Motif ID: GLI1..3.p2

Z-value: 1.116


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GLI2chr2_+_121554866-0.782.1e-02Click!
GLI3chr7_-_42276617-0.452.6e-01Click!
GLI1chr12_+_57853917-0.285.1e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_52845862 1.521 NM_005555
 KRT6B
keratin 6B
chr19_+_45312294 1.031 NM_001013257
NM_005581
 BCAM

basal cell adhesion molecule (Lutheran blood group)

chr6_+_7541863 1.016 NM_001008844
NM_004415
 DSP

desmoplakin

chr20_+_44637539 0.990 NM_004994
 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_+_183155361 0.971 LAMC2
laminin, gamma 2
chr8_+_124194873 0.947 FAM83A
family with sequence similarity 83, member A
chr1_+_183155173 0.931 NM_005562
NM_018891
 LAMC2

laminin, gamma 2

chr17_-_34122547 0.930 NM_001032278
NM_024302
 MMP28

matrix metallopeptidase 28

chr15_+_41136622 0.906 NM_001032367
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr1_+_44064509 0.892 PTPRF
protein tyrosine phosphatase, receptor type, F
chr5_+_52776408 0.875 FST
follistatin
chr7_+_69064316 0.865 AUTS2
autism susceptibility candidate 2
chr18_+_33877630 0.839 NM_025135
 FHOD3
formin homology 2 domain containing 3
chr1_+_234040547 0.830 NM_173508
 SLC35F3
solute carrier family 35, member F3
chr1_+_183155393 0.798 LAMC2
laminin, gamma 2
chrX_-_78622711 0.789 ITM2A
integral membrane protein 2A
chr10_+_47746919 0.763 NM_001630
 ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr17_+_47572592 0.762 NM_002507
 NGFR
nerve growth factor receptor
chrX_+_152954965 0.751 NM_001142806
 SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr19_+_751108 0.751 NM_173481
 C19orf21
chromosome 19 open reading frame 21

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
2.16 6.13e-03 GO:0034330 cell junction organization
2.16 2.23e-02 GO:0034329 cell junction assembly
2.10 4.31e-03 GO:0030155 regulation of cell adhesion
1.62 4.66e-03 GO:0007596 blood coagulation
1.62 4.66e-03 GO:0050817 coagulation
1.61 7.54e-04 GO:0042060 wound healing
1.61 6.28e-03 GO:0007599 hemostasis
1.56 7.63e-03 GO:0050878 regulation of body fluid levels
1.55 4.77e-02 GO:0048585 negative regulation of response to stimulus
1.50 3.02e-04 GO:0009611 response to wounding
1.46 2.76e-04 GO:0010646 regulation of cell communication
1.34 8.83e-04 GO:0023051 regulation of signaling
1.34 6.59e-03 GO:0009966 regulation of signal transduction
1.29 6.47e-03 GO:0048583 regulation of response to stimulus
1.27 8.56e-03 GO:0065008 regulation of biological quality
1.25 4.78e-02 GO:0030154 cell differentiation
1.24 1.88e-03 GO:0048731 system development
1.21 6.28e-03 GO:0048856 anatomical structure development
1.19 6.35e-03 GO:0032502 developmental process
1.19 2.58e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
5.86 4.81e-02 GO:0031095 platelet dense tubular network membrane
1.90 2.02e-02 GO:0070161 anchoring junction
1.56 2.99e-02 GO:0009986 cell surface
1.49 1.55e-03 GO:0005789 endoplasmic reticulum membrane
1.47 3.04e-03 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.45 2.85e-03 GO:0044432 endoplasmic reticulum part
1.40 5.61e-04 GO:0005783 endoplasmic reticulum
1.38 2.53e-02 GO:0005624 membrane fraction
1.37 3.43e-02 GO:0005626 insoluble fraction
1.33 1.29e-02 GO:0000267 cell fraction
1.24 4.11e-03 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.13 1.30e-04 GO:0005515 protein binding