Motif ID: ETS1,2.p2

Z-value: 1.750


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ETS1chr11_-_128391888-0.462.5e-01Click!
ETS2chr21_+_401778470.108.1e-01Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_15939949 3.300 FGFBP1
fibroblast growth factor binding protein 1
chr4_-_15940362 2.609 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr10_-_105845619 2.438 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr13_-_20805371 2.372 NM_006783
GJB6
gap junction protein, beta 6, 30kDa
chr10_-_105845556 2.084 COL17A1
collagen, type XVII, alpha 1
chr10_-_88717319 1.876 NM_024756
MMRN2
multimerin 2
chr14_-_94856926 1.485 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr2_-_46384 1.434 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr15_+_41136622 1.322 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr8_+_56792392 1.316 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr2_-_113542970 1.302 NM_000575
IL1A
interleukin 1, alpha
chr22_+_45098091 1.302 NM_181334
PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr8_+_56792345 1.268 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr15_+_43885251 1.205 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_-_201368716 1.157 LAD1
ladinin 1
chr16_+_57653909 1.156 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr11_+_1861431 1.148 NM_001145841
TNNI2
troponin I type 2 (skeletal, fast)
chr2_-_70781146 1.114 NM_001099691
NM_003236
TGFA

transforming growth factor, alpha

chr7_-_143105897 1.089 NM_005232
EPHA1
EPH receptor A1
chr8_+_56792399 1.080 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr17_+_48610077 1.074 EPN3
epsin 3
chr16_+_30194925 1.055 CORO1A
coronin, actin binding protein, 1A
chr10_+_71390002 1.034 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr18_+_61420276 1.033 NM_001040147
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr4_-_10023094 1.021 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr1_-_183559463 1.012 NCF2
neutrophil cytosolic factor 2
chr14_-_61747956 1.006 TMEM30B
transmembrane protein 30B
chr1_-_183559669 0.986 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr17_+_73553883 0.983 LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr3_-_151034514 0.983 NM_023915
GPR87
G protein-coupled receptor 87
chr1_-_201368617 0.971 NM_005558
LAD1
ladinin 1
chr2_+_69001932 0.959 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr19_+_35739778 0.942 LSR
lipolysis stimulated lipoprotein receptor
chr12_+_107712151 0.926 NM_001018072
BTBD11
BTB (POZ) domain containing 11
chr19_+_49838734 0.915 CD37
CD37 molecule
chr1_-_201368434 0.913 LAD1
ladinin 1
chr13_-_46756295 0.908 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_113931549 0.901 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chr12_-_52914080 0.900 NM_000424
KRT5
keratin 5
chr2_+_68961912 0.897 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr1_+_155100304 0.878 NM_004428
NM_182685
EFNA1

ephrin-A1

chr11_-_118123001 0.875 NM_198275
MPZL3
myelin protein zero-like 3
chr1_-_183560010 0.863 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr1_+_95286099 0.846 NM_152369
SLC44A3
solute carrier family 44, member 3
chr6_+_28048481 0.843 NM_003447
ZNF165
zinc finger protein 165
chr6_-_2840683 0.843 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr21_+_18885296 0.842 CXADR
coxsackie virus and adenovirus receptor
chr14_-_24036532 0.835 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr12_-_6740814 0.832 NM_001142961
LPAR5
lysophosphatidic acid receptor 5
chr1_+_95286193 0.831 SLC44A3
solute carrier family 44, member 3
chr20_+_58630965 0.827 NM_173644
C20orf197
chromosome 20 open reading frame 197
chr1_-_38273846 0.826 YRDC
yrdC domain containing (E. coli)
chr19_+_49838646 0.821 CD37
CD37 molecule
chr7_+_18548899 0.817 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr1_-_38273852 0.817 NM_024640
YRDC
yrdC domain containing (E. coli)
chr2_+_113931565 0.813 PSD4
pleckstrin and Sec7 domain containing 4
chr11_+_66824285 0.804 NM_014578
RHOD
ras homolog gene family, member D
chr19_+_49838673 0.800 NM_001040031
NM_001774
CD37

CD37 molecule

chr5_+_36608430 0.786 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr21_+_18885104 0.781 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr11_+_124933007 0.778 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr11_+_117947726 0.775 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr2_+_102608305 0.775 NM_004633
IL1R2
interleukin 1 receptor, type II
chr1_+_153330329 0.774 NM_002965
S100A9
S100 calcium binding protein A9
chr14_-_67878859 0.771 PLEK2
pleckstrin 2
chr11_-_112034671 0.767 NM_001243211
NM_001562
IL18

interleukin 18 (interferon-gamma-inducing factor)

chr15_+_74833517 0.764 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr10_+_49892860 0.762 WDFY4
WDFY family member 4
chr1_-_38273823 0.757 YRDC
yrdC domain containing (E. coli)
chr18_+_47088400 0.756 NM_006033
LIPG
lipase, endothelial
chr11_+_66824308 0.753 RHOD
ras homolog gene family, member D
chr19_+_35739838 0.750 LSR
lipolysis stimulated lipoprotein receptor
chr13_-_46756291 0.749 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_-_40594663 0.749 MED14
mediator complex subunit 14
chr1_+_3388170 0.740 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr2_-_70780621 0.740 TGFA
transforming growth factor, alpha
chr9_+_93589704 0.739 NM_001174167
SYK
spleen tyrosine kinase
chr7_+_26331493 0.733 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr6_+_41606193 0.732 NM_005586
MDFI
MyoD family inhibitor
chr19_+_49838700 0.715 CD37
CD37 molecule
chr3_-_139258477 0.713 RBP1
retinol binding protein 1, cellular
chr1_+_26872306 0.712 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_238499713 0.709 NM_022449
RAB17
RAB17, member RAS oncogene family
chr6_-_47009992 0.700 NM_025048
NM_153840
GPR110

G protein-coupled receptor 110

chr1_+_95285900 0.696 NM_001114106
SLC44A3
solute carrier family 44, member 3
chrX_+_65235279 0.695


chr2_+_102953716 0.692 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr10_-_131762017 0.691 NM_001005463
EBF3
early B-cell factor 3
chr12_+_107974633 0.684 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr4_-_84255999 0.684 HPSE
heparanase
chr2_+_182321618 0.681 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_-_291335 0.677 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr16_+_22825806 0.676 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr1_-_38273683 0.675 YRDC
yrdC domain containing (E. coli)
chr14_-_67878770 0.673 NM_016445
PLEK2
pleckstrin 2
chr20_+_58179601 0.673 NM_080672
PHACTR3
phosphatase and actin regulator 3
chrX_+_105937067 0.673 NM_024539
RNF128
ring finger protein 128
chrX_-_40594774 0.665 NM_004229
MED14
mediator complex subunit 14
chr3_-_57113292 0.664 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr8_-_134309448 0.660 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr7_+_86274076 0.660 GRM3
glutamate receptor, metabotropic 3
chr13_-_46756326 0.659 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_41130921 0.657 NM_018965
TREM2
triggering receptor expressed on myeloid cells 2
chr1_-_27286875 0.648 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr3_-_124842442 0.644 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr11_+_63753827 0.640 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr16_+_66968390 0.639 CES2
carboxylesterase 2
chr17_+_9548853 0.635 NM_153210
USP43
ubiquitin specific peptidase 43
chr15_+_41136178 0.634 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_57888785 0.631 DAB1
disabled homolog 1 (Drosophila)
chr15_+_43985083 0.626 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr1_+_16083132 0.618 FBLIM1
filamin binding LIM protein 1
chr2_+_182321933 0.618 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr17_-_7166263 0.617 NM_001185023
NM_001307
CLDN7

claudin 7

chr1_+_26872342 0.616 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_52886971 0.616 NM_005554
KRT6A
keratin 6A
chrX_-_40594949 0.613 MED14
mediator complex subunit 14
chr3_-_139258373 0.609 RBP1
retinol binding protein 1, cellular
chr8_-_10587942 0.609 NM_031439
SOX7
SRY (sex determining region Y)-box 7
chr7_+_150148078 0.608 GIMAP8
GTPase, IMAP family member 8
chr3_-_189838673 0.607 LEPREL1
leprecan-like 1
chr6_-_41130864 0.605 TREM2
triggering receptor expressed on myeloid cells 2
chr4_-_84256012 0.601 NM_001098540
HPSE
heparanase
chr11_-_5462782 0.601 NM_001005288
OR51I1
olfactory receptor, family 51, subfamily I, member 1
chr11_+_8703994 0.598 NM_000990
RPL27A
ribosomal protein L27a
chr17_-_7165788 0.597 CLDN7
claudin 7
chr19_-_19738973 0.593 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr14_+_67999915 0.590 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr2_-_75788079 0.587 NM_001135032
FAM176A
family with sequence similarity 176, member A
chr1_+_116519118 0.586 NM_018420
SLC22A15
solute carrier family 22, member 15
chr2_-_75788027 0.584 FAM176A
family with sequence similarity 176, member A
chr19_-_291168 0.580 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr17_-_39942937 0.579 NM_002230
NM_021991
JUP

junction plakoglobin

chr13_-_52980628 0.576 NM_018676
NM_199263
THSD1

thrombospondin, type I, domain containing 1

chrX_+_105969875 0.576 NM_194463
RNF128
ring finger protein 128
chr15_+_90744506 0.574 NM_198925
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr5_+_140345746 0.573 NM_018899
PCDHAC2
protocadherin alpha subfamily C, 2
chr1_+_118472364 0.573 NM_006784
WDR3
WD repeat domain 3
chr1_+_62208091 0.569 NM_176877
INADL
InaD-like (Drosophila)
chr11_+_44785975 0.569 NM_130783
TSPAN18
tetraspanin 18
chr16_+_19422056 0.568 NM_001105248
NM_001105249
TMC5

transmembrane channel-like 5

chr19_+_38755422 0.565 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr1_+_15479298 0.565 TMEM51
transmembrane protein 51
chr8_+_82644663 0.561 NM_152284
CHMP4C
charged multivesicular body protein 4C
chr6_-_41130820 0.560 TREM2
triggering receptor expressed on myeloid cells 2
chr12_-_50616425 0.559 NM_001113547
LIMA1
LIM domain and actin binding 1
chr1_+_186798031 0.558 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr5_+_35856990 0.557 NM_002185
IL7R
interleukin 7 receptor
chr4_-_84256304 0.551 NM_001166498
NM_006665
HPSE

heparanase

chr11_+_34642587 0.547 NM_001206615
NM_012153
EHF

ets homologous factor

chr10_+_129705299 0.540 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr12_+_8975149 0.540 NM_144670
A2ML1
alpha-2-macroglobulin-like 1
chr6_+_111580568 0.539 KIAA1919
KIAA1919
chr8_-_144810691 0.537 FAM83H
family with sequence similarity 83, member H
chr11_+_10471867 0.536 NM_001172431
AMPD3
adenosine monophosphate deaminase 3
chr2_-_96811138 0.535 NM_004418
DUSP2
dual specificity phosphatase 2
chr1_-_117210301 0.535 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr17_-_10741398 0.531 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr19_+_17905907 0.529 NM_014256
B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr11_-_67771527 0.524 NM_030930
UNC93B1
unc-93 homolog B1 (C. elegans)
chr11_-_119999516 0.520 TRIM29
tripartite motif containing 29
chr2_-_110874142 0.516 NM_005434
MALL
mal, T-cell differentiation protein-like
chr8_+_82192717 0.515 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr19_+_42387307 0.515 ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr1_+_82266081 0.512 NM_012302
LPHN2
latrophilin 2
chr11_+_394238 0.511 PKP3
plakophilin 3
chr1_+_111415721 0.509 NM_000560
CD53
CD53 molecule
chr16_+_29674282 0.509 NM_001030288
SPN
sialophorin
chr1_+_35246789 0.509 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr19_-_5851420 0.506 NM_000149
NM_001097639
NM_001097640
NM_001097641
FUT3



fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)



chr6_+_111580481 0.505 NM_153369
KIAA1919
KIAA1919
chr10_+_49893514 0.503 NM_020945
WDFY4
WDFY family member 4
chr1_-_28520379 0.503 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr7_+_86273867 0.502 GRM3
glutamate receptor, metabotropic 3
chr12_-_123201319 0.501 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr10_+_129845806 0.499 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr11_+_34654010 0.498 NM_001206616
EHF
ets homologous factor
chr6_-_33267128 0.496 NM_001243738
NM_004761
RGL2

ral guanine nucleotide dissociation stimulator-like 2

chr19_+_17905935 0.492 B3GNT3
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
chr16_+_4845265 0.491 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr22_+_40390935 0.490 NM_138435
FAM83F
family with sequence similarity 83, member F
chr4_+_77356252 0.490 NM_020859
SHROOM3
shroom family member 3
chr19_+_45281125 0.487 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr14_+_21510384 0.487 NM_032572
RNASE7
ribonuclease, RNase A family, 7
chr12_-_6745087 0.484 NM_020400
LPAR5
lysophosphatidic acid receptor 5
chr21_+_43636186 0.482 NM_207629
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr9_-_104249333 0.481 NM_032342
C9orf125
chromosome 9 open reading frame 125
chr19_+_42387249 0.477 NM_004706
NM_198977
ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1

chr3_-_139258531 0.477 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr7_+_86273951 0.475 GRM3
glutamate receptor, metabotropic 3
chr17_-_76124791 0.474 NM_001127198
TMC6
transmembrane channel-like 6
chr10_-_118680978 0.473 KIAA1598
KIAA1598
chr11_+_10472223 0.472 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr1_-_156786500 0.471 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr1_-_147232684 0.468 NM_181703
GJA5
gap junction protein, alpha 5, 40kDa
chr12_+_56732658 0.465 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr11_+_394199 0.465 NM_007183
PKP3
plakophilin 3
chr6_-_138428477 0.464 NM_022121
PERP
PERP, TP53 apoptosis effector
chr8_+_22437983 0.464 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr7_-_36429695 0.462 NM_001100425
KIAA0895
KIAA0895

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 5.02e-06 GO:0009987 cellular process
1.19 1.86e-05 GO:0044260 cellular macromolecule metabolic process
1.17 6.48e-05 GO:0043170 macromolecule metabolic process
1.36 3.28e-04 GO:0002376 immune system process
1.58 5.23e-04 GO:0001775 cell activation
1.44 2.16e-03 GO:0006955 immune response
1.57 3.73e-03 GO:0002684 positive regulation of immune system process
1.87 7.38e-03 GO:0002696 positive regulation of leukocyte activation
1.89 9.07e-03 GO:0051251 positive regulation of lymphocyte activation
1.84 1.30e-02 GO:0050867 positive regulation of cell activation
1.20 2.65e-02 GO:0044267 cellular protein metabolic process
2.12 4.14e-02 GO:0030098 lymphocyte differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 1.22e-03 GO:0044422 organelle part
1.13 1.28e-03 GO:0044446 intracellular organelle part
1.40 1.53e-03 GO:0044432 endoplasmic reticulum part
1.09 2.16e-03 GO:0005737 cytoplasm
1.41 3.08e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.41 3.19e-03 GO:0005789 endoplasmic reticulum membrane
1.21 1.11e-02 GO:0031090 organelle membrane
1.06 1.16e-02 GO:0044424 intracellular part
1.24 1.59e-02 GO:0012505 endomembrane system
1.05 2.28e-02 GO:0005622 intracellular
1.28 2.35e-02 GO:0005783 endoplasmic reticulum
1.44 2.90e-02 GO:0000139 Golgi membrane
1.38 3.68e-02 GO:0044431 Golgi apparatus part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 5.56e-06 GO:0005515 protein binding
1.73 4.93e-02 GO:0016758 transferase activity, transferring hexosyl groups