Motif ID: EP300.p2

Z-value: 1.073


Transcription factors associated with EP300.p2:

Gene SymbolEntrez IDGene Name
EP300 2033 E1A binding protein p300

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EP300chr22_+_41487787-0.782.2e-02Click!


Activity profile for motif EP300.p2.

activity profile for motif EP300.p2


Sorted Z-values histogram for motif EP300.p2

Sorted Z-values for motif EP300.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EP300.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_54867372 0.971 NM_144594
GTSF1
gametocyte specific factor 1
chr10_-_21462987 0.577 NEBL
nebulette
chr1_-_161008733 0.526 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr6_+_89790412 0.401 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr10_-_21463019 0.377 NM_001173484
NM_213569
NEBL

nebulette

chr19_+_16296211 0.367 NM_014077
FAM32A
family with sequence similarity 32, member A
chr6_+_89790464 0.366 PNRC1
proline-rich nuclear receptor coactivator 1
chr10_+_111985628 0.354 NM_005962
MXI1
MAX interactor 1
chr5_-_149535309 0.320 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr6_+_122793061 0.308 NM_181794
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chrX_-_140271293 0.299 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr12_+_72057676 0.289 NM_031435
THAP2
THAP domain containing, apoptosis associated protein 2
chr6_-_31698033 0.277 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr2_-_99224868 0.271 NM_001008215
COA5
cytochrome C oxidase assembly factor 5
chr2_-_27294491 0.269 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr1_+_26146446 0.266 FAM54B
family with sequence similarity 54, member B
chr15_-_81616439 0.265 NM_181900
STARD5
StAR-related lipid transfer (START) domain containing 5
chr11_-_93276513 0.263 NM_020179
C11orf75
chromosome 11 open reading frame 75
chr6_+_46655611 0.261 NM_001010870
NM_001168359
TDRD6

tudor domain containing 6

chr15_-_82338348 0.260 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr3_+_169755733 0.256 NM_014373
GPR160
G protein-coupled receptor 160
chr1_+_184356186 0.255 C1orf21
chromosome 1 open reading frame 21
chr22_+_27053392 0.251 MIAT
myocardial infarction associated transcript (non-protein coding)
chr6_-_31697953 0.246 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr3_+_169755782 0.246 GPR160
G protein-coupled receptor 160
chr15_-_82338459 0.244 MEX3B
mex-3 homolog B (C. elegans)
chr16_-_67260720 0.240 NM_012163
LRRC29
leucine rich repeat containing 29
chr5_-_149535138 0.236 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_26146622 0.235 NM_019557
FAM54B
family with sequence similarity 54, member B
chr19_-_49828434 0.234 NM_014037
SLC6A16
solute carrier family 6, member 16
chr2_+_217498082 0.229 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chrX_-_140271275 0.227 LDOC1
leucine zipper, down-regulated in cancer 1
chrX_+_135229536 0.222 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr6_+_72596405 0.218 RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_47082529 0.218 NM_201403
MOB3C
MOB kinase activator 3C
chr5_+_56111379 0.212 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr19_-_1401474 0.209 NM_000156
NM_138924
GAMT

guanidinoacetate N-methyltransferase

chr1_-_23694497 0.205 NM_030634
ZNF436
zinc finger protein 436
chr9_-_98270321 0.203 NM_001083604
NM_001083605
PTCH1

patched 1

chr19_+_19627018 0.201 NM_015965
NDUFA13
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr1_+_184356227 0.200 C1orf21
chromosome 1 open reading frame 21
chr16_-_10275743 0.200 NM_001134408
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr12_+_70759974 0.199 NM_014505
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr11_+_47269850 0.198 NM_001251934
NM_001251935
NR1H3

nuclear receptor subfamily 1, group H, member 3

chr11_-_104035023 0.198 NM_025208
NM_033135
PDGFD

platelet derived growth factor D

chr11_-_104905849 0.196 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr1_+_26146376 0.195 NM_001099625
NM_001099627
FAM54B

family with sequence similarity 54, member B

chr8_+_123794043 0.194 ZHX2
zinc fingers and homeoboxes 2
chr4_-_84030995 0.192 NM_001130716
PLAC8
placenta-specific 8
chr2_+_74153987 0.191 DGUOK
deoxyguanosine kinase
chr7_+_142552547 0.191 NM_004445
EPHB6
EPH receptor B6
chr15_+_65134081 0.190 NM_001195059
NM_025201
PLEKHO2

pleckstrin homology domain containing, family O member 2

chr10_-_81205091 0.190 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr11_-_104034685 0.188 PDGFD
platelet derived growth factor D
chr5_-_81046943 0.185 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr11_+_706607 0.183 EPS8L2
EPS8-like 2
chr2_-_25016214 0.183 NM_001013663
PTRHD1
peptidyl-tRNA hydrolase domain containing 1
chr2_+_74154015 0.182 DGUOK
deoxyguanosine kinase
chr2_+_74685526 0.180 NM_012477
WBP1
WW domain binding protein 1
chr6_-_31697568 0.179 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr1_-_184006491 0.177 GLT25D2
glycosyltransferase 25 domain containing 2
chr15_+_42787850 0.177 SNAP23
synaptosomal-associated protein, 23kDa
chr10_-_105212149 0.176 NM_015916
CALHM2
calcium homeostasis modulator 2
chr10_+_120789227 0.175 NM_199461
NANOS1
nanos homolog 1 (Drosophila)
chr2_+_74153931 0.175 NM_080916
NM_080918
DGUOK

deoxyguanosine kinase

chr3_-_51996855 0.175 NM_033010
PCBP4
poly(rC) binding protein 4
chr12_-_51717941 0.174 BIN2
bridging integrator 2
chr16_+_85646923 0.174 NM_014615
KIAA0182
KIAA0182
chr1_-_46598250 0.173 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr7_-_150974179 0.173 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_-_68516311 0.173 NM_004675
DIRAS3
DIRAS family, GTP-binding RAS-like 3
chr11_-_77899640 0.172 NM_001029859
KCTD21
potassium channel tetramerisation domain containing 21
chr7_-_93633527 0.172 NM_005868
BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr11_-_130184314 0.171 ZBTB44
zinc finger and BTB domain containing 44
chr2_+_30369868 0.171 YPEL5
yippee-like 5 (Drosophila)
chr13_-_114103452 0.168 NM_199162
ADPRHL1
ADP-ribosylhydrolase like 1
chr11_-_2925174 0.168 NM_007105
SLC22A18AS
solute carrier family 22 (organic cation transporter), member 18 antisense
chr8_+_17434700 0.167 PDGFRL
platelet-derived growth factor receptor-like
chr17_-_19290471 0.167 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr16_-_2336874 0.167


chr11_-_46722160 0.166 ARHGAP1
Rho GTPase activating protein 1
chr13_+_42031525 0.164 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr17_+_78388979 0.163 ENDOV
endonuclease V
chr13_+_42031679 0.162 C13orf15
chromosome 13 open reading frame 15
chr19_-_3047632 0.162 NM_001144761
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr1_-_161008710 0.161 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr3_-_151987332 0.161 LOC401093
uncharacterized LOC401093
chr20_+_44034632 0.161 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr17_+_43238263 0.161 NM_144608
HEXIM2
hexamethylene bis-acetamide inducible 2
chr21_+_27011588 0.160 NM_021219
JAM2
junctional adhesion molecule 2
chr11_-_46722139 0.159 ARHGAP1
Rho GTPase activating protein 1
chr4_-_142054431 0.159 NM_020724
RNF150
ring finger protein 150
chr15_-_68724434 0.158 NM_001004439
ITGA11
integrin, alpha 11
chr2_+_23608297 0.158 NM_052920
KLHL29
kelch-like 29 (Drosophila)
chr13_+_42031690 0.155 C13orf15
chromosome 13 open reading frame 15
chr1_+_38022514 0.154 NM_003462
DNALI1
dynein, axonemal, light intermediate chain 1
chr11_-_120008738 0.152 TRIM29
tripartite motif containing 29
chr5_+_139028483 0.152 CXXC5
CXXC finger protein 5
chr20_-_30311693 0.151 BCL2L1
BCL2-like 1
chr22_-_29137776 0.150 NM_001005735
NM_007194
NM_145862
CHEK2


checkpoint kinase 2


chrX_-_107019001 0.148 NM_198057
TSC22D3
TSC22 domain family, member 3
chr3_-_18480203 0.147 NM_001131010
SATB1
SATB homeobox 1
chr5_-_176936857 0.146 NM_024872
DOK3
docking protein 3
chr19_+_47104389 0.146 CALM3
calmodulin 3 (phosphorylase kinase, delta)
chr2_+_24346339 0.146 NM_001145710
LOC375190
UPF0638 protein B
chr1_-_54871681 0.146 SSBP3
single stranded DNA binding protein 3
chr17_-_74582144 0.145 NM_006456
ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr3_+_12838170 0.145 NM_001162499
NM_012298
CAND2

cullin-associated and neddylation-dissociated 2 (putative)

chr17_+_73043319 0.144 KCTD2
potassium channel tetramerisation domain containing 2
chr17_+_38230678 0.143 THRA
thyroid hormone receptor, alpha
chr19_+_18530423 0.143


chr19_-_49149252 0.143 NM_001217
CA11
carbonic anhydrase XI
chr5_-_176936834 0.143 DOK3
docking protein 3
chrX_+_135251454 0.142 NM_001159704
FHL1
four and a half LIM domains 1
chr17_+_78388944 0.142 NM_001164637
NM_001164638
NM_173627
ENDOV


endonuclease V


chr15_-_90437171 0.142 AP3S2
adaptor-related protein complex 3, sigma 2 subunit
chr18_-_74207145 0.141 NM_014643
ZNF516
zinc finger protein 516
chr19_-_17516383 0.141 NM_004335
BST2
bone marrow stromal cell antigen 2
chr2_-_229046313 0.140 NM_001142644
NM_030623
SPHKAP

SPHK1 interactor, AKAP domain containing

chr11_-_120008219 0.140 TRIM29
tripartite motif containing 29
chr21_+_27011766 0.140 JAM2
junctional adhesion molecule 2
chr22_+_42475732 0.138 C22orf32
chromosome 22 open reading frame 32
chr1_-_161102367 0.137 DEDD
death effector domain containing
chr11_-_119999516 0.137 TRIM29
tripartite motif containing 29
chr12_-_48744553 0.136 NM_001172681
NM_152320
ZNF641

zinc finger protein 641

chr19_+_9473695 0.136 NM_003451
ZNF177
zinc finger protein 177
chr9_+_130186652 0.135 NM_007135
ZNF79
zinc finger protein 79
chr2_+_233415300 0.135 NM_004846
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chrX_-_107018889 0.135 TSC22D3
TSC22 domain family, member 3
chr3_-_178789535 0.134 ZMAT3
zinc finger, matrin-type 3
chr20_+_44035203 0.133 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr2_+_71295685 0.133 NAGK
N-acetylglucosamine kinase
chr18_+_66382490 0.132 NM_001093729
CCDC102B
coiled-coil domain containing 102B
chr16_-_31085503 0.132 NM_024706
ZNF668
zinc finger protein 668
chr21_-_38639625 0.132 NM_006052
DSCR3
Down syndrome critical region gene 3
chr15_+_74218786 0.131 NM_005576
LOXL1
lysyl oxidase-like 1
chr21_-_45759234 0.130 C21orf2
chromosome 21 open reading frame 2
chr6_-_111136330 0.130 CDK19
cyclin-dependent kinase 19
chr8_+_123793894 0.130 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr2_+_39892637 0.129 NM_001167959
TMEM178
transmembrane protein 178
chr10_-_45496259 0.128 NM_001039380
C10orf25
chromosome 10 open reading frame 25
chr11_-_120008801 0.127 TRIM29
tripartite motif containing 29
chr15_+_74218794 0.127 LOXL1
lysyl oxidase-like 1
chr12_+_7942025 0.127 NANOG
Nanog homeobox
chr21_-_38639593 0.127 DSCR3
Down syndrome critical region gene 3
chr1_+_6086072 0.127 NM_003636
NM_172130
KCNAB2

potassium voltage-gated channel, shaker-related subfamily, beta member 2

chr11_+_64001974 0.127 NM_001243733
NM_003377
VEGFB

vascular endothelial growth factor B

chr2_+_217498205 0.126 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr4_-_156874993 0.126 NM_001334
CTSO
cathepsin O
chr22_+_42475661 0.126 NM_033318
C22orf32
chromosome 22 open reading frame 32
chr20_+_34680569 0.126 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr5_+_119799898 0.125 PRR16
proline rich 16
chr9_-_130667571 0.124 LOC100131355
ST6GALNAC6
uncharacterized LOC100131355
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr1_-_161102457 0.124 NM_001039711
NM_032998
DEDD

death effector domain containing

chr19_-_54984341 0.124 NM_145057
CDC42EP5
CDC42 effector protein (Rho GTPase binding) 5
chr11_-_34535302 0.123 NM_001243080
NM_001422
ELF5

E74-like factor 5 (ets domain transcription factor)

chr19_-_1605462 0.123 UQCR11
ubiquinol-cytochrome c reductase, complex III subunit XI
chr6_-_40555111 0.122 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr8_-_91657898 0.122 NM_001008495
NM_001146273
TMEM64

transmembrane protein 64

chr10_-_64578926 0.122 NM_001136178
EGR2
early growth response 2
chr11_-_67205151 0.121 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr19_+_11039419 0.121 NM_138358
C19orf52
chromosome 19 open reading frame 52
chr9_-_115774471 0.120 NM_001101338
ZNF883
zinc finger protein 883
chr8_+_145159304 0.120 NM_032272
MAF1
MAF1 homolog (S. cerevisiae)
chr1_+_236558715 0.119 NM_080738
EDARADD
EDAR-associated death domain
chrX_+_70315637 0.119 NM_001170931
NM_005938
FOXO4

forkhead box O4

chr10_-_127511795 0.119 UROS
uroporphyrinogen III synthase
chr17_-_74581881 0.119 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr15_+_74218811 0.119 LOXL1
lysyl oxidase-like 1
chr7_+_128864740 0.119 NM_001130720
NM_015328
AHCYL2

adenosylhomocysteinase-like 2

chr22_+_24577417 0.119 SUSD2
sushi domain containing 2
chr10_+_81892497 0.119 PLAC9
placenta-specific 9
chr8_+_356807 0.119 NM_012173
NM_183420
NM_183421
FBXO25


F-box protein 25


chr1_+_221052735 0.118 NM_021958
HLX
H2.0-like homeobox
chr5_-_149535420 0.118 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_3541587 0.118 TPRG1L
tumor protein p63 regulated 1-like
chr17_+_7342688 0.118 NM_004112
FGF11
fibroblast growth factor 11
chr20_+_62688438 0.118 NM_198723
TCEA2
transcription elongation factor A (SII), 2
chr11_+_67250595 0.118 AIP
aryl hydrocarbon receptor interacting protein
chr15_-_93616358 0.118 NM_001166286
RGMA
RGM domain family, member A
chr7_-_45128492 0.118 NM_001146334
NACAD
NAC alpha domain containing
chr12_-_63328663 0.115 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr12_-_92539614 0.115 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr22_-_19435211 0.115 C22orf39
HIRA
chromosome 22 open reading frame 39
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr1_+_111415721 0.114 NM_000560
CD53
CD53 molecule
chr11_-_63933493 0.114 NM_014067
MACROD1
MACRO domain containing 1
chr11_+_134094565 0.114 VPS26B
vacuolar protein sorting 26 homolog B (S. pombe)
chr15_-_93616308 0.114 RGMA
RGM domain family, member A
chr3_+_134514300 0.113 EPHB1
EPH receptor B1
chr1_-_173886401 0.113 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr9_+_130186714 0.113 ZNF79
zinc finger protein 79
chr11_+_2924504 0.113 SLC22A18
solute carrier family 22, member 18
chr15_+_74287132 0.112 PML
promyelocytic leukemia
chr16_-_66952729 0.112 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr8_+_145159398 0.112 MAF1
MAF1 homolog (S. cerevisiae)
chr7_+_130126035 0.111 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr5_+_119800004 0.111 NM_016644
PRR16
proline rich 16
chr1_-_161102210 0.111 NM_001039712
DEDD
death effector domain containing
chr3_+_52279742 0.111 NM_144641
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr14_-_68141205 0.110 VTI1B
vesicle transport through interaction with t-SNAREs homolog 1B (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 9.45e-05 GO:0050794 regulation of cellular process
1.11 1.43e-03 GO:0050789 regulation of biological process
1.38 1.96e-03 GO:0032774 RNA biosynthetic process
1.10 5.82e-03 GO:0065007 biological regulation
1.98 9.56e-03 GO:0006184 GTP catabolic process
1.94 1.07e-02 GO:0046039 GTP metabolic process
1.57 1.22e-02 GO:0007264 small GTPase mediated signal transduction
1.06 1.84e-02 GO:0009987 cellular process
1.71 3.52e-02 GO:0030168 platelet activation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 5.71e-12 GO:0005622 intracellular
1.10 3.49e-11 GO:0044424 intracellular part
1.12 4.41e-08 GO:0005737 cytoplasm
1.31 2.16e-07 GO:0005829 cytosol
1.15 1.74e-05 GO:0005634 nucleus
3.83 3.69e-03 GO:0031201 SNARE complex
1.07 1.08e-02 GO:0043229 intracellular organelle
1.07 1.22e-02 GO:0043226 organelle
1.10 3.92e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 7.32e-07 GO:0005515 protein binding
1.07 1.11e-04 GO:0005488 binding
1.31 2.03e-02 GO:0001071 nucleic acid binding transcription factor activity
1.31 2.03e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.20 3.80e-02 GO:0008270 zinc ion binding