Motif ID: EN1,2.p2

Z-value: 1.775


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_155250705-0.334.3e-01Click!
EN1chr2_-_119605758-0.275.1e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39675078 4.813 NM_002275
 KRT15
keratin 15
chr1_-_242612757 4.742 NM_001195811
NM_001195812
 PLD5

phospholipase D family, member 5

chr10_-_105845619 4.549 NM_000494
 COL17A1
collagen, type XVII, alpha 1
chr10_-_105845556 4.515 COL17A1
collagen, type XVII, alpha 1
chr4_+_40198526 2.778 NM_004310
 RHOH
ras homolog gene family, member H
chr5_+_68800003 2.735 NM_001205255
 OCLN
occludin
chr12_-_53343607 2.385 KRT8
keratin 8
chr12_-_6486522 2.361 NM_001159575
 SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr12_+_53342842 2.257 NM_000224
 KRT18
keratin 18
chr1_+_32050510 2.192 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_-_105322056 1.981 NM_032148
 SLC41A2
solute carrier family 41, member 2
chr1_+_32043745 1.945 NM_001204415
 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_+_53342899 1.835 KRT18
keratin 18
chr15_+_43885251 1.724 NM_020990
 CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_+_31882411 1.691 NM_001199038
 SERINC2
serine incorporator 2
chr1_+_86889768 1.672 NM_006536
 CLCA2
chloride channel accessory 2
chr17_-_4643162 1.614 NM_001100812
NM_022059
 CXCL16

chemokine (C-X-C motif) ligand 16

chr3_-_151034514 1.590 NM_023915
 GPR87
G protein-coupled receptor 87
chr10_+_75673346 1.581 PLAU
plasminogen activator, urokinase
chr21_+_43710190 1.579 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
2.06 2.37e-02 GO:0045087 innate immune response
1.92 8.81e-05 GO:0006955 immune response
1.74 4.37e-03 GO:0006952 defense response
1.63 4.37e-02 GO:0006811 ion transport
1.59 4.61e-03 GO:0002376 immune system process

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.62 1.31e-04 GO:0005887 integral to plasma membrane
1.60 1.82e-04 GO:0031226 intrinsic to plasma membrane
1.47 6.19e-05 GO:0005576 extracellular region
1.44 1.44e-04 GO:0044459 plasma membrane part
1.30 4.86e-05 GO:0005886 plasma membrane
1.29 8.64e-05 GO:0071944 cell periphery
1.27 2.62e-06 GO:0031224 intrinsic to membrane
1.27 9.11e-06 GO:0016021 integral to membrane
1.23 1.95e-05 GO:0044425 membrane part
1.14 1.23e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
3.48 1.91e-02 GO:0005254 chloride channel activity
2.52 4.21e-02 GO:0008509 anion transmembrane transporter activity
2.04 1.73e-03 GO:0015267 channel activity
2.03 1.86e-03 GO:0022803 passive transmembrane transporter activity
1.95 1.37e-02 GO:0005216 ion channel activity
1.92 1.98e-02 GO:0022838 substrate-specific channel activity
1.55 3.39e-02 GO:0022857 transmembrane transporter activity