Motif ID: EGR1..3.p2

Z-value: 3.179


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR1chr5_+_1378011780.865.9e-03Click!
EGR2chr10_-_64576074,
chr10_-_64576123		0.743.4e-02Click!
EGR3chr8_-_22550057,
chr8_-_22550708,
chr8_-_22549901		-0.255.5e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_16964730 7.119 NM_001080975
NM_004726
 REPS2

RALBP1 associated Eps domain containing 2

chr6_-_46459010 5.752 NM_001251974
 RCAN2
regulator of calcineurin 2
chr2_+_109745996 5.053 NM_001099289
 SH3RF3
SH3 domain containing ring finger 3
chr1_-_38471170 3.370 NM_001243878
NM_004468
 FHL3

four and a half LIM domains 3

chr5_-_9546157 3.285 NM_003966
 SEMA5A
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr8_+_16884745 3.200 NM_181723
 EFHA2
EF-hand domain family, member A2
chr8_+_72756335 3.109


chr2_-_99552677 2.982 NM_207362
 C2orf55
chromosome 2 open reading frame 55
chr12_-_124457099 2.914 NM_025140
 CCDC92
coiled-coil domain containing 92
chr8_+_72756218 2.846 LOC100132891
uncharacterized LOC100132891
chr2_+_23608297 2.693 NM_052920
 KLHL29
kelch-like 29 (Drosophila)
chr3_+_12329332 2.684 NM_005037
NM_138712
 PPARG

peroxisome proliferator-activated receptor gamma

chr6_+_84743250 2.537 NM_138409
 MRAP2
melanocortin 2 receptor accessory protein 2
chr5_-_168727715 2.504 NM_003062
 SLIT3
slit homolog 3 (Drosophila)
chr1_+_159141376 2.500 NM_021189
NM_001127173
 CADM3

cell adhesion molecule 3

chr7_+_94023872 2.353 NM_000089
 COL1A2
collagen, type I, alpha 2
chr1_+_78354199 2.296 NM_001172309
NM_144573
 NEXN

nexilin (F actin binding protein)

chr6_-_74363689 2.202 NM_012434
 SLC17A5
solute carrier family 17 (anion/sugar transporter), member 5
chr10_+_131265453 2.020 NM_002412
 MGMT
O-6-methylguanine-DNA methyltransferase
chr21_+_47545896 2.003 COL6A2
collagen, type VI, alpha 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 135 entries
enrichment   p-value GO term description
2.97 9.03e-03 GO:0070936 protein K48-linked ubiquitination
2.27 2.33e-03 GO:0000209 protein polyubiquitination
2.13 1.46e-02 GO:0018205 peptidyl-lysine modification
2.00 5.46e-06 GO:0016569 covalent chromatin modification
1.97 1.67e-05 GO:0016570 histone modification
1.97 2.95e-02 GO:0040029 regulation of gene expression, epigenetic
1.94 1.08e-03 GO:0006184 GTP catabolic process
1.92 7.33e-04 GO:0046039 GTP metabolic process
1.84 1.46e-09 GO:0016568 chromatin modification
1.84 6.78e-07 GO:0032446 protein modification by small protein conjugation
1.81 8.89e-06 GO:0016567 protein ubiquitination
1.80 1.11e-07 GO:0070647 protein modification by small protein conjugation or removal
1.76 2.00e-09 GO:0048667 cell morphogenesis involved in neuron differentiation
1.76 5.23e-09 GO:0007409 axonogenesis
1.75 8.17e-04 GO:0071375 cellular response to peptide hormone stimulus
1.74 4.12e-09 GO:0048812 neuron projection morphogenesis
1.72 3.11e-02 GO:0032869 cellular response to insulin stimulus
1.71 1.26e-05 GO:0007411 axon guidance
1.71 4.39e-05 GO:0032870 cellular response to hormone stimulus
1.71 3.15e-03 GO:0048011 nerve growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
3.13 3.56e-02 GO:0031519 PcG protein complex
2.64 3.85e-02 GO:0000932 cytoplasmic mRNA processing body
2.55 4.06e-02 GO:0042641 actomyosin
2.54 1.01e-02 GO:0000118 histone deacetylase complex
2.38 4.05e-03 GO:0035770 RNA granule
2.18 1.63e-04 GO:0016585 chromatin remodeling complex
2.06 3.95e-03 GO:0030027 lamellipodium
2.05 3.54e-03 GO:0008021 synaptic vesicle
2.04 9.27e-03 GO:0009898 internal side of plasma membrane
1.96 1.18e-06 GO:0031252 cell leading edge
1.91 1.05e-02 GO:0019898 extrinsic to membrane
1.85 3.90e-02 GO:0019717 synaptosome
1.81 6.50e-04 GO:0030136 clathrin-coated vesicle
1.71 1.25e-03 GO:0030135 coated vesicle
1.59 9.53e-06 GO:0045202 synapse
1.56 2.84e-03 GO:0015629 actin cytoskeleton
1.55 3.89e-03 GO:0044456 synapse part
1.49 1.91e-03 GO:0043005 neuron projection
1.39 3.24e-04 GO:0044451 nucleoplasm part
1.38 4.15e-03 GO:0030054 cell junction

Gene overrepresentation in function category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
1.90 4.98e-02 GO:0019887 protein kinase regulator activity
1.84 1.68e-03 GO:0003714 transcription corepressor activity
1.81 1.82e-04 GO:0003682 chromatin binding
1.76 3.80e-05 GO:0019787 small conjugating protein ligase activity
1.73 4.14e-06 GO:0008134 transcription factor binding
1.71 5.13e-05 GO:0016881 acid-amino acid ligase activity
1.71 5.86e-04 GO:0004842 ubiquitin-protein ligase activity
1.71 2.36e-03 GO:0010843 promoter binding
1.67 5.47e-03 GO:0000975 regulatory region DNA binding
1.67 5.47e-03 GO:0001067 regulatory region nucleic acid binding
1.67 5.47e-03 GO:0044212 transcription regulatory region DNA binding
1.64 1.74e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.58 9.90e-04 GO:0016564 transcription repressor activity
1.56 2.16e-04 GO:0000988 protein binding transcription factor activity
1.56 2.16e-04 GO:0000989 transcription factor binding transcription factor activity
1.55 3.44e-04 GO:0003712 transcription cofactor activity
1.50 5.54e-04 GO:0019904 protein domain specific binding
1.47 1.10e-09 GO:0030528 transcription regulator activity
1.42 3.29e-05 GO:0019899 enzyme binding
1.42 2.11e-03 GO:0008092 cytoskeletal protein binding