Motif ID: CEBPA,B_DDIT3.p2

Z-value: 1.598


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CEBPAchr19_-_337934290.696.0e-02Click!
CEBPBchr20_+_488073650.354.0e-01Click!
DDIT3chr12_-_579142870.078.7e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52845862 8.998 NM_005555
KRT6B
keratin 6B
chr19_-_35992798 4.736 NM_001035516
DMKN
dermokine
chr12_-_52867521 2.848 NM_173086
KRT6C
keratin 6C
chr10_-_116444374 2.828 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr10_-_116444112 2.791 ABLIM1
actin binding LIM protein 1
chr19_-_49258646 2.485 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr2_-_113594325 2.386 NM_000576
IL1B
interleukin 1, beta
chr4_-_10023094 2.258 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr4_+_40198526 2.224 NM_004310
RHOH
ras homolog gene family, member H
chr3_+_136676706 1.984 NM_144717
IL20RB
interleukin 20 receptor beta
chr4_-_15940362 1.910 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr6_-_11779279 1.720 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr8_+_124194751 1.710 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr8_+_124194873 1.573 FAM83A
family with sequence similarity 83, member A
chr19_-_44174497 1.455 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chrX_-_133792497 1.433 NM_021796
PLAC1
placenta-specific 1
chr6_+_80340971 1.340 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr10_-_103874661 1.268 NM_003893
LDB1
LIM domain binding 1
chr9_-_117156684 1.042 NM_030767
AKNA
AT-hook transcription factor
chr17_-_39768939 1.037 NM_005557
KRT16
keratin 16
chr7_-_83824216 1.003 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_-_215896809 0.990 NM_015657
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr12_-_25102281 0.973 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr21_+_43619798 0.908 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr11_-_102668892 0.896 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_+_18287807 0.882 NM_000331
NM_001178006
NM_199161
SAA1


serum amyloid A1


chr15_-_72598655 0.879 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr5_-_140013285 0.852 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr12_-_25101923 0.849 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr12_-_25101993 0.845 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr8_-_130799133 0.842 NM_031415
GSDMC
gasdermin C
chr17_-_39092714 0.841 KRT23
keratin 23 (histone deacetylase inducible)
chr5_-_140012730 0.787 CD14
CD14 molecule
chr19_-_54676813 0.711 NM_001145303
NM_144686
TMC4

transmembrane channel-like 4

chr17_-_56492938 0.702 RNF43
ring finger protein 43
chr18_+_29598444 0.633 NM_017831
RNF125
ring finger protein 125
chr1_-_116383692 0.588 NM_005599
NHLH2
nescient helix loop helix 2
chr17_-_7166505 0.563 NM_001185022
CLDN7
claudin 7
chr1_-_23342342 0.542 NM_001242521
LOC729059
uncharacterized LOC729059
chr8_-_38008332 0.536 NM_000349
STAR
steroidogenic acute regulatory protein
chr12_-_58160823 0.533 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chrX_-_15288588 0.514 NM_001168531
ASB9
ankyrin repeat and SOCS box containing 9
chr3_-_143567163 0.506 NM_173653
SLC9A9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr1_+_111770280 0.502 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr4_-_2935650 0.501 MFSD10
major facilitator superfamily domain containing 10
chr5_-_176836488 0.499 F12
coagulation factor XII (Hageman factor)
chr7_+_26400503 0.497 NM_001199837
SNX10
sorting nexin 10
chr11_-_104972147 0.494 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr15_+_89182038 0.475 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr2_-_38525527 0.467 ATL2
atlastin GTPase 2
chr20_+_62795773 0.456 MYT1
myelin transcription factor 1
chr19_+_49078992 0.449 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr8_+_32504250 0.428 NM_013959
NRG1
neuregulin 1
chr12_+_5019048 0.426 NM_000217
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr11_-_102668822 0.425 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr14_-_21572789 0.419 NM_001102454
ZNF219
zinc finger protein 219
chr4_+_108814419 0.413 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr8_-_110657745 0.402 NM_001099751
NM_001099752
SYBU

syntabulin (syntaxin-interacting)

chr7_-_104567089 0.401 LOC723809
uncharacterized LOC723809
chr17_+_56315786 0.401 NM_001160102
NM_006151
LPO

lactoperoxidase

chr1_-_109935869 0.397 NM_001205228
SORT1
sortilin 1
chr16_-_70323407 0.392 NM_001605
AARS
alanyl-tRNA synthetase
chr3_+_130569368 0.389 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr7_+_75124298 0.387 NM_001099435
SPDYE5
speedy homolog E5 (Xenopus laevis)
chr5_+_149151502 0.384 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr16_-_70323343 0.384 AARS
alanyl-tRNA synthetase
chr5_-_140013034 0.383 NM_000591
CD14
CD14 molecule
chr11_+_71846755 0.381 NM_000804
FOLR3
folate receptor 3 (gamma)
chr1_+_150954498 0.368 NM_003568
ANXA9
annexin A9
chr20_+_57766074 0.364 NM_178457
ZNF831
zinc finger protein 831
chr6_-_52109226 0.364 NM_052872
IL17F
interleukin 17F
chr22_+_45072687 0.360 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr15_+_41245635 0.359 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr8_-_66701175 0.354 NM_002603
PDE7A
phosphodiesterase 7A
chr20_+_361938 0.346 TRIB3
tribbles homolog 3 (Drosophila)
chr1_+_26503973 0.346 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr7_-_37024664 0.344 NM_001039459
ELMO1
engulfment and cell motility 1
chr4_-_38806410 0.342 NM_003263
TLR1
toll-like receptor 1
chr2_-_37297372 0.328 HEATR5B
HEAT repeat containing 5B
chr19_+_33864574 0.327 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr1_+_153330329 0.326 NM_002965
S100A9
S100 calcium binding protein A9
chr12_-_50595303 0.324 NM_001243775
LIMA1
LIM domain and actin binding 1
chr3_+_1134619 0.322 NM_014461
CNTN6
contactin 6
chr3_+_186739643 0.315 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr19_+_6887576 0.306 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr1_-_153521717 0.306 NM_002960
S100A3
S100 calcium binding protein A3
chr9_-_95055966 0.306 NM_013417
IARS
isoleucyl-tRNA synthetase
chr9_-_95055913 0.303 IARS
isoleucyl-tRNA synthetase
chr9_-_95055989 0.301 NM_002161
IARS
isoleucyl-tRNA synthetase
chr11_+_10476665 0.300 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr4_+_159131400 0.298 NM_018342
TMEM144
transmembrane protein 144
chr19_+_1450208 0.297 APC2
adenomatosis polyposis coli 2
chr9_-_95055986 0.292 IARS
isoleucyl-tRNA synthetase
chr4_-_153601085 0.285 NM_152680
TMEM154
transmembrane protein 154
chr20_+_68312 0.283 NM_153325
DEFB125
defensin, beta 125
chr20_+_9198036 0.282 NM_182797
PLCB4
phospholipase C, beta 4
chr7_-_83270746 0.280 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr3_-_79817058 0.280 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_-_104211244 0.278 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr5_-_176836535 0.277 NM_000505
F12
coagulation factor XII (Hageman factor)
chr1_+_161676761 0.277 NM_001184866
NM_001184867
NM_001184870
NM_001184871
NM_001184872
NM_001184873
NM_032738
FCRLA






Fc receptor-like A






chr3_-_129599220 0.277 NM_001017395
TMCC1
transmembrane and coiled-coil domain family 1
chr2_+_191301020 0.275 MFSD6
major facilitator superfamily domain containing 6
chr8_-_110661007 0.270 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr4_-_2935851 0.270 NM_001120
MFSD10
major facilitator superfamily domain containing 10
chr17_-_64225496 0.269 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr13_-_30169584 0.265 SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr3_+_127641901 0.257 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_+_7060433 0.251 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr18_-_55288951 0.247 NARS
asparaginyl-tRNA synthetase
chr5_+_131409484 0.240 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr6_-_3272349 0.239 SLC22A23
solute carrier family 22, member 23
chr14_-_23445885 0.238 AJUBA
ajuba LIM protein
chr16_+_56815703 0.229 NM_001242795
NUP93
nucleoporin 93kDa
chr1_+_84630374 0.228 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_-_9595412 0.228 NM_198560
LHFPL4
lipoma HMGIC fusion partner-like 4
chr14_+_96722546 0.228 NM_000710
BDKRB1
bradykinin receptor B1
chr2_-_230933618 0.228 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chrY_-_20935503 0.225 NM_001001877
NM_153716
NM_152584
NM_033108
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chrY_+_20708556 0.225 NM_153716
NM_001001877
NM_033108
NM_152584
HSFY2

HSFY1

heat shock transcription factor, Y linked 2

heat shock transcription factor, Y-linked 1

chr1_+_196857143 0.221 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr1_+_212782103 0.221 ATF3
activating transcription factor 3
chr11_+_59824129 0.219 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr19_+_56511090 0.218 NM_153447
NLRP5
NLR family, pyrin domain containing 5
chrX_-_40506666 0.216 CXorf38
chromosome X open reading frame 38
chr4_+_153864134 0.211 NM_033393
FHDC1
FH2 domain containing 1
chr22_+_23054862 0.208 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr16_+_75252882 0.204 NM_001906
CTRB1
chymotrypsinogen B1
chr18_-_55289014 0.204 NARS
asparaginyl-tRNA synthetase
chr5_-_131630939 0.203


chr17_+_4337218 0.203 NM_182538
SPNS3
spinster homolog 3 (Drosophila)
chr8_+_24151579 0.201 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr6_-_170599568 0.200 NM_005618
DLL1
delta-like 1 (Drosophila)
chr6_+_12717036 0.200 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr7_+_123295860 0.196 NM_207163
LMOD2
leiomodin 2 (cardiac)
chrX_-_114252132 0.195 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr16_+_24266873 0.195 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr3_+_57994087 0.192 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr20_+_54987167 0.190 NM_001164116
NM_001164114
NM_001164115
NM_020356
CASS4



Cas scaffolding protein family member 4



chr16_+_56966025 0.188 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr16_+_3405888 0.187 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chrX_-_40506800 0.187 NM_144970
CXorf38
chromosome X open reading frame 38
chr1_-_153283166 0.185 NM_052891
PGLYRP3
peptidoglycan recognition protein 3
chr11_+_59824054 0.183 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr2_+_32390902 0.183 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chr5_-_24645084 0.180 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr10_-_89577883 0.177 NM_032810
ATAD1
ATPase family, AAA domain containing 1
chr14_+_62462540 0.175 NM_031914
SYT16
synaptotagmin XVI
chr16_+_66995099 0.174 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr6_-_42162693 0.173 NM_002098
GUCA1B
guanylate cyclase activator 1B (retina)
chrX_+_114827818 0.173 NM_001136025
NM_001172335
PLS3

plastin 3

chr9_+_137004913 0.173 NM_052821
WDR5
WD repeat domain 5
chrX_+_144908927 0.171 NM_004709
CXorf1
chromosome X open reading frame 1
chr18_-_61311465 0.168 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr19_-_55580896 0.167 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chrX_-_15288172 0.166 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr12_-_122296619 0.163 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr10_-_47173917 0.160 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr15_+_82944821 0.158 AGSK1
golgin subfamily A member 2-like
chr4_-_71532341 0.156 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr12_+_113344811 0.156 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_-_153273683 0.155 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chrX_-_100129127 0.155 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr6_-_30043547 0.154 NM_170769
NM_025236
RNF39

ring finger protein 39

chr1_+_45965855 0.153 NM_015506
MMACHC
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr3_+_186330859 0.152 AHSG
alpha-2-HS-glycoprotein
chr12_+_54426831 0.150 NM_018953
HOXC5
homeobox C5
chr1_+_241815579 0.149 NM_144625
WDR64
WD repeat domain 64
chr3_-_42843217 0.149


chr14_-_23446431 0.148 NM_198086
AJUBA
ajuba LIM protein
chr18_-_55289026 0.147 NM_004539
NARS
asparaginyl-tRNA synthetase
chr19_+_33865429 0.144 NM_001252296
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr12_-_57009361 0.143 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr3_+_186330711 0.142 AHSG
alpha-2-HS-glycoprotein
chr6_-_143832770 0.139 NM_032020
FUCA2
fucosidase, alpha-L- 2, plasma
chr1_+_212781969 0.139 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr8_+_123793988 0.139 ZHX2
zinc fingers and homeoboxes 2
chr9_-_14779530 0.138 NM_001177704
FREM1
FRAS1 related extracellular matrix 1
chr13_+_32313678 0.138 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr11_+_73661363 0.137 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr5_-_77844975 0.137 LHFPL2
lipoma HMGIC fusion partner-like 2
chr1_-_23886284 0.136 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr16_+_56817367 0.136 NM_001242796
NUP93
nucleoporin 93kDa
chr19_+_13250072 0.136 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr6_+_31895401 0.135 C2
complement component 2
chr1_-_6526150 0.133 NM_001039664
NM_003790
NM_148965
NM_148966
NM_148967
NM_148970
TNFRSF25





tumor necrosis factor receptor superfamily, member 25





chr17_-_15523017 0.129 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr3_+_48264836 0.128 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr5_-_94224601 0.125 MCTP1
multiple C2 domains, transmembrane 1
chr4_+_111397181 0.125 NM_001977
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chrX_+_99899162 0.125 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_-_86290333 0.124 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr1_-_51887740 0.122 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr11_+_2323356 0.121 TSPAN32
tetraspanin 32
chr1_-_40563141 0.121 NM_000310
NM_001142604
PPT1

palmitoyl-protein thioesterase 1

chr14_-_68162419 0.120 NM_001252650
NM_016026
RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr16_+_67381252 0.119 NM_001161575
LRRC36
leucine rich repeat containing 36
chr4_-_123377471 0.118 NM_000586
IL2
interleukin 2
chr12_-_6756533 0.118 NM_032489
ACRBP
acrosin binding protein
chr7_-_56101830 0.116 PSPH
phosphoserine phosphatase

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.48 5.24e-05 GO:0006955 immune response
1.32 2.22e-03 GO:0050896 response to stimulus
2.18 3.27e-03 GO:0006952 defense response
1.87 1.02e-02 GO:0002376 immune system process
2.49 3.88e-02 GO:0071702 organic substance transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.69 2.06e-04 GO:0005576 extracellular region

Nothing significant found in function category.