Motif ID: GLI1..3.p2

Z-value: 1.116


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI2chr2_+_121554866-0.782.1e-02Click!
GLI3chr7_-_42276617-0.452.6e-01Click!
GLI1chr12_+_57853917-0.285.1e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52845862 1.521 NM_005555
KRT6B
keratin 6B
chr19_+_45312294 1.031 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr6_+_7541863 1.016 NM_001008844
NM_004415
DSP

desmoplakin

chr20_+_44637539 0.990 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_+_183155361 0.971 LAMC2
laminin, gamma 2
chr8_+_124194873 0.947 FAM83A
family with sequence similarity 83, member A
chr1_+_183155173 0.931 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr17_-_34122547 0.930 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr15_+_41136622 0.906 NM_001032367
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr1_+_44064509 0.892 PTPRF
protein tyrosine phosphatase, receptor type, F
chr5_+_52776408 0.875 FST
follistatin
chr7_+_69064316 0.865 AUTS2
autism susceptibility candidate 2
chr18_+_33877630 0.839 NM_025135
FHOD3
formin homology 2 domain containing 3
chr1_+_234040547 0.830 NM_173508
SLC35F3
solute carrier family 35, member F3
chr1_+_183155393 0.798 LAMC2
laminin, gamma 2
chrX_-_78622711 0.789 ITM2A
integral membrane protein 2A
chr10_+_47746919 0.763 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr17_+_47572592 0.762 NM_002507
NGFR
nerve growth factor receptor
chrX_+_152954965 0.751 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr19_+_751108 0.751 NM_173481
C19orf21
chromosome 19 open reading frame 21
chr8_+_31497267 0.747 NM_013962
NRG1
neuregulin 1
chr20_+_62328002 0.723 NM_003823
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr1_+_101702561 0.707 S1PR1
sphingosine-1-phosphate receptor 1
chr20_+_62328068 0.696 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr2_-_31361284 0.689 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr11_+_32851469 0.684 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr19_-_35992798 0.682 NM_001035516
DMKN
dermokine
chr2_+_182321933 0.662 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr10_-_116164514 0.656 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr5_+_52776479 0.649 FST
follistatin
chr7_+_69063768 0.642 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr8_+_95653340 0.641 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr1_-_12677347 0.634 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr10_+_82173574 0.630 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr8_+_95653399 0.626 ESRP1
epithelial splicing regulatory protein 1
chr1_-_201368617 0.624 NM_005558
LAD1
ladinin 1
chrX_-_78623006 0.621 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr1_+_32042085 0.618 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr10_-_116164222 0.611 AFAP1L2
actin filament associated protein 1-like 2
chr1_+_32042122 0.610 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr12_-_52886971 0.607 NM_005554
KRT6A
keratin 6A
chr1_+_32042125 0.584 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr21_+_18885104 0.580 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr2_+_182322265 0.576 ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr10_+_48255223 0.575 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr8_+_21916685 0.569 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr13_-_20767100 0.565 NM_004004
GJB2
gap junction protein, beta 2, 26kDa
chr8_-_21988518 0.558 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr6_-_32784727 0.556 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr13_-_20767036 0.550 GJB2
gap junction protein, beta 2, 26kDa
chr1_+_117452359 0.544 NM_020440
PTGFRN
prostaglandin F2 receptor negative regulator
chr16_+_30194925 0.537 CORO1A
coronin, actin binding protein, 1A
chr9_+_35673852 0.533 NM_001216
CA9
carbonic anhydrase IX
chr21_+_18885296 0.532 CXADR
coxsackie virus and adenovirus receptor
chr19_+_35739838 0.530 LSR
lipolysis stimulated lipoprotein receptor
chr11_+_124933007 0.528 NM_001145290
NM_198277
SLC37A2

solute carrier family 37 (glycerol-3-phosphate transporter), member 2

chr1_+_152881022 0.526 NM_005547
IVL
involucrin
chr8_+_21916858 0.525 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_-_51456159 0.521 NM_001077491
NM_001077492
NM_012427
KLK5


kallikrein-related peptidase 5


chr19_+_54371170 0.514 MYADM
myeloid-associated differentiation marker
chr2_+_182321618 0.495 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr6_+_7541892 0.493 DSP
desmoplakin
chr9_+_131644368 0.486 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chr12_+_65563339 0.486 NM_001167614
NM_014319
LEMD3

LEM domain containing 3

chr5_+_140346053 0.482 PCDHAC2
protocadherin alpha subfamily C, 2
chr1_+_101702304 0.479 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr1_-_201368716 0.474 LAD1
ladinin 1
chr6_-_46703429 0.471 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_+_40532034 0.468 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_+_124933197 0.467 SLC37A2
solute carrier family 37 (glycerol-3-phosphate transporter), member 2
chr9_-_124989755 0.464 NM_001242334
LHX6
LIM homeobox 6
chr7_-_41742666 0.463 NM_002192
INHBA
inhibin, beta A
chr11_-_88070901 0.462 CTSC
cathepsin C
chr1_+_156123321 0.461 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr18_+_21452981 0.460 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr20_-_6104056 0.454 NM_017671
FERMT1
fermitin family member 1
chrX_+_37545008 0.454 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr1_+_35220647 0.450 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr16_+_27325269 0.444 IL4R
interleukin 4 receptor
chr20_+_6748744 0.437 NM_001200
BMP2
bone morphogenetic protein 2
chr8_-_127570710 0.433 NM_174911
FAM84B
family with sequence similarity 84, member B
chr10_+_82214066 0.432 TSPAN14
tetraspanin 14
chr6_+_7541837 0.431 DSP
desmoplakin
chr12_+_41582167 0.427 NM_001164595
PDZRN4
PDZ domain containing ring finger 4
chr15_+_41136178 0.426 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr17_-_39768939 0.421 NM_005557
KRT16
keratin 16
chr17_-_27507195 0.419 NM_078471
NM_203318
MYO18A

myosin XVIIIA

chr2_+_220492286 0.418 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr18_+_77724575 0.416 NM_001136180
HSBP1L1
heat shock factor binding protein 1-like 1
chr22_+_45064323 0.408 NM_001017528
NM_001017529
PRR5

proline rich 5 (renal)

chr9_+_131644427 0.407 LRRC8A
leucine rich repeat containing 8 family, member A
chr12_-_52914080 0.406 NM_000424
KRT5
keratin 5
chr11_+_65554566 0.406 OVOL1
ovo-like 1(Drosophila)
chr3_-_46718898 0.404 NM_182775
ALS2CL
ALS2 C-terminal like
chr16_+_30194730 0.398 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr7_-_92465929 0.395 NM_001145306
CDK6
cyclin-dependent kinase 6
chr1_+_220701547 0.395 NM_018650
MARK1
MAP/microtubule affinity-regulating kinase 1
chr20_-_6103860 0.392 FERMT1
fermitin family member 1
chr5_+_140346289 0.391 NM_031883
PCDHAC2
protocadherin alpha subfamily C, 2
chr6_-_138428477 0.388 NM_022121
PERP
PERP, TP53 apoptosis effector
chr10_+_99498233 0.387 NM_001002261
ZFYVE27
zinc finger, FYVE domain containing 27
chr6_+_43738757 0.386 VEGFA
vascular endothelial growth factor A
chr8_-_125740378 0.379 MTSS1
metastasis suppressor 1
chr1_+_40420781 0.372 NM_001136493
NM_032793
MFSD2A

major facilitator superfamily domain containing 2A

chr8_+_32405727 0.372 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr18_+_59992519 0.362 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr22_+_38035683 0.362 NM_018957
SH3BP1
SH3-domain binding protein 1
chr10_+_5566923 0.354 NM_005185
CALML3
calmodulin-like 3
chr1_-_16539103 0.352 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chr20_-_22564893 0.337 FOXA2
forkhead box A2
chr6_-_20212628 0.337 NM_001080480
MBOAT1
membrane bound O-acyltransferase domain containing 1
chr4_+_84457390 0.336 NM_032717
AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr2_+_47596286 0.336 NM_002354
EPCAM
epithelial cell adhesion molecule
chr8_-_17555158 0.332 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr19_+_38810461 0.330 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr19_+_45281125 0.329 NM_001130852
NM_012116
CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

chr19_-_51472003 0.325 NM_001012964
NM_001012965
KLK6

kallikrein-related peptidase 6

chr10_+_82213892 0.325 NM_001128309
NM_030927
TSPAN14

tetraspanin 14

chr10_+_82214074 0.325 TSPAN14
tetraspanin 14
chr7_-_108096693 0.324 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr11_+_9779832 0.324 LOC283104
uncharacterized LOC283104
chr10_+_82214071 0.323 TSPAN14
tetraspanin 14
chr2_-_237416091 0.320 NM_024726
IQCA1
IQ motif containing with AAA domain 1
chr6_+_33589045 0.320 NM_002224
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr11_+_43702142 0.318 NM_016142
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr12_-_54778456 0.318 NM_015481
ZNF385A
zinc finger protein 385A
chr6_+_47666288 0.318 NM_153838
GPR115
G protein-coupled receptor 115
chr11_-_5323174 0.318 NM_033179
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr15_+_43985083 0.317 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr19_+_38810540 0.316 KCNK6
potassium channel, subfamily K, member 6
chr15_+_69591272 0.316 NM_017705
PAQR5
progestin and adipoQ receptor family member V
chr3_-_128840343 0.314 RAB43
RAB43, member RAS oncogene family
chr19_-_49567123 0.314 NM_006179
NTF4
neurotrophin 4
chr11_+_576482 0.312 NM_020901
PHRF1
PHD and ring finger domains 1
chr14_+_23842017 0.312 NM_172314
NM_022789
IL25

interleukin 25

chr3_+_10028579 0.311 LOC442075
uncharacterized LOC442075
chr4_+_48018775 0.310 NM_207330
NIPAL1
NIPA-like domain containing 1
chr6_+_125474800 0.306 NM_001003396
NM_001003397
NM_003287
TPD52L1


tumor protein D52-like 1


chr10_-_47173917 0.306 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr3_+_10068123 0.305 FANCD2
Fanconi anemia, complementation group D2
chr10_+_105156430 0.305 PDCD11
programmed cell death 11
chr16_+_27325244 0.303 NM_000418
NM_001008699
IL4R

interleukin 4 receptor

chr4_-_103265818 0.301 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr13_+_80055366 0.301 NDFIP2
Nedd4 family interacting protein 2
chr4_+_74735107 0.300 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_+_207495009 0.299 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr20_+_49348050 0.298 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr5_-_176836488 0.297 F12
coagulation factor XII (Hageman factor)
chr11_-_72380107 0.296 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr12_-_3862217 0.296 EFCAB4B
EF-hand calcium binding domain 4B
chr14_+_21525980 0.295 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr1_-_32264215 0.293 SPOCD1
SPOC domain containing 1
chr3_-_172241060 0.291 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr13_+_80055257 0.291 NM_001161407
NM_019080
NDFIP2

Nedd4 family interacting protein 2

chr3_-_128840605 0.288 NM_001204886
NM_001204887
NM_001204888
NM_198490
NM_001204885
RAB43




RAB43, member RAS oncogene family




chr4_+_75480628 0.286 NM_001657
AREG
amphiregulin
chr17_+_7342688 0.282 NM_004112
FGF11
fibroblast growth factor 11
chr1_+_40420802 0.282 MFSD2A
major facilitator superfamily domain containing 2A
chr7_+_73245192 0.281 NM_001305
CLDN4
claudin 4
chr8_+_95653272 0.280 ESRP1
epithelial splicing regulatory protein 1
chr3_-_139258531 0.279 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr3_+_136537860 0.279 NM_001097599
NM_001097600
NM_025246
TMEM22


transmembrane protein 22


chr10_+_105156382 0.277 NM_014976
PDCD11
programmed cell death 11
chr12_+_83080901 0.276 NM_152588
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr1_+_43766565 0.275 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr19_+_3539154 0.275 NM_001135580
C19orf71
chromosome 19 open reading frame 71
chr5_+_175792444 0.275 NM_173664
ARL10
ADP-ribosylation factor-like 10
chr2_+_47596447 0.273 EPCAM
epithelial cell adhesion molecule
chr3_+_67048726 0.273 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr12_+_83080621 0.272 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr3_+_10068097 0.271 NM_001018115
NM_033084
FANCD2

Fanconi anemia, complementation group D2

chr11_-_1016736 0.271 MUC6
mucin 6, oligomeric mucus/gel-forming
chr1_+_207494816 0.270 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr1_-_11986455 0.270 NM_138346
KIAA2013
KIAA2013
chr1_+_45140393 0.267 NM_001145636
C1orf228
chromosome 1 open reading frame 228
chr16_+_89778242 0.265 LOC100128881
uncharacterized LOC100128881
chr9_+_93564099 0.265 SYK
spleen tyrosine kinase
chr12_-_125348346 0.263 SCARB1
scavenger receptor class B, member 1
chr1_+_31883020 0.263 NM_001199037
SERINC2
serine incorporator 2
chr19_+_35607218 0.262 FXYD3
FXYD domain containing ion transport regulator 3
chr13_+_80055494 0.261 NDFIP2
Nedd4 family interacting protein 2
chr6_+_49518358 0.260 C6orf141
chromosome 6 open reading frame 141
chr1_-_205782135 0.259 NM_173854
SLC41A1
solute carrier family 41, member 1
chr19_-_44285012 0.259 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr6_+_125475334 0.258 NM_001003395
TPD52L1
tumor protein D52-like 1
chr19_+_54371125 0.257 NM_001020819
NM_138373
MYADM

myeloid-associated differentiation marker

chr11_+_10477480 0.257 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr1_-_1051458 0.257 C1orf159
chromosome 1 open reading frame 159
chr1_+_117602944 0.255 NM_003594
TTF2
transcription termination factor, RNA polymerase II
chr6_-_46703042 0.255 PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_-_41623652 0.254 NM_001079675
ETV4
ets variant 4
chr6_-_33756905 0.254 NM_181336
LEMD2
LEM domain containing 2
chr1_-_160990862 0.252 F11R
F11 receptor
chr10_-_62332666 0.252 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr15_+_40531236 0.252 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr19_+_39279849 0.252 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr19_+_54372659 0.251 NM_001020821
NM_001020818
MYADM

myeloid-associated differentiation marker

chr15_+_39873276 0.250 NM_003246
THBS1
thrombospondin 1
chr3_-_12200850 0.249 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr12_-_57410275 0.248 NM_001178054
NM_013251
TAC3

tachykinin 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.13 1.67e-04 GO:0065007 biological regulation
1.46 2.76e-04 GO:0010646 regulation of cell communication
1.50 3.02e-04 GO:0009611 response to wounding
1.61 7.54e-04 GO:0042060 wound healing
1.34 8.83e-04 GO:0023051 regulation of signaling
1.24 1.88e-03 GO:0048731 system development
1.12 4.30e-03 GO:0050789 regulation of biological process
2.10 4.31e-03 GO:0030155 regulation of cell adhesion
1.62 4.66e-03 GO:0007596 blood coagulation
1.62 4.66e-03 GO:0050817 coagulation
2.16 6.13e-03 GO:0034330 cell junction organization
1.61 6.28e-03 GO:0007599 hemostasis
1.21 6.28e-03 GO:0048856 anatomical structure development
1.19 6.35e-03 GO:0032502 developmental process
1.29 6.47e-03 GO:0048583 regulation of response to stimulus
1.34 6.59e-03 GO:0009966 regulation of signal transduction
1.56 7.63e-03 GO:0050878 regulation of body fluid levels
1.27 8.56e-03 GO:0065008 regulation of biological quality
1.12 1.87e-02 GO:0050794 regulation of cellular process
1.07 2.08e-02 GO:0009987 cellular process
2.16 2.23e-02 GO:0034329 cell junction assembly
1.19 2.58e-02 GO:0007275 multicellular organismal development
1.55 4.77e-02 GO:0048585 negative regulation of response to stimulus
1.25 4.78e-02 GO:0030154 cell differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.40 5.61e-04 GO:0005783 endoplasmic reticulum
1.49 1.55e-03 GO:0005789 endoplasmic reticulum membrane
1.45 2.85e-03 GO:0044432 endoplasmic reticulum part
1.47 3.04e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.24 4.11e-03 GO:0044459 plasma membrane part
1.33 1.29e-02 GO:0000267 cell fraction
1.90 2.02e-02 GO:0070161 anchoring junction
1.38 2.53e-02 GO:0005624 membrane fraction
1.56 2.99e-02 GO:0009986 cell surface
1.37 3.43e-02 GO:0005626 insoluble fraction
5.86 4.81e-02 GO:0031095 platelet dense tubular network membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.30e-04 GO:0005515 protein binding