Motif ID: ALX1.p2

Z-value: 0.770


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_85673884-0.762.8e-02Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_15095791 0.703 NM_139167
SGCZ
sarcoglycan, zeta
chr13_-_20805371 0.641 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr20_+_58296264 0.599 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr4_-_15939949 0.582 FGFBP1
fibroblast growth factor binding protein 1
chr5_+_36608430 0.426 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_+_47088400 0.425 NM_006033
LIPG
lipase, endothelial
chr9_+_125376947 0.364 NM_012364
OR1Q1
olfactory receptor, family 1, subfamily Q, member 1
chr5_+_140220811 0.336 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr5_-_139726173 0.317 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr2_-_215896809 0.305 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr7_-_25268057 0.301 NM_022150
NPVF
neuropeptide VF precursor
chr5_+_35856990 0.296 NM_002185
IL7R
interleukin 7 receptor
chr11_-_115088628 0.293 CADM1
cell adhesion molecule 1
chr11_-_124190092 0.283 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr3_+_111717585 0.274 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr15_+_94899163 0.268 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chrX_-_84634742 0.258 NM_024921
POF1B
premature ovarian failure, 1B
chr5_+_140247767 0.245 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr12_+_13043955 0.241 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr5_+_36606667 0.230 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_101988746 0.229 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr20_-_14318200 0.229 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr1_+_182419255 0.225 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr9_+_35042222 0.222 NM_001040410
NM_203299
C9orf131

chromosome 9 open reading frame 131

chr2_+_207804277 0.213 NM_173077
CPO
carboxypeptidase O
chr2_-_161056762 0.208 ITGB6
integrin, beta 6
chr12_+_20848288 0.205 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chr10_-_42863435 0.203 LOC441666
zinc finger protein 91 pseudogene
chr17_-_29641087 0.197 EVI2B
ecotropic viral integration site 2B
chrM_+_9217 0.197


chr3_-_27498244 0.195 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chrX_-_21776158 0.194 NM_014332
SMPX
small muscle protein, X-linked
chrX_+_91090459 0.191 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr6_-_136847609 0.190 MAP7
microtubule-associated protein 7
chr20_+_43803539 0.185 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr19_-_3557566 0.184 NM_001042680
NM_021731
NM_174983
MFSD12


major facilitator superfamily domain containing 12


chrX_+_78003205 0.175 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr19_-_23941571 0.174 NM_138286
ZNF681
zinc finger protein 681
chr1_+_160370363 0.174 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr17_+_47209821 0.174 NM_001159388
B4GALNT2
beta-1,4-N-acetyl-galactosaminyl transferase 2
chr7_+_143412938 0.174 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr10_+_90424145 0.172 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr17_-_29641094 0.170 NM_006495
EVI2B
ecotropic viral integration site 2B
chr7_-_16844606 0.169 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chrX_+_105412297 0.169 NM_001171020
NM_152423
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr12_+_101188373 0.168 NM_178826
ANO4
anoctamin 4
chr5_-_35048239 0.167 NM_031900
AGXT2
alanine--glyoxylate aminotransferase 2
chr16_+_30034654 0.162 NM_001109659
NM_001109660
C16orf92

chromosome 16 open reading frame 92

chr2_+_102615456 0.155 NM_173343
IL1R2
interleukin 1 receptor, type II
chrX_-_84634664 0.152 POF1B
premature ovarian failure, 1B
chr9_-_117568292 0.152 NM_005118
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr14_-_35344852 0.150 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr19_-_6433772 0.146 NM_173637
SLC25A41
solute carrier family 25, member 41
chrX_-_49089770 0.143 NM_005183
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr14_-_23285011 0.140 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_-_2996289 0.138 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr3_+_127641901 0.138 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr17_-_46651809 0.136 NM_002146
HOXB3
homeobox B3
chr20_+_34556528 0.135 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr10_-_113933517 0.133 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr11_-_102668822 0.130 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_+_196743929 0.124 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr13_-_52980628 0.124 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chr12_+_9142136 0.124 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr12_-_10021932 0.123 CLEC2B
C-type lectin domain family 2, member B
chr6_-_47254143 0.123 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr3_+_108855560 0.123 FLJ22763
uncharacterized LOC401081
chr1_+_115572414 0.123 NM_000549
TSHB
thyroid stimulating hormone, beta
chr1_+_54359859 0.122 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chrX_+_41548225 0.121 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr8_-_130799133 0.120 NM_031415
GSDMC
gasdermin C
chr11_-_85425790 0.120 NM_032379
SYTL2
synaptotagmin-like 2
chr3_+_8775485 0.119 NM_001234
NM_033337
CAV3

caveolin 3

chr4_-_77328457 0.119 NM_001042784
CCDC158
coiled-coil domain containing 158
chr6_+_47624222 0.119 NM_153839
GPR111
G protein-coupled receptor 111
chrX_+_102965836 0.119 NM_182541
TMEM31
transmembrane protein 31
chr7_-_158611301 0.118 ESYT2
extended synaptotagmin-like protein 2
chr8_+_98703361 0.117 MTDH
metadherin
chr17_-_35656691 0.116 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr8_-_110342107 0.116 NM_001128211
NUDCD1
NudC domain containing 1
chr17_+_19976828 0.115 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chrM_+_8857 0.114


chr4_+_166131170 0.114 NM_001161521
NM_001161522
KLHL2

kelch-like 2, Mayven (Drosophila)

chr9_-_114090712 0.112 NM_205859
OR2K2
olfactory receptor, family 2, subfamily K, member 2
chr9_+_125795787 0.112 RABGAP1
GPR21
RAB GTPase activating protein 1
G protein-coupled receptor 21
chrX_-_131261871 0.112 NM_194277
FRMD7
FERM domain containing 7
chr22_+_33196801 0.110 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr2_+_32853086 0.107 NM_001193509
NM_017735
TTC27

tetratricopeptide repeat domain 27

chr11_+_12308446 0.106 NM_032867
MICALCL
MICAL C-terminal like
chrM_+_5245 0.103


chr2_-_142889269 0.103 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr5_+_61874561 0.101 NM_181506
LRRC70
leucine rich repeat containing 70
chr16_-_72206348 0.100 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr2_+_102953716 0.099 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr4_-_46911223 0.098 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr18_-_61329113 0.096 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr19_-_5791198 0.096 NM_001161619
NM_020175
DUS3L

dihydrouridine synthase 3-like (S. cerevisiae)

chr9_-_117444368 0.095 NM_001199233
LOC100505478
uncharacterized LOC100505478
chr11_-_59950498 0.094 NM_022349
NM_152851
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr5_+_140235594 0.094 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chrM_+_9182 0.092


chr7_-_115670774 0.090 TFEC
transcription factor EC
chr6_-_26189303 0.090 NM_003539
HIST1H4D
histone cluster 1, H4d
chr6_+_90604185 0.090 NM_032602
GJA10
gap junction protein, alpha 10, 62kDa
chr11_-_89653575 0.090 NM_001105522
TRIM49L1
tripartite motif containing 49-like 1
chrX_-_31526414 0.090 NM_004014
DMD
dystrophin
chr4_-_123542165 0.090 NM_001207006
NM_021803
IL21

interleukin 21

chrX_+_107288199 0.089 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chrX_-_33357725 0.089 NM_000109
DMD
dystrophin
chrM_+_9725 0.088


chr12_-_10022457 0.087 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr5_+_86676620 0.087


chr7_+_74188308 0.086 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr4_-_72649734 0.086 NM_000583
GC
group-specific component (vitamin D binding protein)
chr14_-_75330535 0.086 NM_001080408
NM_001243007
PROX2

prospero homeobox 2

chr4_-_159956332 0.086 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr11_+_89657231 0.084 NM_001105522
TRIM49L1
tripartite motif containing 49-like 1
chr16_+_31271327 0.083 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr6_-_25874439 0.082 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr11_-_128737132 0.081 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr19_-_21646685 0.081


chr15_+_68908878 0.080 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr3_-_123339423 0.079 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr18_+_61442611 0.079 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr10_-_23633771 0.077 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr7_+_115863004 0.076 NM_152829
TES
testis derived transcript (3 LIM domains)
chr17_-_15523017 0.076 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr16_+_69139466 0.076 NM_001199280
HAS3
hyaluronan synthase 3
chr5_-_98262217 0.075 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr11_-_114466471 0.074 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr19_+_15838833 0.074 NM_013939
OR10H2
olfactory receptor, family 10, subfamily H, member 2
chr3_-_196242190 0.073 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr16_+_31271311 0.073 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr12_+_41831484 0.073 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr19_+_56347943 0.072 NM_134444
NLRP4
NLR family, pyrin domain containing 4
chr1_-_114414245 0.071 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr12_-_71148331 0.070 PTPRR
protein tyrosine phosphatase, receptor type, R
chr12_+_20963637 0.069 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr17_+_66031814 0.069 NM_002266
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr5_+_140261792 0.069 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr4_-_155511838 0.068 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr14_+_39703119 0.068 NM_054024
MIA2
melanoma inhibitory activity 2
chr20_-_1472004 0.068 SIRPB2
signal-regulatory protein beta 2
chr2_+_234959345 0.068 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr12_-_120765555 0.067 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr16_+_31271277 0.067 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr3_+_49235860 0.067 NM_178173
CCDC36
coiled-coil domain containing 36
chr9_-_74675498 0.067 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chrM_+_8364 0.066


chrX_+_114827818 0.066 NM_001136025
NM_001172335
PLS3

plastin 3

chr4_+_156587861 0.066 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr4_-_164534656 0.066 NM_017923
MARCH1
membrane-associated ring finger (C3HC4) 1
chr2_-_88285308 0.065 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr17_-_48945338 0.065 NM_001243877
TOB1
transducer of ERBB2, 1
chr12_+_9980076 0.064 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr12_-_4488707 0.064 NM_020638
FGF23
fibroblast growth factor 23
chr2_-_48115846 0.064 NM_025133
FBXO11
F-box protein 11
chr4_+_53185 0.063 NM_182524
ZNF595
ZNF718
zinc finger protein 595
zinc finger protein 718
chr3_+_189349215 0.063 NM_001114978
NM_001114979
NM_003722
TP63


tumor protein p63


chr10_-_22498911 0.063 NM_001199938
EBLN1
endogenous Bornavirus-like nucleoprotein 1
chr7_-_44580857 0.063 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr10_+_5772610 0.063 FAM208B
family with sequence similarity 208, member B
chr3_+_186560462 0.063 NM_001177800
NM_004797
ADIPOQ

adiponectin, C1Q and collagen domain containing

chr16_-_11375094 0.063 NM_002761
PRM1
protamine 1
chr7_+_150688143 0.063 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr12_-_81991959 0.062 NM_001220477
NM_001220478
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr11_+_124095343 0.061 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr8_-_117023 0.061 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chr19_+_827821 0.061 NM_001700
AZU1
azurocidin 1
chrX_-_75004979 0.061 NM_138703
MAGEE2
melanoma antigen family E, 2
chr17_+_61086897 0.061 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_-_203776200 0.061 WDR12
WD repeat domain 12
chr11_-_30601919 0.061 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr11_-_59633942 0.060 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr1_-_67266930 0.060 NM_005478
INSL5
insulin-like 5
chr21_-_27945267 0.060 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr9_+_12693385 0.060 NM_000550
TYRP1
tyrosinase-related protein 1
chr5_-_138718941 0.059 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr7_+_77469446 0.059 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr1_+_92632608 0.059 NM_015237
KIAA1107
KIAA1107
chr4_-_122085475 0.059 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr13_+_114321469 0.059 NM_002929
GRK1
G protein-coupled receptor kinase 1
chr3_+_121774208 0.058 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr12_-_11139510 0.058 NM_176890
TAS2R50
taste receptor, type 2, member 50
chrM_+_4770 0.057


chr3_-_118959723 0.057 NM_003778
NM_212543
B4GALT4

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4

chr4_+_70796798 0.057 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr13_-_99959649 0.057 NM_004951
GPR183
G protein-coupled receptor 183
chrY_+_4924128 0.057 NM_032972
NM_032973
PCDH11X
PCDH11Y

protocadherin 11 X-linked
protocadherin 11 Y-linked

chr14_+_56078735 0.057 KTN1
kinectin 1 (kinesin receptor)
chr20_+_9288446 0.057 NM_000933
PLCB4
phospholipase C, beta 4
chr4_-_69434215 0.057 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr7_+_142880511 0.056 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr7_+_80267782 0.056 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr5_+_147582338 0.056 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr15_-_90222572 0.056 NM_001145311
NM_002666
PLIN1

perilipin 1

chr1_-_203198772 0.056 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chrM_+_5513 0.055


chr4_-_120243257 0.055 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_-_152552962 0.054 NM_032563
LCE3D
late cornified envelope 3D

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.52 7.53e-04 GO:0044459 plasma membrane part
1.25 1.02e-02 GO:0031224 intrinsic to membrane
1.25 1.12e-02 GO:0016021 integral to membrane
1.62 1.22e-02 GO:0005887 integral to plasma membrane
1.59 2.16e-02 GO:0031226 intrinsic to plasma membrane
1.21 2.27e-02 GO:0044425 membrane part
1.44 3.04e-02 GO:0005576 extracellular region
1.27 4.36e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.65 9.08e-03 GO:0043498 cell surface binding