Motif ID: ATF2.p2

Z-value: 1.044


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_176032850-0.167.0e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_13044352 0.652 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr19_+_50979656 0.583 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr20_+_33146500 0.546 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr16_-_79634610 0.516 NM_001031804
NM_005360
MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

chr19_+_50979788 0.497 C19orf63
chromosome 19 open reading frame 63
chr9_+_17578952 0.490 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr8_-_142377364 0.474 NM_005293
GPR20
G protein-coupled receptor 20
chr8_+_70405080 0.463 SULF1
sulfatase 1
chr12_+_13044493 0.463 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr7_+_28448970 0.456 LOC401317
uncharacterized LOC401317
chr2_-_224467049 0.455 SCG2
secretogranin II
chr5_-_178054072 0.442 CLK4
CDC-like kinase 4
chr2_-_224467095 0.432 SCG2
secretogranin II
chr15_-_72612497 0.400 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr12_+_13043955 0.397 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr2_+_220408742 0.394 NM_001005209
TMEM198
transmembrane protein 198
chrX_+_110339374 0.371 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr10_+_95517565 0.356 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr10_+_99496891 0.355 ZFYVE27
zinc finger, FYVE domain containing 27
chrX_+_118108575 0.349 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr10_+_99496847 0.342 NM_001002262
NM_001174119
NM_001174120
NM_001174121
NM_001174122
NM_144588
ZFYVE27





zinc finger, FYVE domain containing 27





chr17_-_7165788 0.340 CLDN7
claudin 7
chr10_+_99496938 0.328 ZFYVE27
zinc finger, FYVE domain containing 27
chr12_-_4754275 0.328 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr6_+_89791510 0.317 PNRC1
proline-rich nuclear receptor coactivator 1
chr20_-_39317875 0.315 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr3_+_139654001 0.314 NM_022131
CLSTN2
calsyntenin 2
chr5_-_178054001 0.313 NM_020666
CLK4
CDC-like kinase 4
chr20_-_56284945 0.308 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_-_123187842 0.302 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr13_+_97999289 0.297


chr11_+_109292874 0.295 C11orf87
chromosome 11 open reading frame 87
chr8_+_70405027 0.295 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr3_-_56809594 0.294 NM_001128616
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr9_+_101705710 0.294 NM_001855
COL15A1
collagen, type XV, alpha 1
chr6_-_91006580 0.291 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr4_+_85504056 0.290 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr6_-_91006460 0.281 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_-_221915458 0.281 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr17_+_34431219 0.280 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr4_+_668250 0.276 MYL5
myosin, light chain 5, regulatory
chr5_+_32711437 0.273 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr7_+_73442426 0.271 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr17_-_4643162 0.271 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr7_+_73442451 0.270 ELN
elastin
chr20_-_34025955 0.269 NM_000557
GDF5
growth differentiation factor 5
chr12_-_123201319 0.268 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr7_+_30174343 0.258 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr20_-_44420538 0.256 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr7_+_116660263 0.250 ST7
suppression of tumorigenicity 7
chr19_-_52227220 0.239 NM_001523
HAS1
hyaluronan synthase 1
chr2_-_224467142 0.235 NM_003469
SCG2
secretogranin II
chr21_-_43187265 0.233 RIPK4
receptor-interacting serine-threonine kinase 4
chr19_+_45504686 0.231 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr10_+_23983674 0.230 NM_001098500
KIAA1217
KIAA1217
chr6_+_136172802 0.230 NM_018945
PDE7B
phosphodiesterase 7B
chr17_-_4642638 0.226 CXCL16
chemokine (C-X-C motif) ligand 16
chr12_-_123380628 0.226 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr1_-_221915393 0.225 DUSP10
dual specificity phosphatase 10
chr13_-_52378230 0.225 NM_001031719
NM_024705
DHRS12

dehydrogenase/reductase (SDR family) member 12

chr15_-_72612247 0.224 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chrX_+_43514157 0.220 MAOA
monoamine oxidase A
chr1_+_52082755 0.219 OSBPL9
oxysterol binding protein-like 9
chr8_+_26240522 0.218 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr1_+_45266048 0.215 PLK3
polo-like kinase 3
chr1_-_109935869 0.215 NM_001205228
SORT1
sortilin 1
chr6_+_72922513 0.211 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr7_+_73442486 0.210 ELN
elastin
chr21_-_43187197 0.207 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_85527992 0.205 NM_145172
WDR63
WD repeat domain 63
chr14_+_96671015 0.202 NM_000623
BDKRB2
bradykinin receptor B2
chr6_+_139456240 0.201 NM_016217
HECA
headcase homolog (Drosophila)
chrX_+_135730335 0.201 NM_000074
CD40LG
CD40 ligand
chr6_+_39760138 0.201


chr7_+_130131172 0.201 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr12_-_123380682 0.200 NM_024667
VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr9_+_97488993 0.199 C9orf3
chromosome 9 open reading frame 3
chr1_-_47184790 0.198


chr6_-_155777036 0.197 NM_015718
NOX3
NADPH oxidase 3
chr6_-_24383519 0.196 NM_001195610
DCDC2
doublecortin domain containing 2
chr3_+_8543508 0.195 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr7_-_121944485 0.192 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr3_+_8543539 0.190 LMCD1
LIM and cysteine-rich domains 1
chr5_-_138210992 0.189 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr3_-_158390266 0.188 NM_020169
LXN
latexin
chr7_-_129592794 0.184 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr1_-_221915426 0.184 DUSP10
dual specificity phosphatase 10
chr9_+_97488943 0.183 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chrX_+_148863592 0.182 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr9_+_137967088 0.182 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr19_+_57631410 0.181 NM_020903
USP29
ubiquitin specific peptidase 29
chr11_+_66610882 0.181 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein protease (S. cerevisiae)

chr2_-_220408264 0.181 NM_024536
CHPF
chondroitin polymerizing factor
chrX_+_84498993 0.180 NM_021998
ZNF711
zinc finger protein 711
chr11_-_6633400 0.180 TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr5_+_66124603 0.180 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_+_42264300 0.180 NM_001076674
NM_024107
TMUB2

transmembrane and ubiquitin-like domain containing 2

chrX_+_118108595 0.179 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr12_-_50790391 0.179 NM_001145475
FAM186A
family with sequence similarity 186, member A
chr20_-_56285576 0.179 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr12_+_10365415 0.179 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr22_+_31518923 0.179 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr13_+_32605436 0.177 NM_023037
FRY
furry homolog (Drosophila)
chr4_+_74606222 0.177 NM_000584
IL8
interleukin 8
chr6_-_70506768 0.176 LMBRD1
LMBR1 domain containing 1
chr15_-_83240499 0.175 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr3_+_170075449 0.175 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr6_+_108487214 0.173 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr13_-_48987247 0.172 LPAR6
lysophosphatidic acid receptor 6
chr9_+_126773851 0.170 NM_004789
LHX2
LIM homeobox 2
chr17_+_12569305 0.170 MYOCD
myocardin
chr6_-_70506524 0.169 LMBRD1
LMBR1 domain containing 1
chr19_-_51472816 0.168 NM_002774
KLK6
kallikrein-related peptidase 6
chr5_-_1882764 0.168 NM_016358
IRX4
iroquois homeobox 4
chr4_+_668312 0.167 MYL5
myosin, light chain 5, regulatory
chr14_+_101292483 0.166


chr6_+_56819923 0.164 BEND6
BEN domain containing 6
chr10_-_90967048 0.161 NM_003956
CH25H
cholesterol 25-hydroxylase
chr14_+_93389444 0.160 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr12_-_123380608 0.159


chr3_-_156877882 0.159 CCNL1
cyclin L1
chr14_+_101292451 0.159 MEG3
maternally expressed 3 (non-protein coding)
chr5_-_140012730 0.158 CD14
CD14 molecule
chr20_+_58179601 0.157 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr19_-_5340700 0.156 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr1_-_76397975 0.155 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr13_-_48987017 0.154 LPAR6
lysophosphatidic acid receptor 6
chr6_-_31671089 0.153 ABHD16A
abhydrolase domain containing 16A
chr9_-_19786886 0.153 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr10_-_95360959 0.153 NM_006744
RBP4
retinol binding protein 4, plasma
chr14_-_93651242 0.152 NM_022151
MOAP1
modulator of apoptosis 1
chr8_-_72274466 0.151 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr10_+_64133915 0.151 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr5_-_147286064 0.151 NM_206966
C5orf46
chromosome 5 open reading frame 46
chrX_+_102024057 0.150 LOC100287765
uncharacterized LOC100287765
chr12_-_92539614 0.149 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chrX_-_83757398 0.149 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr17_+_53342356 0.148 HLF
hepatic leukemia factor
chr1_+_196946666 0.148 NM_030787
CFHR5
complement factor H-related 5
chr9_-_125027017 0.147 RBM18
RNA binding motif protein 18
chr14_-_93651182 0.147 MOAP1
modulator of apoptosis 1
chr14_+_93389491 0.147 CHGA
chromogranin A (parathyroid secretory protein 1)
chr1_+_29562947 0.147 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr2_-_27531113 0.146 NM_003353
UCN
urocortin
chr11_-_13517525 0.145 NM_000315
PTH
parathyroid hormone
chr10_+_119000583 0.143 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr6_-_70506843 0.143 NM_018368
LMBRD1
LMBR1 domain containing 1
chr19_-_3985460 0.142 NM_001961
EEF2
eukaryotic translation elongation factor 2
chr7_-_45128492 0.142 NM_001146334
NACAD
NAC alpha domain containing
chr5_-_140013285 0.142 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr1_+_25757381 0.141 NM_018202
TMEM57
transmembrane protein 57
chr11_+_5710926 0.140 TRIM22
tripartite motif containing 22
chr17_+_42264573 0.139 NM_177441
TMUB2
transmembrane and ubiquitin-like domain containing 2
chr10_+_22634373 0.139 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr3_-_99594915 0.139 NM_014890
FILIP1L
filamin A interacting protein 1-like
chrX_-_148669108 0.137 NM_005365
NM_001080790
MAGEA9
MAGEA9B
melanoma antigen family A, 9
melanoma antigen family A, 9B
chr1_+_45266035 0.136 NM_004073
PLK3
polo-like kinase 3
chr21_+_27011588 0.136 NM_021219
JAM2
junctional adhesion molecule 2
chr17_+_19990334 0.134 NM_001033553
NM_152904
SPECC1

sperm antigen with calponin homology and coiled-coil domains 1

chr1_-_161039703 0.134 ARHGAP30
Rho GTPase activating protein 30
chr3_-_119182423 0.134 NM_018266
TMEM39A
transmembrane protein 39A
chr1_-_1293907 0.131 NM_032348
MXRA8
matrix-remodelling associated 8
chr2_+_37571752 0.131 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr11_-_66725790 0.131 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr5_+_32711729 0.130 NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr9_+_137967267 0.130 OLFM1
olfactomedin 1
chr10_+_1102295 0.130 WDR37
WD repeat domain 37
chr5_-_138211054 0.130 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr6_-_31671120 0.129 NM_021160
ABHD16A
abhydrolase domain containing 16A
chr17_-_56492938 0.129 RNF43
ring finger protein 43
chr12_+_71833518 0.129 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr2_+_38177595 0.128 NM_001170793
NM_144713
FAM82A1

family with sequence similarity 82, member A1

chr1_+_45265896 0.128 PLK3
polo-like kinase 3
chr5_+_121495870 0.128 NM_001195535
LOC100505841
zinc finger protein 474-like
chr1_-_161039745 0.127 NM_001025598
NM_181720
ARHGAP30

Rho GTPase activating protein 30

chr1_+_87012758 0.124 NM_012128
CLCA4
chloride channel accessory 4
chr3_+_139654206 0.123 CLSTN2
calsyntenin 2
chr15_-_82336880 0.123 MEX3B
mex-3 homolog B (C. elegans)
chr7_+_73442468 0.122 ELN
elastin
chr11_+_117070039 0.122 NM_001001522
NM_003186
TAGLN

transgelin

chr11_-_119599253 0.121 NM_002855
NM_203285
NM_203286
PVRL1


poliovirus receptor-related 1 (herpesvirus entry mediator C)


chr19_-_50979461 0.120 FAM71E1
family with sequence similarity 71, member E1
chr5_-_95768660 0.120 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr1_-_212208779 0.119 NM_001199809
NM_001199811
NM_001199812
NM_015434
INTS7



integrator complex subunit 7



chr3_-_112359962 0.119 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr2_-_133429069 0.119 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr1_+_209878135 0.118 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_+_53342320 0.117 NM_002126
HLF
hepatic leukemia factor
chr11_+_58390145 0.117 NM_000614
CNTF
ciliary neurotrophic factor
chr9_+_131644368 0.117 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chrX_-_47479229 0.117 NM_006950
NM_133499
SYN1

synapsin I

chr16_-_30103204 0.116 NM_004608
TBX6
T-box 6
chr1_+_65613211 0.116 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr5_-_158635080 0.116 NM_001199381
RNF145
ring finger protein 145
chr17_+_42264582 0.115 TMUB2
transmembrane and ubiquitin-like domain containing 2
chr20_+_58296264 0.115 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr5_-_158634833 0.115 NM_144726
RNF145
ring finger protein 145
chr2_-_216300444 0.115 FN1
fibronectin 1
chr5_+_86676620 0.115


chr3_+_132318980 0.113 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.48 5.23e-07 GO:0048856 anatomical structure development
1.43 2.20e-06 GO:0007275 multicellular organismal development
1.40 3.57e-06 GO:0032502 developmental process
1.46 1.68e-05 GO:0048731 system development
1.26 1.31e-03 GO:0032501 multicellular organismal process
1.57 1.35e-02 GO:0051239 regulation of multicellular organismal process
1.41 3.31e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 1.34e-02 GO:0005615 extracellular space
1.56 1.79e-02 GO:0044421 extracellular region part

Nothing significant found in function category.