Motif ID: HIC1.p2

Z-value: 1.263


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512		0.945.4e-04Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_101420032 2.243 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr15_+_41136622 2.171 NM_001032367
 SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_101420004 2.104 NM_000693
 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr14_-_105635114 1.974 NM_002226
NM_145159
 JAG2

jagged 2

chr14_-_105634708 1.826 JAG2
jagged 2
chr8_-_41166931 1.733 NM_003012
 SFRP1
secreted frizzled-related protein 1
chr17_+_54671059 1.657 NM_005450
 NOG
noggin
chr18_-_28681885 1.503 NM_004949
NM_024422
 DSC2

desmocollin 2

chr2_-_46384 1.321 NM_001077710
 FAM110C
family with sequence similarity 110, member C
chr1_-_62784971 1.314 KANK4
KN motif and ankyrin repeat domains 4
chr1_+_117452359 1.296 NM_020440
 PTGFRN
prostaglandin F2 receptor negative regulator
chr8_+_61591358 1.204 CHD7
chromodomain helicase DNA binding protein 7
chr2_-_70781146 1.183 NM_001099691
NM_003236
 TGFA

transforming growth factor, alpha

chr1_-_62785067 1.151 NM_181712
 KANK4
KN motif and ankyrin repeat domains 4
chr8_+_61591239 1.127 NM_017780
 CHD7
chromodomain helicase DNA binding protein 7
chr15_+_41136178 1.116 NM_003710
NM_181642
 SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_-_48462561 1.095 NM_001194986
 LOC388630
UPF0632 protein A
chr7_+_26191732 1.084 NM_004289
 NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr1_+_109792640 1.067 NM_001408
 CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr14_+_65171149 1.027 NM_015549
 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 123 entries
enrichment   p-value GO term description
2.53 1.74e-02 GO:0001707 mesoderm formation
2.35 9.46e-03 GO:0001704 formation of primary germ layer
1.89 3.73e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.78 8.57e-04 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.73 4.27e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.67 2.57e-06 GO:0048729 tissue morphogenesis
1.62 2.49e-03 GO:0002009 morphogenesis of an epithelium
1.61 2.07e-04 GO:0035295 tube development
1.61 2.14e-02 GO:0032582 negative regulation of gene-specific transcription
1.60 2.77e-02 GO:0048732 gland development
1.56 7.86e-08 GO:0007417 central nervous system development
1.55 8.13e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.51 4.12e-03 GO:0001501 skeletal system development
1.51 1.09e-02 GO:0001944 vasculature development
1.51 1.33e-02 GO:0051270 regulation of cellular component movement
1.50 6.30e-03 GO:0060284 regulation of cell development
1.49 1.81e-05 GO:0000904 cell morphogenesis involved in differentiation
1.49 3.69e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.49 4.21e-02 GO:0051960 regulation of nervous system development
1.48 4.36e-03 GO:0007420 brain development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
1.76 5.44e-05 GO:0070161 anchoring junction
1.76 2.11e-04 GO:0005912 adherens junction
1.47 1.95e-02 GO:0005667 transcription factor complex
1.34 2.27e-03 GO:0030054 cell junction
1.32 8.93e-03 GO:0044431 Golgi apparatus part
1.32 4.72e-02 GO:0000139 Golgi membrane
1.29 1.48e-04 GO:0005794 Golgi apparatus
1.27 4.12e-02 GO:0005789 endoplasmic reticulum membrane
1.22 1.16e-06 GO:0044459 plasma membrane part
1.22 5.03e-04 GO:0012505 endomembrane system
1.22 2.88e-02 GO:0005783 endoplasmic reticulum
1.20 9.93e-05 GO:0031090 organelle membrane
1.20 1.97e-02 GO:0005654 nucleoplasm
1.18 3.96e-03 GO:0031981 nuclear lumen
1.16 9.04e-03 GO:0044428 nuclear part
1.10 4.90e-09 GO:0043227 membrane-bounded organelle
1.10 5.85e-09 GO:0043231 intracellular membrane-bounded organelle
1.10 3.79e-06 GO:0016020 membrane
1.10 1.25e-03 GO:0005634 nucleus
1.09 2.03e-06 GO:0005737 cytoplasm

Gene overrepresentation in function category:

Showing 1 to 20 of 38 entries
enrichment   p-value GO term description
2.87 4.95e-02 GO:0004712 protein serine/threonine/tyrosine kinase activity
2.78 4.30e-02 GO:0035250 UDP-galactosyltransferase activity
2.47 3.90e-02 GO:0008378 galactosyltransferase activity
1.89 2.54e-03 GO:0016566 specific transcriptional repressor activity
1.85 2.76e-02 GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
1.76 7.12e-06 GO:0010843 promoter binding
1.69 6.99e-05 GO:0000975 regulatory region DNA binding
1.69 6.99e-05 GO:0001067 regulatory region nucleic acid binding
1.69 6.99e-05 GO:0044212 transcription regulatory region DNA binding
1.51 6.28e-04 GO:0016563 transcription activator activity
1.48 1.03e-07 GO:0004672 protein kinase activity
1.47 7.13e-05 GO:0004674 protein serine/threonine kinase activity
1.46 9.26e-03 GO:0016564 transcription repressor activity
1.46 1.39e-02 GO:0008134 transcription factor binding
1.41 2.13e-03 GO:0019904 protein domain specific binding
1.40 1.93e-06 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.38 5.40e-05 GO:0043565 sequence-specific DNA binding
1.36 2.71e-06 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.36 2.32e-05 GO:0016301 kinase activity
1.35 7.58e-07 GO:0030528 transcription regulator activity