122 0.05 ENST00000468418.3
HOXD3
homeobox D3
chr19_-_12833164 0.05 ENST00000356861.5
TNPO2
transportin 2
chr3_+_29323043 0.05 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr1_-_161008697 0.05 ENST00000318289.10
ENST00000368023.3
ENST00000368024.1
ENST00000423014.2
TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr8_-_145754428 0.04 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr21_+_17792672 0.04 ENST00000602620.1
LINC00478
long intergenic non-protein coding RNA 478
chr13_-_47471155 0.04 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr4_+_88754069 0.04 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr2_-_191878162 0.03 ENST00000540176.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_+_25205446 0.03 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr10_-_52645379 0.03 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr10_-_52645416 0.03 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF
APOBEC1 complementation factor
chr4_+_88754113 0.03 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr13_-_53422640 0.02 ENST00000338862.4
ENST00000377942.3
PCDH8
protocadherin 8
chr6_-_135271219 0.02 ENST00000367847.2
ENST00000367845.2
ALDH8A1
aldehyde dehydrogenase 8 family, member A1
chr8_-_116680833 0.01 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr17_-_42295870 0.01 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
UBTF
upstream binding transcription factor, RNA polymerase I
chr2_+_166150541 0.00 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF35

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.2 0.6 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.3 GO:2000332 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.2 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.2 GO:1902617 response to fluoride(GO:1902617)
0.0 1.0 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 1.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.0 0.1 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.3 GO:0072189 ureter development(GO:0072189)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.6 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 1.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)