ISMARA results: ZNF711_TFAP2A

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Mucociliary differentiation, bronchial epithelial cells, human (Ross 2007)

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Results for ZNF711_TFAP2A_TFAP2D

Z-value: 1.85

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Transcription factors associated with ZNF711_TFAP2A_TFAP2D

Gene Symbol	Gene ID	Gene Info
ZNF711 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000147180.12	zinc finger protein 711
TFAP2A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000137203.6	transcription factor AP-2 alpha
TFAP2D Ensembl NCBI GeneCards UniProt NextProt	ENSG00000008197.4	transcription factor AP-2 delta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZNF711	hg19_v2_chrX_+_84498989_84499003, hg19_v2_chrX_+_84499038_84499078	-0.50	4.5e-03	Click!
TFAP2A	hg19_v2_chr6_-_10415470_10415508	-0.48	7.2e-03	Click!
TFAP2D	hg19_v2_chr6_+_50681541_50681541	-0.48	7.7e-03	Click!

Activity profile of ZNF711_TFAP2A_TFAP2D motif

Sorted Z-values of ZNF711_TFAP2A_TFAP2D motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_180018540 Show fit	11.89	ENST00000292641.3	SCGB3A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	secretoglobin, family 3A, member 1
chr4_-_7044657 Show fit	11.24	ENST00000310085.4	CCDC96 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 96
chr12_+_50355647 Show fit	11.02	ENST00000293599.6	AQP5 Ensembl NCBI GeneCards UniProt NextProt Show fit	aquaporin 5
chr21_-_43916433 Show fit	7.96	ENST00000291536.3	RSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	radial spoke head 1 homolog (Chlamydomonas)
chr22_-_50970506 Show fit	7.71	ENST00000428989.2 ENST00000403326.1	ODF3B Ensembl NCBI GeneCards UniProt NextProt Show fit	outer dense fiber of sperm tails 3B
chr14_+_105953204 Show fit	7.40	ENST00000409393.2	CRIP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine-rich protein 1 (intestinal)
chr2_-_130902567 Show fit	7.08	ENST00000457413.1 ENST00000392984.3 ENST00000409128.1 ENST00000441670.1 ENST00000409943.3 ENST00000409234.3 ENST00000310463.6	CCDC74B Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 74B
chr21_+_36041688 Show fit	6.98	ENST00000360731.3 ENST00000349499.2	CLIC6 Ensembl NCBI GeneCards UniProt NextProt Show fit	chloride intracellular channel 6
chr4_-_16085340 Show fit	6.82	ENST00000508167.1	PROM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	prominin 1
chr5_+_10441970 Show fit	6.81	ENST00000274134.4	ROPN1L Ensembl NCBI GeneCards UniProt NextProt Show fit	rhophilin associated tail protein 1-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF711_TFAP2A_TFAP2D

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	51.9	GO:0060271	cilium morphogenesis(GO:0060271)
1.4	47.4	GO:0070286	axonemal dynein complex assembly(GO:0070286)
0.6	31.8	GO:0042073	intraciliary transport(GO:0042073)
1.0	23.7	GO:0035082	axoneme assembly(GO:0035082)
4.5	22.4	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	19.6	GO:0000209	protein polyubiquitination(GO:0000209)
4.4	17.6	GO:0072139	glomerular parietal epithelial cell differentiation(GO:0072139)
0.8	17.5	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
1.0	16.5	GO:0003351	epithelial cilium movement(GO:0003351)
0.8	15.2	GO:0003341	cilium movement(GO:0003341)

Showing 1 to 10 of 1,287 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	40.1	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	34.6	GO:0005654	nucleoplasm(GO:0005654)
0.1	29.6	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.4	26.1	GO:0036038	MKS complex(GO:0036038)
0.3	21.0	GO:0036064	ciliary basal body(GO:0036064)
1.5	20.3	GO:0001520	outer dense fiber(GO:0001520)
0.2	18.3	GO:0031514	motile cilium(GO:0031514)
0.5	18.0	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.3	15.7	GO:0009925	basal plasma membrane(GO:0009925)
0.7	14.6	GO:0042613	MHC class II protein complex(GO:0042613)

Showing 1 to 10 of 419 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	57.0	GO:0003677	DNA binding(GO:0003677)
0.1	36.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.8	18.2	GO:0045504	dynein heavy chain binding(GO:0045504)
0.2	17.8	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.9	16.0	GO:0003680	AT DNA binding(GO:0003680)
0.2	13.9	GO:0042805	actinin binding(GO:0042805)
0.0	13.2	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1	12.7	GO:0070491	repressing transcription factor binding(GO:0070491)
1.0	12.5	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.3	12.2	GO:0043015	gamma-tubulin binding(GO:0043015)

Showing 1 to 10 of 726 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	17.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	14.3	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	13.7	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.3	12.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.3	11.3	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	10.8	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	9.6	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.3	9.5	PID MYC PATHWAY	C-MYC pathway
0.1	9.5	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.5	8.7	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 10 of 88 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	40.6	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.3	15.6	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.9	13.7	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.1	13.5	REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.2	12.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.2	12.7	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.4	11.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.3	11.1	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.4	10.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.4	10.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines

Showing 1 to 10 of 137 entries

Results for ZNF711_TFAP2A_TFAP2D

Z-value: 1.85

Motif logo

Transcription factors associated with ZNF711_TFAP2A_TFAP2D

Activity-expression correlation:

Activity profile of ZNF711_TFAP2A_TFAP2D motif

Sorted Z-values of ZNF711_TFAP2A_TFAP2D motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF711_TFAP2A_TFAP2D

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: