Motif ID: HMX1.p2

Z-value: 1.794


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMX1chr4_-_88734530.413.1e-01Click!


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_105634708 4.149 JAG2
jagged 2
chr8_+_95653272 3.164 ESRP1
epithelial splicing regulatory protein 1
chr1_-_27286875 2.846 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr8_-_75233461 2.649 NM_020647
JPH1
junctophilin 1
chr1_+_156030965 2.238 NM_020387
RAB25
RAB25, member RAS oncogene family
chr11_+_69924407 2.193 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr19_+_35607218 2.176 FXYD3
FXYD domain containing ion transport regulator 3
chr14_-_105635114 1.998 NM_002226
NM_145159
JAG2

jagged 2

chr3_-_111314181 1.863 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr19_-_10697907 1.848 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_+_38755097 1.848 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755238 1.825 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr8_+_31497267 1.774 NM_013962
NRG1
neuregulin 1
chr6_-_136871956 1.758 NM_001198616
NM_001198617
NM_003980
MAP7


microtubule-associated protein 7


chr19_+_38755422 1.754 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr12_+_4382882 1.730 NM_001759
CCND2
cyclin D2
chr9_-_136024522 1.692 NM_001042368
RALGDS
ral guanine nucleotide dissociation stimulator
chr7_+_145813828 1.661 CNTNAP2
contactin associated protein-like 2
chr17_-_7166263 1.504 NM_001185023
NM_001307
CLDN7

claudin 7

chr9_-_23821477 1.475 NM_001171197
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr1_+_183155393 1.442 LAMC2
laminin, gamma 2
chr1_+_35247838 1.399 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr1_+_60280462 1.383 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr10_+_71390002 1.361 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr6_-_136871542 1.345 MAP7
microtubule-associated protein 7
chr5_+_68788387 1.326 NM_001205254
OCLN
occludin
chr8_+_102504836 1.305 GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_102504661 1.274 NM_024915
GRHL2
grainyhead-like 2 (Drosophila)
chr8_+_82644663 1.258 NM_152284
CHMP4C
charged multivesicular body protein 4C
chr16_-_68269948 1.252 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr3_-_57113292 1.249 NM_001128615
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr12_-_58160823 1.209 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr17_-_31203889 1.196 NM_015194
MYO1D
myosin ID
chr2_+_203499819 1.114 NM_173511
FAM117B
family with sequence similarity 117, member B
chr12_-_54778456 1.105 NM_015481
ZNF385A
zinc finger protein 385A
chr8_+_120220554 1.075 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr13_+_25254548 1.051 NM_001185085
NM_001676
ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide

chr17_+_9548853 1.035 NM_153210
USP43
ubiquitin specific peptidase 43
chr1_+_26856259 1.009 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_-_11430502 0.991 NM_005114
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr1_+_82266081 0.969 NM_012302
LPHN2
latrophilin 2
chr9_-_125941304 0.967 STRBP
spermatid perinuclear RNA binding protein
chr1_-_207095198 0.959 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr9_-_139948448 0.959 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr6_+_150464156 0.954 NM_030949
PPP1R14C
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr6_+_41606193 0.951 NM_005586
MDFI
MyoD family inhibitor
chr1_-_59042827 0.941 TACSTD2
tumor-associated calcium signal transducer 2
chr2_-_165478357 0.936 NM_004490
GRB14
growth factor receptor-bound protein 14
chr17_-_7165788 0.931 CLDN7
claudin 7
chr1_+_95558072 0.924 NM_001199679
TMEM56
transmembrane protein 56
chr18_-_47721165 0.917 NM_001080467
MYO5B
myosin VB
chr11_+_45944155 0.904 GYLTL1B
glycosyltransferase-like 1B
chr8_+_86089618 0.889 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr19_+_55587220 0.887 NM_133180
EPS8L1
EPS8-like 1
chr20_+_43803539 0.879 NM_002638
PI3
peptidase inhibitor 3, skin-derived
chr12_+_7060543 0.842 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060531 0.836 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr4_-_74486100 0.835 NM_177532
NM_201431
RASSF6

Ras association (RalGDS/AF-6) domain family member 6

chr2_-_216878314 0.831 NM_018000
MREG
melanoregulin
chrX_-_78622711 0.830 ITM2A
integral membrane protein 2A
chr1_-_7973286 0.820 UTS2
urotensin 2
chr12_+_7060517 0.813 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_28503454 0.797 NM_000952
NM_001164723
PTAFR

platelet-activating factor receptor

chr12_+_7060538 0.791 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr18_+_11981552 0.789 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr4_-_10023094 0.782 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr18_+_11981421 0.778 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr17_-_31204071 0.777 MYO1D
myosin ID
chr8_+_32405727 0.754 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr12_+_7060554 0.754 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr11_-_63933493 0.752 NM_014067
MACROD1
MACRO domain containing 1
chr8_+_86089641 0.743


chr1_+_95582827 0.739 NM_152487
TMEM56
transmembrane protein 56
chr9_+_841689 0.736 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr19_+_6464259 0.735 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr17_+_73717596 0.722 ITGB4
integrin, beta 4
chr17_+_73717556 0.719 ITGB4
integrin, beta 4
chr10_+_11865310 0.711 NM_153256
C10orf47
chromosome 10 open reading frame 47
chr1_+_26856252 0.707 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr7_-_36406446 0.704 NM_001199707
NM_001199706
NM_015314
NM_001199708
KIAA0895



KIAA0895



chr6_+_36098261 0.703 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr17_-_38657814 0.699 NM_032865
TNS4
tensin 4
chr12_+_7060433 0.698 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr8_+_98881277 0.693 NM_002380
NM_030583
MATN2

matrilin 2

chr7_-_752742 0.689 NM_001164761
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr4_+_6911456 0.688 NM_020773
TBC1D14
TBC1 domain family, member 14
chr21_-_43187265 0.684 RIPK4
receptor-interacting serine-threonine kinase 4
chr8_+_24772454 0.678 NM_001105541
NEFM
neurofilament, medium polypeptide
chr1_+_95285900 0.678 NM_001114106
SLC44A3
solute carrier family 44, member 3
chr21_-_43187197 0.677 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr4_+_85504056 0.677 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr20_-_46414636 0.675 NM_018837
SULF2
sulfatase 2
chr18_+_12254317 0.674 NM_001279
CIDEA
cell death-inducing DFFA-like effector a
chr4_+_75310852 0.670 NM_001657
AREG
amphiregulin
chr14_-_99947080 0.668 SETD3
SET domain containing 3
chr1_+_6052758 0.664 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr1_+_6052699 0.663 KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr11_+_59522801 0.662 STX3
syntaxin 3
chr11_-_17035948 0.658 NM_175058
PLEKHA7
pleckstrin homology domain containing, family A member 7
chr17_+_73717515 0.657 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr20_+_49348050 0.652 NM_032521
PARD6B
par-6 partitioning defective 6 homolog beta (C. elegans)
chr11_+_59522905 0.650 STX3
syntaxin 3
chr17_-_73874634 0.644 NM_033452
TRIM47
tripartite motif containing 47
chr15_+_89182038 0.643 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_40509628 0.643 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr6_-_13486986 0.643 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr19_-_38746978 0.640 PPP1R14A
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr9_+_22447064 0.638


chr10_-_99531712 0.636 NM_003015
SFRP5
secreted frizzled-related protein 5
chr4_+_6911094 0.631 NM_001113361
TBC1D14
TBC1 domain family, member 14
chr5_+_56111379 0.629 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr8_+_32504250 0.629 NM_013959
NRG1
neuregulin 1
chr3_+_113666544 0.626 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr11_-_63933204 0.624 MACROD1
MACRO domain containing 1
chr10_+_126150340 0.623 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr4_+_41258941 0.620 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr1_+_110163667 0.618 AMPD2
adenosine monophosphate deaminase 2
chr5_+_68485367 0.616 NM_022909
CENPH
centromere protein H
chr3_-_128840343 0.605 RAB43
RAB43, member RAS oncogene family
chr4_-_84256304 0.604 NM_001166498
NM_006665
HPSE

heparanase

chr1_-_32801606 0.602 NM_023009
MARCKSL1
MARCKS-like 1
chr3_-_128840605 0.600 NM_001204886
NM_001204887
NM_001204888
NM_198490
NM_001204885
RAB43




RAB43, member RAS oncogene family




chr17_+_40714420 0.599


chr2_-_165477818 0.594 GRB14
growth factor receptor-bound protein 14
chr5_+_68710938 0.594 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr6_+_80340971 0.592 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr6_-_2245655 0.592 NM_001500
GMDS
GDP-mannose 4,6-dehydratase
chr1_-_160068261 0.588 IGSF8
immunoglobulin superfamily, member 8
chr7_-_16844606 0.585 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr14_+_65171149 0.583 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_+_41136178 0.583 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_+_206730456 0.579 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr12_+_104850762 0.579 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr4_+_6911537 0.578 TBC1D14
TBC1 domain family, member 14
chr12_+_122356446 0.571 NM_001178003
NM_144668
WDR66

WD repeat domain 66

chr20_+_30639981 0.569 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr7_-_37488554 0.551 NM_014800
ELMO1
engulfment and cell motility 1
chr1_-_160068617 0.545 NM_001206665
IGSF8
immunoglobulin superfamily, member 8
chr16_-_48269087 0.542 NM_032583
NM_145186
ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

chr17_-_73874056 0.541 TRIM47
tripartite motif containing 47
chrX_+_37545008 0.541 NM_021083
XK
X-linked Kx blood group (McLeod syndrome)
chr6_-_31550065 0.539 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chrX_-_78623006 0.538 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr11_+_68079999 0.530 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr14_-_23623493 0.529 NM_182728
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr19_+_45843997 0.525 NM_177417
KLC3
kinesin light chain 3
chr1_-_160068359 0.516 NM_052868
IGSF8
immunoglobulin superfamily, member 8
chr8_-_24772229 0.513 NEFM
neurofilament, medium polypeptide
chr2_-_165477986 0.510 GRB14
growth factor receptor-bound protein 14
chr9_+_135854097 0.504 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr4_-_90758126 0.497 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr17_-_74533623 0.497 NM_134268
CYGB
cytoglobin
chr18_+_55711890 0.493 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_67070918 0.492 NM_017857
SSH3
slingshot homolog 3 (Drosophila)
chr6_-_32157511 0.490 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr1_+_15256295 0.490 NM_001018001
KAZN
kazrin, periplakin interacting protein
chr11_-_19223516 0.489 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr1_+_183155173 0.484 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr7_-_41742666 0.481 NM_002192
INHBA
inhibin, beta A
chr3_+_50192420 0.481 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr11_+_67070987 0.480 SSH3
slingshot homolog 3 (Drosophila)
chr21_+_43710190 0.479 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr4_+_3465032 0.478 NM_001164673
NM_173660
DOK7

docking protein 7

chr7_-_156803224 0.472 NM_005515
MNX1
motor neuron and pancreas homeobox 1
chr6_+_33043702 0.460 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_-_217311095 0.459 NM_001134285
ESRRG
estrogen-related receptor gamma
chr1_+_3371020 0.458 NM_014448
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr5_+_56110899 0.458 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr20_-_6103860 0.457 FERMT1
fermitin family member 1
chr12_+_104850641 0.455 NM_001173982
NM_018413
CHST11

carbohydrate (chondroitin 4) sulfotransferase 11

chr14_-_51561657 0.455 TRIM9
tripartite motif containing 9
chr1_+_6106173 0.454 NM_001199863
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr2_-_220436267 0.453 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr17_-_8151353 0.452 CTC1
CTS telomere maintenance complex component 1
chr9_+_22446783 0.451 NM_022160
DMRTA1
DMRT-like family A1
chr1_-_6557448 0.450 PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_-_38747171 0.450 NM_001243947
NM_033256
PPP1R14A

protein phosphatase 1, regulatory (inhibitor) subunit 14A

chr9_-_135996287 0.448 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr7_+_26191732 0.443 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr7_+_156803599 0.439 LOC645249
uncharacterized LOC645249
chr8_-_66753968 0.438 NM_001242318
PDE7A
phosphodiesterase 7A
chr20_-_6103562 0.437 FERMT1
fermitin family member 1
chr1_-_160990862 0.436 F11R
F11 receptor
chr1_+_6052357 0.435 NM_001199861
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr16_+_84682126 0.433 NM_024731
KLHL36
kelch-like 36 (Drosophila)
chr4_-_110650965 0.433 NM_030821
PLA2G12A
phospholipase A2, group XIIA
chr19_-_41220977 0.431 ADCK4
aarF domain containing kinase 4
chr1_+_183155361 0.430 LAMC2
laminin, gamma 2
chr17_-_9694613 0.429 NM_001105571
NM_001220493
DHRS7C

dehydrogenase/reductase (SDR family) member 7C

chr4_+_81106423 0.426 NM_020226
PRDM8
PR domain containing 8
chr1_+_206730497 0.426 RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr9_-_131940481 0.425 IER5L
immediate early response 5-like
chr1_-_109940497 0.424 NM_002959
SORT1
sortilin 1
chr12_+_110152186 0.423 NM_032829
C12orf34
chromosome 12 open reading frame 34
chr6_-_40555111 0.421 NM_020737
LRFN2
leucine rich repeat and fibronectin type III domain containing 2
chr4_+_41258895 0.421 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr20_+_45523523 0.418 EYA2
eyes absent homolog 2 (Drosophila)
chr1_+_226411318 0.416 NM_031944
MIXL1
Mix paired-like homeobox
chr3_+_10857867 0.415 NM_014229
SLC6A11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_-_105948464 0.414 NM_152433
NM_198439
KBTBD3

kelch repeat and BTB (POZ) domain containing 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.11 2.07e-05 GO:0009987 cellular process
1.47 4.29e-03 GO:0050790 regulation of catalytic activity
2.84 5.97e-03 GO:0051216 cartilage development
1.28 7.13e-03 GO:0048518 positive regulation of biological process
1.40 7.88e-03 GO:0065009 regulation of molecular function
3.59 1.14e-02 GO:0060560 developmental growth involved in morphogenesis
1.48 1.19e-02 GO:0043067 regulation of programmed cell death
1.48 1.25e-02 GO:0042981 regulation of apoptosis
1.81 1.58e-02 GO:0007264 small GTPase mediated signal transduction
1.34 1.62e-02 GO:0048513 organ development
1.47 1.65e-02 GO:0010941 regulation of cell death
1.22 2.12e-02 GO:0023052 signaling
1.29 2.18e-02 GO:0048522 positive regulation of cellular process
1.13 2.94e-02 GO:0065007 biological regulation
2.04 3.20e-02 GO:0048011 nerve growth factor receptor signaling pathway
1.38 3.20e-02 GO:0009966 regulation of signal transduction
1.23 3.23e-02 GO:0007165 signal transduction
1.39 3.72e-02 GO:0035556 intracellular signal transduction
1.35 3.78e-02 GO:0023051 regulation of signaling
1.71 3.91e-02 GO:0051094 positive regulation of developmental process
8.08 4.68e-02 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.37 4.02e-05 GO:0005829 cytosol
1.27 1.93e-02 GO:0044459 plasma membrane part
1.10 3.67e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.18 1.45e-06 GO:0005515 protein binding
5.65 4.54e-04 GO:0004864 protein phosphatase inhibitor activity
5.17 4.71e-04 GO:0019212 phosphatase inhibitor activity
1.08 1.67e-03 GO:0005488 binding
1.82 3.53e-02 GO:0004857 enzyme inhibitor activity