Motif ID: GAGGUAG

Z-value: 1.242


Mature miRNA associated with seed GAGGUAG:

NamemiRBase Accession
hsa-let-7a MIMAT0000062
hsa-let-7b MIMAT0000063
hsa-let-7c MIMAT0000064
hsa-let-7d MIMAT0000065
hsa-let-7e MIMAT0000066
hsa-let-7f MIMAT0000067
hsa-let-7g MIMAT0000414
hsa-let-7i MIMAT0000415
hsa-miR-4458 MIMAT0018980
hsa-miR-4500 MIMAT0019036
hsa-miR-98 MIMAT0000096



Activity profile for motif GAGGUAG.

activity profile for motif GAGGUAG


Sorted Z-values histogram for motif GAGGUAG

Sorted Z-values for motif GAGGUAG



Network of associatons between targets according to the STRING database.



First level regulatory network of GAGGUAG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_242687997 1.974 NM_152666
PLD5
phospholipase D family, member 5
chr1_-_242612757 1.820 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr10_-_100027943 1.687 NM_032211
LOXL4
lysyl oxidase-like 4
chr9_-_27529434 1.549 NM_024761
MOB3B
MOB kinase activator 3B
chr1_+_60280462 1.240 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr3_-_69435429 1.157 NM_015123
FRMD4B
FERM domain containing 4B
chr8_+_28351694 1.156 NM_017412
NM_145866
FZD3

frizzled family receptor 3

chr1_-_153363544 1.137 NM_002964
S100A8
S100 calcium binding protein A8
chr20_-_46415277 1.115 NM_001161841
NM_198596
SULF2

sulfatase 2

chr20_-_46414636 1.110 NM_018837
SULF2
sulfatase 2
chr12_+_4382882 1.084 NM_001759
CCND2
cyclin D2
chr1_-_28503454 1.043 NM_000952
NM_001164723
PTAFR

platelet-activating factor receptor

chrX_+_37545008 1.014 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr5_+_166711842 0.999 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr2_+_17721806 0.998 NM_003385
VSNL1
visinin-like 1
chr1_+_152486977 0.980 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr18_+_11751470 0.949 NM_001142339
NM_002071
GNAL

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

chr1_-_28520379 0.917 NM_001164721
NM_001164722
PTAFR

platelet-activating factor receptor

chr5_-_139726173 0.908 NM_001945
HBEGF
heparin-binding EGF-like growth factor
chr12_+_72666462 0.899 NM_013381
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr6_-_99797530 0.899 NM_032511
C6orf168
chromosome 6 open reading frame 168
chr18_+_11689135 0.884 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr22_-_39636906 0.871 NM_033016
PDGFB
platelet-derived growth factor beta polypeptide
chr6_+_138188352 0.866 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr8_-_127570710 0.863 NM_174911
FAM84B
family with sequence similarity 84, member B
chr22_-_39640956 0.819 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr2_+_198570027 0.770 NM_138395
MARS2
methionyl-tRNA synthetase 2, mitochondrial
chr14_+_67999915 0.763 NM_020715
PLEKHH1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr3_+_111805174 0.760 NM_001171747
NM_024616
C3orf52

chromosome 3 open reading frame 52

chr5_+_149109814 0.750 NM_001172698
NM_133263
PPARGC1B

peroxisome proliferator-activated receptor gamma, coactivator 1 beta

chr9_+_115913227 0.744 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr8_+_24772454 0.734 NM_001105541
NEFM
neurofilament, medium polypeptide
chr8_-_142238672 0.734 NM_001080431
SLC45A4
solute carrier family 45, member 4
chr6_+_41606193 0.733 NM_005586
MDFI
MyoD family inhibitor
chr1_+_160370363 0.727 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr15_+_74833517 0.723 NM_006465
ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr12_-_95611023 0.717 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr8_+_61591239 0.702 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr5_+_149151502 0.679 NM_001172699
PPARGC1B
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr7_+_20370724 0.675 NM_002214
ITGB8
integrin, beta 8
chr11_+_76571902 0.625 NM_018367
ACER3
alkaline ceramidase 3
chr1_-_175161832 0.623 NM_001162895
NM_014656
NM_001162893
NM_001162894
KIAA0040



KIAA0040



chr1_-_24513737 0.616 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr18_-_47721165 0.604 NM_001080467
MYO5B
myosin VB
chr8_+_24771268 0.600 NM_005382
NEFM
neurofilament, medium polypeptide
chr1_-_41131323 0.588 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr12_-_85306579 0.586 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chrX_-_24665454 0.576 NM_001163265
NM_004845
PCYT1B

phosphate cytidylyltransferase 1, choline, beta

chr12_+_49372235 0.570 NM_005430
WNT1
wingless-type MMTV integration site family, member 1
chr17_+_8924822 0.569 NM_004822
NTN1
netrin 1
chr11_-_88070905 0.569 NM_001114173
NM_001814
NM_148170
CTSC


cathepsin C


chr6_+_106534188 0.564 NM_001198
PRDM1
PR domain containing 1, with ZNF domain
chr3_+_50192847 0.563 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr4_-_170947428 0.561 NM_021647
MFAP3L
microfibrillar-associated protein 3-like
chr22_+_26825220 0.557 NM_020437
ASPHD2
aspartate beta-hydroxylase domain containing 2
chr8_+_74206772 0.551 NM_172037
RDH10
retinol dehydrogenase 10 (all-trans)
chrX_-_24690740 0.550 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr2_-_74667553 0.550 NM_001015056
NM_033046
RTKN

rhotekin

chr12_-_12715244 0.539 NM_030640
DUSP16
dual specificity phosphatase 16
chr8_-_22550708 0.537 NM_004430
EGR3
early growth response 3
chr21_+_42539727 0.537 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chrX_-_33357725 0.534 NM_000109
DMD
dystrophin
chr2_+_219575507 0.525 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr4_-_170924911 0.523 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr16_+_66914380 0.523 NM_020786
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr2_+_70142152 0.523 NM_001202513
NM_001202514
NM_002357
MXD1


MAX dimerization protein 1


chr4_+_78978723 0.520 NM_001166133
NM_025074
FRAS1

Fraser syndrome 1

chr6_+_106546736 0.516 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chrX_-_32430370 0.516 NM_004011
NM_004012
DMD

dystrophin

chr7_-_138665853 0.514 NM_001164665
NM_020910
KIAA1549

KIAA1549

chr8_-_22550057 0.513 NM_001199881
EGR3
early growth response 3
chr11_+_58939539 0.505 NM_015177
DTX4
deltex homolog 4 (Drosophila)
chr2_+_219187858 0.501 NM_022572
PNKD
paroxysmal nonkinesigenic dyskinesia
chrX_-_32173585 0.500 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr8_-_22549901 0.500 NM_001199880
EGR3
early growth response 3
chr11_+_59522531 0.496 NM_001178040
NM_004177
STX3

syntaxin 3

chr18_+_43914186 0.493 NM_152470
RNF165-IT1
RNF165
RNF165 intronic transcript 1 (non-protein coding)
ring finger protein 165
chr2_-_27435014 0.491 NM_021095
SLC5A6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr18_+_55714457 0.490 NM_001144964
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_80656870 0.490 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr6_+_12290528 0.488 NM_001168319
NM_001955
EDN1

endothelin 1

chrX_-_31526414 0.488 NM_004014
DMD
dystrophin
chr7_+_90032647 0.487 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr16_+_57662301 0.484 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr11_+_44785975 0.480 NM_130783
TSPAN18
tetraspanin 18
chr3_-_190040192 0.478 NM_021101
CLDN1
claudin 1
chr16_+_18995255 0.475 NM_024847
TMC7
transmembrane channel-like 7
chr1_-_204380903 0.473 NM_032833
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr2_+_75059781 0.471 NM_000189
HK2
hexokinase 2
chr5_+_148206155 0.468 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr9_-_126030854 0.467 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr3_-_185216545 0.467 NM_080652
TMEM41A
transmembrane protein 41A
chr8_-_17579729 0.466 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr16_+_57653909 0.463 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr16_+_57673206 0.461 NM_001145774
GPR56
G protein-coupled receptor 56
chr8_-_17658385 0.453 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr8_-_17555158 0.451 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr9_-_140196702 0.446 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chrX_-_33229428 0.443 NM_004006
DMD
dystrophin
chr18_+_55711388 0.442 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr8_-_17580024 0.439 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chrX_-_117250624 0.437 NM_001168302
NM_001168303
KLHL13

kelch-like 13 (Drosophila)

chr3_-_52090090 0.436 NM_001947
DUSP7
dual specificity phosphatase 7
chrX_-_33146543 0.435 NM_004010
NM_004009
DMD

dystrophin

chr16_+_18995508 0.432 NM_001160364
TMC7
transmembrane channel-like 7
chr13_-_52585472 0.431 NM_000053
NM_001005918
NM_001243182
ATP7B


ATPase, Cu++ transporting, beta polypeptide


chr19_+_34287662 0.430 NM_001129994
NM_001129995
NM_024076
KCTD15


potassium channel tetramerisation domain containing 15


chrX_-_117251302 0.426 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chr2_+_148602569 0.424 NM_001616
ACVR2A
activin A receptor, type IIA
chr22_+_25960738 0.423 NM_005160
ADRBK2
adrenergic, beta, receptor kinase 2
chr17_+_7342688 0.421 NM_004112
FGF11
fibroblast growth factor 11
chr11_-_118023534 0.417 NM_001142348
NM_174934
SCN4B

sodium channel, voltage-gated, type IV, beta

chr15_+_80987609 0.416 NM_021214
FAM108C1
family with sequence similarity 108, member C1
chr18_+_55816546 0.412 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr6_-_3456734 0.410 NM_015482
SLC22A23
solute carrier family 22, member 23
chrX_+_16804531 0.409 NM_001168683
NM_018360
TXLNG

taxilin gamma

chr14_-_53162418 0.406 NM_014584
ERO1L
ERO1-like (S. cerevisiae)
chr3_-_27498244 0.406 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr11_-_118016134 0.405 NM_001142349
SCN4B
sodium channel, voltage-gated, type IV, beta
chr18_+_55862577 0.403 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_71123105 0.399 NM_001105531
NM_020819
FAM135A

family with sequence similarity 135, member A

chrX_-_117119282 0.398 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr2_+_182321618 0.394 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr2_-_230933618 0.391 NM_152527
SLC16A14
solute carrier family 16, member 14 (monocarboxylic acid transporter 14)
chr6_+_117198375 0.390 NM_173560
RFX6
regulatory factor X, 6
chr3_-_48229800 0.390 NM_001789
NM_201567
CDC25A

cell division cycle 25 homolog A (S. pombe)

chr9_-_126030792 0.388 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr15_+_75494196 0.385 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr3_-_33700932 0.382 NM_001207044
CLASP2
cytoplasmic linker associated protein 2
chrX_-_117107700 0.380 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr7_-_36406446 0.378 NM_001199707
NM_001199706
NM_015314
NM_001199708
KIAA0895



KIAA0895



chr10_+_101419169 0.373 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr12_-_57472573 0.367 NM_001130963
NM_015257
TMEM194A

transmembrane protein 194A

chr7_-_36429695 0.365 NM_001100425
KIAA0895
KIAA0895
chr2_-_74669055 0.362 NM_001015055
RTKN
rhotekin
chr15_+_90544608 0.362 NM_198526
ZNF710
zinc finger protein 710
chr11_-_16497917 0.361 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr20_+_49348050 0.360 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr17_+_3539761 0.353 NM_001031681
NM_004937
CTNS

cystinosin, lysosomal cystine transporter

chr2_+_191002485 0.349 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr17_-_38721701 0.346 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chrX_+_105066531 0.344 NM_198465
NRK
Nik related kinase
chr3_-_33759684 0.343 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr15_+_73976621 0.343 NM_001024736
NM_025240
CD276

CD276 molecule

chr5_-_55008125 0.339 NM_173514
SLC38A9
solute carrier family 38, member 9
chr2_+_191045588 0.339 NM_001042519
NM_032321
C2orf88

chromosome 2 open reading frame 88

chr16_-_17564737 0.338 NM_022166
XYLT1
xylosyltransferase I
chr7_-_71877359 0.337 NM_031468
CALN1
calneuron 1
chr11_-_16430425 0.337 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr8_-_144623611 0.334 NM_015117
ZC3H3
zinc finger CCCH-type containing 3
chr11_-_16424391 0.332 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr11_-_102668892 0.330 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr2_-_74781061 0.329 NM_032603
LOXL3
lysyl oxidase-like 3
chrX_+_152907892 0.329 NM_001395
DUSP9
dual specificity phosphatase 9
chr2_+_191014971 0.328 NM_001042520
C2orf88
chromosome 2 open reading frame 88
chr7_+_76090971 0.328 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr4_+_177241003 0.326 NM_021928
SPCS3
signal peptidase complex subunit 3 homolog (S. cerevisiae)
chr16_+_22019438 0.323 NM_001164579
C16orf52
chromosome 16 open reading frame 52
chr3_-_53080038 0.322 NM_001005158
NM_016329
SFMBT1

Scm-like with four mbt domains 1

chr16_+_81348564 0.320 NM_022041
GAN
gigaxonin
chr6_-_134373618 0.319 NM_145176
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chr12_-_25055966 0.314 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr22_+_21771661 0.312 NM_015094
HIC2
hypermethylated in cancer 2
chr22_+_50624353 0.312 NM_025204
TRABD
TraB domain containing
chr18_+_55888750 0.311 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_134654546 0.308 NM_182540
DDX26B
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B
chr16_+_70147528 0.308 NM_017990
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr12_-_25102281 0.307 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr12_-_25055228 0.307 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_-_41836132 0.306 NM_025237
SOST
sclerostin
chr2_+_32390902 0.304 NM_001193513
NM_001193514
NM_001193515
NM_017964
SLC30A6



solute carrier family 30 (zinc transporter), member 6



chrX_-_31284946 0.301 NM_004015
NM_004016
NM_004017
NM_004018
NM_004019
DMD




dystrophin




chr9_+_101569933 0.299 NM_024642
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chr6_-_3445198 0.298 NM_021945
SLC22A23
solute carrier family 22, member 23
chr12_+_54366909 0.298 NM_014212
HOXC11
homeobox C11
chr7_+_107221203 0.294 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chrX_+_147582133 0.294 NM_001169122
NM_001169123
NM_001169124
NM_001169125
NM_002025
AFF2




AF4/FMR2 family, member 2




chr7_+_107220421 0.294 NM_018844
BCAP29
B-cell receptor-associated protein 29
chrX_+_118370205 0.292 NM_006667
PGRMC1
progesterone receptor membrane component 1
chr5_+_56110899 0.292 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr12_-_123451031 0.292 NM_001243013
NM_001243014
NM_019624
NM_019625
NM_203444
ABCB9




ATP-binding cassette, sub-family B (MDR/TAP), member 9




chr17_-_6459746 0.291 NM_001165966
NM_031220
PITPNM3

PITPNM family member 3

chr6_+_71136141 0.291 NM_001162529
FAM135A
family with sequence similarity 135, member A
chr16_-_2908105 0.288 NM_022119
PRSS22
protease, serine, 22
chr8_+_86099909 0.288 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr14_-_95599794 0.287 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr4_+_74606222 0.286 NM_000584
IL8
interleukin 8
chr2_+_153574385 0.285 NM_152522
ARL6IP6
ADP-ribosylation-like factor 6 interacting protein 6
chr1_+_32645322 0.284 NM_175852
TXLNA
taxilin alpha
chr20_+_9198036 0.284 NM_182797
PLCB4
phospholipase C, beta 4
chr2_+_86668270 0.283 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chrX_+_49832214 0.281 NM_000084
CLCN5
chloride channel 5
chr1_-_24126891 0.281 NM_000403
GALE
UDP-galactose-4-epimerase
chr22_+_29468887 0.279 NM_001039570
NM_032045
KREMEN1

kringle containing transmembrane protein 1

chr15_+_98503907 0.279 NM_183376
ARRDC4
arrestin domain containing 4
chr1_-_93646245 0.277 NM_001167830
NM_016040
TMED5

transmembrane emp24 protein transport domain containing 5

chr2_+_204801453 0.277 NM_012092
ICOS
inducible T-cell co-stimulator
chr17_+_29718641 0.276 NM_032932
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr17_+_1959512 0.276 NM_001098202
HIC1
hypermethylated in cancer 1
chr5_-_175964223 0.273 NM_014901
RNF44
ring finger protein 44

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.38 2.39e-02 GO:0051179 localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.28 1.98e-04 GO:0044425 membrane part
1.69 3.61e-04 GO:0012505 endomembrane system
1.30 8.23e-04 GO:0016021 integral to membrane
1.28 3.55e-03 GO:0031224 intrinsic to membrane
2.19 4.87e-03 GO:0000139 Golgi membrane
2.06 4.97e-03 GO:0044431 Golgi apparatus part
1.74 1.34e-02 GO:0005794 Golgi apparatus
1.20 1.35e-02 GO:0016020 membrane
1.47 1.48e-02 GO:0031090 organelle membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
29.27 1.72e-02 GO:0004939 beta-adrenergic receptor activity
16.73 1.89e-02 GO:0017002 activin receptor activity