Motif ID: ATF5_CREB3.p2

Z-value: 0.962


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CREB3chr9_+_35732207-0.686.6e-02Click!
ATF5chr19_+_50431958-0.118.0e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_68086633 1.192 ARG2
arginase, type II
chr14_+_68086655 0.759 ARG2
arginase, type II
chr2_+_75061234 0.621 HK2
hexokinase 2
chr20_+_58179601 0.620 NM_080672
 PHACTR3
phosphatase and actin regulator 3
chr1_+_156030965 0.601 NM_020387
 RAB25
RAB25, member RAS oncogene family
chr4_+_75480628 0.580 NM_001657
 AREG
amphiregulin
chr4_+_75310852 0.575 NM_001657
 AREG
amphiregulin
chr14_+_68086570 0.555 NM_001172
 ARG2
arginase, type II
chr2_-_60780767 0.538 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr5_-_95297424 0.441 ELL2
elongation factor, RNA polymerase II, 2
chr12_-_31881949 0.403 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr22_-_44258210 0.390 NM_014351
 SULT4A1
sulfotransferase family 4A, member 1
chr12_-_31882006 0.382 NM_001113402
 AMN1
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr2_-_60780404 0.372 NM_018014
NM_022893
NM_138559
 BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr8_-_95274520 0.369 GEM
GTP binding protein overexpressed in skeletal muscle
chr16_+_19078958 0.355 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr12_-_132628841 0.340 NM_175066
 DDX51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr8_-_66754276 0.335 PDE7A
phosphodiesterase 7A
chr5_-_95297597 0.324 NM_012081
 ELL2
elongation factor, RNA polymerase II, 2
chr6_-_15248886 0.324



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 103 entries
enrichment   p-value GO term description
3.17 2.70e-04 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
3.08 1.53e-03 GO:0034130 toll-like receptor 1 signaling pathway
3.08 1.53e-03 GO:0034134 toll-like receptor 2 signaling pathway
3.08 4.77e-03 GO:0034138 toll-like receptor 3 signaling pathway
2.99 8.46e-03 GO:0002756 MyD88-independent toll-like receptor signaling pathway
2.92 2.67e-03 GO:0034142 toll-like receptor 4 signaling pathway
2.83 1.90e-03 GO:0002224 toll-like receptor signaling pathway
2.80 1.02e-02 GO:0008063 Toll signaling pathway
2.70 5.06e-03 GO:0002221 pattern recognition receptor signaling pathway
2.61 1.00e-02 GO:0002758 innate immune response-activating signal transduction
2.56 1.55e-02 GO:0002218 activation of innate immune response
2.42 2.20e-02 GO:0000086 G2/M transition of mitotic cell cycle
2.40 2.67e-02 GO:0051028 mRNA transport
2.35 1.01e-02 GO:0006470 protein dephosphorylation
2.35 1.41e-02 GO:0006403 RNA localization
2.35 1.98e-02 GO:0050657 nucleic acid transport
2.35 1.98e-02 GO:0050658 RNA transport
2.35 1.98e-02 GO:0051236 establishment of RNA localization
2.24 3.88e-07 GO:0051329 interphase of mitotic cell cycle
2.20 8.81e-07 GO:0051325 interphase

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
5.65 1.91e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.03 2.57e-06 GO:0005815 microtubule organizing center
1.80 7.04e-06 GO:0005730 nucleolus
1.79 4.57e-08 GO:0015630 microtubule cytoskeleton
1.77 1.55e-16 GO:0005654 nucleoplasm
1.75 1.52e-04 GO:0044427 chromosomal part
1.74 2.80e-22 GO:0031981 nuclear lumen
1.71 7.48e-07 GO:0044451 nucleoplasm part
1.71 4.41e-05 GO:0005694 chromosome
1.65 4.34e-21 GO:0044428 nuclear part
1.65 1.14e-03 GO:0030529 ribonucleoprotein complex
1.64 1.77e-21 GO:0070013 intracellular organelle lumen
1.62 1.05e-20 GO:0043233 organelle lumen
1.61 1.66e-20 GO:0031974 membrane-enclosed lumen
1.51 3.55e-12 GO:0005829 cytosol
1.37 7.66e-09 GO:0043228 non-membrane-bounded organelle
1.37 7.66e-09 GO:0043232 intracellular non-membrane-bounded organelle
1.35 4.10e-22 GO:0005634 nucleus
1.35 3.97e-11 GO:0032991 macromolecular complex
1.34 2.28e-08 GO:0043234 protein complex

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
3.36 5.72e-03 GO:0004722 protein serine/threonine phosphatase activity
2.28 4.80e-04 GO:0004721 phosphoprotein phosphatase activity
1.93 3.24e-03 GO:0016791 phosphatase activity
1.89 3.14e-02 GO:0003924 GTPase activity
1.83 2.76e-05 GO:0004674 protein serine/threonine kinase activity
1.81 4.86e-02 GO:0019787 small conjugating protein ligase activity
1.77 1.50e-09 GO:0003723 RNA binding
1.77 4.28e-03 GO:0042578 phosphoric ester hydrolase activity
1.64 1.15e-13 GO:0032559 adenyl ribonucleotide binding
1.64 1.23e-13 GO:0030554 adenyl nucleotide binding
1.63 7.82e-17 GO:0032553 ribonucleotide binding
1.63 7.82e-17 GO:0032555 purine ribonucleotide binding
1.63 4.15e-13 GO:0005524 ATP binding
1.62 9.83e-17 GO:0017076 purine nucleotide binding
1.62 3.01e-16 GO:0035639 purine ribonucleoside triphosphate binding
1.62 3.14e-05 GO:0017111 nucleoside-triphosphatase activity
1.62 4.35e-04 GO:0004672 protein kinase activity
1.59 4.75e-05 GO:0016462 pyrophosphatase activity
1.59 6.01e-05 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.59 1.43e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor