Motif ID: AAGGUGC

Z-value: 1.139


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a MIMAT0000072
hsa-miR-18b MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_163038395 1.597 NM_001102445
RGS4
regulator of G-protein signaling 4
chr1_+_163038564 1.592 NM_005613
RGS4
regulator of G-protein signaling 4
chr1_+_163041694 1.590 NM_001113380
RGS4
regulator of G-protein signaling 4
chr1_+_163038934 1.565 NM_001113381
RGS4
regulator of G-protein signaling 4
chr6_-_132272311 0.890 NM_001901
CTGF
connective tissue growth factor
chr22_+_38092994 0.883 NM_001039141
TRIOBP
TRIO and F-actin binding protein
chr20_+_34700257 0.794 NM_177996
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr20_+_34742656 0.745 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr6_+_11538486 0.743 NM_001100829
TMEM170B
transmembrane protein 170B
chr6_+_39760772 0.650 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_+_201708940 0.647 NM_001167738
NAV1
neuron navigator 1
chr10_-_81205091 0.611 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr1_+_201617449 0.601 NM_020443
NAV1
neuron navigator 1
chr6_+_39760148 0.561 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr1_+_162466963 0.514 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr9_-_138987096 0.503 NM_144653
NACC2
NACC family member 2, BEN and BTB (POZ) domain containing
chr3_+_42695175 0.501 NM_145166
ZBTB47
zinc finger and BTB domain containing 47
chr5_-_171710794 0.498 NM_152277
UBTD2
ubiquitin domain containing 2
chr2_+_24807345 0.477 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr12_+_12764755 0.474 NM_001310
CREBL2
cAMP responsive element binding protein-like 2
chr1_+_162467594 0.459 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chr5_-_58334936 0.459 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr18_+_48086402 0.429 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr4_-_125633716 0.425 NM_001167882
NM_020337
ANKRD50

ankyrin repeat domain 50

chr6_-_11382501 0.418 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_-_111136407 0.391 NM_015076
CDK19
cyclin-dependent kinase 19
chr3_+_105085553 0.387 NM_001243280
NM_001243281
NM_001243283
NM_001627
ALCAM



activated leukocyte cell adhesion molecule



chr5_-_59783885 0.386 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_+_38142230 0.378 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr12_+_104458235 0.364 NM_013320
HCFC2
host cell factor C2
chr2_-_145277879 0.351 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr9_+_118916069 0.350 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr7_-_139477437 0.343 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr5_-_73937248 0.339 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr9_-_74383301 0.337 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr2_+_109745996 0.335 NM_001099289
SH3RF3
SH3 domain containing ring finger 3
chr3_+_187930720 0.316 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_+_151985828 0.310 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr9_-_132805456 0.301 NM_015033
FNBP1
formin binding protein 1
chr13_-_38172862 0.297 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr6_+_112408673 0.293 NM_001033564
C6orf225
chromosome 6 open reading frame 225
chr5_-_59189620 0.289 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_+_173684061 0.275 NM_014458
KLHL20
kelch-like 20 (Drosophila)
chr9_+_120466453 0.274 NM_138554
TLR4
toll-like receptor 4
chr15_-_60919642 0.273 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr3_+_187871473 0.272 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_153032141 0.270 NM_005843
STAM2
signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
chr3_+_152017193 0.270 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr5_-_58295758 0.264 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_9546157 0.259 NM_003966
SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr9_-_99180661 0.254 NM_153695
ZNF367
zinc finger protein 367
chr15_-_56209305 0.254 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr3_+_187943192 0.251 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_-_83931973 0.251 NM_001115008
NM_194282
LIN54

lin-54 homolog (C. elegans)

chr15_-_60884615 0.248 NM_134262
RORA
RAR-related orphan receptor A
chr10_-_79397546 0.245 NM_001014797
NM_001161352
NM_001161353
NM_002247
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr17_+_27717942 0.242 NM_020791
NM_025142
TAOK1

TAO kinase 1

chr7_-_100286869 0.232 NM_022574
GIGYF1
GRB10 interacting GYF protein 1
chr22_+_31090792 0.229 NM_030758
OSBP2
oxysterol binding protein 2
chr5_-_59064437 0.227 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_43595119 0.227 NM_006282
STK4
serine/threonine kinase 4
chr12_-_15038724 0.225 NM_000900
NM_001190839
MGP

matrix Gla protein

chr5_-_142783225 0.223 NM_000176
NM_001020825
NM_001024094
NM_001204258
NM_001204259
NM_001204260
NM_001204261
NM_001204262
NM_001204263
NM_001204264
NM_001204265
NR3C1










nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)










chr10_-_119805673 0.220 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chrX_-_19688991 0.219 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr20_+_56884749 0.218 NM_020673
RAB22A
RAB22A, member RAS oncogene family
chr13_-_77601296 0.217 NM_012158
FBXL3
F-box and leucine-rich repeat protein 3
chr22_-_44708730 0.217 NM_001099294
KIAA1644
KIAA1644
chr2_-_55646946 0.215 NM_001135597
NM_018084
CCDC88A

coiled-coil domain containing 88A

chr5_-_58652671 0.215 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr15_-_56285732 0.213 NM_006154
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr5_-_58571916 0.213 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr1_-_70820363 0.212 NM_030816
ANKRD13C
ankyrin repeat domain 13C
chr17_-_76921453 0.211 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr7_-_111846384 0.207 NM_014705
DOCK4
dedicator of cytokinesis 4
chr5_-_180288275 0.206 NM_001172638
NM_152283
ZFP62

zinc finger protein 62 homolog (mouse)

chr11_+_108093558 0.196 NM_000051
ATM
ataxia telangiectasia mutated
chr4_+_55523906 0.194 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr16_+_71879893 0.193 NM_001137675
ATXN1L
ataxin 1-like
chr2_+_45169036 0.187 NM_005413
SIX3
SIX homeobox 3
chr2_-_179343225 0.185 NM_001135212
NM_181342
FKBP7

FK506 binding protein 7

chr16_-_57219951 0.181 NM_024946
FAM192A
family with sequence similarity 192, member A
chr1_-_23521221 0.181 NM_000864
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D
chrX_-_19817907 0.179 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr21_+_45285101 0.176 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr6_-_52441815 0.171 NM_012288
TRAM2
translocation associated membrane protein 2
chr2_+_12856813 0.169 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr21_+_45345278 0.167 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr14_+_62162042 0.167 NM_001530
NM_181054
HIF1A

hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

chr1_+_145575987 0.167 NM_006099
PIAS3
protein inhibitor of activated STAT, 3
chr1_-_161993586 0.165 NM_015441
OLFML2B
olfactomedin-like 2B
chr19_-_23578226 0.165 NM_003430
ZNF91
zinc finger protein 91
chr6_-_11232901 0.163 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr5_+_122424840 0.163 NM_001136239
PRDM6
PR domain containing 6
chr4_+_154074269 0.158 NM_001130067
TRIM2
tripartite motif containing 2
chr5_-_41510627 0.157 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr4_-_186578122 0.155 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr1_+_145438437 0.153 NM_006472
TXNIP
thioredoxin interacting protein
chr16_+_28996146 0.151 NM_001014989
LAT
linker for activation of T cells
chr5_-_142783975 0.150 NM_001018076
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_50879681 0.149 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chrX_+_108780235 0.148 NM_001242618
NXT2
nuclear transport factor 2-like export factor 2
chr16_+_28996369 0.147 NM_001014987
NM_001014988
NM_014387
LAT


linker for activation of T cells


chr17_+_68165660 0.146 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr12_-_29936685 0.144 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr7_+_7606549 0.142 NM_019005
MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr5_-_142815076 0.142 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chrX_+_108779009 0.141 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr4_-_2263706 0.140 NM_006454
MXD4
MAX dimerization protein 4
chr22_-_30867944 0.138 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr12_-_29937691 0.138 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr6_+_124125068 0.135 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr20_+_30865435 0.133 NM_004798
KIF3B
kinesin family member 3B
chr16_+_85061303 0.131 NM_014732
KIAA0513
KIAA0513
chr12_-_15374290 0.131 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr9_-_123639566 0.131 NM_001009936
NM_015651
PHF19

PHD finger protein 19

chr17_+_40834571 0.130 NM_003632
CNTNAP1
contactin associated protein 1
chr5_+_153570270 0.130 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr17_-_62340652 0.128 NM_018469
TEX2
testis expressed 2
chr2_-_202316227 0.127 NM_015049
TRAK2
trafficking protein, kinesin binding 2
chr1_+_90098643 0.125 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr4_+_154125589 0.125 NM_015271
TRIM2
tripartite motif containing 2
chr11_-_2162340 0.125 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr16_-_17564737 0.123 NM_022166
XYLT1
xylosyltransferase I
chr10_-_38265452 0.122 NM_145011
ZNF25
zinc finger protein 25
chr8_-_145701717 0.121 NM_003923
FOXH1
forkhead box H1
chr18_-_3011944 0.119 NM_014646
LPIN2
lipin 2
chr11_-_2170792 0.117 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_124774735 0.117 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr7_+_117824085 0.116 NM_016200
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr15_-_90294359 0.115 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr12_-_121734543 0.114 NM_172226
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr10_+_111767685 0.114 NM_001121
NM_016824
ADD3

adducin 3 (gamma)

chr2_+_201997687 0.111 NM_001202518
CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_-_1395950 0.111 NM_001080779
MYO1C
myosin IC
chr2_+_36583369 0.111 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr1_-_182361311 0.110 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr5_-_151066492 0.109 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr7_+_44788453 0.105 NM_031449
ZMIZ2
zinc finger, MIZ-type containing 2
chr7_-_64451413 0.105 NM_015852
ZNF117
zinc finger protein 117
chr2_-_180129245 0.104 NM_178123
SESTD1
SEC14 and spectrin domains 1
chrX_+_108780058 0.103 NM_001242617
NXT2
nuclear transport factor 2-like export factor 2
chr11_-_2160199 0.101 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr6_-_35656677 0.100 NM_001145776
NM_001145777
NM_004117
FKBP5


FK506 binding protein 5


chr1_-_182360400 0.099 NM_001033056
GLUL
glutamate-ammonia ligase
chr4_+_157997181 0.096 NM_000824
NM_001166061
NM_001166060
GLRB


glycine receptor, beta


chr15_+_63569748 0.096 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr17_-_1389013 0.096 NM_001080950
MYO1C
myosin IC
chr2_+_173940505 0.094 NM_016653
NM_133646
ZAK

sterile alpha motif and leucine zipper containing kinase AZK

chr22_+_40440664 0.094 NM_001024843
TNRC6B
trinucleotide repeat containing 6B
chr18_+_6834431 0.094 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chrX_-_19905665 0.093 NM_031892
SH3KBP1
SH3-domain kinase binding protein 1
chr7_+_66386129 0.092 NM_017994
C7orf42
chromosome 7 open reading frame 42
chr7_-_23509972 0.092 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr15_-_61521478 0.087 NM_134261
RORA
RAR-related orphan receptor A
chr9_+_91003238 0.087 NM_006717
SPIN1
spindlin 1
chr12_+_49212253 0.086 NM_000725
NM_001206915
CACNB3

calcium channel, voltage-dependent, beta 3 subunit

chr6_+_152128685 0.085 NM_000125
ESR1
estrogen receptor 1
chr4_-_83933961 0.085 NM_001115007
LIN54
lin-54 homolog (C. elegans)
chr5_+_98104998 0.084 NM_001012761
RGMB
RGM domain family, member B
chr7_-_121036355 0.084 NM_001040020
NM_014888
FAM3C

family with sequence similarity 3, member C

chr18_-_32870143 0.083 NM_001112734
NM_001166012
ZSCAN30

zinc finger and SCAN domain containing 30

chr7_+_90893735 0.083 NM_003505
FZD1
frizzled family receptor 1
chr5_-_58882274 0.082 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_142557722 0.082 NM_000585
NM_172175
IL15

interleukin 15

chr17_-_1394849 0.081 NM_033375
MYO1C
myosin IC
chr22_-_20307511 0.081 NM_033257
DGCR6L
DiGeorge syndrome critical region gene 6-like
chr3_+_171758289 0.081 NM_001135095
FNDC3B
fibronectin type III domain containing 3B
chr5_+_153825497 0.080 NM_001131062
NM_001131063
NM_024632
SAP30L


SAP30-like


chr3_-_64211111 0.080 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr2_+_46926323 0.080 NM_144949
SOCS5
suppressor of cytokine signaling 5
chr2_+_201983268 0.079 NM_001127183
CFLAR
CASP8 and FADD-like apoptosis regulator
chr8_+_104152876 0.079 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr19_+_3572903 0.078 NM_006339
HMG20B
high mobility group 20B
chr22_+_18893735 0.078 NM_005675
DGCR6
DiGeorge syndrome critical region gene 6
chr1_+_43282775 0.077 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr2_+_202004997 0.075 NM_001202515
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_15900928 0.075 NM_015199
ANKRD28
ankyrin repeat domain 28
chr6_+_52284948 0.075 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chrX_+_77166178 0.074 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr19_-_22018940 0.074 NM_003423
ZNF43
zinc finger protein 43
chr16_+_30960377 0.074 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chrX_+_109662284 0.074 NM_020769
RGAG1
retrotransposon gag domain containing 1
chr15_-_90437616 0.073 NM_005829
AP3S2
adaptor-related protein complex 3, sigma 2 subunit
chr2_+_46926049 0.073 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr19_-_7293876 0.072 NM_000208
NM_001079817
INSR

insulin receptor

chr19_-_21512148 0.072 NM_021269
ZNF708
zinc finger protein 708
chrX_+_152599544 0.071 NM_001080485
ZNF275
zinc finger protein 275
chr1_+_40862471 0.070 NM_001198980
SMAP2
small ArfGAP2
chr12_+_56661026 0.070 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr2_+_63277191 0.068 NM_001199770
OTX1
orthodenticle homeobox 1
chr4_-_100242487 0.067 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr1_-_159825136 0.067 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr9_-_72374855 0.067 NM_001099666
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr10_+_133918312 0.067 NM_001105521
JAKMIP3
Janus kinase and microtubule interacting protein 3
chr5_+_141346401 0.065 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr8_+_8860313 0.065 NM_153332
ERI1
exoribonuclease 1
chr3_-_15798057 0.065 NM_001195099
ANKRD28
ankyrin repeat domain 28
chr12_+_133707212 0.065 NM_015394
ZNF10
zinc finger protein 10
chr19_-_53606603 0.065 NM_001102603
NM_033288
NM_198893
ZNF160


zinc finger protein 160



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.82 1.52e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.78 2.99e-05 GO:0010468 regulation of gene expression
1.80 4.22e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.75 4.67e-05 GO:0009889 regulation of biosynthetic process
1.73 1.14e-04 GO:0031326 regulation of cellular biosynthetic process
1.60 1.24e-04 GO:0031323 regulation of cellular metabolic process
1.59 2.13e-04 GO:0080090 regulation of primary metabolic process
1.59 6.36e-04 GO:0060255 regulation of macromolecule metabolic process
1.77 7.36e-04 GO:0006355 regulation of transcription, DNA-dependent
1.67 8.81e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.72 1.62e-03 GO:0051252 regulation of RNA metabolic process
1.62 3.14e-03 GO:0051171 regulation of nitrogen compound metabolic process
1.49 3.35e-03 GO:0019222 regulation of metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 8.89e-04 GO:0005634 nucleus
1.22 5.78e-03 GO:0043231 intracellular membrane-bounded organelle
1.22 6.31e-03 GO:0043227 membrane-bounded organelle
1.14 2.76e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.85 1.84e-05 GO:0008270 zinc ion binding
1.69 4.41e-04 GO:0046914 transition metal ion binding
1.47 9.15e-04 GO:0046872 metal ion binding
1.46 1.61e-03 GO:0043169 cation binding
1.45 1.82e-03 GO:0043167 ion binding