Motif ID: ESR1.p2

Z-value: 0.604


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_152128453-0.911.7e-03Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_33010174 0.669 NM_001191322
NM_001191323
NM_013372
 GREM1


gremlin 1


chr17_-_43045612 0.594 NM_006688
 C1QL1
complement component 1, q subcomponent-like 1
chr11_-_63381840 0.473 PLA2G16
phospholipase A2, group XVI
chr11_-_63381485 0.471 PLA2G16
phospholipase A2, group XVI
chr11_-_63381940 0.463 NM_001128203
 PLA2G16
phospholipase A2, group XVI
chr11_-_63381907 0.462 NM_007069
 PLA2G16
phospholipase A2, group XVI
chr17_-_48264039 0.445 COL1A1
collagen, type I, alpha 1
chr13_+_76210449 0.438 LMO7
LIM domain 7
chr1_+_215256559 0.414 NM_001017425
NM_014217
 KCNK2

potassium channel, subfamily K, member 2

chr9_+_90112419 0.406 DAPK1
death-associated protein kinase 1
chr9_+_90112754 0.406 NM_004938
 DAPK1
death-associated protein kinase 1
chr17_-_19290471 0.396 NM_001198695
NM_002404
 MFAP4

microfibrillar-associated protein 4

chr16_+_55515468 0.394 NM_001127891
 MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_-_124457099 0.373 NM_025140
 CCDC92
coiled-coil domain containing 92
chr3_+_154797435 0.370 NM_000902
 MME
membrane metallo-endopeptidase
chr2_-_175869910 0.364 NM_001822
NM_001025201
 CHN1

chimerin (chimaerin) 1

chr1_+_77748286 0.315 NM_012093
 AK5
adenylate kinase 5
chr9_-_89562103 0.309 NM_002048
 GAS1
growth arrest-specific 1
chr8_+_16884745 0.305 NM_181723
 EFHA2
EF-hand domain family, member A2
chr7_+_44143945 0.295 NM_001129
 AEBP1
AE binding protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
1.99 4.08e-02 GO:0071375 cellular response to peptide hormone stimulus
1.95 3.78e-02 GO:0030036 actin cytoskeleton organization
1.91 4.20e-03 GO:0071495 cellular response to endogenous stimulus
1.90 1.03e-02 GO:0032870 cellular response to hormone stimulus
1.88 6.40e-03 GO:0043434 response to peptide hormone stimulus
1.87 3.87e-02 GO:0030029 actin filament-based process
1.45 4.08e-02 GO:0032879 regulation of localization
1.29 4.64e-02 GO:0048523 negative regulation of cellular process
1.13 3.44e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
1.84 6.57e-03 GO:0015629 actin cytoskeleton
1.27 1.65e-02 GO:0005829 cytosol
1.17 4.22e-08 GO:0005737 cytoplasm
1.15 5.82e-03 GO:0044444 cytoplasmic part
1.12 1.16e-10 GO:0005622 intracellular
1.12 1.79e-08 GO:0044424 intracellular part
1.10 1.85e-02 GO:0043231 intracellular membrane-bounded organelle
1.10 2.24e-02 GO:0043227 membrane-bounded organelle
1.09 1.25e-02 GO:0043229 intracellular organelle
1.09 1.41e-02 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
3.03 4.90e-02 GO:0005097 Rab GTPase activator activity
1.18 2.48e-07 GO:0005515 protein binding
1.11 1.91e-08 GO:0005488 binding