Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.976


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNTchr1_-_150849211-0.811.5e-02Click!
AHRchr7_+_17338182-0.541.7e-01Click!
ARNT2chr15_+_806965690.442.7e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_160822625 2.662 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr15_+_41136622 2.379 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_41136178 2.223 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr6_+_43738757 2.215 VEGFA
vascular endothelial growth factor A
chr10_-_103879933 2.170 NM_001113407
LDB1
LIM domain binding 1
chr16_+_22825806 2.060 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr2_+_219575507 1.971 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr16_+_22825481 1.824 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr8_+_31497267 1.786 NM_013962
NRG1
neuregulin 1
chr4_+_94750041 1.732 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr20_+_20348744 1.697 NM_002196
INSM1
insulinoma-associated 1
chr2_+_219575684 1.663 TTLL4
tubulin tyrosine ligase-like family, member 4
chr3_+_57994087 1.638 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr12_+_4382882 1.619 NM_001759
CCND2
cyclin D2
chr1_-_205649616 1.436 NM_033102
SLC45A3
solute carrier family 45, member 3
chr1_-_205649537 1.402 SLC45A3
solute carrier family 45, member 3
chr12_+_83080901 1.331 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr1_-_6662681 1.285 KLHL21
kelch-like 21 (Drosophila)
chr2_+_26568900 1.275 NM_033505
EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr3_-_171177851 1.263 NM_001161560
NM_001161561
NM_001161562
NM_001161563
NM_001161564
NM_001161565
NM_001161566
NM_015028
TNIK







TRAF2 and NCK interacting kinase







chr12_+_83080621 1.259 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr6_+_15245702 1.222 JARID2
jumonji, AT rich interactive domain 2
chr17_+_55162530 1.217 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1
chr2_+_206547131 1.207 NM_003872
NM_018534
NM_201264
NM_201266
NM_201267
NM_201279
NRP2





neuropilin 2





chr12_-_46662533 1.203 SLC38A1
solute carrier family 38, member 1
chr14_-_105634708 1.202 JAG2
jagged 2
chrX_+_37545008 1.196 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr6_-_43543767 1.184 NM_020750
XPO5
exportin 5
chr19_+_17666381 1.136 GLT25D1
glycosyltransferase 25 domain containing 1
chr1_+_1407158 1.130 NM_031921
ATAD3B
ATPase family, AAA domain containing 3B
chr18_+_47088400 1.127 NM_006033
LIPG
lipase, endothelial
chr19_+_17666457 1.127 GLT25D1
glycosyltransferase 25 domain containing 1
chr1_+_1407112 1.123 ATAD3B
ATPase family, AAA domain containing 3B
chr12_+_72666462 1.113 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr15_-_63673918 1.101 CA12
carbonic anhydrase XII
chrX_+_152954965 1.081 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr11_-_79151694 1.078 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr13_-_21476849 1.077 XPO4
exportin 4
chr10_+_105156430 1.075 PDCD11
programmed cell death 11
chr13_-_21476895 1.073 NM_022459
XPO4
exportin 4
chr1_+_60280462 1.072 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr18_+_23806385 1.065 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr6_-_43543749 1.063 XPO5
exportin 5
chr17_+_54671059 1.063 NM_005450
NOG
noggin
chr6_-_43543600 1.055 XPO5
exportin 5
chr5_+_151151483 1.045 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr15_-_63674074 1.043 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chr1_-_12677347 1.039 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr9_-_139137646 1.032 NM_181701
QSOX2
quiescin Q6 sulfhydryl oxidase 2
chr19_+_45909466 1.027 NM_012099
CD3EAP
CD3e molecule, epsilon associated protein
chr16_+_69139466 1.010 NM_001199280
HAS3
hyaluronan synthase 3
chr3_+_14444083 0.999 NM_001134367
NM_001134368
NM_003043
SLC6A6


solute carrier family 6 (neurotransmitter transporter, taurine), member 6


chr8_-_125740650 0.997 NM_014751
MTSS1
metastasis suppressor 1
chr3_-_189838673 0.980 LEPREL1
leprecan-like 1
chr19_-_663155 0.979 RNF126
ring finger protein 126
chr11_-_115375065 0.972 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr6_-_13486986 0.967 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr19_+_17666502 0.960 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr19_-_663158 0.949 RNF126
ring finger protein 126
chr19_-_663219 0.939 NM_194460
RNF126
ring finger protein 126
chr19_+_7968774 0.939 MAP2K7
mitogen-activated protein kinase kinase 7
chr1_+_1447537 0.920 ATAD3A
ATAD3B
ATPase family, AAA domain containing 3A
ATPase family, AAA domain containing 3B
chr14_-_24780626 0.903


chr14_-_24780570 0.900 NM_014430
CIDEB
cell death-inducing DFFA-like effector b
chrX_+_105969875 0.897 NM_194463
RNF128
ring finger protein 128
chr10_+_105156382 0.897 NM_014976
PDCD11
programmed cell death 11
chr15_-_79382839 0.891 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr1_+_1447495 0.891 NM_001170535
NM_018188
ATAD3A

ATPase family, AAA domain containing 3A

chr2_+_26568991 0.890 EPT1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr19_-_663195 0.877 RNF126
ring finger protein 126
chr2_+_32582046 0.873 NM_016252
BIRC6
baculoviral IAP repeat containing 6
chr8_+_126010719 0.873 NM_003129
SQLE
squalene epoxidase
chr7_+_121513158 0.871 NM_001206838
NM_001206839
NM_002851
PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr1_-_54303933 0.866 TMEM48
transmembrane protein 48
chr20_+_58179601 0.865 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr14_-_24780641 0.862 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_54304107 0.850 NM_001168551
NM_018087
TMEM48

transmembrane protein 48

chr1_+_150336989 0.849 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr7_+_24612714 0.835 NM_016447
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr15_+_80987953 0.832 FAM108C1
family with sequence similarity 108, member C1
chr1_+_1447871 0.829 NM_001170536
ATAD3A
ATPase family, AAA domain containing 3A
chr16_+_67233013 0.828 NM_024712
ELMO3
engulfment and cell motility 3
chr10_+_23983674 0.822 NM_001098500
KIAA1217
KIAA1217
chr12_+_104850986 0.820 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr1_-_6662898 0.810 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr12_+_104850750 0.808 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr17_+_72427535 0.807 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr12_+_104850784 0.802 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_+_104850762 0.801 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr14_-_54421269 0.801 NM_130851
BMP4
bone morphogenetic protein 4
chr6_+_73331570 0.796 NM_001160130
NM_001160132
NM_001160133
NM_001160134
NM_019842
KCNQ5




potassium voltage-gated channel, KQT-like subfamily, member 5




chr21_-_42219038 0.790 NM_001389
DSCAM
Down syndrome cell adhesion molecule
chr5_+_151151516 0.782 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr8_+_126010748 0.780 SQLE
squalene epoxidase
chr1_+_234349995 0.778 SLC35F3
solute carrier family 35, member F3
chr5_+_151151514 0.772 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr1_-_43424324 0.761 SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr19_-_44174271 0.759 PLAUR
plasminogen activator, urokinase receptor
chr6_-_86352650 0.755 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr4_-_38666429 0.752 FLJ13197
uncharacterized FLJ13197
chr3_+_10857867 0.751 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr10_-_35930357 0.749 NM_031866
FZD8
frizzled family receptor 8
chr5_+_151151511 0.742 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr12_-_31479038 0.738 FAM60A
family with sequence similarity 60, member A
chrX_+_38420690 0.733 NM_004615
TSPAN7
tetraspanin 7
chr5_+_151151660 0.732 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr7_-_95951268 0.721 NM_001160210
NM_014251
SLC25A13

solute carrier family 25, member 13 (citrin)

chr1_+_150336584 0.721 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr14_+_103243832 0.720 TRAF3
TNF receptor-associated factor 3
chr6_-_86352696 0.716 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr19_+_38755422 0.713 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr12_-_31479084 0.712 FAM60A
family with sequence similarity 60, member A
chr16_-_3030473 0.711 NM_004203
NM_182687
PKMYT1

protein kinase, membrane associated tyrosine/threonine 1

chr19_+_1753661 0.710 NM_001080488
ONECUT3
one cut homeobox 3
chr6_-_86352564 0.709 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr1_+_201252579 0.708 NM_000299
NM_001005337
PKP1

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

chr8_+_102504836 0.705 GRHL2
grainyhead-like 2 (Drosophila)
chr6_-_86352982 0.702 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr5_+_151151462 0.699 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr6_-_86352635 0.698 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr2_-_165477818 0.696 GRB14
growth factor receptor-bound protein 14
chr1_+_40420802 0.686 MFSD2A
major facilitator superfamily domain containing 2A
chr12_-_31479120 0.685 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr12_+_104850641 0.685 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr3_+_6902812 0.679 GRM7
glutamate receptor, metabotropic 7
chr2_+_29117503 0.675 NM_015131
WDR43
WD repeat domain 43
chr16_-_3030391 0.674 PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr2_-_101925051 0.672 NM_173647
RNF149
ring finger protein 149
chr4_+_38665587 0.670 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr21_-_36260972 0.667 NM_001001890
NM_001122607
RUNX1

runt-related transcription factor 1

chr1_-_113498828 0.665 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr5_-_60140041 0.663 NM_001104558
NM_024930
ELOVL7

ELOVL fatty acid elongase 7

chr8_+_102504661 0.663 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr11_+_73087670 0.661 NM_032871
RELT
RELT tumor necrosis factor receptor
chr6_-_107435635 0.658 NM_001080450
BEND3
BEN domain containing 3
chr15_+_80987609 0.656 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr4_-_128886283 0.642 MFSD8
major facilitator superfamily domain containing 8
chr22_+_45098091 0.642 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr17_-_41623246 0.640 NM_001986
ETV4
ets variant 4
chr8_-_145050896 0.639 NM_000445
PLEC
plectin
chr6_-_86352656 0.636 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr2_+_198570027 0.636 NM_138395
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr9_-_140196702 0.636 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr19_-_8373157 0.634 NM_001165895
NM_016579
CD320

CD320 molecule

chr15_-_72612497 0.633 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr2_+_182322265 0.630 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_+_38755097 0.627 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755238 0.624 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_-_45909566 0.612 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr11_+_62623466 0.610 NM_001012662
NM_001012664
NM_002394
SLC3A2


solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2


chr19_+_11071713 0.605 SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr2_+_148602050 0.598 ACVR2A
activin A receptor, type IIA
chr1_+_117452359 0.597 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr22_+_45098046 0.595 NM_181333
PRR5
proline rich 5 (renal)
chr14_+_24780654 0.589 NM_001143919
LTB4R
leukotriene B4 receptor
chr3_+_67048726 0.587 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr11_+_66886735 0.586 NM_012308
KDM2A
lysine (K)-specific demethylase 2A
chr2_+_73441344 0.584 NM_006062
SMYD5
SMYD family member 5
chr1_+_9648931 0.583 NM_001010866
NM_001130924
TMEM201

transmembrane protein 201

chr6_+_125474800 0.583 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr5_-_159739482 0.583 NM_024565
CCNJL
cyclin J-like
chr11_-_11643542 0.583 NM_198516
GALNTL4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
chr7_+_89783789 0.581 STEAP1
six transmembrane epithelial antigen of the prostate 1
chr1_-_38273852 0.581 NM_024640
YRDC
yrdC domain containing (E. coli)
chr9_-_23826062 0.580 NM_004432
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr7_-_92462637 0.578 CDK6
cyclin-dependent kinase 6
chr15_-_72612247 0.578 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr3_+_52273247 0.577


chr6_+_138188352 0.575 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_-_167369990 0.575 RNASET2
ribonuclease T2
chr1_-_38273846 0.574 YRDC
yrdC domain containing (E. coli)
chr16_-_1968230 0.572 NM_001009606
HS3ST6
heparan sulfate (glucosamine) 3-O-sulfotransferase 6
chr19_+_11071583 0.570 NM_001128844
NM_003072
SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

chr9_-_99801365 0.567 NM_001333
CTSL2
cathepsin L2
chr7_-_100860991 0.567 NM_001084
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr11_+_124933197 0.566 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr7_+_86273867 0.564 GRM3
glutamate receptor, metabotropic 3
chr7_-_36429695 0.563 NM_001100425
KIAA0895
KIAA0895
chr7_+_89783688 0.560 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr6_+_150464156 0.559 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr1_-_113498615 0.558 NM_001166496
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr19_+_11071792 0.558 NM_001128849
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr8_-_41166931 0.555 NM_003012
SFRP1
secreted frizzled-related protein 1
chr17_-_41623652 0.554 NM_001079675
ETV4
ets variant 4
chr17_+_72428228 0.553 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr7_+_86274076 0.553 GRM3
glutamate receptor, metabotropic 3
chr7_+_145813828 0.552 CNTNAP2
contactin associated protein-like 2
chr5_-_6633347 0.551 NM_001193455
NM_017755
NSUN2

NOP2/Sun domain family, member 2

chr19_+_2164119 0.550 NM_032482
DOT1L
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
chr1_+_151483861 0.549 NM_020770
CGN
cingulin
chr19_-_15490523 0.548 NM_005858
AKAP8
A kinase (PRKA) anchor protein 8
chr4_-_130014405 0.547 NM_144643
SCLT1
sodium channel and clathrin linker 1
chr5_-_6633149 0.546 NSUN2
NOP2/Sun domain family, member 2
chr13_+_37006408 0.544 NM_001111045
NM_003914
CCNA1

cyclin A1

chr1_-_38273683 0.542 YRDC
yrdC domain containing (E. coli)
chr4_-_89080010 0.540 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr19_-_18314731 0.537 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr1_-_38273823 0.534 YRDC
yrdC domain containing (E. coli)
chr5_-_134914447 0.533 CXCL14
chemokine (C-X-C motif) ligand 14
chr19_-_38747171 0.533 NM_001243947
NM_033256
PPP1R14A

protein phosphatase 1, regulatory (inhibitor) subunit 14A


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 3.41e-24 GO:0044260 cellular macromolecule metabolic process
1.16 4.75e-24 GO:0009987 cellular process
1.59 4.60e-18 GO:0010467 gene expression
1.31 5.12e-18 GO:0043170 macromolecule metabolic process
1.51 2.09e-16 GO:0090304 nucleic acid metabolic process
1.43 1.62e-15 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.57 3.18e-15 GO:0016070 RNA metabolic process
1.24 4.22e-15 GO:0044237 cellular metabolic process
1.23 2.84e-13 GO:0044238 primary metabolic process
1.36 3.10e-12 GO:0034641 cellular nitrogen compound metabolic process
1.34 2.02e-11 GO:0006807 nitrogen compound metabolic process
1.19 1.04e-10 GO:0008152 metabolic process
1.84 1.05e-10 GO:0006396 RNA processing
1.35 1.42e-09 GO:0071841 cellular component organization or biogenesis at cellular level
1.18 2.95e-09 GO:0050794 regulation of cellular process
1.30 3.45e-09 GO:0060255 regulation of macromolecule metabolic process
1.29 4.67e-09 GO:0031323 regulation of cellular metabolic process
1.35 6.06e-09 GO:0071842 cellular component organization at cellular level
1.48 1.24e-08 GO:0007399 nervous system development
1.27 1.51e-08 GO:0019222 regulation of metabolic process
1.16 2.33e-08 GO:0065007 biological regulation
1.28 4.16e-08 GO:0071840 cellular component organization or biogenesis
1.28 8.07e-08 GO:0016043 cellular component organization
1.50 8.45e-08 GO:0009893 positive regulation of metabolic process
1.44 1.00e-07 GO:0006996 organelle organization
1.16 3.36e-07 GO:0050789 regulation of biological process
1.56 3.65e-07 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.51 4.76e-07 GO:0010604 positive regulation of macromolecule metabolic process
1.77 5.90e-07 GO:0016071 mRNA metabolic process
1.26 6.03e-07 GO:0080090 regulation of primary metabolic process
1.91 6.90e-07 GO:0006397 mRNA processing
1.41 9.39e-07 GO:0034645 cellular macromolecule biosynthetic process
1.93 1.23e-06 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.67 1.28e-06 GO:0051254 positive regulation of RNA metabolic process
1.67 1.35e-06 GO:0010628 positive regulation of gene expression
1.92 2.06e-06 GO:0007420 brain development
2.35 2.21e-06 GO:0030900 forebrain development
1.40 2.25e-06 GO:0009059 macromolecule biosynthetic process
1.48 2.41e-06 GO:0031325 positive regulation of cellular metabolic process
1.57 3.14e-06 GO:0009891 positive regulation of biosynthetic process
1.57 4.83e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.66 7.11e-06 GO:0045893 positive regulation of transcription, DNA-dependent
1.66 8.53e-06 GO:0051276 chromosome organization
1.73 1.05e-05 GO:0007417 central nervous system development
1.23 1.63e-05 GO:0023052 signaling
1.58 1.88e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
1.58 2.00e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.29 2.11e-05 GO:0044267 cellular protein metabolic process
1.53 2.49e-05 GO:0006351 transcription, DNA-dependent
1.28 3.27e-05 GO:0048518 positive regulation of biological process
1.55 5.22e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
2.33 5.80e-05 GO:0045165 cell fate commitment
1.28 1.01e-04 GO:0009058 biosynthetic process
1.74 1.13e-04 GO:0032583 regulation of gene-specific transcription
1.32 1.52e-04 GO:0043412 macromolecule modification
1.22 2.44e-04 GO:0007275 multicellular organismal development
1.26 2.69e-04 GO:0031326 regulation of cellular biosynthetic process
1.28 2.94e-04 GO:0044249 cellular biosynthetic process
1.36 3.89e-04 GO:0009653 anatomical structure morphogenesis
1.49 4.13e-04 GO:0048699 generation of neurons
1.25 5.39e-04 GO:0009889 regulation of biosynthetic process
1.21 5.51e-04 GO:0032502 developmental process
1.42 6.51e-04 GO:0051246 regulation of protein metabolic process
1.27 6.84e-04 GO:0048519 negative regulation of biological process
2.63 9.31e-04 GO:0051168 nuclear export
1.31 9.60e-04 GO:0006464 protein modification process
1.21 1.02e-03 GO:0051179 localization
1.45 1.08e-03 GO:0022008 neurogenesis
1.42 1.25e-03 GO:0032268 regulation of cellular protein metabolic process
1.28 1.42e-03 GO:0048523 negative regulation of cellular process
2.85 1.54e-03 GO:0031124 mRNA 3'-end processing
1.83 2.42e-03 GO:0034660 ncRNA metabolic process
1.26 2.45e-03 GO:0051252 regulation of RNA metabolic process
1.42 2.73e-03 GO:0009892 negative regulation of metabolic process
2.48 2.76e-03 GO:0021537 telencephalon development
1.25 2.80e-03 GO:0010468 regulation of gene expression
1.44 2.80e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.62 3.08e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.21 3.16e-03 GO:0007165 signal transduction
1.51 3.21e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.27 3.33e-03 GO:0048869 cellular developmental process
1.72 3.48e-03 GO:0051301 cell division
1.25 3.54e-03 GO:0048522 positive regulation of cellular process
1.44 3.55e-03 GO:0031324 negative regulation of cellular metabolic process
1.53 3.65e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.21 3.72e-03 GO:0048856 anatomical structure development
1.23 4.51e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.27 4.76e-03 GO:0030154 cell differentiation
1.49 6.05e-03 GO:0009890 negative regulation of biosynthetic process
2.06 6.17e-03 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.52 6.65e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.75 7.27e-03 GO:0008380 RNA splicing
1.50 7.96e-03 GO:0010558 negative regulation of macromolecule biosynthetic process
1.24 8.77e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.24 9.14e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.36 9.40e-03 GO:0044085 cellular component biogenesis
1.79 1.01e-02 GO:0007017 microtubule-based process
1.21 1.01e-02 GO:0051234 establishment of localization
1.79 1.21e-02 GO:0045596 negative regulation of cell differentiation
1.50 1.26e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.47 1.66e-02 GO:0030182 neuron differentiation
1.48 1.71e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.39 1.74e-02 GO:0032774 RNA biosynthetic process
1.43 1.84e-02 GO:0022402 cell cycle process
2.49 1.84e-02 GO:0031123 RNA 3'-end processing
2.01 1.85e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.17 1.95e-02 GO:0051716 cellular response to stimulus
1.38 2.18e-02 GO:0007154 cell communication
1.53 2.30e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.21 2.31e-02 GO:0048731 system development
1.21 2.57e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.92 2.59e-02 GO:0051169 nuclear transport
2.01 2.65e-02 GO:0000226 microtubule cytoskeleton organization
1.49 2.67e-02 GO:0010629 negative regulation of gene expression
1.39 2.85e-02 GO:0048468 cell development
1.89 2.94e-02 GO:0032582 negative regulation of gene-specific transcription
1.20 2.96e-02 GO:0019538 protein metabolic process
2.15 3.28e-02 GO:0006399 tRNA metabolic process
1.51 3.39e-02 GO:0051253 negative regulation of RNA metabolic process
1.46 3.41e-02 GO:0045595 regulation of cell differentiation
1.45 3.43e-02 GO:0009790 embryo development
1.70 3.74e-02 GO:0006366 transcription from RNA polymerase II promoter
1.83 4.27e-02 GO:0043193 positive regulation of gene-specific transcription
1.90 4.32e-02 GO:0006913 nucleocytoplasmic transport
1.32 4.94e-02 GO:0051641 cellular localization
1.20 4.99e-02 GO:0006810 transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.57 8.76e-23 GO:0070013 intracellular organelle lumen
1.55 1.71e-22 GO:0031974 membrane-enclosed lumen
1.63 6.38e-22 GO:0031981 nuclear lumen
1.57 8.42e-22 GO:0044428 nuclear part
1.55 1.17e-21 GO:0043233 organelle lumen
1.20 5.65e-20 GO:0043231 intracellular membrane-bounded organelle
1.14 6.56e-20 GO:0005622 intracellular
1.19 9.77e-20 GO:0043227 membrane-bounded organelle
1.14 2.77e-19 GO:0044424 intracellular part
1.28 7.39e-19 GO:0005634 nucleus
1.17 8.24e-19 GO:0043226 organelle
1.17 1.18e-18 GO:0043229 intracellular organelle
1.69 5.73e-18 GO:0005654 nucleoplasm
1.26 3.46e-15 GO:0044446 intracellular organelle part
1.25 1.20e-14 GO:0044422 organelle part
1.06 9.63e-10 GO:0044464 cell part
1.06 1.02e-09 GO:0005623 cell
1.67 1.85e-08 GO:0044451 nucleoplasm part
1.14 7.95e-08 GO:0005737 cytoplasm
1.15 1.81e-05 GO:0044444 cytoplasmic part
1.26 2.74e-05 GO:0043228 non-membrane-bounded organelle
1.26 2.74e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.60 2.96e-04 GO:0005730 nucleolus
1.18 4.35e-03 GO:0032991 macromolecular complex
1.18 2.09e-02 GO:0043234 protein complex
1.69 2.32e-02 GO:0005667 transcription factor complex
1.25 3.11e-02 GO:0012505 endomembrane system
1.71 3.50e-02 GO:0016604 nuclear body
2.15 4.98e-02 GO:0008076 voltage-gated potassium channel complex
2.15 4.98e-02 GO:0034705 potassium channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 9.76e-20 GO:0005488 binding
1.22 7.23e-17 GO:0005515 protein binding
1.46 1.71e-15 GO:0000166 nucleotide binding
1.29 3.18e-09 GO:0003676 nucleic acid binding
1.64 5.02e-09 GO:0003723 RNA binding
1.39 3.54e-08 GO:0035639 purine ribonucleoside triphosphate binding
1.38 9.76e-08 GO:0017076 purine nucleotide binding
1.37 1.16e-07 GO:0032553 ribonucleotide binding
1.37 1.16e-07 GO:0032555 purine ribonucleotide binding
1.40 1.13e-06 GO:0005524 ATP binding
1.39 1.68e-06 GO:0030554 adenyl nucleotide binding
1.39 2.29e-06 GO:0032559 adenyl ribonucleotide binding
1.49 3.07e-06 GO:0030528 transcription regulator activity
1.34 1.79e-05 GO:0016740 transferase activity
1.45 2.03e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.54 5.23e-04 GO:0004672 protein kinase activity
1.25 1.06e-03 GO:0003677 DNA binding
1.73 1.27e-03 GO:0016563 transcription activator activity
1.61 1.35e-03 GO:0004674 protein serine/threonine kinase activity
1.99 1.98e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.45 3.48e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.38 3.85e-03 GO:0001071 nucleic acid binding transcription factor activity
1.38 3.85e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.96 4.80e-03 GO:0008168 methyltransferase activity
1.44 8.90e-03 GO:0043565 sequence-specific DNA binding
1.41 1.08e-02 GO:0016301 kinase activity
3.34 3.38e-02 GO:0003727 single-stranded RNA binding