Motif ID: FOSL2.p2

Z-value: 0.681


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSL2chr2_+_28616360-0.658.1e-02Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_21452981 3.678 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr19_-_44174497 1.488 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr17_-_39768939 1.427 NM_005557
KRT16
keratin 16
chr20_+_44637539 1.308 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr19_-_36004553 1.251 NM_001126056
NM_001126057
NM_001126058
NM_001190347
NM_001190348
NM_001190349
NM_033317
DMKN






dermokine






chr11_-_102668822 1.240 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr19_-_35992798 1.228 NM_001035516
DMKN
dermokine
chr11_-_102668892 1.207 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr7_+_73245192 1.154 NM_001305
CLDN4
claudin 4
chr7_+_26331611 1.108 SNX10
sorting nexin 10
chr1_-_209824641 1.104 NM_001017402
LAMB3
laminin, beta 3
chr19_-_51523272 1.103 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr18_+_61442611 1.103 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr16_+_57662301 1.068 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_+_41136178 1.008 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_+_152956563 1.003 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr19_-_44174271 0.927 PLAUR
plasminogen activator, urokinase receptor
chr15_+_41136622 0.906 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr4_+_84457390 0.876 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr1_+_32043745 0.856 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr15_+_40532034 0.843 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_86889768 0.811 NM_006536
CLCA2
chloride channel accessory 2
chr15_+_40531236 0.802 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_10476665 0.790 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr10_-_88730928 0.766 LOC100133190
uncharacterized LOC100133190
chr10_+_118187381 0.766 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr14_-_94854910 0.744 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_-_39538635 0.722 NM_021013
KRT34
keratin 34
chr10_-_129691202 0.721 NM_152311
CLRN3
clarin 3
chr8_+_82644663 0.706 NM_152284
CHMP4C
charged multivesicular body protein 4C
chr6_+_47624222 0.681 NM_153839
GPR111
G protein-coupled receptor 111
chr19_+_35739838 0.637 LSR
lipolysis stimulated lipoprotein receptor
chr5_+_145317297 0.631 SH3RF2
SH3 domain containing ring finger 2
chr11_+_12308446 0.623 NM_032867
MICALCL
MICAL C-terminal like
chr19_-_51472816 0.622 NM_002774
KLK6
kallikrein-related peptidase 6
chr11_+_394199 0.612 NM_007183
PKP3
plakophilin 3
chr4_+_84457256 0.610 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr14_-_94855120 0.605 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr7_+_26331493 0.602 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr2_+_68961912 0.577 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr6_-_136847078 0.572 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr3_-_12800739 0.571 NM_018306
TMEM40
transmembrane protein 40
chr12_-_53343607 0.563 KRT8
keratin 8
chr1_+_35246789 0.543 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr14_-_94849552 0.537 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_+_78225068 0.537 NM_014903
NAV3
neuron navigator 3
chr2_+_220492286 0.536 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr13_-_86373328 0.536 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr11_+_117947726 0.524 NM_001083947
NM_001173551
NM_001173552
NM_019894
TMPRSS4



transmembrane protease, serine 4



chr3_-_151034514 0.521 NM_023915
GPR87
G protein-coupled receptor 87
chr11_+_117947785 0.504 TMPRSS4
transmembrane protease, serine 4
chrX_-_15683153 0.499 NM_020665
TMEM27
transmembrane protein 27
chr11_-_115088628 0.495 CADM1
cell adhesion molecule 1
chr17_-_7166505 0.495 NM_001185022
CLDN7
claudin 7
chr8_-_41166931 0.494 NM_003012
SFRP1
secreted frizzled-related protein 1
chr4_-_89080010 0.492 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr19_+_35739519 0.487 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr19_-_19738973 0.487 NM_004720
LPAR2
lysophosphatidic acid receptor 2
chr8_+_120220554 0.486 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr4_-_15940362 0.486 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr6_-_30712294 0.486 NM_003897
IER3
immediate early response 3
chr11_-_118134956 0.485 MPZL2
myelin protein zero-like 2
chr11_+_10482677 0.481 NM_001172430
AMPD3
adenosine monophosphate deaminase 3
chr11_-_118134986 0.472 MPZL2
myelin protein zero-like 2
chr5_+_147582338 0.460 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr12_+_107974633 0.459 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr12_-_52845862 0.449 NM_005555
KRT6B
keratin 6B
chr6_+_30856462 0.444 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr1_+_183155361 0.442 LAMC2
laminin, gamma 2
chr9_-_139948448 0.432 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr13_+_78109808 0.422 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr17_-_10741398 0.420 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr6_+_106546736 0.420 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr6_+_13924676 0.420 NM_001165034
RNF182
ring finger protein 182
chr1_+_3388170 0.419 ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr12_+_56732658 0.417 NM_016584
IL23A
interleukin 23, alpha subunit p19
chr19_-_11688441 0.415 ACP5
acid phosphatase 5, tartrate resistant
chr10_+_24755459 0.409 KIAA1217
KIAA1217
chr17_-_56494889 0.400 RNF43
ring finger protein 43
chr1_+_183155173 0.399 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr5_+_140261792 0.395 NM_018904
NM_031865
PCDHA13

protocadherin alpha 13

chr19_+_35739778 0.393 LSR
lipolysis stimulated lipoprotein receptor
chr1_-_6662898 0.393 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr19_-_16045669 0.388 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr1_-_28520379 0.385 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr22_+_22758538 0.377


chr4_-_170924911 0.373 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr11_-_120008801 0.370 TRIM29
tripartite motif containing 29
chr1_-_153521717 0.369 NM_002960
S100A3
S100 calcium binding protein A3
chr11_+_62649160 0.368 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr18_+_55888838 0.365 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_110874142 0.363 NM_005434
MALL
mal, T-cell differentiation protein-like
chr1_+_65613971 0.361 AK4
adenylate kinase 4
chr17_-_56494930 0.358 NM_017763
RNF43
ring finger protein 43
chr4_-_80994309 0.354 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr18_+_55888799 0.352 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_-_207205996 0.344 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr19_-_11688484 0.342 ACP5
acid phosphatase 5, tartrate resistant
chr6_-_149806025 0.339 ZC3H12D
zinc finger CCCH-type containing 12D
chr19_-_36019194 0.338 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr2_+_90077732 0.336


chr9_-_86983412 0.331 NM_022127
SLC28A3
solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
chr21_+_43619798 0.329 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr9_+_35673852 0.328 NM_001216
CA9
carbonic anhydrase IX
chr2_+_113875469 0.328 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr6_+_44195008 0.327 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr1_-_6662681 0.327 KLHL21
kelch-like 21 (Drosophila)
chr4_-_36245893 0.326 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_138428477 0.324 NM_022121
PERP
PERP, TP53 apoptosis effector
chr5_-_134914968 0.324 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr11_-_118135197 0.320 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr5_+_36606667 0.319 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_205473683 0.318 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr8_-_21998994 0.318 NM_025232
REEP4
receptor accessory protein 4
chr19_+_7953380 0.314 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr4_+_40198526 0.313 NM_004310
RHOH
ras homolog gene family, member H
chr11_-_120008848 0.312 NM_012101
TRIM29
tripartite motif containing 29
chr7_+_86273219 0.311 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr6_+_138188352 0.308 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chrX_-_154563735 0.306 NM_001289
CLIC2
chloride intracellular channel 2
chr5_-_54281345 0.305 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_+_183155393 0.303 LAMC2
laminin, gamma 2
chr16_-_30124829 0.299 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr3_+_36421944 0.298 NM_003149
STAC
SH3 and cysteine rich domain
chr7_+_48128225 0.295 NM_181597
UPP1
uridine phosphorylase 1
chr12_-_106533810 0.293 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr5_+_35856990 0.293 NM_002185
IL7R
interleukin 7 receptor
chr3_-_124842442 0.290 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr17_-_39942937 0.289 NM_002230
NM_021991
JUP

junction plakoglobin

chr22_+_45072936 0.288 PRR5
proline rich 5 (renal)
chr5_-_140012730 0.286 CD14
CD14 molecule
chr7_+_23286401 0.284 GPNMB
glycoprotein (transmembrane) nmb
chr3_-_191048324 0.283 NM_198152
UTS2D
urotensin 2 domain containing
chr14_-_24777160 0.282 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777184 0.279 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777153 0.276 CIDEB
cell death-inducing DFFA-like effector b
chr11_+_121461070 0.276 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr12_-_8219001 0.275 C3AR1
complement component 3a receptor 1
chr2_-_64371444 0.274 NM_020651
PELI1
pellino homolog 1 (Drosophila)
chr1_+_200863948 0.272 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr19_+_41949062 0.271 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr1_+_172389827 0.269 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr10_-_6019454 0.268 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr4_+_76481257 0.265 NM_001206981
NM_178497
C4orf26

chromosome 4 open reading frame 26

chr19_-_44285012 0.262 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_+_39279849 0.262 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr12_-_8218930 0.261 NM_004054
C3AR1
complement component 3a receptor 1
chr11_+_66742747 0.259 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr1_+_65613771 0.259 NM_013410
AK4
adenylate kinase 4
chr12_+_95676175 0.255 VEZT
vezatin, adherens junctions transmembrane protein
chr11_+_32851469 0.255 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr19_+_11200037 0.255 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr4_+_74606222 0.252 NM_000584
IL8
interleukin 8
chr6_+_32121228 0.250 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr19_-_11688508 0.250 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr11_+_35639734 0.249 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr4_-_123542165 0.248 NM_001207006
NM_021803
IL21

interleukin 21

chr6_-_31745048 0.247 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr14_-_38064440 0.245 NM_004496
FOXA1
forkhead box A1
chr7_-_36429695 0.242 NM_001100425
KIAA0895
KIAA0895
chr15_+_74833517 0.241 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr9_-_117111278 0.239 AKNA
AT-hook transcription factor
chr8_+_124780679 0.238 FAM91A1
family with sequence similarity 91, member A1
chr7_-_158611301 0.237 ESYT2
extended synaptotagmin-like protein 2
chr6_+_30852326 0.236 NM_013993
DDR1
discoidin domain receptor tyrosine kinase 1
chr19_+_50084586 0.236 NM_000951
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr1_-_153538305 0.236 NM_005978
S100A2
S100 calcium binding protein A2
chr11_-_120008738 0.235 TRIM29
tripartite motif containing 29
chr14_+_96722546 0.234 NM_000710
BDKRB1
bradykinin receptor B1
chr1_+_3371020 0.233 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr6_+_30852756 0.233 NM_001202523
DDR1
discoidin domain receptor tyrosine kinase 1
chr2_-_165697927 0.233 NM_014900
COBLL1
COBL-like 1
chr11_+_34654010 0.230 NM_001206616
EHF
ets homologous factor
chr2_-_165697852 0.228 COBLL1
COBL-like 1
chrX_+_115567746 0.228 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr2_+_47596447 0.226 EPCAM
epithelial cell adhesion molecule
chr1_-_223853359 0.225 CAPN8
calpain 8
chr12_-_8815479 0.224 MFAP5
microfibrillar associated protein 5
chr6_+_1611544 0.224 FOXC1
forkhead box C1
chr2_+_47596286 0.223 NM_002354
EPCAM
epithelial cell adhesion molecule
chr5_-_140013034 0.223 NM_000591
CD14
CD14 molecule
chr17_-_8021806 0.219 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr17_+_48610077 0.218 EPN3
epsin 3
chr19_-_49243836 0.218 NM_017805
RASIP1
Ras interacting protein 1
chr19_-_44285407 0.218 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr19_-_55881740 0.218 NM_000641
IL11
interleukin 11
chr2_-_71062904 0.216 NM_015717
CD207
CD207 molecule, langerin
chr12_-_51403028 0.216 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr12_-_105322056 0.216 NM_032148
SLC41A2
solute carrier family 41, member 2
chrX_+_105937067 0.216 NM_024539
RNF128
ring finger protein 128
chr1_+_160709038 0.212 NM_021181
SLAMF7
SLAM family member 7
chr19_-_39264144 0.211 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr17_+_73717515 0.210 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr17_-_39661803 0.209 NM_002274
NM_153490
KRT13

keratin 13

chr6_-_44233499 0.207 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr20_-_44539542 0.206 PLTP
phospholipid transfer protein
chr1_+_186798031 0.206 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr17_+_74381419 0.205 SPHK1
sphingosine kinase 1
chr17_-_38721701 0.204 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr4_+_47487230 0.203 NM_020453
ATP10D
ATPase, class V, type 10D

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.64 6.52e-05 GO:0002376 immune system process
1.75 1.49e-03 GO:0006955 immune response
2.80 2.64e-03 GO:0002237 response to molecule of bacterial origin
2.85 4.58e-03 GO:0032496 response to lipopolysaccharide
2.25 8.05e-03 GO:0030334 regulation of cell migration
2.22 1.08e-02 GO:2000145 regulation of cell motility
1.85 1.12e-02 GO:0009607 response to biotic stimulus
1.90 2.97e-02 GO:0051707 response to other organism
1.56 3.21e-02 GO:0042127 regulation of cell proliferation
2.09 3.61e-02 GO:0040012 regulation of locomotion
2.54 3.99e-02 GO:0030335 positive regulation of cell migration
2.54 3.99e-02 GO:2000147 positive regulation of cell motility

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 2.91e-03 GO:0016020 membrane
1.34 9.17e-03 GO:0005576 extracellular region

Nothing significant found in function category.