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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)
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Results for ZNF524
Z-value: 1.76
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Transcription factors associated with ZNF524
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF524 | hg19_v2_chr19_+_56111680_56111735 | 0.40 | 2.7e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF524
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 22.4 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
| 7.3 | 21.8 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.2 | 12.6 | GO:1901998 | toxin transport(GO:1901998) |
| 1.1 | 10.3 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.2 | 10.1 | GO:0090224 | regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224) |
| 2.2 | 8.9 | GO:0046086 | adenosine biosynthetic process(GO:0046086) |
| 0.5 | 8.5 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 1.2 | 8.3 | GO:0051121 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.1 | 7.9 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 2.5 | 7.4 | GO:0019074 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 22.4 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 16.3 | GO:0005924 | cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925) |
| 0.4 | 10.6 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 10.1 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.6 | 9.8 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.1 | 8.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 7.3 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.3 | 7.1 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.9 | 6.9 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.1 | 6.9 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 22.1 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.7 | 10.4 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.5 | 10.0 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 9.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 9.6 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.0 | 9.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.8 | 8.3 | GO:0016165 | linoleate 13S-lipoxygenase activity(GO:0016165) |
| 2.0 | 8.2 | GO:0008431 | vitamin E binding(GO:0008431) |
| 0.8 | 7.6 | GO:0004075 | biotin carboxylase activity(GO:0004075) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.4 | 13.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 11.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 11.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 9.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 9.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 6.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 6.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 5.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.2 | PID NOTCH PATHWAY | Notch signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 14.9 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 9.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 9.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 9.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.5 | 9.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.3 | 6.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 5.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 5.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 5.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |