Motif ID: FOXO1,3,4.p2

Z-value: 1.155


Transcription factors associated with FOXO1,3,4.p2:

Gene SymbolEntrez IDGene Name
FOXO1 2308 forkhead box O1
FOXO3 2309 forkhead box O3
FOXO4 4303 forkhead box O4

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXO4chrX_+_70315637-0.676.8e-02Click!
FOXO3chr6_+_1088820680.658.1e-02Click!
FOXO1chr13_-_41240607-0.393.4e-01Click!


Activity profile for motif FOXO1,3,4.p2.

activity profile for motif FOXO1,3,4.p2


Sorted Z-values histogram for motif FOXO1,3,4.p2

Sorted Z-values for motif FOXO1,3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO1,3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_95186559 2.978 NM_005014
OMD
osteomodulin
chr1_-_57044980 2.821 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045235 2.812 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045129 2.055 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_+_163041694 1.533 NM_001113380
RGS4
regulator of G-protein signaling 4
chr4_+_70916158 1.434 NM_002159
HTN1
histatin 1
chr1_-_57045214 1.397 PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_55512801 1.389 NM_004530
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr11_+_113931228 1.150 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr14_-_60097314 0.958 RTN1
reticulon 1
chr10_+_70847817 0.928 NM_002727
SRGN
serglycin
chr14_-_60097223 0.898 RTN1
reticulon 1
chr19_+_18111923 0.898 NM_001025604
ARRDC2
arrestin domain containing 2
chr8_-_13134028 0.885 DLC1
deleted in liver cancer 1
chr8_+_70405080 0.871 SULF1
sulfatase 1
chr10_+_70847857 0.842 SRGN
serglycin
chr3_-_149086884 0.838 TM4SF1
transmembrane 4 L six family member 1
chr6_-_117747017 0.780 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr9_+_120466607 0.758 TLR4
toll-like receptor 4
chr10_-_49482912 0.752 NM_001018071
FRMPD2
FERM and PDZ domain containing 2
chr4_+_55095263 0.751 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_+_189839078 0.750 NM_000090
COL3A1
collagen, type III, alpha 1
chr13_-_38172862 0.749 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr9_+_120466453 0.748 NM_138554
TLR4
toll-like receptor 4
chr2_+_189839113 0.744 COL3A1
collagen, type III, alpha 1
chr17_-_67138013 0.737 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr13_-_33760215 0.720 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr2_-_188419185 0.716 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr8_+_70405027 0.695 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr1_+_163038564 0.649 NM_005613
RGS4
regulator of G-protein signaling 4
chr16_+_55515468 0.647 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr1_+_163038934 0.636 NM_001113381
RGS4
regulator of G-protein signaling 4
chr9_+_120466625 0.635 TLR4
toll-like receptor 4
chr5_+_75699003 0.627 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr17_-_19290471 0.617 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr3_-_112359962 0.603 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr9_+_5510544 0.593 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr2_-_163099877 0.585 NM_004460
FAP
fibroblast activation protein, alpha
chr2_+_189839132 0.584 COL3A1
collagen, type III, alpha 1
chr7_-_50772997 0.583 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr3_+_154797910 0.570 NM_007288
MME
membrane metallo-endopeptidase
chr21_+_37507209 0.568 NM_001236
CBR3
carbonyl reductase 3
chr20_-_18477811 0.567 NM_006606
RBBP9
retinoblastoma binding protein 9
chr1_+_145524989 0.564 NM_003637
ITGA10
integrin, alpha 10
chr17_-_53809444 0.562 NM_001099640
TMEM100
transmembrane protein 100
chr4_+_124320664 0.561 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr6_+_136172802 0.559 NM_018945
PDE7B
phosphodiesterase 7B
chr2_-_200325200 0.557 SATB2
SATB homeobox 2
chr6_+_72922513 0.555 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr8_-_93115453 0.529 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr4_-_138453628 0.529 NM_019035
PCDH18
protocadherin 18
chr8_-_93075190 0.527 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr18_-_56296188 0.525 NM_052947
ALPK2
alpha-kinase 2
chrX_+_80457302 0.517 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr3_-_112359863 0.516 CCDC80
coiled-coil domain containing 80
chr1_+_163038395 0.510 NM_001102445
RGS4
regulator of G-protein signaling 4
chr18_+_6834431 0.491 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr17_+_1665306 0.483 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_+_69812620 0.482 NM_001184967
MITF
microphthalmia-associated transcription factor
chr10_+_91087601 0.480 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_+_72596699 0.477 RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_238322840 0.475 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr13_+_24144402 0.474 NM_001204459
NM_148957
TNFRSF19

tumor necrosis factor receptor superfamily, member 19

chr18_-_500583 0.466 NM_130386
COLEC12
collectin sub-family member 12
chr1_-_27998719 0.464 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr2_+_61389628 0.463 NM_001143959
C2orf74
chromosome 2 open reading frame 74
chrX_-_19688991 0.463 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr19_+_50031232 0.462 RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr6_+_73076431 0.457 NM_001168411
RIMS1
regulating synaptic membrane exocytosis 1
chr1_+_162602308 0.454 DDR2
discoidin domain receptor tyrosine kinase 2
chr11_-_27681195 0.454 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr9_+_79093256 0.452 NM_001097635
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr17_+_1665233 0.451 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_31514620 0.436 NM_001204078
NM_130463
NM_138282
ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr11_-_27743604 0.433 NM_170731
BDNF
brain-derived neurotrophic factor
chr20_-_34543280 0.431 NM_016558
SCAND1
SCAN domain containing 1
chr6_+_108882104 0.431 FOXO3
forkhead box O3
chr1_+_162602198 0.428 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr5_-_178054001 0.426 NM_020666
CLK4
CDC-like kinase 4
chr5_-_149535138 0.424 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_-_27998700 0.419 IFI6
interferon, alpha-inducible protein 6
chr7_+_149570004 0.413 NM_001100592
NM_145230
ATP6V0E2

ATPase, H+ transporting V0 subunit e2

chr1_-_24194760 0.411 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr20_+_45338125 0.405 NM_030777
SLC2A10
solute carrier family 2 (facilitated glucose transporter), member 10
chr12_-_15374290 0.402 NM_001190726
NM_032918
RERG

RAS-like, estrogen-regulated, growth inhibitor

chr3_-_169587598 0.399 NM_024727
LRRC31
leucine rich repeat containing 31
chr1_-_27998658 0.393 IFI6
interferon, alpha-inducible protein 6
chr1_-_232651227 0.392 NM_020808
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_+_140529619 0.392 NM_018939
PCDHB6
protocadherin beta 6
chr1_+_150122415 0.388 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr4_+_41614725 0.386 LIMCH1
LIM and calponin homology domains 1
chr12_-_102591547 0.384 NM_002674
PMCH
pro-melanin-concentrating hormone
chr10_-_25241504 0.382 NM_020200
PRTFDC1
phosphoribosyl transferase domain containing 1
chr5_-_111312522 0.379 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr6_+_108882068 0.372 NM_001455
FOXO3
forkhead box O3
chr9_-_95244634 0.370 ASPN
asporin
chr4_-_159092509 0.369 FAM198B
family with sequence similarity 198, member B
chr6_-_58287651 0.366 GUSBP4
glucuronidase, beta pseudogene 4
chr3_+_154798078 0.366 NM_007289
MME
membrane metallo-endopeptidase
chr13_+_93879011 0.364 NM_005708
GPC6
glypican 6
chr2_-_224467142 0.356 NM_003469
SCG2
secretogranin II
chr20_-_45976626 0.354 ZMYND8
zinc finger, MYND-type containing 8
chr12_+_79439432 0.351 NM_001135806
SYT1
synaptotagmin I
chr2_-_224467095 0.351 SCG2
secretogranin II
chr2_+_201997687 0.351 NM_001202518
CFLAR
CASP8 and FADD-like apoptosis regulator
chr18_+_72922725 0.350 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr1_-_31845818 0.348 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr2_-_224467049 0.346 SCG2
secretogranin II
chr2_-_166060552 0.342 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr5_-_149535420 0.341 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr20_+_57022460 0.341 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_+_226016428 0.338 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr2_-_190044330 0.336 NM_000393
COL5A2
collagen, type V, alpha 2
chr18_-_52625278 0.328 NM_001143829
CCDC68
coiled-coil domain containing 68
chr17_+_1665342 0.328 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_+_101846860 0.328 NM_001166247
NM_021956
NM_175768
GRIK2


glutamate receptor, ionotropic, kainate 2


chr2_+_29038862 0.327 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr15_-_52970808 0.326 NM_019600
FAM214A
family with sequence similarity 214, member A
chr16_+_29823557 0.326 PRRT2
proline-rich transmembrane protein 2
chr4_-_186697065 0.324 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr7_+_20655244 0.323 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr6_-_152702450 0.323 SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_77532159 0.320 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr17_+_1665281 0.319 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_+_21679190 0.318 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr2_+_175260455 0.316 NM_001193528
NM_024583
SCRN3

secernin 3

chr1_+_150122095 0.316 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr10_-_50732142 0.316 NM_170753
PGBD3
piggyBac transposable element derived 3
chr2_-_238322770 0.316 COL6A3
collagen, type VI, alpha 3
chr19_-_40732563 0.315 NM_024877
CNTD2
cyclin N-terminal domain containing 2
chr6_+_155411422 0.314 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_+_104681378 0.311 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr12_-_7596722 0.311 NM_174941
CD163L1
CD163 molecule-like 1
chr9_+_66553254 0.310 MGC21881
uncharacterized locus MGC21881
chr2_-_192711923 0.309 NM_004657
SDPR
serum deprivation response
chr1_+_162039469 0.307 NM_001164757
NM_014697
NOS1AP

nitric oxide synthase 1 (neuronal) adaptor protein

chr12_-_13248581 0.305 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr2_-_238322815 0.303 COL6A3
collagen, type VI, alpha 3
chr14_+_21156922 0.302 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr5_-_158526698 0.301 NM_024007
EBF1
early B-cell factor 1
chr11_+_5710926 0.301 TRIM22
tripartite motif containing 22
chr2_+_201450730 0.300 NM_001159
AOX1
aldehyde oxidase 1
chr5_-_139937677 0.299 NM_001035235
SRA1
steroid receptor RNA activator 1
chr1_-_241803203 0.297 NM_014322
OPN3
opsin 3
chr2_+_175260505 0.296 SCRN3
secernin 3
chr6_-_46459710 0.292 NM_001251973
RCAN2
regulator of calcineurin 2
chr1_+_164528914 0.291 PBX1
pre-B-cell leukemia homeobox 1
chr8_-_42623928 0.291 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chr2_-_101767714 0.290 NM_001102426
TBC1D8
TBC1 domain family, member 8 (with GRAM domain)
chr17_-_8424217 0.289 MYH10
myosin, heavy chain 10, non-muscle
chr9_-_95298251 0.289 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr2_-_192711651 0.286 SDPR
serum deprivation response
chr15_-_43910959 0.286 NM_153700
STRC
stereocilin
chr11_-_61584451 0.286 NM_013402
FADS1
fatty acid desaturase 1
chr6_+_72596648 0.286 NM_014989
RIMS1
regulating synaptic membrane exocytosis 1
chr1_-_241799101 0.286 NM_001821
CHML
choroideremia-like (Rab escort protein 2)
chr9_-_86432546 0.285 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr17_+_48821106 0.284 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr8_+_23427477 0.284 SLC25A37
solute carrier family 25, member 37
chr5_+_118965253 0.281 NM_001163991
NM_182761
FAM170A

family with sequence similarity 170, member A

chrX_-_57147850 0.281 NM_001006681
NM_001006682
NM_001006683
SPIN2B


spindlin family, member 2B


chr19_+_30863318 0.277 NM_014717
ZNF536
zinc finger protein 536
chr1_+_222988324 0.276 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr2_+_24807345 0.274 NM_003743
NM_147223
NM_147233
NCOA1


nuclear receptor coactivator 1


chr17_-_66951381 0.273 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_+_51318743 0.271 METTL7A
methyltransferase like 7A
chr2_-_158300517 0.270 NM_004288
CYTIP
cytohesin 1 interacting protein
chr15_-_82338348 0.268 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr1_-_163172863 0.267 NM_003617
RGS5
regulator of G-protein signaling 5
chr8_+_38585703 0.266 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr2_+_233498206 0.266 NM_025202
EFHD1
EF-hand domain family, member D1
chr2_+_109204777 0.265 LIMS1
LIM and senescent cell antigen-like domains 1
chr5_+_156820161 0.263 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_+_131683173 0.262 NM_001100876
NM_174933
PHYHD1

phytanoyl-CoA dioxygenase domain containing 1

chr1_+_150122246 0.257 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr2_+_207406815 0.253 ADAM23
ADAM metallopeptidase domain 23
chr5_+_140571903 0.252 NM_018930
PCDHB10
protocadherin beta 10
chr17_-_33446632 0.250 RAD51D
RAD51 homolog D (S. cerevisiae)
chr2_+_210444154 0.249 MAP2
microtubule-associated protein 2
chr3_-_58522873 0.248 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr3_-_15382874 0.246 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr11_+_5710816 0.245 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr3_-_196242190 0.241 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr4_+_39063851 0.240 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr12_-_9268440 0.239 A2M
alpha-2-macroglobulin
chr13_+_76194569 0.238 NM_005358
LMO7
LIM domain 7
chr2_-_214015053 0.238 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr20_+_23420321 0.237 NM_138283
CSTL1
cystatin-like 1
chrX_-_63005212 0.237 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr17_-_67323185 0.236 NM_172232
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr15_+_32933869 0.234 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr1_-_182360400 0.234 NM_001033056
GLUL
glutamate-ammonia ligase
chr21_+_38455246 0.233 NM_003316
TTC3
tetratricopeptide repeat domain 3
chr17_+_3377346 0.233 NM_001128085
ASPA
aspartoacylase
chr1_-_47655603 0.232 PDZK1IP1
PDZK1 interacting protein 1
chr5_+_137203544 0.232 NM_001135940
NM_006790
MYOT

myotilin

chr5_+_137203559 0.232 MYOT
myotilin
chr7_+_55980330 0.231 NM_182633
ZNF713
zinc finger protein 713
chr11_+_17332454 0.228


chr5_+_140625146 0.228 NM_018935
PCDHB15
protocadherin beta 15

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.