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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZNF423

Z-value: 1.00

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ZNF423
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49698136_496982090.505.4e-03Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_22022800 4.53 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr5_+_150400124 4.42 ENST00000388825.4
ENST00000521650.1
ENST00000517973.1
GPX3
glutathione peroxidase 3 (plasma)
chr6_+_151186554 3.40 ENST00000367321.3
ENST00000367307.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr11_-_61062762 3.24 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr1_-_204121013 3.22 ENST00000367201.3
ETNK2
ethanolamine kinase 2
chr1_-_204121102 3.21 ENST00000367202.4
ETNK2
ethanolamine kinase 2
chr1_-_204121298 3.14 ENST00000367199.2
ETNK2
ethanolamine kinase 2
chr19_-_11689752 3.14 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
ACP5
acid phosphatase 5, tartrate resistant
chr10_-_121296045 3.13 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr8_+_22022223 2.94 ENST00000306385.5
BMP1
bone morphogenetic protein 1
chr5_+_135385202 2.55 ENST00000514554.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr8_+_22022653 2.49 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr17_+_6347729 2.35 ENST00000572447.1
FAM64A
family with sequence similarity 64, member A
chr17_+_6347761 2.32 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
FAM64A
family with sequence similarity 64, member A
chr12_-_125348329 2.31 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
SCARB1
scavenger receptor class B, member 1
chr16_+_71392616 2.28 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr9_-_131486367 2.25 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr10_+_17271266 2.21 ENST00000224237.5
VIM
vimentin
chr22_-_37823468 2.18 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chrX_-_51239425 2.17 ENST00000375992.3
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr12_-_125348448 2.03 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr11_+_60691924 2.00 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
TMEM132A
transmembrane protein 132A
chr1_-_155177677 1.69 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3
thrombospondin 3
chr6_+_151187074 1.57 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chrX_-_107019181 1.56 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr10_+_135340859 1.51 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr20_-_62475273 1.50 ENST00000596861.1
AL158091.1
Protein LOC100509861
chr15_+_41523417 1.50 ENST00000560397.1
CHP1
calcineurin-like EF-hand protein 1
chr11_-_61659006 1.48 ENST00000278829.2
FADS3
fatty acid desaturase 3
chrX_+_49028265 1.47 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr7_-_23053719 1.47 ENST00000432176.2
ENST00000440481.1
FAM126A
family with sequence similarity 126, member A
chr7_-_23053693 1.47 ENST00000409763.1
ENST00000409923.1
FAM126A
family with sequence similarity 126, member A
chr10_-_76859247 1.46 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
DUSP13
dual specificity phosphatase 13
chr3_-_48594248 1.43 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr11_-_61658853 1.40 ENST00000525588.1
ENST00000540820.1
FADS3
fatty acid desaturase 3
chr17_+_7341586 1.36 ENST00000575235.1
FGF11
fibroblast growth factor 11
chr9_+_112542572 1.34 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr8_+_22423219 1.29 ENST00000523965.1
ENST00000521554.1
SORBS3
sorbin and SH3 domain containing 3
chr19_-_10679644 1.27 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chrX_-_107018969 1.26 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr9_+_116638562 1.26 ENST00000374126.5
ENST00000288466.7
ZNF618
zinc finger protein 618
chr16_+_27325202 1.17 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R
interleukin 4 receptor
chr19_-_15311713 1.16 ENST00000601011.1
ENST00000263388.2
NOTCH3
notch 3
chr19_+_45971246 1.05 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr17_+_36584662 1.05 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr2_+_62932779 1.04 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EHBP1
EH domain binding protein 1
chr8_+_22422749 1.02 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr3_-_195808980 1.01 ENST00000360110.4
TFRC
transferrin receptor
chr8_+_30241934 1.00 ENST00000538486.1
RBPMS
RNA binding protein with multiple splicing
chr10_+_124913793 0.98 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr3_-_195808952 0.97 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC
transferrin receptor
chr13_+_21277482 0.96 ENST00000304920.3
IL17D
interleukin 17D
chr1_+_155278625 0.95 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr11_-_47207950 0.94 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr12_-_54779511 0.89 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr19_+_45582453 0.88 ENST00000591607.1
ENST00000591747.1
ENST00000270257.4
ENST00000391951.2
ENST00000587566.1
GEMIN7
MARK4
gem (nuclear organelle) associated protein 7
MAP/microtubule affinity-regulating kinase 4
chr4_+_4388805 0.87 ENST00000504171.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr6_+_33589161 0.83 ENST00000605930.1
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr11_+_61595752 0.80 ENST00000521849.1
FADS2
fatty acid desaturase 2
chr6_+_142468361 0.78 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr5_-_172756506 0.77 ENST00000265087.4
STC2
stanniocalcin 2
chr13_+_96743093 0.76 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr22_+_35653445 0.73 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr4_-_20985632 0.73 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr9_-_35619539 0.71 ENST00000396757.1
CD72
CD72 molecule
chr3_+_6902794 0.69 ENST00000357716.4
ENST00000486284.1
ENST00000389336.4
ENST00000403881.1
ENST00000402647.2
GRM7
glutamate receptor, metabotropic 7
chr17_-_48227877 0.69 ENST00000316878.6
PPP1R9B
protein phosphatase 1, regulatory subunit 9B
chr9_+_112542591 0.63 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr4_+_4388245 0.62 ENST00000433139.2
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr1_+_55271736 0.62 ENST00000358193.3
ENST00000371273.3
C1orf177
chromosome 1 open reading frame 177
chr6_-_35480640 0.61 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr6_+_42896865 0.60 ENST00000372836.4
ENST00000394142.3
CNPY3
canopy FGF signaling regulator 3
chr8_+_30241995 0.59 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RBPMS
RNA binding protein with multiple splicing
chr11_-_67120974 0.59 ENST00000539074.1
ENST00000312419.3
POLD4
polymerase (DNA-directed), delta 4, accessory subunit
chr1_-_102462565 0.57 ENST00000370103.4
OLFM3
olfactomedin 3
chr3_+_180630444 0.55 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr11_-_64013663 0.53 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_+_136648297 0.53 ENST00000287538.5
ZIC3
Zic family member 3
chr6_-_35480705 0.52 ENST00000229771.6
TULP1
tubby like protein 1
chr8_+_22423168 0.51 ENST00000518912.1
ENST00000428103.1
SORBS3
sorbin and SH3 domain containing 3
chr15_+_41523335 0.51 ENST00000334660.5
CHP1
calcineurin-like EF-hand protein 1
chr16_+_3014269 0.51 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
KREMEN2
kringle containing transmembrane protein 2
chr4_+_4387983 0.49 ENST00000397958.1
NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr12_-_118810688 0.49 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr16_+_3014217 0.47 ENST00000572045.1
KREMEN2
kringle containing transmembrane protein 2
chrX_+_106163626 0.46 ENST00000336803.1
CLDN2
claudin 2
chr12_-_50101003 0.45 ENST00000550488.1
FMNL3
formin-like 3
chr6_-_91296602 0.43 ENST00000369325.3
ENST00000369327.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr18_-_60985914 0.42 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chr13_-_46626847 0.42 ENST00000242848.4
ENST00000282007.3
ZC3H13
zinc finger CCCH-type containing 13
chr19_+_20011775 0.40 ENST00000592245.1
ENST00000592160.1
ENST00000343769.5
AC007204.2
ZNF93
AC007204.2
zinc finger protein 93
chr6_-_91296737 0.40 ENST00000369332.3
ENST00000369329.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr12_-_4554780 0.39 ENST00000228837.2
FGF6
fibroblast growth factor 6
chr7_-_5570229 0.38 ENST00000331789.5
ACTB
actin, beta
chr4_+_128982490 0.37 ENST00000394288.3
ENST00000432347.2
ENST00000264584.5
ENST00000441387.1
ENST00000427266.1
ENST00000354456.3
LARP1B
La ribonucleoprotein domain family, member 1B
chr10_+_124914285 0.37 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr8_-_42234745 0.37 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr3_+_9958758 0.35 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
IL17RC
interleukin 17 receptor C
chr15_-_75660919 0.35 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
MAN2C1
mannosidase, alpha, class 2C, member 1
chr1_+_10459111 0.34 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr11_-_62783276 0.33 ENST00000535878.1
ENST00000545207.1
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr2_+_171785824 0.33 ENST00000452526.2
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr7_+_20370746 0.30 ENST00000222573.4
ITGB8
integrin, beta 8
chr7_-_100253993 0.30 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chr4_-_120548779 0.30 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chr5_+_78407602 0.28 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr7_-_27219849 0.27 ENST00000396344.4
HOXA10
homeobox A10
chr9_+_135037334 0.27 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
NTNG2
netrin G2
chr1_+_53527854 0.27 ENST00000371500.3
ENST00000395871.2
ENST00000312553.5
PODN
podocan
chr5_-_176057365 0.27 ENST00000310112.3
SNCB
synuclein, beta
chr4_+_128982430 0.25 ENST00000512292.1
ENST00000508819.1
LARP1B
La ribonucleoprotein domain family, member 1B
chr9_-_39239171 0.24 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr8_-_133493200 0.24 ENST00000388996.4
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr10_+_124913930 0.22 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr4_+_152330390 0.20 ENST00000503146.1
ENST00000435205.1
FAM160A1
family with sequence similarity 160, member A1
chr2_+_171785012 0.20 ENST00000234160.4
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr5_-_176057518 0.20 ENST00000393693.2
SNCB
synuclein, beta
chr11_-_62783303 0.20 ENST00000336232.2
ENST00000430500.2
SLC22A8
solute carrier family 22 (organic anion transporter), member 8
chr3_+_9958870 0.19 ENST00000413608.1
IL17RC
interleukin 17 receptor C
chrX_-_48827976 0.19 ENST00000218176.3
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr14_-_77608121 0.18 ENST00000319374.4
ZDHHC22
zinc finger, DHHC-type containing 22
chr2_+_135011731 0.18 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr1_+_26644441 0.17 ENST00000374213.2
CD52
CD52 molecule
chr4_-_78740511 0.17 ENST00000504123.1
ENST00000264903.4
ENST00000515441.1
CNOT6L
CCR4-NOT transcription complex, subunit 6-like
chr7_+_150748288 0.16 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr2_+_12246664 0.16 ENST00000449986.1
AC096559.1
AC096559.1
chr7_-_44265492 0.15 ENST00000425809.1
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr10_-_75255724 0.15 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr3_+_196439275 0.14 ENST00000296333.5
PIGX
phosphatidylinositol glycan anchor biosynthesis, class X
chr22_-_38484922 0.14 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr9_-_16870704 0.10 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr16_-_11681023 0.09 ENST00000570904.1
ENST00000574701.1
LITAF
lipopolysaccharide-induced TNF factor
chr19_-_57183114 0.09 ENST00000537055.2
ENST00000601659.1
ZNF835
zinc finger protein 835
chr6_+_168841817 0.08 ENST00000356284.2
ENST00000354536.5
SMOC2
SPARC related modular calcium binding 2
chr20_+_23016057 0.07 ENST00000255008.3
SSTR4
somatostatin receptor 4
chr1_-_48462566 0.07 ENST00000606738.2
TRABD2B
TraB domain containing 2B
chr5_+_68788594 0.06 ENST00000396442.2
ENST00000380766.2
OCLN
occludin
chrX_+_30265256 0.06 ENST00000397548.2
MAGEB1
melanoma antigen family B, 1
chr17_+_28705921 0.06 ENST00000225719.4
CPD
carboxypeptidase D
chr19_-_36391434 0.06 ENST00000396901.1
ENST00000585925.1
NFKBID
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
chr6_+_30130969 0.05 ENST00000376694.4
TRIM15
tripartite motif containing 15
chr3_+_196439170 0.05 ENST00000392391.3
ENST00000314118.4
PIGX
phosphatidylinositol glycan anchor biosynthesis, class X
chr12_+_7037461 0.03 ENST00000396684.2
ATN1
atrophin 1
chr3_+_32726774 0.03 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr4_-_166034029 0.02 ENST00000306480.6
TMEM192
transmembrane protein 192
chr14_-_93582214 0.02 ENST00000556603.2
ENST00000354313.3
ITPK1
inositol-tetrakisphosphate 1-kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0015920 lipopolysaccharide transport(GO:0015920)
1.2 5.0 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.7 4.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.6 3.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.4 10.4 GO:0001502 cartilage condensation(GO:0001502)
0.4 2.2 GO:1901906 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.4 9.6 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 2.8 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.3 1.5 GO:0010193 response to ozone(GO:0010193)
0.3 2.0 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.2 1.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 1.2 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834)
0.2 0.7 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.2 1.0 GO:0045337 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.2 2.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.2 0.9 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.2 2.0 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.2 0.8 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.2 0.8 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.2 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 3.1 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 1.3 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.3 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051) aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.1 1.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 1.7 GO:0060346 bone trabecula formation(GO:0060346)
0.1 0.4 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.7 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 2.0 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 0.3 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.5 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.6 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.1 2.3 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.1 0.8 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.5 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 3.7 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.8 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 1.1 GO:0051412 response to corticosterone(GO:0051412)
0.0 1.6 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 2.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.2 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.4 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:1904808 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.5 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 2.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.9 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.6 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 0.2 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0038170 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.7 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 1.0 GO:0030279 negative regulation of ossification(GO:0030279)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.2 2.0 GO:0098845 postsynaptic endosome(GO:0098845)
0.2 1.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 4.3 GO:0031528 microvillus membrane(GO:0031528)
0.1 2.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.9 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 0.7 GO:0016589 NURF complex(GO:0016589)
0.1 2.3 GO:0005921 gap junction(GO:0005921)
0.1 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.8 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 4.3 GO:0043679 axon terminus(GO:0043679)
0.0 12.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.4 GO:0046930 pore complex(GO:0046930)
0.0 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 2.2 GO:0005882 intermediate filament(GO:0005882)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.3 GO:0016514 SWI/SNF complex(GO:0016514)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
1.2 5.0 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
1.0 9.6 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.7 2.0 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.4 4.4 GO:0008430 selenium binding(GO:0008430)
0.4 1.2 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.4 2.2 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.3 2.2 GO:1990254 keratin filament binding(GO:1990254)
0.3 2.8 GO:0043426 MRF binding(GO:0043426)
0.3 0.8 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 3.1 GO:0008199 ferric iron binding(GO:0008199)
0.2 1.4 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.2 1.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.2 2.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 0.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 1.0 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2 0.8 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 0.7 GO:0070905 serine binding(GO:0070905)
0.1 2.8 GO:0017166 vinculin binding(GO:0017166)
0.1 3.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.3 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 0.3 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.1 2.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.5 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 10.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 3.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 1.5 GO:0019956 chemokine binding(GO:0019956)
0.0 1.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.5 GO:1903136 cuprous ion binding(GO:1903136)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 2.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 2.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 2.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.5 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 2.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 2.2 PID AURORA B PATHWAY Aurora B signaling
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 8.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 5.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.6 PID P73PATHWAY p73 transcription factor network
0.0 1.1 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 14.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.4 9.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 0.8 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 1.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.5 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 0.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 2.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 2.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.8 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 2.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.9 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions