Motif ID: EOMES.p2

Z-value: 0.640


Transcription factors associated with EOMES.p2:

Gene SymbolEntrez IDGene Name
EOMES 8320 eomesodermin

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EOMESchr3_-_27763784-0.314.6e-01Click!


Activity profile for motif EOMES.p2.

activity profile for motif EOMES.p2


Sorted Z-values histogram for motif EOMES.p2

Sorted Z-values for motif EOMES.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EOMES.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_124125068 0.548 NM_001040214
NM_153355
NKAIN2

Na+/K+ transporting ATPase interacting 2

chr14_+_95078713 0.384 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_+_150245182 0.382 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr4_-_186732208 0.371 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr4_+_124317884 0.336 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr4_-_186732047 0.325 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr8_-_120651019 0.321 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr19_-_44831907 0.316 ZFP112
zinc finger protein 112 homolog (mouse)
chr1_+_38022514 0.310 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr6_-_46459710 0.271 NM_001251973
RCAN2
regulator of calcineurin 2
chr15_+_60296506 0.241 FOXB1
forkhead box B1
chr6_-_46293628 0.240 NM_005822
RCAN2
regulator of calcineurin 2
chr5_+_110407389 0.233 NM_033035
TSLP
thymic stromal lymphopoietin
chr8_-_146202727 0.229 ZNF252
zinc finger protein 252
chr15_+_60296420 0.228 NM_012182
FOXB1
forkhead box B1
chr4_-_57547845 0.222 NM_001145460
NM_032495
NM_139212
HOPX


HOP homeobox


chr14_+_21467413 0.214 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr8_-_72268720 0.214 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr3_-_49459870 0.209 AMT
aminomethyltransferase
chr3_-_66551341 0.205 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr9_+_34990715 0.194 DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr6_+_39760138 0.193


chr9_-_16727887 0.193 BNC2
basonuclin 2
chr17_+_38230678 0.190 THRA
thyroid hormone receptor, alpha
chr6_+_84222252 0.190 PRSS35
protease, serine, 35
chr1_-_85930610 0.185 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_-_186578122 0.182 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chrX_+_152770083 0.180 BGN
biglycan
chr1_+_215178884 0.179 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr1_-_46598250 0.174 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr11_+_73358593 0.169 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chrX_+_99899162 0.167 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chrX_+_99899388 0.167 SRPX2
sushi-repeat containing protein, X-linked 2
chr3_-_171528227 0.166 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr17_+_58755158 0.165 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr11_+_66790815 0.161 NM_177963
SYT12
synaptotagmin XII
chr17_+_25958257 0.159 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_-_44405934 0.158 LOC100505715
uncharacterized LOC100505715
chr16_+_30386097 0.155 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr14_+_105941061 0.154 NM_001312
CRIP2
cysteine-rich protein 2
chr15_-_90294359 0.154 NM_018670
MESP1
mesoderm posterior 1 homolog (mouse)
chr21_+_40823779 0.152 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr7_-_27142301 0.152 NM_006735
HOXA2
homeobox A2
chr17_+_25958245 0.151 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_-_49726081 0.150 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr16_-_28550227 0.149 NUPR1
nuclear protein, transcriptional regulator, 1
chr17_-_46871596 0.149 NM_173623
TTLL6
tubulin tyrosine ligase-like family, member 6
chr1_-_153600714 0.148 NM_005979
S100A13
S100 calcium binding protein A13
chr3_+_148447966 0.147 NM_032049
AGTR1
angiotensin II receptor, type 1
chr11_+_65192284 0.147 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chrX_+_102862833 0.144 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr5_-_95158365 0.144 GLRX
glutaredoxin (thioltransferase)
chr10_+_118305427 0.143 NM_000936
PNLIP
pancreatic lipase
chrX_-_15872905 0.143


chr15_+_65914269 0.142 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr9_-_79520878 0.141 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chrX_-_15872921 0.138 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr7_-_28220342 0.137 NM_175061
JAZF1
JAZF zinc finger 1
chr6_-_46293404 0.131 RCAN2
regulator of calcineurin 2
chrX_-_15872938 0.130 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_-_114478117 0.130 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr20_+_33146500 0.129 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr6_+_36646455 0.129 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr2_-_56151273 0.124 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr10_-_92680784 0.123 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr17_+_4046941 0.123 CYB5D2
cytochrome b5 domain containing 2
chr4_+_86396251 0.122 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr19_-_36236291 0.122 NM_001040425
NM_144987
U2AF1L4

U2 small nuclear RNA auxiliary factor 1-like 4

chr5_+_156820161 0.122 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr12_+_131438451 0.120 NM_198827
GPR133
G protein-coupled receptor 133
chr3_-_187463474 0.120 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr3_-_99833348 0.118 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr21_-_31852631 0.117 NM_181607
KRTAP19-1
keratin associated protein 19-1
chr9_-_139890984 0.116 NM_004669
CLIC3
chloride intracellular channel 3
chr18_-_56296188 0.114 NM_052947
ALPK2
alpha-kinase 2
chr17_-_39222126 0.114 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr2_-_157189040 0.112 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr5_-_95158465 0.112 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr12_+_26348488 0.111 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr6_+_84562984 0.111 NM_001009994
RIPPLY2
ripply2 homolog (zebrafish)
chr20_+_43029973 0.110 HNF4A
hepatocyte nuclear factor 4, alpha
chrX_-_15873094 0.109 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr4_+_8951476 0.107 NM_001040071
LOC650293
seven transmembrane helix receptor
chr17_-_8198124 0.107 NM_201520
SLC25A35
solute carrier family 25, member 35
chr1_+_145438437 0.106 NM_006472
TXNIP
thioredoxin interacting protein
chr19_-_46285752 0.106 NM_001081560
NM_001081562
NM_004409
DMPK


dystrophia myotonica-protein kinase


chr5_+_140749830 0.105 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr16_+_85645014 0.105 NM_001134473
KIAA0182
KIAA0182
chr4_-_186577858 0.105 SORBS2
sorbin and SH3 domain containing 2
chr17_+_180995 0.103 NM_001242780
LOC100506388
uncharacterized LOC100506388
chr7_-_50772997 0.103 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr2_-_211179765 0.103 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr14_+_75894508 0.103 NM_001135047
JDP2
Jun dimerization protein 2
chr19_+_18111923 0.102 NM_001025604
ARRDC2
arrestin domain containing 2
chr12_-_4754275 0.102 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr9_+_34652125 0.102 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr15_-_40857178 0.101 C15orf57
chromosome 15 open reading frame 57
chr13_+_102104941 0.100 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr19_-_11565612 0.099


chr10_+_70847817 0.099 NM_002727
SRGN
serglycin
chr15_-_52970808 0.099 NM_019600
FAM214A
family with sequence similarity 214, member A
chr19_+_12863406 0.098 NM_017682
BEST2
bestrophin 2
chrX_-_135749436 0.097 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr2_+_219472631 0.094 PLCD4
phospholipase C, delta 4
chr12_+_7169192 0.094


chr3_-_108672547 0.093 NM_005459
GUCA1C
guanylate cyclase activator 1C
chrX_-_107018889 0.093 TSC22D3
TSC22 domain family, member 3
chr11_+_27015627 0.092 NM_203371
FIBIN
fin bud initiation factor homolog (zebrafish)
chr15_-_83474805 0.092 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr5_-_132112887 0.092 NM_001098811
NM_001098812
NM_015146
SEPT8


septin 8


chr2_+_71295685 0.091 NAGK
N-acetylglucosamine kinase
chr2_-_74753311 0.091 NM_133637
DQX1
DEAQ box RNA-dependent ATPase 1
chr9_+_34990266 0.090 NM_001135005
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr1_-_202858225 0.089 NM_002871
RABIF
RAB interacting factor
chr17_-_61950997 0.089 NM_020991
NM_022644
NM_022645
CSH2


chorionic somatomammotropin hormone 2


chr1_+_184356364 0.089 C1orf21
chromosome 1 open reading frame 21
chr20_+_138121 0.089 NM_139074
DEFB127
defensin, beta 127
chr9_+_17134974 0.088 NM_001114395
NM_017738
CNTLN

centlein, centrosomal protein

chr3_+_38347426 0.088 NM_004803
SLC22A14
solute carrier family 22, member 14
chr20_-_5295014 0.088 NM_144773
PROKR2
prokineticin receptor 2
chr19_+_2289996 0.088


chrX_+_109662284 0.088 NM_020769
RGAG1
retrotransposon gag domain containing 1
chrX_-_62648209 0.087 LOC92249
uncharacterized LOC92249
chr21_+_27011588 0.087 NM_021219
JAM2
junctional adhesion molecule 2
chr16_+_67311412 0.086 NM_015432
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr21_+_27011766 0.086 JAM2
junctional adhesion molecule 2
chr3_+_158991035 0.086 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr2_+_27799388 0.085 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr3_-_187463227 0.084 BCL6
B-cell CLL/lymphoma 6
chr3_-_195310985 0.084 NM_001647
APOD
apolipoprotein D
chr18_+_66465316 0.084 NM_024781
CCDC102B
coiled-coil domain containing 102B
chr4_+_156824846 0.083 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chrX_+_66763868 0.083 NM_000044
AR
androgen receptor
chr21_-_31869427 0.083 NM_181610
KRTAP19-4
keratin associated protein 19-4
chr17_-_61996135 0.082 NM_000515
NM_022559
NM_022560
NM_022561
NM_022562
GH1




growth hormone 1




chr3_-_100712248 0.082 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr3_-_9920633 0.082 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr16_+_57702156 0.082 NM_170776
GPR97
G protein-coupled receptor 97
chr2_+_102770401 0.081 NM_000877
IL1R1
interleukin 1 receptor, type I
chr2_+_219472487 0.081 NM_032726
PLCD4
phospholipase C, delta 4
chr17_+_46908371 0.081 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr5_-_168271852 0.080


chrX_-_69509714 0.079 NM_016484
PDZD11
PDZ domain containing 11
chr19_-_46285746 0.079 DMPK
dystrophia myotonica-protein kinase
chr12_+_124773709 0.078 NM_181709
FAM101A
family with sequence similarity 101, member A
chr6_-_130536417 0.078 NM_152552
SAMD3
sterile alpha motif domain containing 3
chr19_-_38188344 0.078 ZNF607
zinc finger protein 607
chr17_+_25958192 0.077 LGALS9
lectin, galactoside-binding, soluble, 9
chr12_-_7818467 0.077 NM_001644
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr10_-_92681025 0.077 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_-_99766238 0.077 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr19_-_7990974 0.077 NM_206833
CTXN1
cortexin 1
chr12_+_26348268 0.077 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr3_+_16216155 0.076 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr16_+_77233348 0.075 NM_001129979
SYCE1L
synaptonemal complex central element protein 1-like
chr2_-_190044330 0.075 NM_000393
COL5A2
collagen, type V, alpha 2
chr17_+_25958151 0.075 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr5_+_140734767 0.075 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr6_+_84743250 0.074 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr7_-_150652861 0.074 NM_001204798
NM_172057
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr12_-_71551778 0.074 NM_004616
TSPAN8
tetraspanin 8
chr4_-_8073711 0.073 ABLIM2
actin binding LIM protein family, member 2
chr1_-_28969516 0.073 NM_001135218
NM_005644
TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr18_-_29340698 0.072 NM_001034172
MCART2
mitochondrial carrier triple repeat 2
chrX_-_70474402 0.072 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr19_-_14016908 0.072 NM_024323
C19orf57
chromosome 19 open reading frame 57
chr19_-_17958773 0.070 JAK3
Janus kinase 3
chr1_+_45266048 0.070 PLK3
polo-like kinase 3
chr4_-_82126200 0.070 NM_006259
PRKG2
protein kinase, cGMP-dependent, type II
chr17_+_25958217 0.069 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_16971177 0.069 CROCCP2
ciliary rootlet coiled-coil, rootletin pseudogene 2
chr15_-_52483564 0.068 NM_016194
GNB5
guanine nucleotide binding protein (G protein), beta 5
chr6_+_131894343 0.068 NM_000045
NM_001244438
ARG1

arginase, liver

chr7_-_99766191 0.067 GAL3ST4
galactose-3-O-sulfotransferase 4
chr17_-_5138049 0.067 NM_207103
SCIMP
SLP adaptor and CSK interacting membrane protein
chr2_-_178257380 0.067 LOC100130691
uncharacterized LOC100130691
chr10_+_70847857 0.067 SRGN
serglycin
chr15_-_40857229 0.067 NM_001080791
NM_001080792
NM_052849
C15orf57


chromosome 15 open reading frame 57


chr20_+_17207669 0.067 PCSK2
proprotein convertase subtilisin/kexin type 2
chr1_+_184356186 0.067 C1orf21
chromosome 1 open reading frame 21
chr1_-_76397975 0.066 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr4_-_140060601 0.066 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr19_-_14992166 0.066 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr2_+_228678556 0.066 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr12_-_71551564 0.066 TSPAN8
tetraspanin 8
chr20_+_33299315 0.065 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr4_-_90759446 0.065 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr2_-_175869910 0.065 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr20_-_50179338 0.065 NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr20_+_34680569 0.064 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_-_39092714 0.063 KRT23
keratin 23 (histone deacetylase inducible)
chr5_+_137419580 0.063 NM_058244
WNT8A
wingless-type MMTV integration site family, member 8A
chr11_+_36397534 0.062 NM_001160168
NM_024841
PRR5L

proline rich 5 like

chr1_-_161039413 0.062 ARHGAP30
Rho GTPase activating protein 30
chr6_-_152702329 0.062 SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_-_182642016 0.062 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr6_-_112041253 0.062 NM_153047
FYN
FYN oncogene related to SRC, FGR, YES
chrX_-_99987072 0.060 NM_001129896
SYTL4
synaptotagmin-like 4
chr2_-_200322699 0.060 NM_001172509
SATB2
SATB homeobox 2
chr17_-_61973870 0.060 NM_001317
CSH1
chorionic somatomammotropin hormone 1 (placental lactogen)

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.80 2.06e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor