Motif ID: HES1.p2

Z-value: 1.538


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_193853930-0.413.2e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_201368434 0.872 LAD1
ladinin 1
chr18_+_33877630 0.668 NM_025135
 FHOD3
formin homology 2 domain containing 3
chr1_-_94374986 0.626 NM_002061
 GCLM
glutamate-cysteine ligase, modifier subunit
chr22_+_45098091 0.620 NM_181334
 PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr21_-_46962281 0.594 NM_001205206
NM_194255
 SLC19A1

solute carrier family 19 (folate transporter), member 1

chr10_-_14646237 0.575 FAM107B
family with sequence similarity 107, member B
chr19_+_39833132 0.573 SAMD4B
sterile alpha motif domain containing 4B
chr1_+_234040547 0.568 NM_173508
 SLC35F3
solute carrier family 35, member F3
chr2_-_96811138 0.555 NM_004418
 DUSP2
dual specificity phosphatase 2
chr1_-_33430285 0.544 NM_001127361
NM_153341
 RNF19B

ring finger protein 19B

chr8_+_31497267 0.544 NM_013962
 NRG1
neuregulin 1
chr1_-_231175971 0.539 NM_198552
 FAM89A
family with sequence similarity 89, member A
chr7_-_44365019 0.532 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr16_+_577833 0.526 NM_005632
 SOLH
small optic lobes homolog (Drosophila)
chr5_+_149737296 0.498 TCOF1
Treacher Collins-Franceschetti syndrome 1
chr16_+_30194730 0.490 NM_001193333
NM_007074
 CORO1A

coronin, actin binding protein, 1A

chr1_-_201368617 0.485 NM_005558
 LAD1
ladinin 1
chr2_-_38604380 0.480 ATL2
atlastin GTPase 2
chr16_-_85784628 0.480 NM_206967
 C16orf74
chromosome 16 open reading frame 74
chr9_-_126030792 0.477 NM_018387
 STRBP
spermatid perinuclear RNA binding protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 114 entries
enrichment   p-value GO term description
6.54 4.96e-02 GO:0018026 peptidyl-lysine monomethylation
2.36 7.28e-03 GO:0018196 peptidyl-asparagine modification
2.36 7.28e-03 GO:0018279 protein N-linked glycosylation via asparagine
2.28 1.22e-02 GO:0006487 protein N-linked glycosylation
2.18 3.39e-02 GO:0043414 macromolecule methylation
1.96 9.93e-03 GO:0006730 one-carbon metabolic process
1.91 1.03e-02 GO:0016569 covalent chromatin modification
1.91 1.39e-02 GO:0016570 histone modification
1.89 5.64e-07 GO:0016568 chromatin modification
1.85 4.59e-02 GO:0006913 nucleocytoplasmic transport
1.81 7.02e-04 GO:0071900 regulation of protein serine/threonine kinase activity
1.80 1.51e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.76 1.59e-04 GO:0051301 cell division
1.75 2.21e-03 GO:0051329 interphase of mitotic cell cycle
1.72 4.59e-03 GO:0051325 interphase
1.70 1.09e-07 GO:0051276 chromosome organization
1.69 3.06e-05 GO:0006325 chromatin organization
1.68 5.30e-05 GO:0045859 regulation of protein kinase activity
1.67 2.58e-06 GO:0000278 mitotic cell cycle
1.67 5.38e-03 GO:0018193 peptidyl-amino acid modification

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
enrichment   p-value GO term description
2.68 2.18e-02 GO:0017053 transcriptional repressor complex
2.16 1.20e-02 GO:0016585 chromatin remodeling complex
2.13 3.97e-02 GO:0046930 pore complex
1.78 3.17e-02 GO:0070161 anchoring junction
1.64 7.47e-06 GO:0005730 nucleolus
1.54 1.91e-12 GO:0005654 nucleoplasm
1.53 3.24e-21 GO:0044428 nuclear part
1.53 2.08e-17 GO:0031981 nuclear lumen
1.48 1.06e-02 GO:0000139 Golgi membrane
1.46 6.46e-03 GO:0005694 chromosome
1.45 7.25e-17 GO:0031974 membrane-enclosed lumen
1.45 2.24e-16 GO:0070013 intracellular organelle lumen
1.44 8.77e-16 GO:0043233 organelle lumen
1.44 1.10e-03 GO:0044451 nucleoplasm part
1.44 8.39e-03 GO:0044431 Golgi apparatus part
1.36 7.11e-09 GO:0005829 cytosol
1.34 1.25e-05 GO:0012505 endomembrane system
1.31 3.14e-02 GO:0005794 Golgi apparatus
1.27 3.20e-19 GO:0005634 nucleus
1.27 1.41e-18 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
2.85 2.42e-02 GO:0016278 lysine N-methyltransferase activity
2.85 2.42e-02 GO:0016279 protein-lysine N-methyltransferase activity
2.62 3.43e-03 GO:0008276 protein methyltransferase activity
2.30 1.83e-03 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
1.96 9.50e-04 GO:0016741 transferase activity, transferring one-carbon groups
1.94 2.13e-03 GO:0000287 magnesium ion binding
1.94 2.13e-03 GO:0008168 methyltransferase activity
1.79 1.63e-02 GO:0003682 chromatin binding
1.66 6.27e-05 GO:0004674 protein serine/threonine kinase activity
1.64 3.31e-07 GO:0004672 protein kinase activity
1.64 8.20e-03 GO:0016564 transcription repressor activity
1.62 1.82e-02 GO:0008134 transcription factor binding
1.58 8.28e-04 GO:0016874 ligase activity
1.56 9.20e-07 GO:0019899 enzyme binding
1.55 4.09e-03 GO:0019904 protein domain specific binding
1.54 4.55e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.51 3.72e-06 GO:0003723 RNA binding
1.50 2.53e-14 GO:0016740 transferase activity
1.50 1.25e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.49 3.30e-05 GO:0016301 kinase activity