Motif ID: HIF1A.p2

Z-value: 2.008


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_62162042,
chr14_+_62164339		-0.715.1e-02Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_95653272 4.777 ESRP1
epithelial splicing regulatory protein 1
chr22_+_40390935 3.638 NM_138435
 FAM83F
family with sequence similarity 83, member F
chr17_-_3599298 3.213 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr11_+_69924407 2.721 NM_018043
 ANO1
anoctamin 1, calcium activated chloride channel
chr1_+_117452359 2.511 NM_020440
 PTGFRN
prostaglandin F2 receptor negative regulator
chr22_+_45148437 2.503 NM_001017526
NM_001198726
NM_181335
 ARHGAP8


Rho GTPase activating protein 8


chr11_+_32851469 2.425 NM_024081
 PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr22_+_45098091 2.418 NM_181334
 PRR5-ARHGAP8
PRR5
PRR5-ARHGAP8 readthrough
proline rich 5 (renal)
chr6_+_36098261 2.413 NM_002754
 MAPK13
mitogen-activated protein kinase 13
chr3_-_57113292 2.409 NM_001128615
 ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr13_-_20806533 2.357 NM_001110219
NM_001110220
NM_001110221
 GJB6


gap junction protein, beta 6, 30kDa


chr17_-_3599359 2.356 P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_74497406 2.287 NM_024599
 RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr8_+_31497267 2.168 NM_013962
 NRG1
neuregulin 1
chr1_+_65613211 2.055 NM_203464
NM_001005353
 AK4

adenylate kinase 4

chr8_-_75233461 2.004 NM_020647
 JPH1
junctophilin 1
chr4_+_106816593 1.995 NM_001033047
NM_001184690
NM_001184691
NM_001184692
NM_001184693
 NPNT




nephronectin




chr2_+_47596447 1.972 EPCAM
epithelial cell adhesion molecule
chr1_+_65613971 1.888 AK4
adenylate kinase 4
chr14_-_105634708 1.853 JAG2
jagged 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
5.11 1.93e-02 GO:0071407 cellular response to organic cyclic compound
1.29 2.45e-07 GO:0044260 cellular macromolecule metabolic process
1.29 1.44e-02 GO:0044267 cellular protein metabolic process
1.27 1.07e-02 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.26 2.80e-03 GO:0006807 nitrogen compound metabolic process
1.25 2.28e-09 GO:0044237 cellular metabolic process
1.25 1.04e-02 GO:0034641 cellular nitrogen compound metabolic process
1.21 6.42e-04 GO:0043170 macromolecule metabolic process
1.19 6.87e-05 GO:0044238 primary metabolic process
1.18 1.39e-05 GO:0008152 metabolic process
1.13 5.35e-09 GO:0009987 cellular process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
4.29 1.97e-02 GO:0044452 nucleolar part
2.28 6.46e-03 GO:0031965 nuclear membrane
1.73 6.54e-04 GO:0005730 nucleolus
1.56 1.26e-03 GO:0044432 endoplasmic reticulum part
1.54 1.00e-02 GO:0005789 endoplasmic reticulum membrane
1.52 1.47e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.40 1.80e-02 GO:0005783 endoplasmic reticulum
1.35 4.44e-03 GO:0012505 endomembrane system
1.31 1.42e-03 GO:0070013 intracellular organelle lumen
1.30 3.38e-03 GO:0031090 organelle membrane
1.29 2.05e-03 GO:0031974 membrane-enclosed lumen
1.29 3.25e-03 GO:0043233 organelle lumen
1.29 5.19e-03 GO:0044428 nuclear part
1.21 7.60e-15 GO:0043227 membrane-bounded organelle
1.21 8.20e-15 GO:0043231 intracellular membrane-bounded organelle
1.21 5.73e-07 GO:0044444 cytoplasmic part
1.19 8.59e-05 GO:0005634 nucleus
1.18 6.74e-04 GO:0044446 intracellular organelle part
1.17 5.81e-12 GO:0043226 organelle
1.17 1.11e-11 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.21 4.71e-03 GO:0016741 transferase activity, transferring one-carbon groups
2.15 1.61e-02 GO:0008168 methyltransferase activity
1.49 1.36e-02 GO:0003723 RNA binding
1.36 1.26e-03 GO:0016740 transferase activity
1.36 5.15e-03 GO:0030554 adenyl nucleotide binding
1.36 5.44e-03 GO:0032559 adenyl ribonucleotide binding
1.36 6.99e-03 GO:0005524 ATP binding
1.31 9.64e-04 GO:0000166 nucleotide binding
1.31 8.09e-03 GO:0032553 ribonucleotide binding
1.31 8.09e-03 GO:0032555 purine ribonucleotide binding
1.31 8.25e-03 GO:0017076 purine nucleotide binding
1.31 1.13e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.17 4.11e-03 GO:0003824 catalytic activity
1.16 8.29e-05 GO:0005515 protein binding
1.08 1.76e-03 GO:0005488 binding