Motif ID: ESRRA.p2

Z-value: 0.876


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_640730400.696.0e-02Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_35629727 0.747 NM_021902
 FXYD1
FXYD domain containing ion transport regulator 1
chr20_+_58179601 0.721 NM_080672
 PHACTR3
phosphatase and actin regulator 3
chr15_-_81616439 0.636 NM_181900
 STARD5
StAR-related lipid transfer (START) domain containing 5
chr15_-_83621350 0.596 NM_004839
NM_199330
 HOMER2

homer homolog 2 (Drosophila)

chr15_+_43885251 0.555 NM_020990
 CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr16_-_4588379 0.504 NM_001199054
 C16orf5
chromosome 16 open reading frame 5
chr15_+_43985083 0.478 NM_001015001
 CKMT1A
creatine kinase, mitochondrial 1A
chr3_-_121379701 0.469 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_29213619 0.466 EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr6_-_34360310 0.441 NUDT3
nudix (nucleoside diphosphate linked moiety X)-type motif 3
chr15_+_59730272 0.422 NM_152450
 FAM81A
family with sequence similarity 81, member A
chr14_-_103989112 0.410 CKB
creatine kinase, brain
chr6_-_43027114 0.406 NM_015950
 MRPL2
mitochondrial ribosomal protein L2
chr1_-_173886401 0.390 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_+_29213569 0.388 NM_001166005
NM_001166007
NM_004437
NM_203342
NM_203343
 EPB41




erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)




chr11_+_47270433 0.385 NM_001130102
 NR1H3
nuclear receptor subfamily 1, group H, member 3
chr6_+_89790412 0.383 NM_006813
 PNRC1
proline-rich nuclear receptor coactivator 1
chr16_+_691827 0.383 NM_138418
 FAM195A
family with sequence similarity 195, member A
chr11_-_63933204 0.378 MACROD1
MACRO domain containing 1
chr8_-_127570710 0.373 NM_174911
 FAM84B
family with sequence similarity 84, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
19.32 1.37e-02 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
8.20 5.78e-07 GO:0009060 aerobic respiration
7.52 3.63e-02 GO:0015985 energy coupled proton transport, down electrochemical gradient
7.52 3.63e-02 GO:0015986 ATP synthesis coupled proton transport
7.03 4.91e-07 GO:0042773 ATP synthesis coupled electron transport
7.03 4.91e-07 GO:0042775 mitochondrial ATP synthesis coupled electron transport
6.96 4.81e-03 GO:0046356 acetyl-CoA catabolic process
6.93 2.36e-16 GO:0022904 respiratory electron transport chain
6.70 3.20e-07 GO:0006119 oxidative phosphorylation
6.44 3.40e-02 GO:0006099 tricarboxylic acid cycle
6.02 1.17e-16 GO:0045333 cellular respiration
6.00 1.96e-02 GO:0009109 coenzyme catabolic process
5.90 2.40e-03 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
4.98 1.63e-11 GO:0022900 electron transport chain
4.02 3.21e-03 GO:0006839 mitochondrial transport
3.77 5.40e-13 GO:0015980 energy derivation by oxidation of organic compounds
3.19 2.28e-12 GO:0006091 generation of precursor metabolites and energy
2.65 3.78e-02 GO:0006732 coenzyme metabolic process
2.56 4.32e-02 GO:0006979 response to oxidative stress
2.20 1.09e-09 GO:0055114 oxidation-reduction process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
19.32 2.53e-03 GO:0005749 mitochondrial respiratory chain complex II
19.32 2.53e-03 GO:0045257 succinate dehydrogenase complex (ubiquinone)
19.32 2.53e-03 GO:0045273 respiratory chain complex II
19.32 2.53e-03 GO:0045281 succinate dehydrogenase complex
19.32 2.53e-03 GO:0045283 fumarate reductase complex
10.54 2.49e-03 GO:0005744 mitochondrial inner membrane presequence translocase complex
7.96 4.28e-03 GO:0005753 mitochondrial proton-transporting ATP synthase complex
7.12 1.01e-02 GO:0045259 proton-transporting ATP synthase complex
7.03 2.97e-12 GO:0070469 respiratory chain
6.97 4.77e-11 GO:0005746 mitochondrial respiratory chain
6.12 1.13e-17 GO:0044455 mitochondrial membrane part
5.95 1.33e-04 GO:0005747 mitochondrial respiratory chain complex I
5.95 1.33e-04 GO:0030964 NADH dehydrogenase complex
5.95 1.33e-04 GO:0045271 respiratory chain complex I
4.35 1.67e-22 GO:0005743 mitochondrial inner membrane
3.98 3.05e-20 GO:0019866 organelle inner membrane
3.63 2.20e-21 GO:0031966 mitochondrial membrane
3.56 2.10e-21 GO:0005740 mitochondrial envelope
3.13 4.32e-23 GO:0044429 mitochondrial part
2.60 1.64e-14 GO:0031967 organelle envelope

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
19.32 3.98e-03 GO:0000104 succinate dehydrogenase activity
15.46 1.91e-02 GO:0008048 calcium sensitive guanylate cyclase activator activity
5.75 9.43e-04 GO:0003954 NADH dehydrogenase activity
5.75 9.43e-04 GO:0008137 NADH dehydrogenase (ubiquinone) activity
5.75 9.43e-04 GO:0050136 NADH dehydrogenase (quinone) activity
5.39 6.77e-04 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
3.82 1.88e-03 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
3.59 1.21e-03 GO:0015078 hydrogen ion transmembrane transporter activity
2.62 1.33e-02 GO:0009055 electron carrier activity
2.05 3.86e-06 GO:0016491 oxidoreductase activity
1.24 2.10e-03 GO:0003824 catalytic activity
1.16 4.73e-02 GO:0005515 protein binding