Motif ID: AIRE.p2

Z-value: 0.744


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_45705720-0.226.1e-01Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_70916158 1.104 NM_002159
HTN1
histatin 1
chr2_+_152214105 0.868 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr8_-_13134028 0.644 DLC1
deleted in liver cancer 1
chr13_-_33859835 0.557 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr1_-_182357871 0.546 GLUL
glutamate-ammonia ligase
chr12_-_46357949 0.495


chr5_-_64777703 0.394 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr17_-_67138013 0.355 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr14_-_106714594 0.338


chr10_-_101841593 0.295 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_55248298 0.291 NM_058173
MUCL1
mucin-like 1
chr16_+_2809933 0.287


chr5_+_118965253 0.282 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chr1_+_84630575 0.269 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr19_-_49220213 0.255 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr17_+_4692226 0.238 NM_001014985
GLTPD2
glycolipid transfer protein domain containing 2
chr8_+_144731829 0.233 NM_014789
ZNF623
zinc finger protein 623
chr17_+_65936590 0.223 BPTF
bromodomain PHD finger transcription factor
chr19_-_23869939 0.220 NM_138330
ZNF675
zinc finger protein 675
chr1_+_210501595 0.204 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr12_-_53600999 0.203 NM_000889
ITGB7
integrin, beta 7
chr5_+_140529619 0.195 NM_018939
PCDHB6
protocadherin beta 6
chr18_-_47814691 0.193 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr15_-_99789585 0.189 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr17_-_8424217 0.189 MYH10
myosin, heavy chain 10, non-muscle
chr9_-_99540327 0.174 NM_014930
ZNF510
zinc finger protein 510
chr19_+_21264952 0.173 NM_182515
ZNF714
zinc finger protein 714
chr3_+_172472246 0.171 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr2_+_201980873 0.169 NM_001127184
NM_001202516
NM_001202517
NM_001202519
NM_003879
CFLAR




CASP8 and FADD-like apoptosis regulator




chr5_-_39394423 0.168 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr7_+_55433140 0.165 NM_018697
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr2_+_201473942 0.164 AOX1
aldehyde oxidase 1
chr18_-_65182507 0.161 DSEL
dermatan sulfate epimerase-like
chr4_+_87968191 0.156 AFF1
AF4/FMR2 family, member 1
chr1_+_84609941 0.155 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_101767714 0.153 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr19_+_39786964 0.153 NM_172140
IL29
interleukin 29 (interferon, lambda 1)
chr20_-_3766905 0.152 NM_001810
CENPB
centromere protein B, 80kDa
chr19_-_6591012 0.151 CD70
CD70 molecule
chr1_+_210111537 0.150 NM_001146261
NM_001146262
NM_001146264
NM_153262
SYT14



synaptotagmin XIV



chr1_+_43282775 0.150 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr5_+_75699003 0.149 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr2_+_65215577 0.148 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr11_+_65479685 0.147 KAT5
K(lysine) acetyltransferase 5
chr16_+_15528324 0.146 NM_033201
C16orf45
chromosome 16 open reading frame 45
chr5_+_176811431 0.144 NM_001167579
NM_003052
SLC34A1

solute carrier family 34 (sodium phosphate), member 1

chr7_-_14025826 0.144 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr2_-_214015053 0.142 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_-_201465700 0.139 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chrM_+_9182 0.139


chr19_+_10123861 0.136 NM_015725
RDH8
retinol dehydrogenase 8 (all-trans)
chr15_-_50411405 0.134 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr19_-_48752921 0.130 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr2_-_40739570 0.129 NM_001112802
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr7_-_138363789 0.127 NM_001139456
SVOPL
SVOP-like
chr13_+_50070096 0.126 PHF11
PHD finger protein 11
chr12_-_30848805 0.126 NM_006390
IPO8
importin 8
chr1_-_32385258 0.124 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chr18_+_29171729 0.123 NM_000371
TTR
transthyretin
chr21_+_25801042 0.123 FLJ42200
FLJ42200 protein
chr7_+_77469446 0.122 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr1_-_225616556 0.121 NM_194442
LBR
lamin B receptor
chr17_-_50237342 0.120 NM_001082534
CA10
carbonic anhydrase X
chrX_-_102531673 0.119 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr7_-_64023454 0.119 NM_001130022
NM_178558
ZNF680

zinc finger protein 680

chr11_-_1629614 0.119 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr17_-_50237160 0.116 NM_001082533
CA10
carbonic anhydrase X
chr20_-_42939737 0.115 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chrM_+_9217 0.113


chr19_-_48759141 0.112 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr5_+_65372744 0.112 ERBB2IP
erbb2 interacting protein
chr19_+_50936159 0.111 NM_004533
MYBPC2
myosin binding protein C, fast type
chr4_+_56212456 0.111 SRD5A3
steroid 5 alpha-reductase 3
chr5_+_108083522 0.111 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr19_-_51334747 0.111 NM_017509
NM_138563
NM_138564
KLK15


kallikrein-related peptidase 15


chr3_-_186262114 0.110 NM_017541
CRYGS
crystallin, gamma S
chr11_+_125756954 0.110 NM_001134793
HYLS1
hydrolethalus syndrome 1
chr4_-_156787377 0.109 NM_017419
ACCN5
amiloride-sensitive cation channel 5, intestinal
chrX_-_100307042 0.108 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr14_+_74035762 0.108 NM_006821
ACOT2
acyl-CoA thioesterase 2
chr2_-_216241321 0.106 FN1
fibronectin 1
chr12_+_133614052 0.106 ZNF84
zinc finger protein 84
chrM_+_8857 0.104


chr16_-_4817124 0.103 NM_021646
ZNF500
zinc finger protein 500
chr1_+_153631193 0.103 SNAPIN
SNAP-associated protein
chr5_-_156569785 0.103 NM_001100816
NM_004270
MED7

mediator complex subunit 7

chr12_+_133614138 0.102 ZNF84
zinc finger protein 84
chr6_+_119215240 0.102 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chrX_-_100307091 0.101 NM_001167970
NM_001167971
NM_001167972
NM_024917
TRMT2B



TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)



chr3_+_29322802 0.100 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr15_-_55800431 0.100 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr20_-_18477811 0.099 NM_006606
RBBP9
retinoblastoma binding protein 9
chr12_+_71833518 0.099 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr1_-_21377387 0.098 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr5_-_32403310 0.097 ZFR
zinc finger RNA binding protein
chr5_+_102201526 0.096 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chr1_-_17308072 0.093 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr19_-_39826676 0.093 NM_004877
GMFG
glia maturation factor, gamma
chr1_-_20445991 0.092 NM_012400
PLA2G2D
phospholipase A2, group IID
chr20_+_36322451 0.092 CTNNBL1
catenin, beta like 1
chr4_-_39033981 0.092 NM_024943
TMEM156
transmembrane protein 156
chr2_-_32490688 0.091 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr4_+_17578838 0.091 NM_015907
LAP3
leucine aminopeptidase 3
chr17_-_33390676 0.090 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr19_+_18208596 0.090 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr3_+_107096187 0.090 NM_032600
CCDC54
coiled-coil domain containing 54
chr4_+_69681709 0.090 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr12_+_51318743 0.086 METTL7A
methyltransferase like 7A
chrX_-_100306859 0.086 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr15_+_99645152 0.086 NM_015286
NM_145728
SYNM

synemin, intermediate filament protein

chr19_-_10613767 0.085 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chr15_+_100173182 0.085 NM_001130928
MEF2A
myocyte enhancer factor 2A
chrM_+_4465 0.085


chr2_-_190627923 0.085 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr3_-_71180061 0.084 NM_001244815
FOXP1
forkhead box P1
chr20_+_36322443 0.084 CTNNBL1
catenin, beta like 1
chr17_-_18177716 0.084 TOP3A
topoisomerase (DNA) III alpha
chr14_-_106725620 0.082 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr6_-_13295817 0.082 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr12_+_75874512 0.081 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr8_-_37727937 0.081 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr3_-_100712248 0.081 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_-_15798057 0.080 NM_001195099
ANKRD28
ankyrin repeat domain 28
chr19_+_50031232 0.080 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr8_+_38644754 0.079 TACC1
transforming, acidic coiled-coil containing protein 1
chrX_+_22050920 0.079 NM_000444
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr15_+_66585632 0.078 NM_133375
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr21_-_19775958 0.078 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr5_+_138629419 0.078 NM_001194955
NM_001194956
MATR3

matrin 3

chr4_+_123091757 0.077 NM_015312
KIAA1109
KIAA1109
chr2_+_169757749 0.077 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr5_+_126859157 0.075 PRRC1
proline-rich coiled-coil 1
chr20_+_33299315 0.074 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr15_+_24920540 0.074 NM_018958
C15orf2
chromosome 15 open reading frame 2
chr1_+_148577356 0.073 NM_001102663
NBPF15
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 16
chr9_-_85946875 0.072 NM_001244961
FRMD3
FERM domain containing 3
chr1_-_109618568 0.072 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chrM_+_4770 0.071


chr8_-_7673137 0.071 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chrM_+_9725 0.069


chr6_+_31683084 0.069 NM_021246
LY6G6D
lymphocyte antigen 6 complex, locus G6D
chr7_-_92777657 0.069 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr5_+_173472737 0.069 HMP19
HMP19 protein
chr10_-_32667543 0.068 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr3_-_151102536 0.067 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr6_-_31830593 0.066 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr19_-_58220535 0.066 NM_001085384
ZNF154
zinc finger protein 154
chr12_-_89920038 0.065 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr4_+_170581212 0.064 NM_001243374
CLCN3
chloride channel 3
chr10_+_135207607 0.064 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr1_+_145883867 0.064 NM_001097616
GPR89C
G protein-coupled receptor 89C
chr17_+_41006094 0.063 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr3_-_15382874 0.063 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr17_-_79838899 0.063


chr1_+_145524989 0.062 NM_003637
ITGA10
integrin, alpha 10
chr4_-_177241488 0.061


chr6_+_52935770 0.060 NM_012347
FBXO9
F-box protein 9
chr1_+_148739441 0.060 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr8_+_38644721 0.059 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr16_-_71523177 0.058 NM_006961
ZNF19
zinc finger protein 19
chr1_-_169680677 0.058 NM_000655
SELL
selectin L
chr19_-_46285752 0.058 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr19_+_13135368 0.058 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr9_+_79968344 0.057 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr6_+_163984574 0.056 QKI
QKI, KH domain containing, RNA binding
chr6_+_10521564 0.056 NM_145649
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_-_85637486 0.056 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr12_-_53558276 0.056 NM_001244706
CSAD
cysteine sulfinic acid decarboxylase
chr19_-_10614083 0.055 KEAP1
kelch-like ECH-associated protein 1
chr5_-_158526698 0.054 NM_024007
EBF1
early B-cell factor 1
chr22_-_24951842 0.054 C22orf13
chromosome 22 open reading frame 13
chr10_+_104613966 0.053 NM_001136200
NM_144591
C10orf32-AS3MT
C10orf32

C10orf32-AS3MT readthrough
chromosome 10 open reading frame 32

chr13_-_37573474 0.053 NM_001142364
NM_013338
ALG5

asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae)

chr5_-_149535138 0.053 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr14_+_58906398 0.052 NM_001244193
KIAA0586
KIAA0586
chr20_+_57022460 0.052 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr13_-_36429798 0.051 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr16_+_28699878 0.051 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr6_-_159240367 0.051 EZR
ezrin
chr3_-_9920633 0.051 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr21_-_43735705 0.050 NM_003226
TFF3
trefoil factor 3 (intestinal)
chrX_+_135067634 0.050 SLC9A6
solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr13_-_99910548 0.050 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_+_28764660 0.049 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr1_+_153631144 0.049 NM_012437
SNAPIN
SNAP-associated protein
chr11_+_113845796 0.049 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr22_+_35796294 0.049 MCM5
minichromosome maintenance complex component 5
chr8_+_17829848 0.048 PCM1
pericentriolar material 1
chr6_-_43021390 0.048 CUL7
cullin 7
chr3_-_145968819 0.048 PLSCR4
phospholipid scramblase 4
chr5_+_140514787 0.047 NM_015669
PCDHB5
protocadherin beta 5
chr18_-_58040000 0.047 NM_005912
MC4R
melanocortin 4 receptor
chrX_-_57936853 0.047 NM_007156
ZXDA
zinc finger, X-linked, duplicated A
chr17_+_76000248 0.047 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr15_-_77154284 0.046 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr16_+_66586518 0.046 CKLF
chemokine-like factor
chr2_+_109204777 0.045 LIMS1
LIM and senescent cell antigen-like domains 1
chr10_+_22605300 0.045 NM_001204062
NM_012071
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr12_+_26126687 0.045 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr6_-_159240398 0.045 EZR
ezrin

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.