Motif ID: GTF2I.p2

Z-value: 2.038


Transcription factors associated with GTF2I.p2:

Gene SymbolEntrez IDGene Name
GTF2I 2969 general transcription factor II, i

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2Ichr7_+_740720380.667.8e-02Click!


Activity profile for motif GTF2I.p2.

activity profile for motif GTF2I.p2


Sorted Z-values histogram for motif GTF2I.p2

Sorted Z-values for motif GTF2I.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2I.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_152760452 2.302 BGN
biglycan
chrX_+_152760346 2.301 NM_001711
BGN
biglycan
chr2_+_128175989 1.562 NM_000312
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr2_+_128176019 1.555 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr5_-_81046858 1.464 SSBP2
single-stranded DNA binding protein 2
chr8_+_97506141 1.359 SDC2
syndecan 2
chr8_-_93115453 1.332 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr19_-_2015628 1.326 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr5_-_81046943 1.311 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr5_+_139028025 1.281 NM_016463
CXXC5
CXXC finger protein 5
chr19_-_49149252 1.220 NM_001217
CA11
carbonic anhydrase XI
chr2_+_148778573 1.216 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr7_+_94024201 1.192 COL1A2
collagen, type I, alpha 2
chr7_-_150973819 1.154 NM_001003802
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr13_+_88324777 1.154 NM_015567
SLITRK5
SLIT and NTRK-like family, member 5
chr8_+_97505895 1.136 SDC2
syndecan 2
chr12_+_94542239 1.114 NM_005761
PLXNC1
plexin C1
chr5_-_149535309 1.089 PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr6_+_72596699 1.081 RIMS1
regulating synaptic membrane exocytosis 1
chr14_-_61115906 1.050 NM_005982
SIX1
SIX homeobox 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 139 entries
enrichment   p-value GO term description
1.73 9.38e-03 GO:0007050 cell cycle arrest
1.52 2.53e-04 GO:0001501 skeletal system development
1.51 8.72e-03 GO:0030036 actin cytoskeleton organization
1.48 1.29e-03 GO:0071495 cellular response to endogenous stimulus
1.48 4.46e-02 GO:0007507 heart development
1.47 4.75e-02 GO:0000165 MAPKKK cascade
1.45 8.90e-05 GO:0048812 neuron projection morphogenesis
1.44 3.28e-05 GO:0031175 neuron projection development
1.44 2.30e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
1.44 2.31e-02 GO:0032870 cellular response to hormone stimulus
1.44 4.69e-02 GO:0030029 actin filament-based process
1.43 8.43e-04 GO:0007409 axonogenesis
1.43 4.82e-02 GO:0051130 positive regulation of cellular component organization
1.42 1.86e-05 GO:0048666 neuron development
1.42 7.15e-03 GO:0043009 chordate embryonic development
1.42 8.68e-03 GO:0009792 embryo development ending in birth or egg hatching
1.42 1.23e-02 GO:0007420 brain development
1.41 1.60e-06 GO:0009719 response to endogenous stimulus
1.41 1.35e-05 GO:0009725 response to hormone stimulus
1.41 2.65e-04 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
1.55 2.65e-02 GO:0005912 adherens junction
1.44 8.16e-05 GO:0043005 neuron projection
1.42 8.44e-03 GO:0015629 actin cytoskeleton
1.37 3.01e-03 GO:0045202 synapse
1.23 1.24e-02 GO:0042995 cell projection
1.21 1.66e-06 GO:0005829 cytosol
1.20 3.32e-03 GO:0005654 nucleoplasm
1.12 2.00e-08 GO:0005634 nucleus
1.10 5.60e-12 GO:0005737 cytoplasm
1.08 2.30e-16 GO:0005622 intracellular
1.08 5.54e-15 GO:0044424 intracellular part
1.06 6.70e-05 GO:0043226 organelle
1.06 7.38e-05 GO:0043229 intracellular organelle
1.06 2.49e-04 GO:0043227 membrane-bounded organelle
1.06 2.70e-04 GO:0043231 intracellular membrane-bounded organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 28 entries
enrichment   p-value GO term description
2.96 2.33e-03 GO:0008601 protein phosphatase type 2A regulator activity
2.20 6.78e-03 GO:0019888 protein phosphatase regulator activity
2.10 7.09e-03 GO:0019208 phosphatase regulator activity
1.72 2.73e-04 GO:0003714 transcription corepressor activity
1.61 6.86e-04 GO:0003682 chromatin binding
1.47 3.51e-04 GO:0003779 actin binding
1.43 6.53e-05 GO:0019904 protein domain specific binding
1.43 8.84e-03 GO:0008134 transcription factor binding
1.40 1.75e-11 GO:0001071 nucleic acid binding transcription factor activity
1.40 1.75e-11 GO:0003700 sequence-specific DNA binding transcription factor activity
1.40 2.34e-03 GO:0000988 protein binding transcription factor activity
1.40 2.34e-03 GO:0000989 transcription factor binding transcription factor activity
1.40 3.33e-03 GO:0003712 transcription cofactor activity
1.38 2.06e-06 GO:0043565 sequence-specific DNA binding
1.36 4.44e-04 GO:0008092 cytoskeletal protein binding
1.34 7.74e-08 GO:0030528 transcription regulator activity
1.32 1.05e-03 GO:0046983 protein dimerization activity
1.27 9.25e-03 GO:0019899 enzyme binding
1.25 2.36e-02 GO:0042802 identical protein binding
1.18 2.26e-04 GO:0008270 zinc ion binding