Motif ID: ATF4.p2

Z-value: 0.912


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_399165630.422.9e-01Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_68086633 2.908 ARG2
arginase, type II
chr20_+_58179601 1.820 NM_080672
 PHACTR3
phosphatase and actin regulator 3
chr14_+_68086570 1.814 NM_001172
 ARG2
arginase, type II
chr16_+_22825481 1.572 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr14_+_68086655 1.329 ARG2
arginase, type II
chr8_-_95274540 1.137 NM_005261
NM_181702
 GEM

GTP binding protein overexpressed in skeletal muscle

chr4_+_75310852 0.984 NM_001657
 AREG
amphiregulin
chr1_+_156030965 0.964 NM_020387
 RAB25
RAB25, member RAS oncogene family
chr1_+_2005083 0.876 NM_001033581
 PRKCZ
protein kinase C, zeta
chr8_-_95274520 0.874 GEM
GTP binding protein overexpressed in skeletal muscle
chr6_+_139456240 0.795 NM_016217
 HECA
headcase homolog (Drosophila)
chr12_-_31881949 0.790 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr8_-_66754276 0.781 PDE7A
phosphodiesterase 7A
chr12_-_123380628 0.735 VPS37B
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr8_+_82644663 0.712 NM_152284
 CHMP4C
charged multivesicular body protein 4C
chr12_-_31882006 0.704 NM_001113402
 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr4_+_85504056 0.696 NM_001263
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr8_+_61591239 0.675 NM_017780
 CHD7
chromodomain helicase DNA binding protein 7
chr1_+_44398991 0.673 NM_001136215
NM_057090
NM_057091
 ARTN


artemin


chr10_+_134210691 0.628 NM_001098637
NM_138499
 PWWP2B

PWWP domain containing 2B


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
2.87 4.30e-02 GO:0050657 nucleic acid transport
2.87 4.30e-02 GO:0050658 RNA transport
2.87 4.30e-02 GO:0051236 establishment of RNA localization
2.25 1.83e-02 GO:0034660 ncRNA metabolic process
2.19 1.50e-02 GO:0051325 interphase
2.18 1.63e-02 GO:0006412 translation
1.77 2.42e-02 GO:0006396 RNA processing
1.72 4.82e-02 GO:0022403 cell cycle phase
1.71 4.75e-09 GO:0010467 gene expression
1.69 1.87e-02 GO:0022402 cell cycle process
1.66 8.33e-10 GO:0090304 nucleic acid metabolic process
1.66 5.75e-03 GO:0032774 RNA biosynthetic process
1.65 2.53e-02 GO:0006351 transcription, DNA-dependent
1.62 9.50e-06 GO:0034645 cellular macromolecule biosynthetic process
1.61 6.24e-06 GO:0016070 RNA metabolic process
1.61 1.16e-05 GO:0009059 macromolecule biosynthetic process
1.60 1.10e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.60 2.30e-02 GO:0007049 cell cycle
1.53 6.47e-10 GO:0034641 cellular nitrogen compound metabolic process
1.53 1.44e-03 GO:0006996 organelle organization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 29 entries
enrichment   p-value GO term description
13.52 2.24e-02 GO:0005663 DNA replication factor C complex
2.12 1.18e-05 GO:0005730 nucleolus
1.97 1.35e-04 GO:0005694 chromosome
1.89 6.04e-03 GO:0044427 chromosomal part
1.86 4.07e-10 GO:0005654 nucleoplasm
1.81 2.01e-13 GO:0031981 nuclear lumen
1.80 1.27e-02 GO:0030529 ribonucleoprotein complex
1.75 6.06e-14 GO:0044428 nuclear part
1.75 1.60e-03 GO:0044451 nucleoplasm part
1.72 2.45e-13 GO:0070013 intracellular organelle lumen
1.70 6.65e-03 GO:0031967 organelle envelope
1.69 8.25e-13 GO:0031974 membrane-enclosed lumen
1.69 1.08e-12 GO:0043233 organelle lumen
1.67 1.17e-02 GO:0031975 envelope
1.43 5.90e-06 GO:0043228 non-membrane-bounded organelle
1.43 5.90e-06 GO:0043232 intracellular non-membrane-bounded organelle
1.38 7.40e-13 GO:0044422 organelle part
1.38 8.14e-13 GO:0044446 intracellular organelle part
1.38 6.97e-03 GO:0005829 cytosol
1.37 3.61e-12 GO:0005634 nucleus

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
4.61 3.47e-03 GO:0004722 protein serine/threonine phosphatase activity
1.78 1.48e-04 GO:0003723 RNA binding
1.54 2.38e-04 GO:0005524 ATP binding
1.53 2.61e-04 GO:0030554 adenyl nucleotide binding
1.53 3.25e-04 GO:0032559 adenyl ribonucleotide binding
1.47 3.94e-04 GO:0035639 purine ribonucleoside triphosphate binding
1.46 5.62e-04 GO:0017076 purine nucleotide binding
1.45 6.47e-04 GO:0032553 ribonucleotide binding
1.45 6.47e-04 GO:0032555 purine ribonucleotide binding
1.38 2.79e-03 GO:0000166 nucleotide binding
1.34 2.88e-16 GO:0005515 protein binding
1.34 2.37e-04 GO:0003676 nucleic acid binding
1.20 1.97e-02 GO:0003824 catalytic activity
1.15 2.89e-09 GO:0005488 binding