Motif ID: E2F1..5.p2

Z-value: 4.581


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F2chr1_-_238572840.839.9e-03Click!
E2F1chr20_-_322740700.677.1e-02Click!
E2F3chr6_+_204020400.657.8e-02Click!
E2F5chr8_+_86089618-0.502.1e-01Click!
E2F4chr16_+_67226098,
chr16_+_67226027		0.442.8e-01Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_124408665 2.320 ATAD2
ATPase family, AAA domain containing 2
chr8_-_124408458 2.248 ATAD2
ATPase family, AAA domain containing 2
chr8_-_124408688 2.246 NM_014109
 ATAD2
ATPase family, AAA domain containing 2
chr11_-_19263144 2.237 E2F8
E2F transcription factor 8
chr1_-_36235422 2.234 NM_001190481
NM_022111
 CLSPN

claspin

chr8_-_124408669 2.206 ATAD2
ATPase family, AAA domain containing 2
chr11_-_19262424 2.033 NM_024680
 E2F8
E2F transcription factor 8
chr20_-_35724330 2.005 RBL1
retinoblastoma-like 1 (p107)
chr1_-_23857711 1.874 NM_004091
 E2F2
E2F transcription factor 2
chr13_+_32889594 1.644 NM_000059
 BRCA2
breast cancer 2, early onset
chr12_-_77459198 1.588 NM_203394
 E2F7
E2F transcription factor 7
chr1_-_23857284 1.584 E2F2
E2F transcription factor 2
chr10_-_73848263 1.575 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr20_-_32274070 1.561 E2F1
E2F transcription factor 1
chr7_+_121513158 1.493 NM_001206838
NM_001206839
NM_002851
 PTPRZ1


protein tyrosine phosphatase, receptor-type, Z polypeptide 1


chr20_-_35724401 1.449 NM_002895
NM_183404
 RBL1

retinoblastoma-like 1 (p107)

chr20_-_32274154 1.374 NM_005225
 E2F1
E2F transcription factor 1
chr9_-_99180661 1.281 NM_153695
 ZNF367
zinc finger protein 367
chr2_+_27498288 1.268 NM_173650
 DNAJC5G
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma
chr3_+_10068123 1.250 FANCD2
Fanconi anemia, complementation group D2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 147 entries
enrichment   p-value GO term description
9.49 5.38e-05 GO:0071897 DNA biosynthetic process
9.49 1.51e-02 GO:0000731 DNA synthesis involved in DNA repair
9.49 1.51e-02 GO:0007064 mitotic sister chromatid cohesion
8.86 2.25e-08 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
7.74 3.57e-05 GO:0007062 sister chromatid cohesion
7.69 4.09e-09 GO:0006271 DNA strand elongation involved in DNA replication
7.17 1.95e-08 GO:0022616 DNA strand elongation
7.12 2.09e-03 GO:0006297 nucleotide-excision repair, DNA gap filling
6.96 1.62e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
6.91 4.53e-05 GO:0006270 DNA-dependent DNA replication initiation
6.66 1.14e-03 GO:0032201 telomere maintenance via semi-conservative replication
6.61 8.80e-05 GO:0090329 regulation of DNA-dependent DNA replication
6.33 2.12e-03 GO:0000722 telomere maintenance via recombination
5.80 1.79e-03 GO:0031055 chromatin remodeling at centromere
5.70 2.29e-02 GO:0006298 mismatch repair
5.43 3.73e-02 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
5.43 3.73e-02 GO:0016444 somatic cell DNA recombination
5.36 4.78e-03 GO:0006312 mitotic recombination
5.25 3.72e-11 GO:0006261 DNA-dependent DNA replication
5.00 1.93e-04 GO:0008156 negative regulation of DNA replication

Gene overrepresentation in compartment category:

Showing 1 to 20 of 56 entries
enrichment   p-value GO term description
11.25 5.78e-06 GO:0035098 ESC/E(Z) complex
11.08 6.53e-05 GO:0042555 MCM complex
7.74 6.37e-06 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
7.33 1.40e-05 GO:0031519 PcG protein complex
5.96 8.76e-03 GO:0030894 replisome
5.96 8.76e-03 GO:0043601 nuclear replisome
5.47 2.61e-06 GO:0005657 replication fork
5.18 1.05e-02 GO:0043596 nuclear replication fork
4.03 1.94e-03 GO:0000792 heterochromatin
3.82 8.91e-04 GO:0034708 methyltransferase complex
3.82 8.91e-04 GO:0035097 histone methyltransferase complex
3.59 1.14e-03 GO:0000123 histone acetyltransferase complex
3.45 1.07e-03 GO:0000922 spindle pole
3.38 9.95e-14 GO:0000228 nuclear chromosome
3.37 2.51e-04 GO:0071013 catalytic step 2 spliceosome
3.35 1.19e-10 GO:0044454 nuclear chromosome part
3.24 4.91e-04 GO:0000790 nuclear chromatin
2.98 2.84e-02 GO:0034399 nuclear periphery
2.93 1.93e-05 GO:0005681 spliceosomal complex
2.82 4.73e-05 GO:0000793 condensed chromosome

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
6.33 2.73e-02 GO:0030983 mismatched DNA binding
4.02 2.77e-05 GO:0008094 DNA-dependent ATPase activity
3.78 7.72e-04 GO:0003697 single-stranded DNA binding
2.66 1.04e-05 GO:0003682 chromatin binding
2.40 7.51e-04 GO:0043566 structure-specific DNA binding
1.89 1.10e-08 GO:0003723 RNA binding
1.58 1.77e-12 GO:0000166 nucleotide binding
1.57 7.22e-03 GO:0016462 pyrophosphatase activity
1.57 8.66e-03 GO:0017111 nucleoside-triphosphatase activity
1.56 8.47e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.56 9.94e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.54 1.52e-17 GO:0003676 nucleic acid binding
1.52 4.76e-02 GO:0019899 enzyme binding
1.51 8.54e-10 GO:0003677 DNA binding
1.42 1.84e-03 GO:0030554 adenyl nucleotide binding
1.42 2.06e-03 GO:0032559 adenyl ribonucleotide binding
1.41 3.12e-03 GO:0005524 ATP binding
1.39 6.32e-04 GO:0017076 purine nucleotide binding
1.38 9.96e-04 GO:0032553 ribonucleotide binding
1.38 9.96e-04 GO:0032555 purine ribonucleotide binding